Instrument separation is a critical complication during root canal therapy,impacting treatment success and long-term tooth preservation.The etiology of instrument separation is multifactorial,involving the intricate a...Instrument separation is a critical complication during root canal therapy,impacting treatment success and long-term tooth preservation.The etiology of instrument separation is multifactorial,involving the intricate anatomy of the root canal system,instrument-related factors,and instrumentation techniques.Instrument separation can hinder thorough cleaning,shaping,and obturation of the root canal,posing challenges to successful treatment outcomes.Although retrieval of separated instrument is often feasible,it carries risks including perforation,excessive removal of tooth structure and root fractures.Effective management of separated instruments requires a comprehensive understanding of the contributing factors,meticulous preoperative assessment,and precise evaluation of the retrieval difficulty.The application of appropriate retrieval techniques is essential to minimize complications and optimize clinical outcomes.The current manuscript provides a framework for understanding the causes,risk factors,and clinical management principles of instrument separation.By integrating effective strategies,endodontists can enhance decision-making,improve endodontic treatment success and ensure the preservation of natural dentition.展开更多
Background:Computed tomography(CT)plays a great role in characterizing and quantifying changes in lung structure and function of chronic obstructive pulmonary disease(COPD).This study aimed to explore the performance ...Background:Computed tomography(CT)plays a great role in characterizing and quantifying changes in lung structure and function of chronic obstructive pulmonary disease(COPD).This study aimed to explore the performance of CT-based whole lung radiomic in discriminating COPD patients and non-COPD patients.Methods:This retrospective study was performed on 2785 patients who underwent pulmonary function examination in 5 hospitals and were divided into non-COPD group and COPD group.The radiomic features of the whole lung volume were extracted.Least absolute shrinkage and selection operator(LASSO)logistic regression was applied for feature selection and radiomic signature construction.A radiomic nomogram was established by combining the radiomic score and clinical factors.Receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA)were used to evaluate the predictive performance of the radiomic nomogram in the training,internal validation,and independent external validation cohorts.Results:Eighteen radiomic features were collected from the whole lung volume to construct a radiomic model.The area under the curve(AUC)of the radiomic model in the training,internal,and independent external validation cohorts were 0.888[95%confidence interval(CI)0.869–0.906],0.874(95%CI 0.844–0.904),and 0.846(95%CI 0.822–0.870),respectively.All were higher than the clinical model(AUC were 0.732,0.714,and 0.777,respectively,P<0.001).DCA demonstrated that the nomogram constructed by combining radiomic score,age,sex,height,and smoking status was superior to the clinical factor model.Conclusions:The intuitive nomogram constructed by CT-based whole-lung radiomic has shown good performance and high accuracy in identifying COPD in this multicenter study.展开更多
Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical regi...Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes.展开更多
Phenyl-C_(61)-butyric acid methyl ester(PCBM) serves as a common electron transport layer(ETL) in inverted p-i-n structure perovskite solar cells(IPSCs),yet energy barriers and insufficient passivation at the PCBM-per...Phenyl-C_(61)-butyric acid methyl ester(PCBM) serves as a common electron transport layer(ETL) in inverted p-i-n structure perovskite solar cells(IPSCs),yet energy barriers and insufficient passivation at the PCBM-perovskite interface hinder device effectiveness and durability.In this study,we present a series of novel Fullerene Phenylacid Ester Derivatives(FPEDs:FPP,FTPP,FDPP) incorporated into PCBM.Our investigations illustrate that FPEDs effectively act to passivate the perovskite surface by forming robust interactions with uncoordinated Pb^(2+) ions via the phosphine oxide groups present in their molecular structures,thereby enhancing the stability of the devices.Moreover,these additives elevate the energy level of the lowest unoccupied molecular orbital(LUMO) of ETL,diminish the electron injection barrier,and enhance the efficiency of interlayer electron transport.Incorporating FPEDs enhances ETL coverage on the perovskite layer,reducing leakage current significantly.Notably,Devices with PCBM/FTPP achieved a peak PCE of 23.62% and showed superior stability,maintaining 96,8% of the initial PCE after 500 h,while control devices retained merely 80.7% over the same period.展开更多
We develop assembled reinforcement structures(ARSs)composed of connection parts,connecting rods,and straight bolts to strengthen segmental joints in the lining of shield tunnels.Through full-scale bending experiments ...We develop assembled reinforcement structures(ARSs)composed of connection parts,connecting rods,and straight bolts to strengthen segmental joints in the lining of shield tunnels.Through full-scale bending experiments and numerical simulations,we investigate the deformation and failure characteristics of segmental joints strengthened by ARSs,and propose a novel optimization method for ARSs.The experimental results show that the ARSs can effectively limit the opening of a segmental joint,but also that separation can occur during loading if the connection between the ARSs and segments is not designed properly.Importantly,this connection can be improved by embedding anchor parts in the concrete.In numerical modeling,we investigate the failure modes of segmental joints strengthened by ARSs for both positive bending and negative bending loading cases.In the case of positive bending loading,first the concrete around the anchor parts cracks,and subsequently the concrete on the external side of the joint is crushed.The joint failure is caused by the crushing of concrete on the external side of the joint.While the un-strengthened segmental joint fails with an opening of 5.884 mm,the strengthened segmental joint only opens by 0.288 mm under the same loading,corresponding to a reduction of 95.1%.In the case of negative bending loading,the concrete around the anchor parts first cracks,and then the amount of joint opening exceeds a limiting value for waterproofing(6 mm),i.e.,the joint’s failure is caused by water leakage.While the opening of the un-strengthened segmental joint is 9.033 mm and experiences waterproofing failure,the opening of the strengthened segmental joint is only 2.793 mm under the same loading,corresponding to a reduction of 69.1%.When constructing a new shield tunnel,anchor parts could be embedded in the concrete segments in tandem with ARSs for improved resistance to joint opening.For existing shield tunnel linings,anchor parts cannot be embedded in the concrete segments;therefore,the connections between the ARSs and concrete need to be optimized to strengthen the segmental joint.展开更多
The dental operative microscope has been widely employed in the field of dentistry,particularly in endodontics and operative dentistry,resulting in significant advancements in the effectiveness of root canal therapy,e...The dental operative microscope has been widely employed in the field of dentistry,particularly in endodontics and operative dentistry,resulting in significant advancements in the effectiveness of root canal therapy,endodontic surgery,and dental restoration.However,the improper use of this microscope continues to be common in clinical settings,primarily due to operators’insufficient understanding and proficiency in both the features and established operating procedures of this equipment.In October 2019,Professor Jingping Liang,Vice Chairman of the Society of Cariology and Endodontology,Chinese Stomatological Association,organized a consensus meeting with Chinese experts in endodontics and operative dentistry.The objective of this meeting was to establish a standard operation procedure for the dental operative microscope.Subsequently,a consensus was reached and officially issued.Over the span of about four years,the content of this consensus has been further developed and improved through practical experience.展开更多
Wise healthcare is a typical application of wireless sensor network(WSN), which uses sensors to monitor the physiological state of nursing targets and locate their position in case of an emergency situation. The locat...Wise healthcare is a typical application of wireless sensor network(WSN), which uses sensors to monitor the physiological state of nursing targets and locate their position in case of an emergency situation. The location of targets need to be determined and reported to the control center,and this leads to the localization problem. While localization in healthcare field demands high accuracy and regional adaptability, the information processing mechanism of human thinking has been introduced,which includes knowledge accumulation, knowledge fusion and knowledge expansion. Furthermore, a fuzzy decision based localization approach is proposed. Received signal strength(RSS) at references points are obtained and processed as position relationship indicators, using fuzzy set theory in the knowledge accumulation stage; after that, optimize degree of membership corresponding to each anchor nodes in different environments during knowledge fusion; the matching degree of reference points is further calculated and sorted in decision-making, and the coordinates of several points with the highest matching degree are utilized to estimate the location of unknown nodes while knowledge expansion. Simulation results show that the proposed algorithm get better accuracy performance compared to several traditional algorithms under different typical occasions.展开更多
Microorganisms,physical factors such as temperature or mechanical injury,and chemical factors such as free monomers from composite resin are the main causes of dental pulp diseases.Current clinical treatment methods f...Microorganisms,physical factors such as temperature or mechanical injury,and chemical factors such as free monomers from composite resin are the main causes of dental pulp diseases.Current clinical treatment methods for pulp diseases include the root canal therapy,vital pulp therapy and regenerative endodontic therapy.Regenerative endodontic therapy serves the purpose of inducing the regeneration of new functional pulp tissues through autologous revascularization or pulp tissue engineering.This article first discusses the current clinical methods and reviews strategies as well as the research outcomes regarding the pulp regeneration.Then the in vivo models,the prospects and challenges for regenerative endodontic therapy were further discussed.展开更多
文摘Instrument separation is a critical complication during root canal therapy,impacting treatment success and long-term tooth preservation.The etiology of instrument separation is multifactorial,involving the intricate anatomy of the root canal system,instrument-related factors,and instrumentation techniques.Instrument separation can hinder thorough cleaning,shaping,and obturation of the root canal,posing challenges to successful treatment outcomes.Although retrieval of separated instrument is often feasible,it carries risks including perforation,excessive removal of tooth structure and root fractures.Effective management of separated instruments requires a comprehensive understanding of the contributing factors,meticulous preoperative assessment,and precise evaluation of the retrieval difficulty.The application of appropriate retrieval techniques is essential to minimize complications and optimize clinical outcomes.The current manuscript provides a framework for understanding the causes,risk factors,and clinical management principles of instrument separation.By integrating effective strategies,endodontists can enhance decision-making,improve endodontic treatment success and ensure the preservation of natural dentition.
基金supported by the National Key Research and Development Program of China(2022YFC2010002,2022YFC2010000 and 2022YFC2010005)the National Natural Science Foundation of China(82171926,81930049 and 82202140)+3 种基金the Medical Imaging Database Construction Program of National Health Commission(YXFSC2022JJSJ002)the Clinical Innovative Project of Shanghai Changzheng Hospital(2020YLCYJ-Y24)the Program of Science and Technology Commission of Shanghai Municipality(21DZ2202600)the Shanghai Sailing Program(20YF1449000).
文摘Background:Computed tomography(CT)plays a great role in characterizing and quantifying changes in lung structure and function of chronic obstructive pulmonary disease(COPD).This study aimed to explore the performance of CT-based whole lung radiomic in discriminating COPD patients and non-COPD patients.Methods:This retrospective study was performed on 2785 patients who underwent pulmonary function examination in 5 hospitals and were divided into non-COPD group and COPD group.The radiomic features of the whole lung volume were extracted.Least absolute shrinkage and selection operator(LASSO)logistic regression was applied for feature selection and radiomic signature construction.A radiomic nomogram was established by combining the radiomic score and clinical factors.Receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA)were used to evaluate the predictive performance of the radiomic nomogram in the training,internal validation,and independent external validation cohorts.Results:Eighteen radiomic features were collected from the whole lung volume to construct a radiomic model.The area under the curve(AUC)of the radiomic model in the training,internal,and independent external validation cohorts were 0.888[95%confidence interval(CI)0.869–0.906],0.874(95%CI 0.844–0.904),and 0.846(95%CI 0.822–0.870),respectively.All were higher than the clinical model(AUC were 0.732,0.714,and 0.777,respectively,P<0.001).DCA demonstrated that the nomogram constructed by combining radiomic score,age,sex,height,and smoking status was superior to the clinical factor model.Conclusions:The intuitive nomogram constructed by CT-based whole-lung radiomic has shown good performance and high accuracy in identifying COPD in this multicenter study.
文摘Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes.
基金Natural Science Foundation of China (51972278)Outstanding Youth Science and Technology Talents Program of Sichuan (19JCQN0085)Open Project of State Key Laboratory of Environment-friendly Energy Materials (Southwest University of Science and Technology, 21fksy19)。
文摘Phenyl-C_(61)-butyric acid methyl ester(PCBM) serves as a common electron transport layer(ETL) in inverted p-i-n structure perovskite solar cells(IPSCs),yet energy barriers and insufficient passivation at the PCBM-perovskite interface hinder device effectiveness and durability.In this study,we present a series of novel Fullerene Phenylacid Ester Derivatives(FPEDs:FPP,FTPP,FDPP) incorporated into PCBM.Our investigations illustrate that FPEDs effectively act to passivate the perovskite surface by forming robust interactions with uncoordinated Pb^(2+) ions via the phosphine oxide groups present in their molecular structures,thereby enhancing the stability of the devices.Moreover,these additives elevate the energy level of the lowest unoccupied molecular orbital(LUMO) of ETL,diminish the electron injection barrier,and enhance the efficiency of interlayer electron transport.Incorporating FPEDs enhances ETL coverage on the perovskite layer,reducing leakage current significantly.Notably,Devices with PCBM/FTPP achieved a peak PCE of 23.62% and showed superior stability,maintaining 96,8% of the initial PCE after 500 h,while control devices retained merely 80.7% over the same period.
基金supported by the National Natural Science Foundation of China(No.52008308)the China Postdoctoral Science Foundation(Nos.BX20200247 and 2021M692447)the Research Project from Jinan Rail Transit Group Co.,Ltd.and China Railway No.5 Engineering Group Co.,Ltd.(No.R2-ZF-2019-039).
文摘We develop assembled reinforcement structures(ARSs)composed of connection parts,connecting rods,and straight bolts to strengthen segmental joints in the lining of shield tunnels.Through full-scale bending experiments and numerical simulations,we investigate the deformation and failure characteristics of segmental joints strengthened by ARSs,and propose a novel optimization method for ARSs.The experimental results show that the ARSs can effectively limit the opening of a segmental joint,but also that separation can occur during loading if the connection between the ARSs and segments is not designed properly.Importantly,this connection can be improved by embedding anchor parts in the concrete.In numerical modeling,we investigate the failure modes of segmental joints strengthened by ARSs for both positive bending and negative bending loading cases.In the case of positive bending loading,first the concrete around the anchor parts cracks,and subsequently the concrete on the external side of the joint is crushed.The joint failure is caused by the crushing of concrete on the external side of the joint.While the un-strengthened segmental joint fails with an opening of 5.884 mm,the strengthened segmental joint only opens by 0.288 mm under the same loading,corresponding to a reduction of 95.1%.In the case of negative bending loading,the concrete around the anchor parts first cracks,and then the amount of joint opening exceeds a limiting value for waterproofing(6 mm),i.e.,the joint’s failure is caused by water leakage.While the opening of the un-strengthened segmental joint is 9.033 mm and experiences waterproofing failure,the opening of the strengthened segmental joint is only 2.793 mm under the same loading,corresponding to a reduction of 69.1%.When constructing a new shield tunnel,anchor parts could be embedded in the concrete segments in tandem with ARSs for improved resistance to joint opening.For existing shield tunnel linings,anchor parts cannot be embedded in the concrete segments;therefore,the connections between the ARSs and concrete need to be optimized to strengthen the segmental joint.
文摘The dental operative microscope has been widely employed in the field of dentistry,particularly in endodontics and operative dentistry,resulting in significant advancements in the effectiveness of root canal therapy,endodontic surgery,and dental restoration.However,the improper use of this microscope continues to be common in clinical settings,primarily due to operators’insufficient understanding and proficiency in both the features and established operating procedures of this equipment.In October 2019,Professor Jingping Liang,Vice Chairman of the Society of Cariology and Endodontology,Chinese Stomatological Association,organized a consensus meeting with Chinese experts in endodontics and operative dentistry.The objective of this meeting was to establish a standard operation procedure for the dental operative microscope.Subsequently,a consensus was reached and officially issued.Over the span of about four years,the content of this consensus has been further developed and improved through practical experience.
基金supported by the National Natural Science Foundation of China (Grant No. 51677065)
文摘Wise healthcare is a typical application of wireless sensor network(WSN), which uses sensors to monitor the physiological state of nursing targets and locate their position in case of an emergency situation. The location of targets need to be determined and reported to the control center,and this leads to the localization problem. While localization in healthcare field demands high accuracy and regional adaptability, the information processing mechanism of human thinking has been introduced,which includes knowledge accumulation, knowledge fusion and knowledge expansion. Furthermore, a fuzzy decision based localization approach is proposed. Received signal strength(RSS) at references points are obtained and processed as position relationship indicators, using fuzzy set theory in the knowledge accumulation stage; after that, optimize degree of membership corresponding to each anchor nodes in different environments during knowledge fusion; the matching degree of reference points is further calculated and sorted in decision-making, and the coordinates of several points with the highest matching degree are utilized to estimate the location of unknown nodes while knowledge expansion. Simulation results show that the proposed algorithm get better accuracy performance compared to several traditional algorithms under different typical occasions.
基金funded by the National Natural Science Foundation of China(Grant No.82270968&82170943)the Top Youth Talent in Medicine Program of Hubei Province,China.
文摘Microorganisms,physical factors such as temperature or mechanical injury,and chemical factors such as free monomers from composite resin are the main causes of dental pulp diseases.Current clinical treatment methods for pulp diseases include the root canal therapy,vital pulp therapy and regenerative endodontic therapy.Regenerative endodontic therapy serves the purpose of inducing the regeneration of new functional pulp tissues through autologous revascularization or pulp tissue engineering.This article first discusses the current clinical methods and reviews strategies as well as the research outcomes regarding the pulp regeneration.Then the in vivo models,the prospects and challenges for regenerative endodontic therapy were further discussed.
