Objective Observational studies have found associations between inflammatory bowel disease(IBD)and the risk of dementia,including Alzheimer’s dementia(AD)and vascular dementia(VD);however,these findings are inconsist...Objective Observational studies have found associations between inflammatory bowel disease(IBD)and the risk of dementia,including Alzheimer’s dementia(AD)and vascular dementia(VD);however,these findings are inconsistent.It remains unclear whether these associations are causal.Methods We conducted a meta-analysis by systematically searching for observational studies on the association between IBD and dementia.Mendelian randomization(MR)analysis based on summary genome-wide association studies(GWASs)was performed.Genetic correlation and Bayesian colocalization analyses were used to provide robust genetic evidence.Results Ten observational studies involving 80,565,688 participants were included in this metaanalysis.IBD was significantly associated with dementia(risk ratio[RR]=1.36,95%CI=1.04-1.78;I2=84.8%)and VD(RR=2.60,95%CI=1.18-5.70;only one study),but not with AD(RR=2.00,95%CI=0.96-4.13;I^(2)=99.8%).MR analyses did not supported significant causal associations of IBD with dementia(dementia:odds ratio[OR]=1.01,95%CI=0.98-1.03;AD:OR=0.98,95%CI=0.95-1.01;VD:OR=1.02,95%CI=0.97-1.07).In addition,genetic correlation and co-localization analyses did not reveal any genetic associations between IBD and dementia.Conclusion Our study did not provide genetic evidence for a causal association between IBD and dementia risk.The increased risk of dementia observed in observational studies may be attributed to unobserved confounding factors or detection bias.展开更多
Data analysis on tokamak plasmas is mainly based on various diagnostic systems,which are usually modularized and independent of each other.This leads to a large amount of data not being fully and effectively exploited...Data analysis on tokamak plasmas is mainly based on various diagnostic systems,which are usually modularized and independent of each other.This leads to a large amount of data not being fully and effectively exploited so that it is not conducive to revealing the deep physical mechanism.In this work,Bayesian probability inference with machine learning methods have been applied to the electron cyclotron emission and Thomson scattering diagnostic systems on HL-2A/2M,and the effects of integrated data analysis(IDA)on the electron temperature of HL-2A with Bayesian probability inference are demonstrated.A program is developed to infer the whole electron temperature profile with a confidence interval,and the program can be applied in online analysis.The IDA results show that the full profile of the electron temperature can be obtained and the diagnostic information is more comprehensive and abundant with IDA.The inference models for electron temperature analysis are established and the developed programs will serve as an experimental data analysis tool for HL-2A/2M in the near future.展开更多
A newly developed Doppler coherence imaging spectroscopy(CIS)technique has been implemented in the HL-2 A tokamak for carbon impurity emissivity and flow measurement.In CIS diagnostics,the emissivity and flow profiles...A newly developed Doppler coherence imaging spectroscopy(CIS)technique has been implemented in the HL-2 A tokamak for carbon impurity emissivity and flow measurement.In CIS diagnostics,the emissivity and flow profiles inside the plasma are measured by a camera from the line-integrated emissivity and line-averaged flow,respectively.A standard inference method,called tomographic inversion,is necessary.Such an inversion is relatively challenging due to the ill-conditioned nature.In this article,we report the recent application and comparison of two different tomography algorithms,Gaussian process tomography and Tikhonov tomography,on light intensity measured by CIS,including feasibility and benchmark studies.Finally,the tomographic results for real measurement data in HL-2A are presented.展开更多
Summary What is already known about this topic?During the coronavirus disease 2019(COVID-19)pandemic,tremendous efforts have been made in countries to suppress epidemic peaks and strengthen hospital services to avoid ...Summary What is already known about this topic?During the coronavirus disease 2019(COVID-19)pandemic,tremendous efforts have been made in countries to suppress epidemic peaks and strengthen hospital services to avoid hospital strain and ultimately reduce the risk of death from COVID-19.However,there is limited empirical evidence that hospital strain increases COVID-19 deaths.展开更多
What is already known about this topic?After the initial coronavirus disease 2019(COVID-19)outbreak in Wuhan,China,the outbreaks during the dynamic-zero policy period in the mainland of China have not been systematica...What is already known about this topic?After the initial coronavirus disease 2019(COVID-19)outbreak in Wuhan,China,the outbreaks during the dynamic-zero policy period in the mainland of China have not been systematically documented.What is added by this report?We summarized the characteristics of 74 imported COVID-19 outbreaks between March 19,2020 and December 31,2021.All outbreaks of early severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants were successfully contained with the aid of nucleic acid testing,modern communication technologies,and non-pharmacological interventions.What are the implications for public health practice?These findings provide us with confidence for the containment of future emerging infectious diseases alike at early stages to prevent pandemics or to win time to gain experience,develop vaccines and drugs,vaccinate people,and wait for the possible lessening of the virus’pathogenicity.展开更多
基金supported by the China Postdoctoral Science Foundation(Grant No.2021M703366)Shenzhen Science and Technology Program(Grant No.KQTD20190929172835662).
文摘Objective Observational studies have found associations between inflammatory bowel disease(IBD)and the risk of dementia,including Alzheimer’s dementia(AD)and vascular dementia(VD);however,these findings are inconsistent.It remains unclear whether these associations are causal.Methods We conducted a meta-analysis by systematically searching for observational studies on the association between IBD and dementia.Mendelian randomization(MR)analysis based on summary genome-wide association studies(GWASs)was performed.Genetic correlation and Bayesian colocalization analyses were used to provide robust genetic evidence.Results Ten observational studies involving 80,565,688 participants were included in this metaanalysis.IBD was significantly associated with dementia(risk ratio[RR]=1.36,95%CI=1.04-1.78;I2=84.8%)and VD(RR=2.60,95%CI=1.18-5.70;only one study),but not with AD(RR=2.00,95%CI=0.96-4.13;I^(2)=99.8%).MR analyses did not supported significant causal associations of IBD with dementia(dementia:odds ratio[OR]=1.01,95%CI=0.98-1.03;AD:OR=0.98,95%CI=0.95-1.01;VD:OR=1.02,95%CI=0.97-1.07).In addition,genetic correlation and co-localization analyses did not reveal any genetic associations between IBD and dementia.Conclusion Our study did not provide genetic evidence for a causal association between IBD and dementia risk.The increased risk of dementia observed in observational studies may be attributed to unobserved confounding factors or detection bias.
基金supported by the National Magnetic Confinement Fusion Energy Research and Development Program of China(Nos.2019YFE03090100,2019YFE03040004)the National Science Foundation for Young Scientists of China(No.12005052)。
文摘Data analysis on tokamak plasmas is mainly based on various diagnostic systems,which are usually modularized and independent of each other.This leads to a large amount of data not being fully and effectively exploited so that it is not conducive to revealing the deep physical mechanism.In this work,Bayesian probability inference with machine learning methods have been applied to the electron cyclotron emission and Thomson scattering diagnostic systems on HL-2A/2M,and the effects of integrated data analysis(IDA)on the electron temperature of HL-2A with Bayesian probability inference are demonstrated.A program is developed to infer the whole electron temperature profile with a confidence interval,and the program can be applied in online analysis.The IDA results show that the full profile of the electron temperature can be obtained and the diagnostic information is more comprehensive and abundant with IDA.The inference models for electron temperature analysis are established and the developed programs will serve as an experimental data analysis tool for HL-2A/2M in the near future.
文摘A newly developed Doppler coherence imaging spectroscopy(CIS)technique has been implemented in the HL-2 A tokamak for carbon impurity emissivity and flow measurement.In CIS diagnostics,the emissivity and flow profiles inside the plasma are measured by a camera from the line-integrated emissivity and line-averaged flow,respectively.A standard inference method,called tomographic inversion,is necessary.Such an inversion is relatively challenging due to the ill-conditioned nature.In this article,we report the recent application and comparison of two different tomography algorithms,Gaussian process tomography and Tikhonov tomography,on light intensity measured by CIS,including feasibility and benchmark studies.Finally,the tomographic results for real measurement data in HL-2A are presented.
基金the Shenzhen Science and Technology Programs(JSGG20220301090202005,KQTD20190929172835662).
文摘Summary What is already known about this topic?During the coronavirus disease 2019(COVID-19)pandemic,tremendous efforts have been made in countries to suppress epidemic peaks and strengthen hospital services to avoid hospital strain and ultimately reduce the risk of death from COVID-19.However,there is limited empirical evidence that hospital strain increases COVID-19 deaths.
基金Supported by the Shenzhen Science and Technology Programs(RKX20210901150004012,KQTD20190929172835662,JSGG20220301090202005).
文摘What is already known about this topic?After the initial coronavirus disease 2019(COVID-19)outbreak in Wuhan,China,the outbreaks during the dynamic-zero policy period in the mainland of China have not been systematically documented.What is added by this report?We summarized the characteristics of 74 imported COVID-19 outbreaks between March 19,2020 and December 31,2021.All outbreaks of early severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants were successfully contained with the aid of nucleic acid testing,modern communication technologies,and non-pharmacological interventions.What are the implications for public health practice?These findings provide us with confidence for the containment of future emerging infectious diseases alike at early stages to prevent pandemics or to win time to gain experience,develop vaccines and drugs,vaccinate people,and wait for the possible lessening of the virus’pathogenicity.
