Reaction kinetics of nanoparticles can be controlled by tuning the Peclet number(Pe)as it is an essential parameter in synthesis of multi-sized nanoparticles.Herein,we propose to implement a self-driven multi-dimensio...Reaction kinetics of nanoparticles can be controlled by tuning the Peclet number(Pe)as it is an essential parameter in synthesis of multi-sized nanoparticles.Herein,we propose to implement a self-driven multi-dimension microchannels reactor(MMR)for the one droplet synthesis of multi-sized nanoparticles.By carefully controlling the Pe at the gas-liquid interface,the newly formed seed crystals selectively accumulate and grow to a specific size.By the combination of microchannels of different widths and lengths,one droplet reaction in the same apparatus achieves the synchronous synthesis of diverse nanoparticles.MMR enables precise control of nanoparticle diameter at 5 nm precision in the range of 10-110 nm.The use of MMR can be extended to the synthesis of uniform Ag,Au,Pt,and Pd nanoparticles,opening towards the production and engineering of nanostructured materials.This approach gives the chance to regulate the accumulation probability for precise synthesis of nanoparticles with different diameters.展开更多
High refractive index(HRI,n>1.8)photonic structures offer strong light confinement and refractive efficiencies,cover the entire visible spectrum and can be tuned by designing geometric arrayed features.However,its ...High refractive index(HRI,n>1.8)photonic structures offer strong light confinement and refractive efficiencies,cover the entire visible spectrum and can be tuned by designing geometric arrayed features.However,its practical applications are still hindered by the applicability and material limitation of lithography-based micro/nano fabrication approaches.Herein,we demonstrate a fluid-guided printing process for preparing HRI selenium microarrays.The microstructured flexible template is replicated from the diced silicon wafer without any lithography-based methods.When heated above the glass transition temperature,the flow characteristics of selenium endows the structure downsizing and orientation patterning between the target substrate and the template.Near 10 times narrowing selenium microarrays(1.9μm width)are patterned from the non-lithography template(18μm width).HRI selenium microarrays offer high refractive efficiencies and strong optical confinement abilities,which achieve angledependent structurally coloration and polarization.Meanwhile,the color difference can be recognized under the one degree distinction of the angle between incident and refracted light.This printing platform will facilitate HRI optical metasurfaces in a variety of applications,ranging from photonic sensor,polarization modulation to light manipulation.展开更多
Histopathology plays a great role in diagnosing various diseases,which is considered as a golden standard for tumor identification.The tissue constituents must be stained by visible labels for microscopic analysis by ...Histopathology plays a great role in diagnosing various diseases,which is considered as a golden standard for tumor identification.The tissue constituents must be stained by visible labels for microscopic analysis by medical experts.However,this process is time-consuming,labor-intensive,and expensive,which requires rapid pathological approaches for diagnosis in the operating room.Here,we present an easy-to-process and high-performance perovskite biological probes for rapid and visual pathological diagnosis of glioma.Perovskite quantum dots can be encapsulated by the copolymer into nanocrystals(PNCs)with a diameter of 100 nm,which is modified with chlorotoxin to achieve the specific recognition of glioma.Benefiting from the super photoluminescence quantum yield(above 93%)of EVA@PNCs aqueous solution,the glioma can be clearly imaged and captured via a smartphone under the excitation of a handheld UV lamp.To demonstrate the visualization and efficiency of PNC probes,different malignant grades of brain tumor sections can be distinguished in no more than 5 min.This strategy provides a general auxiliary diagnosis platform for achieving the histopathology analysis near the operating bed,which is currently not feasible with standard histochemical staining methods.展开更多
基金supported by the National Key R&D Program of China(2023YFE0111500 and 2023YFC3040900)the National Natural Science Foundation of China(52222313,22075296,52321006,T2394480,T2394484 and 52203247)+2 种基金the China Postdoctoral Science Foundation(2022TQ0340)Beijing National Laboratory for Molecular Sciences(BNLMS-CXXM-202005)Junior Fellow Program of Beijing National Laboratory for Molecular Sciences(2021BMS20063)。
基金supported by the Beijing Nova Program from Beijing Municipal Science&Technology Commission(Nos.Z201100006820037 and Z211100002121001)the National Key R&D Program of China(No.2018YFA0208501)+3 种基金the National Natural Science Foundation of China(Nos.22075296,91963212,and 51961145102)the Youth Innovation Promotion Association,the Chinese Academy of Sciences(No.2020032)Beijing National Laboratory for Molecular Sciences(No.BNLMS-CXXM-202005)F.F.Q.and J.C.acknowledge the Swiss National Super Computing Center(Project No.s1081)for providing the computing support.B.D.C.acknowledges Jiarong Yang for his support in graphing.
文摘Reaction kinetics of nanoparticles can be controlled by tuning the Peclet number(Pe)as it is an essential parameter in synthesis of multi-sized nanoparticles.Herein,we propose to implement a self-driven multi-dimension microchannels reactor(MMR)for the one droplet synthesis of multi-sized nanoparticles.By carefully controlling the Pe at the gas-liquid interface,the newly formed seed crystals selectively accumulate and grow to a specific size.By the combination of microchannels of different widths and lengths,one droplet reaction in the same apparatus achieves the synchronous synthesis of diverse nanoparticles.MMR enables precise control of nanoparticle diameter at 5 nm precision in the range of 10-110 nm.The use of MMR can be extended to the synthesis of uniform Ag,Au,Pt,and Pd nanoparticles,opening towards the production and engineering of nanostructured materials.This approach gives the chance to regulate the accumulation probability for precise synthesis of nanoparticles with different diameters.
基金the National Key R&D Program of China(2018YFA0208501)the National Natural Science Foundation of China(51803217,51773206,91963212,and 51961145102(BRICS Project))+3 种基金the Youth Innovation Promotion Association CAS(2020032)Beijing National Laboratory for Molecular Sciences(BNLMS-CXXM-202005)Russian Foundation for Basic Research(19-52-80036(BRICS Project))K.C.Wong Education Foundation。
文摘High refractive index(HRI,n>1.8)photonic structures offer strong light confinement and refractive efficiencies,cover the entire visible spectrum and can be tuned by designing geometric arrayed features.However,its practical applications are still hindered by the applicability and material limitation of lithography-based micro/nano fabrication approaches.Herein,we demonstrate a fluid-guided printing process for preparing HRI selenium microarrays.The microstructured flexible template is replicated from the diced silicon wafer without any lithography-based methods.When heated above the glass transition temperature,the flow characteristics of selenium endows the structure downsizing and orientation patterning between the target substrate and the template.Near 10 times narrowing selenium microarrays(1.9μm width)are patterned from the non-lithography template(18μm width).HRI selenium microarrays offer high refractive efficiencies and strong optical confinement abilities,which achieve angledependent structurally coloration and polarization.Meanwhile,the color difference can be recognized under the one degree distinction of the angle between incident and refracted light.This printing platform will facilitate HRI optical metasurfaces in a variety of applications,ranging from photonic sensor,polarization modulation to light manipulation.
基金National Natural Science Foundation of China,Grant/Award Numbers:52222313,22075296,91963212,32271108Beijing Municipal Science and Technology Commission,Grant/Award Numbers:Z201100006820037,Z211100002121001+1 种基金Youth Innovation Promotion Association CAS,Grant/Award Number:2020032Beijing National Laboratory for Molecular Sciences,Grant/Award Number:BNLMSCXXM-202005。
文摘Histopathology plays a great role in diagnosing various diseases,which is considered as a golden standard for tumor identification.The tissue constituents must be stained by visible labels for microscopic analysis by medical experts.However,this process is time-consuming,labor-intensive,and expensive,which requires rapid pathological approaches for diagnosis in the operating room.Here,we present an easy-to-process and high-performance perovskite biological probes for rapid and visual pathological diagnosis of glioma.Perovskite quantum dots can be encapsulated by the copolymer into nanocrystals(PNCs)with a diameter of 100 nm,which is modified with chlorotoxin to achieve the specific recognition of glioma.Benefiting from the super photoluminescence quantum yield(above 93%)of EVA@PNCs aqueous solution,the glioma can be clearly imaged and captured via a smartphone under the excitation of a handheld UV lamp.To demonstrate the visualization and efficiency of PNC probes,different malignant grades of brain tumor sections can be distinguished in no more than 5 min.This strategy provides a general auxiliary diagnosis platform for achieving the histopathology analysis near the operating bed,which is currently not feasible with standard histochemical staining methods.
