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《注射用多黏菌素用于儿童的临床实践指南》计划书 被引量:2
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作者 唐琳 沈姗 +8 位作者 邹东娜 冷冰 聂瑞芳 金炎 林丽开 曾宪涛 翟所迪 张伶俐 侯宁 《药物流行病学杂志》 CAS 2023年第11期1231-1237,共7页
为促进多黏菌素在儿童患者中的合理使用,山东省药学会立项,由山东第一医科大学附属省立医院牵头,参照《世界卫生组织指南制订手册》及卫生保健实践指南的报告规范(RIGHT)等标准与要求,组织全国相关领域知名专家编写《注射用多黏菌素用... 为促进多黏菌素在儿童患者中的合理使用,山东省药学会立项,由山东第一医科大学附属省立医院牵头,参照《世界卫生组织指南制订手册》及卫生保健实践指南的报告规范(RIGHT)等标准与要求,组织全国相关领域知名专家编写《注射用多黏菌素用于儿童的临床实践指南》。本指南计划书主要介绍该指南的制订背景、目的与意义、应用人群、指南制作方法和流程,使指南编写全过程规范透明,通过全面的证据检索、规范的证据评价、科学的推荐意见形成方法,提高指南的严谨性和科学性。 展开更多
关键词 多黏菌素 儿童用药 抗感染 指南计划书
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Highly efficient visible-light photocatalytic degradation and antibacterial activity by GaN:ZnO solid solution nanoparticles 被引量:3
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作者 bing leng Xinglai Zhang +7 位作者 Shanshan Chen Jing Li Ziqing Sun Zongyi Ma Wenjin Yang bingchun Zhang Ke Yang Shu Guo 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2021年第35期67-76,共10页
The development of high-efficiency photocatalysts is the primary goal in the field of photocatalytic antibacterial research.In this work,the Ga N:Zn O solid solution nanoparticles(NPs)photocatalyst with strong visible... The development of high-efficiency photocatalysts is the primary goal in the field of photocatalytic antibacterial research.In this work,the Ga N:Zn O solid solution nanoparticles(NPs)photocatalyst with strong visible absorption and large specific surface area was synthesized via the sol-gel and nitridation reaction process.Also,we systematically investigated the removal efficiency of the organic pollutant and antibacterial activity on E.coli and S.aureus.Notably,methylene blue solution could be completely degraded after 100 min of visible light illumination using 2 mg/m L Ga N:Zn O catalyst.Moreover,~94%of the E.coli were inactivated within 120 min,whereas 100%antibacterial activity against S.aureus was achieved after 90 min of visible light illumination mediated by Ga N:Zn O NPs.We further explore the potential mechanism of visible light photocatalytic antibacterial activity enhanced by Ga N:Zn O NPs photocatalyst.The current work not only provides a new and efficient photocatalytic antibacterial nanomaterial but also demonstrates its promising applications in environmental and biological fields. 展开更多
关键词 GaN:ZnO solid solution Photocatalysis ANTIBACTERIAL Photocatalytic degradation PHOTOCATALYSTS
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SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma mimicking solid pseudopapillary neoplasm: A case report and review of the literature 被引量:2
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作者 Yinan Hua Piyush Soni +3 位作者 Douglas Larsen Riyam Zreik bing leng Debby Rampisela 《World Journal of Gastroenterology》 SCIE CAS 2020年第36期5520-5526,共7页
BACKGROUND SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma is a very aggressive tumor that is rarely reported in the literature.The tumor has a predominant rhabdoid cell component and different p... BACKGROUND SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma is a very aggressive tumor that is rarely reported in the literature.The tumor has a predominant rhabdoid cell component and different patterns of growth have been reported.CASE SUMMARY A 59-year-old woman presented with diffuse abdominal pain,increasing in severity and accompanied by weight loss,nausea,and vomiting.Imaging showed a pancreatic head mass.Fine needle aspiration demonstrated atypical epithelioid cells with a pseudopapillary growth pattern suggestive of solid pseudopapillary neoplasm.The excised neoplasm showed monotonous epithelioid and focally spindle cells with pseudopapillary structures,rhabdoid features,and loss of SMARCB1 protein expression with wild-type KRAS,consistent with a SMARCB1/INI1-deficient undifferentiated rhabdoid carcinoma.The patient’s condition deteriorated rapidly following surgery and she expired 3 mo post operation.CONCLUSION In this article,we report the first case of SMARCB1/INI1-deficient undifferentiated pancreatic rhabdoid carcinoma mimicking solid pseudopapillary neoplasm. 展开更多
关键词 Pancreatic undifferentiated rhabdoid carcinoma Solid pseudopapillary neoplasm SMARCB1/INI1 KRAS Case report
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Photoresponsive organic field-effect transistors involving photochromic molecules 被引量:1
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作者 Li-Na Fu bing leng +1 位作者 Yong-Sheng Li Xi-Ke Gao 《Chinese Chemical Letters》 SCIE CAS CSCD 2016年第8期1319-1329,共11页
In recent years,organic field-effect transistors(OFETs) with high performance and novel multifunctionalities have attracted considerable attention.Meanwhile,featured with reversible photoisomerization and the corres... In recent years,organic field-effect transistors(OFETs) with high performance and novel multifunctionalities have attracted considerable attention.Meanwhile,featured with reversible photoisomerization and the corresponding variation in color,chemical/physical properties,photochromic molecules have been applied in sensors,photo-switches and memories.Incorporation of photochromic molecules to blend in the device functional layers or to modify the interfaces of OFETs is common way to build photo-transistors.In this review,we focus on the recent advantages on the study of photoresponsive transistors involving one of three typical photochromic compounds spiropyran,diarylethene and azobenzene.Three main strategies are demonstrated in detail.Firstly,photochromic molecules are doped in active layers or combined with semiconductor structure thus forming photoreversible active layers.Secondly,the modification of dielectric layer/active layer interface is mainly carried out by bilayer dielectric.Thirdly,the photo-isomerization of self-assembled monolayer(SAM) on the electrode/active layer interface can reversibly modulate the work functions and charge injection barrier,result in bifunctional OFETs.All in all,the combination of photochromic molecules and OFETs is an efficient way for the fabrication of organic photoelectric devices.Photoresponsive transistors consisted of photochromic molecules are potential candidate for real applications in the future. 展开更多
关键词 Organic field-effect transistors Photoresponsive transistors Photochromic molecules SPIROPYRAN DIARYLETHENE AZOBENZENE
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High-performance and broadband photodetection of bicrystalline(GaN)_(1-x)(ZnO)_(x)solid solution nanowires via crystal defect engineering 被引量:1
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作者 Zongyi Ma Gang Li +8 位作者 Xinglai Zhang Jing Li Cai Zhang Yonghui Ma Jian Zhang bing leng Natalia Usoltseva Vladimir An Baodan Liu 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2021年第26期255-262,共8页
Crystal defect engineering is widely used as an effective approach to regulate the optical and optoelectronic properties of semiconductor nanostructures.However,photogenerated electron-hole pair recombination centers ... Crystal defect engineering is widely used as an effective approach to regulate the optical and optoelectronic properties of semiconductor nanostructures.However,photogenerated electron-hole pair recombination centers caused by structural defects usually lead to the reduction of optoelectronic performance.In this work,a high-performance photodetector based on(GaN)_(1-x)(ZnO)_(x)solid solution nanowire with bicrystal structure is fabricated and it shows excellent photoresponse to ultraviolet and visible light.The highest responsivity of the photodetector is as high as 60,86 and 43 A/W under the irradiation of365 nm,532 nm and 650 nm,respectively.The corresponding response time is as fast as 170,320 and 160 ms.Such wide spectral responses can be attributed to various intermediate energy levels induced by the introduction of various structural defects and dopants in the solid solution nanowire.Moreover,the peculiar bicrystal boundary along the axial direction of the nanowire provides two parallel and fast transmission channels for photo-generated carriers,reducing the recombination of photo-generated carriers.Our findings provide a valued example using crystal defect engineering to broaden the photoresponse range and improve the photodetector performance and thus can be extended to other material systems for various optoelectronic applications. 展开更多
关键词 (GaN)1-x(ZnO)x NANOWIRES Photodetectors Broadband photodetection Crystal defect engineering
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Fine-tuning the molecular energy levels by incorporating thiophene units onto the π-backbone of core-expanded naphthalene diimides
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作者 Dong Lu Xiao-Chun Yang +4 位作者 bing leng Xiao-Di Yang Cong-Wu Ge Xue-Shun Jia Xi-Ke Gao 《Chinese Chemical Letters》 SCIE CAS CSCD 2016年第7期1022-1026,共5页
A series of core-expanded naphthalene diimides(NDI-DTYM) and thiophene-based derivatives(1a-c)were designed and synthesized to investigate the relationship between molecular structures and the highest occupied mol... A series of core-expanded naphthalene diimides(NDI-DTYM) and thiophene-based derivatives(1a-c)were designed and synthesized to investigate the relationship between molecular structures and the highest occupied molecular orbital(HOMO) energy levels but has little impact on the lowest unoccupied molecular orbital(LUMO) energy levels.The results demonstrated that increasing the number of thiophene units can gradually elevate the HOMO energy levels but had little impact on the LUMO energy levels.The n-channel organic field-effect transistors(OFETs) based on 1b and 1c have demonstrated that these almost unchanged LUMO energy levels are proper to transport electrons. 展开更多
关键词 Naphthalene diimide THIOPHENE Molecular energy level Organic transistor Organic semiconductor
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Photoresponsive n-channel organic field-effect transistors based on a tri-component active layer
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作者 Li-Na Fu bing leng +1 位作者 Yong-Sheng Li Xi-Ke Gao 《Chinese Chemical Letters》 SCIE CAS CSCD 2018年第1期175-178,共4页
Introducing photochromic molecules into the active layer of organic field-effect transistors (OFETs) is a direct way to implement a photoresponse nature in OFETs. However, active layer blended photo- responsive tran... Introducing photochromic molecules into the active layer of organic field-effect transistors (OFETs) is a direct way to implement a photoresponse nature in OFETs. However, active layer blended photo- responsive transistors based on n-type semiconductors are challenging and rarely studied, which are crucial for multifunctional organic-based logic applications. Herein, we fabricated n-channel photo- responsive OFETs based on a tri-component active layer spin-coated from the mixed solution of an n-type semiconductor (NDI2OD-DTYM2), spiropyran and polystyrene with a weight ratio of 1:1:1. The morphology of the blended films was improved by the introduction of the polymer matrix. Photochromic spiropyran molecules dispersed in the semiconductor layer could switch between the closed-ring state and ionic open-ring state flexibly under the irradiation of different wavelengths of light, and thus change the channel conductivity reversibly and modulate the OFET characteristics. Therefore, under the irradiation of alternate UV and vis light, both the device carrier mobility and current on and off ratio successfully realized a reversible switch. 展开更多
关键词 Organic field-effect transistorsPhotoresponsen-Type organic semiconductorSpiropyranPolystyrene
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Problems and Strategies:A Study of Cross-Cultural Adaptation of Chinese Undergraduates in the Philippines
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作者 bing leng 《Journal of Contemporary Educational Research》 2022年第11期28-35,共8页
Investigating the intercultural adaptation of Chinese undergraduates in the Philippines provides an effective example of bridging the gap between theories of intercultural adaptation.A questionnaire and interviews wer... Investigating the intercultural adaptation of Chinese undergraduates in the Philippines provides an effective example of bridging the gap between theories of intercultural adaptation.A questionnaire and interviews were conducted to explore the problems and challenges faced by Chinese undergraduates in the Philippines,thereby providing some first-hand information for subsequent studies on cultural adaptation.Chinese undergraduates in the Philippines faced four main challenges,namely interpersonal communication,living environment,social services,and course study.As coping strategies,four suggestions are presented,including cultural integration,life experience,bridge building,and rational docking. 展开更多
关键词 Cross-cultural adaptation Chinese undergraduates in the Philippines Problems and strategies
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Numerical Investigation of Rainfall-Induced Shear Crack Propagation in Railway Embankment Slopes
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作者 Jiye Chen Min Fu +1 位作者 Sudath Loku-Pathirage bing leng 《Computer Modeling in Engineering & Sciences》 2026年第3期341-361,共21页
Slope failures,particularly in railway embankments during intense rainfall,are a major cause of economic damage and humanitarian loss.To forecast how shear cracks develop in slopes under heavy precipitation,we present... Slope failures,particularly in railway embankments during intense rainfall,are a major cause of economic damage and humanitarian loss.To forecast how shear cracks develop in slopes under heavy precipitation,we present a novel modeling framework:the Extended Cohesive Damage Element enhanced by soil moisture(SMECDE).The method first translates forecasted rainfall into soil moisture levels via an established correspondence.Then,recognizing that rainfall infiltration lowers soil cohesion—particularly at varying depths—we introduce a Soil Moisture Decoherence Model(SMDM)based on experimental data,which quantifies how cohesion degrades with moisture and how depth affects this process.By embedding SMDM within the ECDE technique,we investigate how shear fractures propagate under different moisture conditions throughout the slope profile.We apply SMECDE to a real railway embankment case to identify critical moisture thresholds and crack growth patterns.Validation is performed by comparing predictions against field measurements and weather station records,and further checked through simulations of large-scale plastic deformation in ABAQUS. 展开更多
关键词 Soil moisture extended cohesive damage element method railway slope shear crack propagation soil moisture-rainfall intensity correlation soil moisture decohesion model
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MATRIEX imaging:multiarea two-photon real-time in vivo explorer 被引量:8
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作者 Mengke Yang Zhenqiao Zhou +19 位作者 Jianxiong Zhang Shanshan Jia Tong Li Jiangheng Guan Xiang Liao bing leng Jing Lyu Kuan Zhang Min Li Yan Gong Zhiming Zhu Junan Yan Yi Zhou Jian K Liu Zsuzsanna Varga Arthur Konnerth Yuguo Tang Jinsong Gao Xiaowei Chen Hongbo Jia 《Light: Science & Applications》 SCIE EI CAS CSCD 2019年第1期156-166,共11页
Two-photon laser scanning microscopy has been extensively applied to study in vivo neuronal activity at cellular and subcellular resolutions in mammalian brains.However,the extent of such studies is typically confined... Two-photon laser scanning microscopy has been extensively applied to study in vivo neuronal activity at cellular and subcellular resolutions in mammalian brains.However,the extent of such studies is typically confined to a single functional region of the brain.Here,we demonstrate a novel technique,termed the multiarea two-photon real-time in vivo explorer(MATRIEX),that allows the user to target multiple functional brain regions distributed within a zone of up to 12mm in diameter,each with a field of view(FOV)of ~200μm in diameter,thus performing two-photon Ca2+imaging with single-cell resolution in all of the regions simultaneously.For example,we demonstrate real-time functional imaging of single-neuron activities in the primary visual cortex,primary motor cortex and hippocampal CA1 region of mice in both anesthetized and awake states.A unique advantage of the MATRIEX technique is the configuration of multiple microscopic FOVs that are distributed in three-dimensional space over macroscopic distances(>1 mm)both laterally and axially but that are imaged by a single conventional laser scanning device.In particular,the MATRIEX technique can be effectively implemented as an add-on optical module for an existing conventional single-beam-scanning two-photon microscope without requiring any modification to the microscope itself.Thus,the MATRIEX technique can be readily applied to substantially facilitate the exploration of multiarea neuronal activity in vivo for studies of brain-wide neural circuit function with single-cell resolution. 展开更多
关键词 PHOTON readily typically
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High-performance ultraviolet-visible photodetector with high sensitivity and fast response speed based on MoS_(2)-on-ZnO photogating heterojunction 被引量:7
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作者 Xing-Lai Zhang Jing Li +8 位作者 bing leng Liu Yang Yan-Dong Song Si-Yu Feng Li-Zhi Feng Zi-Tong Liu Zheng-Wei Fu Xin Jiang Bao-Dan Liu 《Tungsten》 EI CSCD 2023年第1期91-99,共9页
Photogating is an effective strategy to modulate the channel conductance of the device with light-induced gate field or voltage,thereby improving the performance of optoelectronic devices.In this work,to overcome the ... Photogating is an effective strategy to modulate the channel conductance of the device with light-induced gate field or voltage,thereby improving the performance of optoelectronic devices.In this work,to overcome the long response time and low photoresponse of one-dimensional ZnO,a MoS_(2)-on-ZnO photogating vertical heterojunction photodetector is design and constructed.Herein,the ZnO nanowire with high carrier mobility can response ultraviolet light and supply a highspeed carrier transport channel,while the MoS_(2) flake as a photogating layer can response with visible light and transfer photogenerated electrons into the ZnO nanowire to adjust its conductivity.Thus,the irradiation of visible light is equivalent to applying a photo-induced gate voltage on the ZnO nanowire.In addition,the photogenerated electrons will not transmit through the MoS_(2) with low carrier mobility,so that not only the visible light response of the photodetector can be realized,but also its ultraviolet light response is able to be improved.Under ultraviolet light irradiation,the photoresponsivity of the photodetector can be reached to 273 A W-1and the response speed is less than 24 ms.More important,based on this unique heterojunction structure,MoS_(2)-on-ZnO photodetector also illustrates an excellent visible light response with a high photoresponsivity(74 A W-1) and fast response speed(<24 ms) due to the photogating effect.This work not only paves the way to design high-performance photodetectors with high photoresponsivity and fast response speed,but also provide a promising approach to improve the performance of optoelectronic devices using photogating effect. 展开更多
关键词 MoS_(2) ZNO Two-dimension Photogating PHOTODETECTORS
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A brief view of international conference on plant cell wall biology 2017 被引量:1
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作者 Xin Fang Juncong Sun +5 位作者 bing leng Guoan Sheng Jirong Huang Xiaoquan Qi Xiaoya Chen Laigeng Li 《Science Bulletin》 SCIE EI CAS CSCD 2017年第20期1357-1358,共2页
The triennial International Conference on Plant Cell Wall Biology has been held 5 times since it was initiated in the United States. PCWB2017 for the first time is organized in China. The conference was attended with ... The triennial International Conference on Plant Cell Wall Biology has been held 5 times since it was initiated in the United States. PCWB2017 for the first time is organized in China. The conference was attended with more than 220 participants and featured with oral and poster presentations, reflecting the contemporarv status of plant cell wall studies. 展开更多
关键词 nternational conference on plant cell wall biology 2017 triennial
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Biosynthesis and functions of metabolites 被引量:1
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作者 juncong sun bing leng +5 位作者 guoan sheng xin fang laigeng li jirong huang xiaoquan qi xiaoya chen 《Science China(Life Sciences)》 SCIE CAS CSCD 2017年第11期1280-1282,共3页
Metabolism is the basic activity of life. Two in- ternational conferences, including the 4th Interna- tional Conference on Plant Metabolism (ICPM2017, http://www.cspb.org.cn/2017/icpm.asp), and the 13th Internation... Metabolism is the basic activity of life. Two in- ternational conferences, including the 4th Interna- tional Conference on Plant Metabolism (ICPM2017, http://www.cspb.org.cn/2017/icpm.asp), and the 13th International Meeting on Biosynthesis, Function and Synthetic Biology of Isoprenoids (TERPNET2017,http://www.cspb.org.cn/2017/terpnet.asp) were concurrently convened side by side in Dalian from July 16 to 20, 2017. 展开更多
关键词 BIOSYNTHESIS functions of metabolites
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