Glioblastoma multiforme(GBM),defined as IDH-wild-type diffuse gliomas(WHO CNS grade IV),is the most common and aggressive primary brain tumor.1 Age significantly influences GBM,with mutational landscape varied by age....Glioblastoma multiforme(GBM),defined as IDH-wild-type diffuse gliomas(WHO CNS grade IV),is the most common and aggressive primary brain tumor.1 Age significantly influences GBM,with mutational landscape varied by age.2 One of the most significant updates in the 2021 WHO classification is the division of diffuse gliomas into pediatric-type and adult-type gliomas,reflecting the growing understanding of their distinct molecular drivers and prognostic implications.展开更多
基金supported by the National Natural Science Foundation of China(No.82373403 to Y.C.)the Association Foundation Program of Yunnan Provincial Science and Technology Department and Kunming Medical University(China)(No.202001AY070001-160 to P.D.)the Special Grant for High-level Personnel of Yunnan Province,China(No.L-2019020 to P.D.)。
文摘Glioblastoma multiforme(GBM),defined as IDH-wild-type diffuse gliomas(WHO CNS grade IV),is the most common and aggressive primary brain tumor.1 Age significantly influences GBM,with mutational landscape varied by age.2 One of the most significant updates in the 2021 WHO classification is the division of diffuse gliomas into pediatric-type and adult-type gliomas,reflecting the growing understanding of their distinct molecular drivers and prognostic implications.
