Alkaloids,a diverse group of naturally occurring organic compounds have demonstrated significant potential in the management of allergic responses.These bioactive compounds are commonly found in plants and possess var...Alkaloids,a diverse group of naturally occurring organic compounds have demonstrated significant potential in the management of allergic responses.These bioactive compounds are commonly found in plants and possess various pharmacological properties including immunomodulatory,anti-inflammatory and antihistaminic effects.Recent studies highlight their ability to inhibit the release of histamines and other proinflammatory mediators such as interleukins,NF-κB,TNF-α,CD4+regulatory T cells and T helper 2(Th2)cells etc.,thereby reducing the severity of allergic reactions.Alkaloids such as berberine,ephedrine and quinine have shown particular promises in preclinical models.Additionally,the modulation of immune cells activity by alkaloids suggests their role in preventing the onset of allergic symptoms.Despite these promising findings,further research is needed to fully elucidate the molecular mechanism and to explore the therapeutic potential of many alkaloids in clinical settings.This review discusses the source and potential of alkaloids as therapeutic agents in treating allergic conditions and examines the mechanism through which they exert their anti-allergy effects.展开更多
基金supported by Postdoctoral research startup funding from Zhejiang Sci-Tech University(22042342-Y).
文摘Alkaloids,a diverse group of naturally occurring organic compounds have demonstrated significant potential in the management of allergic responses.These bioactive compounds are commonly found in plants and possess various pharmacological properties including immunomodulatory,anti-inflammatory and antihistaminic effects.Recent studies highlight their ability to inhibit the release of histamines and other proinflammatory mediators such as interleukins,NF-κB,TNF-α,CD4+regulatory T cells and T helper 2(Th2)cells etc.,thereby reducing the severity of allergic reactions.Alkaloids such as berberine,ephedrine and quinine have shown particular promises in preclinical models.Additionally,the modulation of immune cells activity by alkaloids suggests their role in preventing the onset of allergic symptoms.Despite these promising findings,further research is needed to fully elucidate the molecular mechanism and to explore the therapeutic potential of many alkaloids in clinical settings.This review discusses the source and potential of alkaloids as therapeutic agents in treating allergic conditions and examines the mechanism through which they exert their anti-allergy effects.
