Objective:Guided by the theory of syndrome differentiation of yin and yang in traditional Chinese medicine surgery,through visual observation of internal medicine thoracoscope,comprehensive observation of pleural cavi...Objective:Guided by the theory of syndrome differentiation of yin and yang in traditional Chinese medicine surgery,through visual observation of internal medicine thoracoscope,comprehensive observation of pleural cavity and immunohistochemistry of biopsy tissue,to classify malignant pleural effusion according to syndrome differentiation,and to explore the scientific nature of its theory.Methods:From March 1,2014 to February 28,2015,40 cases of malignant pleural effusion were treated in Beijing Chaoyang Hospital affiliated to Capital Medical University.According to the proposed TCM diagnostic criteria for yin and yang syndrome differentiation,and collect age,gender,course of disease,clinical symptoms,tumor primary focus,histomorphological manifestations and immunohistochemical results and other related information,and carry out statistical data processing.Results:The positive syndrome was mainly metastatic lung adenocarcinoma,which accounted for the majority of all MPE cases,up to 75%.The immunohistochemical results of biopsy tissues were mainly CEA and TTF-1 positive;While pleural effusion caused by pleural mesothelioma was the main type of yin syndrome,and the results of immunohistochemistry combined with biopsy were mainly positive for D2-40,Calretinin,WT-1 and CK5/6.Conclusion:TCM syndrome differentiation of MPE based on internal thoracoscopy combined with biopsy immunohistochemical results has sufficient theoretical basis and certain scientific nature,and further clinical research is needed to verify its effectiveness and practicability in the future.展开更多
To the Editor:Prostate cancer is one of the most common malignant tumors of the male genital system,with approximately 1.1 million new cases in 2012.[1]The accurate diagnosis of prostate cancer leads to a better chanc...To the Editor:Prostate cancer is one of the most common malignant tumors of the male genital system,with approximately 1.1 million new cases in 2012.[1]The accurate diagnosis of prostate cancer leads to a better chance of successful treatment when it is still confined to the prostate gland.The Gleason grading(GD)system was first established by Donald Gleason during 1966 to 1974.[2,3]The Gleason pattern ranges from 1 to 5.A higher score corresponds to poorer differentiation,which indicates a worse prognosis and higher metastasis possibility.The total score is calculated with the first half of the dominant Gleason pattern and the second half based on the non-dominant one.展开更多
文摘Objective:Guided by the theory of syndrome differentiation of yin and yang in traditional Chinese medicine surgery,through visual observation of internal medicine thoracoscope,comprehensive observation of pleural cavity and immunohistochemistry of biopsy tissue,to classify malignant pleural effusion according to syndrome differentiation,and to explore the scientific nature of its theory.Methods:From March 1,2014 to February 28,2015,40 cases of malignant pleural effusion were treated in Beijing Chaoyang Hospital affiliated to Capital Medical University.According to the proposed TCM diagnostic criteria for yin and yang syndrome differentiation,and collect age,gender,course of disease,clinical symptoms,tumor primary focus,histomorphological manifestations and immunohistochemical results and other related information,and carry out statistical data processing.Results:The positive syndrome was mainly metastatic lung adenocarcinoma,which accounted for the majority of all MPE cases,up to 75%.The immunohistochemical results of biopsy tissues were mainly CEA and TTF-1 positive;While pleural effusion caused by pleural mesothelioma was the main type of yin syndrome,and the results of immunohistochemistry combined with biopsy were mainly positive for D2-40,Calretinin,WT-1 and CK5/6.Conclusion:TCM syndrome differentiation of MPE based on internal thoracoscopy combined with biopsy immunohistochemical results has sufficient theoretical basis and certain scientific nature,and further clinical research is needed to verify its effectiveness and practicability in the future.
基金supported by the National Natural Science Foundation of China(22171105 and 12004384)Shandong Provincial Natural Science Foundation(ZR2020KB012,ZR2021MB001,and ZR2022YQ14)+1 种基金the Fund of State Key Laboratory of Structural Chemistry(20210015)the Special Foundation of Taishan Scholar Project.
基金National Natural Science Foundation of China(No.61532001)Tsinghua Initiative Research Program(No.20151080475)。
文摘To the Editor:Prostate cancer is one of the most common malignant tumors of the male genital system,with approximately 1.1 million new cases in 2012.[1]The accurate diagnosis of prostate cancer leads to a better chance of successful treatment when it is still confined to the prostate gland.The Gleason grading(GD)system was first established by Donald Gleason during 1966 to 1974.[2,3]The Gleason pattern ranges from 1 to 5.A higher score corresponds to poorer differentiation,which indicates a worse prognosis and higher metastasis possibility.The total score is calculated with the first half of the dominant Gleason pattern and the second half based on the non-dominant one.
