BACKGROUND Schizophrenia is a complex psychiatric disorder with significant functional impairment.Although olanzapine is effective in treating positive symptoms,its efficacy against negative symptoms and cognitive def...BACKGROUND Schizophrenia is a complex psychiatric disorder with significant functional impairment.Although olanzapine is effective in treating positive symptoms,its efficacy against negative symptoms and cognitive deficits is limited.Yueju pill,a traditional Chinese herbal formula,has shown potential in improving these domains,but its mechanisms remain largely unexplored.AIM To evaluate the therapeutic efficacy and underlying mechanisms of Yueju pill combined with olanzapine in treating schizophrenia.METHODS Ninety-seven patients with schizophrenia were randomly assigned to an intervention group(n=48)receiving olanzapine and Yueju pill,or a control group(n=49)receiving olanzapine and a placebo for 8 weeks.Symptom severity was assessed using the positive and negative syndrome scale,the scale for the assessment of negative symptoms,and cognitive and social function scales.Serum levels of brain-derived neurotrophic factor(BDNF),dopamine(DA),and serotonin(5-HT)were measured.Network pharmacology analysis identified key chemical components and target genes involved in the treatment response.RESULTS The intervention group demonstrated a significantly higher overall efficacy rate(93.75%)compared to the control group(73.47%,P<0.05).Improvements in psychiatric symptoms,cognitive function,and social performance were more pronounced in the intervention group.Additionally,serum levels of BDNF,DA,and 5-HT were significantly higher in the intervention group(P<0.05).Network pharmacology analysis revealed quercetin as a key component,modulating genes such as CHRM1,GSK3B,and KCNH2,crucial in DA signaling.CONCLUSION Yueju pill,when combined with olanzapine,significantly improves clinical outcomes in schizophrenia patients,with safety comparable to olanzapine alone.展开更多
In designing a fixed-bed adsorber, it is vital to understand dynamic adsorption properties of the unit. Temperature is an important effect on adsorbent performance, as the dynamic adsorption coefficients tend to incre...In designing a fixed-bed adsorber, it is vital to understand dynamic adsorption properties of the unit. Temperature is an important effect on adsorbent performance, as the dynamic adsorption coefficients tend to increase with decreasing temperature. To minimize the volume of the fixed-bed adsorber, the dynamic adsorption characteristics of Xe were studied at 77 K by employing a variety of adsorbents under different operational conditions. The carbon molecular sieve performed better than that of activated carbon. Both operational conditions and the presence of gaseous impurities were found to affect the adsorption properties.展开更多
Three different castables were prepared as steel-ladle purging-plug refractory materials： corundum-based low-cement castable （C-LCC）, corundum-spinel-based low-cement castable （C-S-LCC）, and no-cement corundum-sp...Three different castables were prepared as steel-ladle purging-plug refractory materials： corundum-based low-cement castable （C-LCC）, corundum-spinel-based low-cement castable （C-S-LCC）, and no-cement corundum-spinel castable （C-S-NCC） （hydratable alu- mina p-A1203 bonded）. The properties of these castables were characterized with regard to water demand/flow ability, cold crushing strength （CCS）, cold modulus of rupture （CMoR）, permanent linear change （PLC）, apparent porosity, and hot modulus of rupture （HMoR）. The re- sults show the CCS/CMoR and HMoR of C-LCC and C-S-LCC are greater than those of the castable C-S-NCC. According to the micro- structure analysis, the sintering effect and the bonding type of the matrix material differ among the three castables. The calcium hexaluminate （CA6） phase in the matrix of C-LCC enhances the cold and hot mechanical strengths. In the case of C-S-LCC, the CA6 and 2CaO·2MgO·14A12O3（C2MEA14） ternary phases generated from the matrix can greatly increase the cold and hot mechanical strengths. In the case of the no-cement castable, sintering becomes difficult, resulting in a lower mechanical strength.展开更多
As the biggest agricultural country, China has an abundant rice straw energy resource. The characteristics of typical china rice straws are presented as high moisture contents, high volatile contents, high ash content...As the biggest agricultural country, China has an abundant rice straw energy resource. The characteristics of typical china rice straws are presented as high moisture contents, high volatile contents, high ash contents and low bulk density. At present, rice straw is mainly used as fuel, feedstuff, fertilizer and industrial raw material. With improved living conditions in rural areas, farmers tend to rely more on commercial fuel, which leads to even more open field burning of rice straw, and brings air pollutions and potential energy waste as well. The Chinese government is studying relevant policies on acceleration of comprehensive utilization of rice straw with the goal of utilization rate exceeding 80% in 2015. In this paper, focus is on the combustion of rice straw to extract energy, and related challenges face to china is put forward in this paper also.展开更多
Cynops orientalis(C.orientalis)has a pronounced ability to regenerate its spinal cord after injury.Thus,exploring the molecular mechanism of this process could provide new approaches for promoting mammalian spinal cor...Cynops orientalis(C.orientalis)has a pronounced ability to regenerate its spinal cord after injury.Thus,exploring the molecular mechanism of this process could provide new approaches for promoting mammalian spinal cord regeneration.In this study,we established a model of spinal cord thoracic transection injury in C.orientalis,which is an endemic species in China.We performed RNA sequencing of the contused axolotl spinal cord at two early time points after spinal cord injury–during the very acute stage(4 days)and the subacute stage(7 days)–and identified differentially expressed genes;additionally,we performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses,at each time point.Transcriptome sequencing showed that 13,059 genes were differentially expressed during C.orientalis spinal cord regeneration compared with uninjured animals,among which 4273 were continuously downregulated and 1564 were continuously up-regulated.Down-regulated genes were most enriched in the Gene Ontology term“multicellular organismal process”and in the ribosome pathway at 10 days following spinal cord injury.We found that multiple genes associated with energy metabolism were down-regulated and multiple genes associated with the lysosome were up-regulated after spinal cord injury,indicating the importance of low metabolic activity during wound healing.Immune response-associated pathways were activated during the early acute phase(4 days),while the expression of extracellular matrix proteins such as glycosaminoglycan and collagen,as well as tight junction proteins,was lower at 10 days post-spinal cord injury than 4 days post-spinal cord injury.However,compared with 4 days post-injury,at 10 days post-injury neuroactive ligand-receptor interactions were no longer down-regulated,up-regulated differentially expressed genes were enriched in pathways associated with cancer and the cell cycle,and SHH,VIM,and Sox2 were prominently up-regulated.Immunofluorescence staining showed that glial fibrillary acidic protein was up-regulated in axolotl ependymoglial cells after injury,similar to what is observed in mammalian astrocytes after spinal cord injury,even though axolotls do not form a glial scar during regeneration.We suggest that low intracellular energy production could slow the rapid amplification of ependymoglial cells,thereby inhibiting reactive gliosis,at early stages after spinal cord injury.Extracellular matrix degradation slows cellular responses,represses the expression of neurogenic genes,and reactivates a transcriptional program similar to that of embryonic neuroepithelial cells.These ependymoglial cells act as neural stem cells:they migrate and proliferate to repair the lesion and then differentiate to replace lost glial cells and neurons.This provides the regenerative microenvironment that allows axon growth after injury.展开更多
Three different castables based on the Al_2O_3–MgO –CaO system were prepared as steel-ladle purging plug refractories： corundum-based low-cement castable（C-LCC）, corundum-spinel-based low-cement castable（C-S-LCC...Three different castables based on the Al_2O_3–MgO –CaO system were prepared as steel-ladle purging plug refractories： corundum-based low-cement castable（C-LCC）, corundum-spinel-based low-cement castable（C-S-LCC）, and corundum-spinel no-cement castable（C-S-NCC）（hydratable alumina（ρ-Al_2O_3） bonded）. The fracture behavior at room temperature was tested by the method of ＂wedge-splitting＂ on samples pre-fired at different temperatures; the specific fracture energy G′f and notched tensile strength σNT were obtained from these tests. In addition, the Young＇s modulus E was measured by the method of resonance frequency of damping analysis（RFDA）. The thermal stress resistance parameter R′′′′ calculated using the values of G′f, σNT, and E was used to evaluate the thermal shock resistance of the materials. According to the microstructure analysis results, the sintering effect and the bonding type of the matrix material were different among these three castables, which explains their different fracture behaviors.展开更多
Historically,ground calcined aluminas were the first high-alumina matrix products that were used in refractory formulations, in both shaped and unshaped products. At that time the flow properties of castables were enh...Historically,ground calcined aluminas were the first high-alumina matrix products that were used in refractory formulations, in both shaped and unshaped products. At that time the flow properties of castables were enhanced by the use of silica fume. This was followed later by the development of fully ground reactive aluminas which contributed to the design of the matrix below 63 μm. In addition to aggregate fines,a range of bi-modal and multi-modal reactive aluminas were also developed. These not only gave improved physical properties but also better castable workability. This paper reviews matrix alumina developments over time,from basic ground calcines to complex multi-modal matrix products and their globally standardised manufacture.展开更多
This study investigates the impact of silicon(Si)on the corrosion resistance and post-corrosion toughness of ferrite/martensitic(F/M)steels in a liquid lead-bismuth eutectic(LBE)environment.Corrosion tests were perfor...This study investigates the impact of silicon(Si)on the corrosion resistance and post-corrosion toughness of ferrite/martensitic(F/M)steels in a liquid lead-bismuth eutectic(LBE)environment.Corrosion tests were performed on HT-9 and EP-823(1.17 wt%Si)steels at 550℃for 1000 h under oxygen-controlled conditions.The resulting oxide layer consisted of an outer magnetite layer,a spinel layer and an inner oxide zone(IOZ).A Si-rich oxide layer was identified within the spinel and IOZ layers of EP-823,which slowed the growth rate of the oxide layer,enhanced antioxidant performance,and inhibited dissolution corrosion by the LBE.Post-corrosion mechanical properties were evaluated using a small punch test.Results showed a significant reduction in HT-9's toughness within 240 h of corrosion,while EP-823 exhibited increased brittleness after 500 h due to Si-promoted carbide and Laves phase precipitation,significantly reducing its toughness.展开更多
1 Project overview The“Beishan No.1”,the world’s first-ever hard rock Tunnel Boring Machine(TBM)tailored for high-gradient spiral tunnels,constitutes a pivotal element within the Beishan Underground Research Labora...1 Project overview The“Beishan No.1”,the world’s first-ever hard rock Tunnel Boring Machine(TBM)tailored for high-gradient spiral tunnels,constitutes a pivotal element within the Beishan Underground Research Laboratory(URL)initiative in China.Beishan URL,the first URL for geological disposal of high level radioactive waste(HLW)in China,is a national key construction project listed in the“13th Five-Year Plan”.In 2019,subsequent to receiving approval from the China Atomic Energy Authority,the Beijing Research Institute of Uranium Geology(BRIUG),serving as the project’s owner,initiated its construction.This underground facility,categorized as a“third generation”URL for HLW disposal,i.e.,area-specific URL,was located in Beishan,Jiuquan City,Gansu Province,China,following more than three decades of rigorous research on site selection.展开更多
Photosynthetic terpene production represents one of the most carbon and energy-efficient routes for converting CO_(2)into hydrocarbon.In photosynthetic organisms,metabolic engineering has led to limited success in enh...Photosynthetic terpene production represents one of the most carbon and energy-efficient routes for converting CO_(2)into hydrocarbon.In photosynthetic organisms,metabolic engineering has led to limited success in enhancing terpene productivity,partially due to the low carbon partitioning.In this study,we employed systems biology analysis to reveal the strong competition for carbon substrates between primary metabolism(e.g.,sucrose,glycogen,and protein synthesis)and terpene biosynthesis in Synechococcus elongatus PCC 7942.We then engineered key“source”and“sink”enzymes.The“source”limitation was overcome by knocking out either sucrose or glycogen biosynthesis to significantly enhance limonene production via altered carbon partitioning.Moreover,a fusion enzyme complex with geranyl diphosphate synthase(GPPS)and limonene synthase(LS)was designed to further improve pathway kinetics and substrate channeling.The synergy between“source”and“sink”achieved a limonene titer of 21.0 mg/L.Overall,the study demonstrates that balancing carbon flux between primary and secondary metabolism can be an effective approach to enhance terpene bioproduction in cyanobacteria.The design of“source”and“sink”synergy has significant potential in improving natural product yield in photosynthetic species.展开更多
文摘BACKGROUND Schizophrenia is a complex psychiatric disorder with significant functional impairment.Although olanzapine is effective in treating positive symptoms,its efficacy against negative symptoms and cognitive deficits is limited.Yueju pill,a traditional Chinese herbal formula,has shown potential in improving these domains,but its mechanisms remain largely unexplored.AIM To evaluate the therapeutic efficacy and underlying mechanisms of Yueju pill combined with olanzapine in treating schizophrenia.METHODS Ninety-seven patients with schizophrenia were randomly assigned to an intervention group(n=48)receiving olanzapine and Yueju pill,or a control group(n=49)receiving olanzapine and a placebo for 8 weeks.Symptom severity was assessed using the positive and negative syndrome scale,the scale for the assessment of negative symptoms,and cognitive and social function scales.Serum levels of brain-derived neurotrophic factor(BDNF),dopamine(DA),and serotonin(5-HT)were measured.Network pharmacology analysis identified key chemical components and target genes involved in the treatment response.RESULTS The intervention group demonstrated a significantly higher overall efficacy rate(93.75%)compared to the control group(73.47%,P<0.05).Improvements in psychiatric symptoms,cognitive function,and social performance were more pronounced in the intervention group.Additionally,serum levels of BDNF,DA,and 5-HT were significantly higher in the intervention group(P<0.05).Network pharmacology analysis revealed quercetin as a key component,modulating genes such as CHRM1,GSK3B,and KCNH2,crucial in DA signaling.CONCLUSION Yueju pill,when combined with olanzapine,significantly improves clinical outcomes in schizophrenia patients,with safety comparable to olanzapine alone.
基金supported by the National Natural Science Foundation of China(No.11405134)
文摘In designing a fixed-bed adsorber, it is vital to understand dynamic adsorption properties of the unit. Temperature is an important effect on adsorbent performance, as the dynamic adsorption coefficients tend to increase with decreasing temperature. To minimize the volume of the fixed-bed adsorber, the dynamic adsorption characteristics of Xe were studied at 77 K by employing a variety of adsorbents under different operational conditions. The carbon molecular sieve performed better than that of activated carbon. Both operational conditions and the presence of gaseous impurities were found to affect the adsorption properties.
文摘Three different castables were prepared as steel-ladle purging-plug refractory materials： corundum-based low-cement castable （C-LCC）, corundum-spinel-based low-cement castable （C-S-LCC）, and no-cement corundum-spinel castable （C-S-NCC） （hydratable alu- mina p-A1203 bonded）. The properties of these castables were characterized with regard to water demand/flow ability, cold crushing strength （CCS）, cold modulus of rupture （CMoR）, permanent linear change （PLC）, apparent porosity, and hot modulus of rupture （HMoR）. The re- sults show the CCS/CMoR and HMoR of C-LCC and C-S-LCC are greater than those of the castable C-S-NCC. According to the micro- structure analysis, the sintering effect and the bonding type of the matrix material differ among the three castables. The calcium hexaluminate （CA6） phase in the matrix of C-LCC enhances the cold and hot mechanical strengths. In the case of C-S-LCC, the CA6 and 2CaO·2MgO·14A12O3（C2MEA14） ternary phases generated from the matrix can greatly increase the cold and hot mechanical strengths. In the case of the no-cement castable, sintering becomes difficult, resulting in a lower mechanical strength.
文摘As the biggest agricultural country, China has an abundant rice straw energy resource. The characteristics of typical china rice straws are presented as high moisture contents, high volatile contents, high ash contents and low bulk density. At present, rice straw is mainly used as fuel, feedstuff, fertilizer and industrial raw material. With improved living conditions in rural areas, farmers tend to rely more on commercial fuel, which leads to even more open field burning of rice straw, and brings air pollutions and potential energy waste as well. The Chinese government is studying relevant policies on acceleration of comprehensive utilization of rice straw with the goal of utilization rate exceeding 80% in 2015. In this paper, focus is on the combustion of rice straw to extract energy, and related challenges face to china is put forward in this paper also.
基金the National Natural Science Foundation of China,Nos.32270516,31970413the Natural Science Foundation of Anhui Province,No.1908085MC83(to JL)a Start-up grant from Nanjing Agricultural University,No.804090。
文摘Cynops orientalis(C.orientalis)has a pronounced ability to regenerate its spinal cord after injury.Thus,exploring the molecular mechanism of this process could provide new approaches for promoting mammalian spinal cord regeneration.In this study,we established a model of spinal cord thoracic transection injury in C.orientalis,which is an endemic species in China.We performed RNA sequencing of the contused axolotl spinal cord at two early time points after spinal cord injury–during the very acute stage(4 days)and the subacute stage(7 days)–and identified differentially expressed genes;additionally,we performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses,at each time point.Transcriptome sequencing showed that 13,059 genes were differentially expressed during C.orientalis spinal cord regeneration compared with uninjured animals,among which 4273 were continuously downregulated and 1564 were continuously up-regulated.Down-regulated genes were most enriched in the Gene Ontology term“multicellular organismal process”and in the ribosome pathway at 10 days following spinal cord injury.We found that multiple genes associated with energy metabolism were down-regulated and multiple genes associated with the lysosome were up-regulated after spinal cord injury,indicating the importance of low metabolic activity during wound healing.Immune response-associated pathways were activated during the early acute phase(4 days),while the expression of extracellular matrix proteins such as glycosaminoglycan and collagen,as well as tight junction proteins,was lower at 10 days post-spinal cord injury than 4 days post-spinal cord injury.However,compared with 4 days post-injury,at 10 days post-injury neuroactive ligand-receptor interactions were no longer down-regulated,up-regulated differentially expressed genes were enriched in pathways associated with cancer and the cell cycle,and SHH,VIM,and Sox2 were prominently up-regulated.Immunofluorescence staining showed that glial fibrillary acidic protein was up-regulated in axolotl ependymoglial cells after injury,similar to what is observed in mammalian astrocytes after spinal cord injury,even though axolotls do not form a glial scar during regeneration.We suggest that low intracellular energy production could slow the rapid amplification of ependymoglial cells,thereby inhibiting reactive gliosis,at early stages after spinal cord injury.Extracellular matrix degradation slows cellular responses,represses the expression of neurogenic genes,and reactivates a transcriptional program similar to that of embryonic neuroepithelial cells.These ependymoglial cells act as neural stem cells:they migrate and proliferate to repair the lesion and then differentiate to replace lost glial cells and neurons.This provides the regenerative microenvironment that allows axon growth after injury.
文摘Three different castables based on the Al_2O_3–MgO –CaO system were prepared as steel-ladle purging plug refractories： corundum-based low-cement castable（C-LCC）, corundum-spinel-based low-cement castable（C-S-LCC）, and corundum-spinel no-cement castable（C-S-NCC）（hydratable alumina（ρ-Al_2O_3） bonded）. The fracture behavior at room temperature was tested by the method of ＂wedge-splitting＂ on samples pre-fired at different temperatures; the specific fracture energy G′f and notched tensile strength σNT were obtained from these tests. In addition, the Young＇s modulus E was measured by the method of resonance frequency of damping analysis（RFDA）. The thermal stress resistance parameter R′′′′ calculated using the values of G′f, σNT, and E was used to evaluate the thermal shock resistance of the materials. According to the microstructure analysis results, the sintering effect and the bonding type of the matrix material were different among these three castables, which explains their different fracture behaviors.
文摘Historically,ground calcined aluminas were the first high-alumina matrix products that were used in refractory formulations, in both shaped and unshaped products. At that time the flow properties of castables were enhanced by the use of silica fume. This was followed later by the development of fully ground reactive aluminas which contributed to the design of the matrix below 63 μm. In addition to aggregate fines,a range of bi-modal and multi-modal reactive aluminas were also developed. These not only gave improved physical properties but also better castable workability. This paper reviews matrix alumina developments over time,from basic ground calcines to complex multi-modal matrix products and their globally standardised manufacture.
基金supported by the National Natural Science Foundation of China(No.52301121).
文摘This study investigates the impact of silicon(Si)on the corrosion resistance and post-corrosion toughness of ferrite/martensitic(F/M)steels in a liquid lead-bismuth eutectic(LBE)environment.Corrosion tests were performed on HT-9 and EP-823(1.17 wt%Si)steels at 550℃for 1000 h under oxygen-controlled conditions.The resulting oxide layer consisted of an outer magnetite layer,a spinel layer and an inner oxide zone(IOZ).A Si-rich oxide layer was identified within the spinel and IOZ layers of EP-823,which slowed the growth rate of the oxide layer,enhanced antioxidant performance,and inhibited dissolution corrosion by the LBE.Post-corrosion mechanical properties were evaluated using a small punch test.Results showed a significant reduction in HT-9's toughness within 240 h of corrosion,while EP-823 exhibited increased brittleness after 500 h due to Si-promoted carbide and Laves phase precipitation,significantly reducing its toughness.
文摘1 Project overview The“Beishan No.1”,the world’s first-ever hard rock Tunnel Boring Machine(TBM)tailored for high-gradient spiral tunnels,constitutes a pivotal element within the Beishan Underground Research Laboratory(URL)initiative in China.Beishan URL,the first URL for geological disposal of high level radioactive waste(HLW)in China,is a national key construction project listed in the“13th Five-Year Plan”.In 2019,subsequent to receiving approval from the China Atomic Energy Authority,the Beijing Research Institute of Uranium Geology(BRIUG),serving as the project’s owner,initiated its construction.This underground facility,categorized as a“third generation”URL for HLW disposal,i.e.,area-specific URL,was located in Beishan,Jiuquan City,Gansu Province,China,following more than three decades of rigorous research on site selection.
文摘Photosynthetic terpene production represents one of the most carbon and energy-efficient routes for converting CO_(2)into hydrocarbon.In photosynthetic organisms,metabolic engineering has led to limited success in enhancing terpene productivity,partially due to the low carbon partitioning.In this study,we employed systems biology analysis to reveal the strong competition for carbon substrates between primary metabolism(e.g.,sucrose,glycogen,and protein synthesis)and terpene biosynthesis in Synechococcus elongatus PCC 7942.We then engineered key“source”and“sink”enzymes.The“source”limitation was overcome by knocking out either sucrose or glycogen biosynthesis to significantly enhance limonene production via altered carbon partitioning.Moreover,a fusion enzyme complex with geranyl diphosphate synthase(GPPS)and limonene synthase(LS)was designed to further improve pathway kinetics and substrate channeling.The synergy between“source”and“sink”achieved a limonene titer of 21.0 mg/L.Overall,the study demonstrates that balancing carbon flux between primary and secondary metabolism can be an effective approach to enhance terpene bioproduction in cyanobacteria.The design of“source”and“sink”synergy has significant potential in improving natural product yield in photosynthetic species.
