Icing can significantly change the geometric parameters of wind turbine blades,which in turn,can reduce the aerodynamic characteristics of the airfoil.In-depth research is conducted in this study to identify the reaso...Icing can significantly change the geometric parameters of wind turbine blades,which in turn,can reduce the aerodynamic characteristics of the airfoil.In-depth research is conducted in this study to identify the reasons for the decline of wind power equipment performance through the icing process.An accurate experimental test method is proposed in a natural environment that examines the growth and distribution of ice formation over the airfoil profile.The mathematical models of the airfoil chord length,camber,and thickness are established in order to investigate the variation of geometric airfoil parameters under different icing states.The results show that ice accumulation varies considerably along the blade span.By environmental temperature drop,the minimum and maximum extents of ice accumulation are observed near the blade root(0.2 R)and the blade tip(0.95 R),respectively(R represents the blade length).The icing process steadily increases the chord length and decreases the airfoil curvature,reaching the largest value at the blade tip region.Furthermore,the maximum curvature is reduced to 41.50%of the original curvature.The maximum camber position of the airfoil moves towards the trailing edge,and the most prominent position occurs at the middle blade region(0.6 R),where it moves back by 19.43%.Ice accumulation steadily increases airfoil thickness.It leads to the maximum thickness growth of 53.40%that occurs at the blade tip region and moves forward to the leading edge by 10%.The research results can provide the required theoretical support for further monitoring the blades operating conditions to ensure reliable wind turbines’operation.展开更多
With the continuous increase in the proportional use of wind energy across the globe,the reduction of power generation efficiency and safety hazards caused by the icing on wind turbine blades have attracted more consi...With the continuous increase in the proportional use of wind energy across the globe,the reduction of power generation efficiency and safety hazards caused by the icing on wind turbine blades have attracted more consideration for research.Therefore,it is crucial to accurately analyze the thickness of icing on wind turbine blades,which can serve as a basis for formulating corresponding control measures and ensure a safe and stable operation of wind turbines in winter times and/or in high altitude areas.This paper fully utilized the advantages of the support vector machine(SVM)and back-propagation neural network(BPNN),with the incorporation of particle swarm optimization(PSO)algorithms to optimize the parameters of the SVM.The paper proposes a hybrid assessment model of PSO-SVM and BPNN based on dynamic weighting rules.Three sets of icing data under a rotating working state of the wind turbine were used as examples for model verification.Based on a comparative analysis with other models,the results showed that the proposed model has better accuracy and stability in analyzing the icing on wind turbine blades.展开更多
One of the factors for the evaluation of the space environment is the comfort of outdoor activities spaces in urban parks. The space composed of different landscape elements has different microclimate environment. In ...One of the factors for the evaluation of the space environment is the comfort of outdoor activities spaces in urban parks. The space composed of different landscape elements has different microclimate environment. In this paper, in order to evaluate the role of thermal comfort in influencing resident’s assessment of the outdoor space and activities of the park, a thermal comfort survey was conducted on the outdoor open space of Mianyang Urban Park in summer. In this article, meteorological surveys, questionnaire surveys and observation of park attendance are selected to collect data. The physiological equivalent temperature (PET) assessment was selected as the index to evaluate resident’s thermal comfort level, and the comprehensive evaluation and analysis of the spatial thermal environment of different outdoor landscape elements in the park. The overall comfort of current visitors is mainly influenced by their subjective heat perception voting (TSV). In this article, we focus on providing microclimate adjustment considerations for urban park landscape design, and may help people understand the outdoor thermal comfort of Mianyang in summer, increase the using time of outdoor activities, and promote the use of outdoor space.展开更多
Layer pseudospins,exhibiting quantum coherence and precise multistate controllability,present significant potential for the advancement of future computing technologies.In this work,we propose an in-memory probabilist...Layer pseudospins,exhibiting quantum coherence and precise multistate controllability,present significant potential for the advancement of future computing technologies.In this work,we propose an in-memory probabilistic computing scheme based on the electrical manipulation of layer pseudospins in layered materials,by exploiting the interaction between real spins and layer pseudospins.展开更多
Radiochemotherapy-induced oral mucositis(OM)is a common oral complication in patients with tumors following head and neck radiotherapy or chemotherapy.Erosion and ulcers are the main features of OM that seriously affe...Radiochemotherapy-induced oral mucositis(OM)is a common oral complication in patients with tumors following head and neck radiotherapy or chemotherapy.Erosion and ulcers are the main features of OM that seriously affect the quality of life of patients and even the progress of tumor treatment.To date,differences in clinical prevention and treatment plans for OM have been noted among doctors of various specialties,which has increased the uncertainty of treatment effects.On the basis of current research evidence,this expert consensus outlines risk factors,clinical manifestations,clinical grading,ancillary examinations,diagnostic basis,prevention and treatment strategies and efficacy indicators for OM.In addition to strategies such as basic oral care,antiinflammatory and analgesic agents,anti-infective agents,pro-healing agents,and photobiotherapy recommended in previous guidelines,we also emphasize the role of traditional Chinese medicine in OM prevention and treatment.This expert consensus aims to provide references and guidance for dental physicians and oncologists in formulating strategies for OM prevention,diagnosis,and treatment,standardizing clinical practice,reducing OM occurrence,promoting healing,and improving the quality of life of patients.展开更多
Six rearranged nor-diterpenoids with 5/6/6-fused tricyclic system(1–6),and one unprecedented dimer with 5/6/6/6/6/5-fused carbon core(7)were isolated from Strophioblachia glandulosa.Spectroscopic techniques,electroni...Six rearranged nor-diterpenoids with 5/6/6-fused tricyclic system(1–6),and one unprecedented dimer with 5/6/6/6/6/5-fused carbon core(7)were isolated from Strophioblachia glandulosa.Spectroscopic techniques,electronic circular dichroism(ECD),quantum chemical calculations,and single-crystal X-ray diffraction analysis were used to elucidate their structures.A preliminary bioactivity assay revealed compounds 2 and 3 exhibited potent anti-myocardial hypertrophy effect in vitro by significantly inhibiting the expression levels of atrial natriuretic peptide(ANP)and myosin heavy chain 7(MYH7)proteins.Additionally,mitogen-activated protein kinase 14(Mapk14)may be involved in the regulation of compound3 on cardiac hypertrophic disease by network pharmacology prediction and experimental verification.展开更多
The thaw-freezing transition period is crucial to determine the initial sea ice status prior to the freezing season.The heat and mass balance at ice-ocean interface is the major driving process.In this study,we analyz...The thaw-freezing transition period is crucial to determine the initial sea ice status prior to the freezing season.The heat and mass balance at ice-ocean interface is the major driving process.In this study,we analyze heat fluxes profile through the ice from ice surface down to basal ice-ocean interface using the data measured by 11 thermistor stringbased ice mass balance buoys(IMBs)between September and December 2018 in the Pacific sector of Arctic Ocean.The conductive heat fluxes gradually decreased from surface downward through the lower ice layers due to the thermal inertia and energy storage in the brine pockets.At the ice bottom,the oceanic heat flux decreased from(5.9±1.3)W/m^(2)in mid-September to(1.8±0.8)W/m^(2)by the end of December in response to the decreasing of available absorbed solar radiation regulated by the latitude and sea ice concentration.The initial ice thicknesses can explain the onset of ice basal growth by 44.8%(R^(2)).From 15 September to the average onset of ice basal growth by 13 November,the accumulated heat fluxes released from the ice surface to the atmosphere,caused by the cooling of the ice layer,and from the ocean to the ice bottom were estimated as 25.73 MJ/m^(2),6.49 MJ/m^(2),and 20.30 MJ/m^(2),respectively.The latter two components mainly play the roles in buffering the onset of ice basal growth.展开更多
Electrically tunable homojunctions based on ambipolar two-dimensional materials have attracted widespread attention in the field of intelligent vision.These devices exhibit inherent switchable positive and negative ph...Electrically tunable homojunctions based on ambipolar two-dimensional materials have attracted widespread attention in the field of intelligent vision.These devices exhibit inherent switchable positive and negative photovoltaic properties that effectively mimic the behavior of human retinal cells.However,the photovoltaic responsivity of most electrically tunable homojunctions remains significantly low due to the weak light absorption,making it challenging to meet the application requirements for high-sensitivity target detection in the field of intelligent vision.Here,we propose a gate-tunable photodiode based on two-dimensional ambipolar WSe_(2)with an asymmetric gate electrode,achieving high photovoltaic responsivity.By adjusting the gate voltage and keeping bias voltage zero,we can dynamically realize reconfigurable n-–p and n-–n homojunction states,as well as gate-tunable photovoltaic response characteristics that range from positive to negative.The maximum photovoltaic responsivity of the electrically tunable WSe_(2)homojunction is approximately 0.4 A/W,which is significantly larger than the previously reported value~0.1 A/W in homojunction devices.In addition,the responsivity can be further enhanced to approximately 1.0 A/W when the n-–p photodiode operates in reverse bias mode,enabling highsensitivity detection of targets.Our work paves the way for developing gate-tunable photodiodes with high photovoltaic responsivity and advancing high-performance intelligent vision technology.展开更多
With regard to the rapid growth of China’s building area and the increasing energy consumption of buildings, green buildings have become an important issue for balancing economic development and environmental impact....With regard to the rapid growth of China’s building area and the increasing energy consumption of buildings, green buildings have become an important issue for balancing economic development and environmental impact. However, the current evaluation systems for various types of green buildings are often unable to achieve a set of standards in practice due to the distinct regional characteristics of each region. Therefore, in view of the regional characteristics of the climate, terrain, ecology, and economic development in the cold regions of Sichuan, it is important to study the evaluation system of green residential buildings suitable for the cold regions of Sichuan. This article focuses on the regional characteristics of climate, topography, ecology, and economic development in the cold regions of Sichuan, and discusses the limitations of the current standards on the practice of green building in cold regions of Sichuan through a sociological questionnaire survey on the comfort of living in the local population. Then from the two dimensions of the advantages of traditional houses and the particularity of national culture, the strategies for the optimization and improvement of the evaluation index system for green residential buildings in the cold regions of Sichuan were proposed. After comprehensively considering the factors that affect the green residential buildings, including the regional characteristics of the cold regions of Sichuan, and the green performance of buildings, local characteristics and ethnic features were included in the evaluation system. The evaluation index system of green residential buildings in the cold regions of Sichuan, consists of 92 three-level indicators. A professional hierarchical analysis software yaahp was used to establish a multi-level hierarchical model between the indicators, and the indicators were compared with each other layer by layer to clarify the importance of the indicators. Based on this, a judgment matrix for each layer was constructed and obtained. The weight of each indicator is accurate, and the scoring mechanism and grading standards are constructed according to it. Through the calculation, the consistency test of the entire model was passed, thereby confirming the scientificity and rationality of the entire evaluation system.展开更多
AIM:To investigate the function of microRNA-143(miR-143)in gastric cancer and explore the target genes of miR-143.METHODS:A quantitative real-time reverse transcription-polymerase chain reaction(RT-PCR)analysis was pe...AIM:To investigate the function of microRNA-143(miR-143)in gastric cancer and explore the target genes of miR-143.METHODS:A quantitative real-time reverse transcription-polymerase chain reaction(RT-PCR)analysis was performed to evaluate miR-143 expression in gastric cancer cell lines.After transfecting gastric cancer cells with miR-143-5p and miR-143-3p precursors,Alamar blue and apoptosis assays were used to measure the respective proliferation and apoptosis rates.Cyclooxygenase-2(COX-2)expression was determined by realtime RT-PCR and Western blot assays after miR-143transfection.Reporter plasmids were constructed,and a luciferase reporter assay was used to identify the miR-143 binding site on COX-2.RESULTS:Both miR-143-5p and miR-143-3p were significantly downregulated in multiple gastric cancer cell lines.Forced miR-143-5p and miR-143-3p expression in gastric cancer cells produced a profound cytotoxic effect.MiR-145-5p transfection into gastric cancer cells resulted in a greater growth inhibitory effect(61.23%±3.16%vs 46.58%±4.28%,P<0.05 in the MKN-1cell line)and a higher apoptosis rate(28.74%±1.93%vs 22.13%±3.31%,P<0.05 in the MKN-1 cell line)than miR-143-3p transfection.Further analysis indicated that COX-2 expression was potently suppressed by miR-143-5p but not by miR-143-3p.The activity of a luciferase reporter construct that contained the 3’-untranslated region(UTR)of COX-2 was downregulated by miR-143-5p(43.6%±4.86%,P<0.01)but not by miR-143-3p.A mutation in the miR-145-5p binding site completely ablated the regulatory effect on luciferase activity,which suggests that there is a direct miR-145-5p binding site in the 3’-UTR of COX-2.CONCLUSION:Both miR-143-5p and miR-143-3p function as anti-oncomirs in gastric cancer.However,miR-143-5p alone directly targets COX-2,and it exhibits a stronger tumor suppressive effect than miR-143-3p.展开更多
Tertiary lymphoid structures(TLS)are ectopic lymphoid structures in cancers that are largely associated with favourable prognosis.However,the prognostic value of TLSs in oral squamous cell carcinoma(OSCC)is largely un...Tertiary lymphoid structures(TLS)are ectopic lymphoid structures in cancers that are largely associated with favourable prognosis.However,the prognostic value of TLSs in oral squamous cell carcinoma(OSCC)is largely unknown,and the association between tumour infiltrating lymphocytes(TILs)and TLSs has been rarely explored in OSCC.In this study,associated markers of TLS,including peripheral node address(PNAd)in high endothelial venules,CD20 in B cells and CD3 in T cells,were examined in 168 OSCC patients,and survival analysis was performed between TLS-positive and TLS-negative cohorts.We detected the presence of TILs by staining CD8+cytotoxic T cells and CD57+NK cells as well.TLSs appeared as highly organized structures in 45(26.8%)cases.TLSpositive patients had a better 5-year overall survival(OS)rate(88.9%vs.56.1%,P<0.001)and relapse-free survival(RFS)rate(88.9%vs.63.4%,P=0.002).Moreover,the presence of TLS was an independent prognostic factor for both the 5-year OS rate(hazard ratio[HR]=3.784;95%confidence interval[CI],1.498–9.562)and RFS rate(HR=3.296;95%CI,1.279–8.490)in multivariate analysis.Furthermore,a higher density of CD8+T cells and CD57+NK cells was found in TLS-positive sections than in TLS-negative counterparts(P<0.001),and their combination provided a higher predictive accuracy(AUC=0.730;95%CI,0.654–0.805).In conclusion,our results suggest that TLS is an independent positive prognostic factor for OSCC patients.These findings provide a theoretical basis for the future diagnostic and therapeutic value of TLSs in OSCC treatment.展开更多
Mesenchymal stem cells(MSCs)have been widely exploited as promising candidates in clinical settings for bone repair and regeneration in view of their self-renewal capacity and multipotentiality.However,little is known...Mesenchymal stem cells(MSCs)have been widely exploited as promising candidates in clinical settings for bone repair and regeneration in view of their self-renewal capacity and multipotentiality.However,little is known about the mechanisms underlying their fate determination,which would illustrate their effectiveness in regenerative medicine.Recent evidence has shed light on a fundamental biological role of autophagy in the maintenance of the regenerative capability of MSCs and bone homeostasis.Autophagy has been implicated in provoking an immediately available cytoprotective mechanism in MSCs against stress,while dysfunction of autophagy impairs the function of MSCs,leading to imbalances of bone remodeling and a wide range of aging and degenerative bone diseases.This review aims to summarize the up-to-date knowledge about the effects of autophagy on MSC fate determination and its role as a stress adaptation response.Meanwhile,we highlight autophagy as a dynamic process and a double-edged sword to account for some discrepancies in the current research.We also discuss the contribution of autophagy to the regulation of bone cells and bone remodeling and emphasize its potential involvement in bone disease.展开更多
Very little is known about the role of melatonin in the trigeminal system, including the function of melatonin receptor 1. In the present study, adult rats were injected with formaldehyde into the right vibrissae pad ...Very little is known about the role of melatonin in the trigeminal system, including the function of melatonin receptor 1. In the present study, adult rats were injected with formaldehyde into the right vibrissae pad to establish a model of orofacial inflammatory pain. The distribution of melatonin re- ceptor 1 and nicotinamide adenine dinucleotide phosphate diaphorase in the caudal spinal trigeminal nucleus and trigeminal ganglion was determined with immunohistochemistry and histo- chemistry. The results show that there are significant differences in melatonin receptor 1 expression and nicotinamide adenine dinucleotide phosphate diaphorase expression in the trigeminal ganglia and caudal spinal nucleus during the early stage of orofacial inflammatory pain. Our findings sug- gest that when melatonin receptor 1 expression in the caudal spinal nucleus is significantly reduced, melatonin＇s regulatory effect on pain is attenuated.展开更多
Annual observations of first-year ice(FYI) and second-year ice(SYI) near Zhongshan Station, East Antarctica,were conducted for the first time from December 2011 to December 2012. Melt ponds appeared from early Decembe...Annual observations of first-year ice(FYI) and second-year ice(SYI) near Zhongshan Station, East Antarctica,were conducted for the first time from December 2011 to December 2012. Melt ponds appeared from early December 2011. Landfast ice partly broke in late January, 2012 after a strong cyclone. Open water was refrozen to form new ice cover in mid-February, and then FYI and SYI co-existed in March with a growth rate of 0.8 cm/d for FYI and a melting rate of 2.7 cm/d for SYI. This difference was due to the oceanic heat flux and the thickness of ice,with weaker heat flux through thicker ice. From May onward, FYI and SYI showed a similar growth by 0.5 cm/d.Their maximum thickness reached 160.5 cm and 167.0 cm, respectively, in late October. Drillings showed variations of FYI thickness to be generally less than 1.0 cm, but variations were up to 33.0 cm for SYI in March,suggesting that the SYI bottom was particularly uneven. Snow distribution was strongly affected by wind and surface roughness, leading to large thickness differences in the different sites. Snow and ice thickness in Nella Fjord had a similar "east thicker, west thinner" spatial distribution. Easterly prevailing wind and local topography led to this snow pattern. Superimposed ice induced by snow cover melting in summer thickened multi-year ice,causing it to be thicker than the snow-free SYI. The estimated monthly oceanic heat flux was ～30.0 W/m2 in March–May, reducing to ～10.0 W/m2 during July–October, and increasing to ～15.0 W/m2 in November. The seasonal change and mean value of 15.6 W/m2 was similar to the findings of previous research. The results can be used to further our understanding of landfast ice for climate change study and Chinese Antarctic Expedition services.展开更多
The crude oils typically from the CambrianLower Ordovician source rocks of Tarim Basin, NW"China, such as TD2 and TZ62S, are13C-enriched with the stable carbon isotopic ratios(VPDB) approaching-28 %.In this paper...The crude oils typically from the CambrianLower Ordovician source rocks of Tarim Basin, NW"China, such as TD2 and TZ62S, are13C-enriched with the stable carbon isotopic ratios(VPDB) approaching-28 %.In this paper, the main research viewpoints on this issue are summarized, and combined with results from organic and inorganic carbon isotope stratum curves of the outcrop at the Ya'erdang Mountain in Tarim Basin. In addition, more alternative interpretations are discussed. On one hand, the inverse fractionation features of stable carbon and hydrogen isotopes of these crude oils may imply their protogenous nature. On the other hand, the anisotropy of source rocks and contribution from older stratum source rocks need verifying as well. For the sake of the final resolution of this issue, some further study topics are recommended.展开更多
The annual cycle of the thickness and temperature of landfast sea ice in the East Siberian Sea has been examined using a one-dimensional thermodynamic model. The model was calibrated for the year August 2012-July 2013...The annual cycle of the thickness and temperature of landfast sea ice in the East Siberian Sea has been examined using a one-dimensional thermodynamic model. The model was calibrated for the year August 2012-July 2013, forced using the data of the Russian weather station Kotel＇ny Island and ECMWF reanalyses. Thermal growth and decay of ice were reproduced well, and the maximum annual ice thickness and breakup day became 1.64 m and the end of July. Oceanic heat flux was 2 W.m^-2 in winter and raised to 25 W.m^-2 in summer, albedo was 0.3-0.8 depending on the surface type （snow/ice and wet/dry）. The model outcome showed sensitivity to the albedo, air temperature and oceanic heat flux. The modelled snow cover was less than 10 cm having a small influence on the ice thickness. In situ sea ice thickness in the East Siberian Sea is rarely available in publications. This study provides a method for quantitative ice thickness estimation by modelling. The result can be used as a proxy to understand the sea ice conditions on the Eurasian Arctic coast, which is important for shipping and high-resolution Arctic climate modelling.展开更多
Snow depth and sea ice thickness were observed applying an ice mass balance buoy(IMB)in the drifting ice station Tara during the International Polar Year in 2007.Detailed in situ observations on meteorological variabl...Snow depth and sea ice thickness were observed applying an ice mass balance buoy(IMB)in the drifting ice station Tara during the International Polar Year in 2007.Detailed in situ observations on meteorological variables and surface fluxes were taken during May to August.For this study,the operational analyses and short-term forecasts from two numerical weather prediction(NWP)models(ECMWF and HIRLAM)were extracted for the Tara drift trajectory.We compared the IMB,meteorological and surface flux observations against the NWP products,also applying a one-dimensional thermodynamic sea ice model(HIGHTSI)to calculate the snow and ice mass balance and its sensitivity to atmospheric forcing.The modelled snow depth time series,controlled by NWP-based precipitation,was in line with the observed one.HIGHTSI reproduced well the snowmelt onset,the progress of the melt,and the first date of snow-free conditions.HIGHTSI performed well also in the late August freezing season.Challenges remain to model the“false bottom”observed during the melting season.The evolution of the vertical temperature profiles in snow and ice was better simulated when the model was forced by in situ observations instead of NWP results.During the melting period,the nonlinear ice temperature profile was successfully modelled with both forcing options.During spring and the melting season,total sea ice mass balance was most sensitive to uncertainties in NWP results for the downward longwave radiation,followed by the downward shortwave radiation,air temperature,and wind speed.展开更多
基金supported by a grant of National Natural Science Foundation of China,Grant No.51665052.
文摘Icing can significantly change the geometric parameters of wind turbine blades,which in turn,can reduce the aerodynamic characteristics of the airfoil.In-depth research is conducted in this study to identify the reasons for the decline of wind power equipment performance through the icing process.An accurate experimental test method is proposed in a natural environment that examines the growth and distribution of ice formation over the airfoil profile.The mathematical models of the airfoil chord length,camber,and thickness are established in order to investigate the variation of geometric airfoil parameters under different icing states.The results show that ice accumulation varies considerably along the blade span.By environmental temperature drop,the minimum and maximum extents of ice accumulation are observed near the blade root(0.2 R)and the blade tip(0.95 R),respectively(R represents the blade length).The icing process steadily increases the chord length and decreases the airfoil curvature,reaching the largest value at the blade tip region.Furthermore,the maximum curvature is reduced to 41.50%of the original curvature.The maximum camber position of the airfoil moves towards the trailing edge,and the most prominent position occurs at the middle blade region(0.6 R),where it moves back by 19.43%.Ice accumulation steadily increases airfoil thickness.It leads to the maximum thickness growth of 53.40%that occurs at the blade tip region and moves forward to the leading edge by 10%.The research results can provide the required theoretical support for further monitoring the blades operating conditions to ensure reliable wind turbines’operation.
基金supported by the Natural Science Foundation of China(Project No.51665052).
文摘With the continuous increase in the proportional use of wind energy across the globe,the reduction of power generation efficiency and safety hazards caused by the icing on wind turbine blades have attracted more consideration for research.Therefore,it is crucial to accurately analyze the thickness of icing on wind turbine blades,which can serve as a basis for formulating corresponding control measures and ensure a safe and stable operation of wind turbines in winter times and/or in high altitude areas.This paper fully utilized the advantages of the support vector machine(SVM)and back-propagation neural network(BPNN),with the incorporation of particle swarm optimization(PSO)algorithms to optimize the parameters of the SVM.The paper proposes a hybrid assessment model of PSO-SVM and BPNN based on dynamic weighting rules.Three sets of icing data under a rotating working state of the wind turbine were used as examples for model verification.Based on a comparative analysis with other models,the results showed that the proposed model has better accuracy and stability in analyzing the icing on wind turbine blades.
文摘One of the factors for the evaluation of the space environment is the comfort of outdoor activities spaces in urban parks. The space composed of different landscape elements has different microclimate environment. In this paper, in order to evaluate the role of thermal comfort in influencing resident’s assessment of the outdoor space and activities of the park, a thermal comfort survey was conducted on the outdoor open space of Mianyang Urban Park in summer. In this article, meteorological surveys, questionnaire surveys and observation of park attendance are selected to collect data. The physiological equivalent temperature (PET) assessment was selected as the index to evaluate resident’s thermal comfort level, and the comprehensive evaluation and analysis of the spatial thermal environment of different outdoor landscape elements in the park. The overall comfort of current visitors is mainly influenced by their subjective heat perception voting (TSV). In this article, we focus on providing microclimate adjustment considerations for urban park landscape design, and may help people understand the outdoor thermal comfort of Mianyang in summer, increase the using time of outdoor activities, and promote the use of outdoor space.
基金supported by the National Natural Science Foundation of China(Grant Nos.12322407,62122036,and 62034004)the Natural Science Foundation of Jiangsu Province(Grant No.BK20233001)+5 种基金the National Key R&D Program of China(Grant Nos.2023YFF0718400 and 2023YFF1203600)the Leading-edge Technology Program of Jiangsu Natural Science Foundation(Grant No.BK20232004)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB44000000)Innovation Program for Quantum Science and Technologysupport from the Fundamental Research Funds for the Central Universities(Grant Nos.020414380227,020414380240,and 020414380242)the e-Science Center of Collaborative Innovation Center of Advanced Microstructures。
文摘Layer pseudospins,exhibiting quantum coherence and precise multistate controllability,present significant potential for the advancement of future computing technologies.In this work,we propose an in-memory probabilistic computing scheme based on the electrical manipulation of layer pseudospins in layered materials,by exploiting the interaction between real spins and layer pseudospins.
基金supported by the National Natural Science Foundation of China(U23A20445)the Science and Technology Program of Guangzhou(202206080009)。
文摘Radiochemotherapy-induced oral mucositis(OM)is a common oral complication in patients with tumors following head and neck radiotherapy or chemotherapy.Erosion and ulcers are the main features of OM that seriously affect the quality of life of patients and even the progress of tumor treatment.To date,differences in clinical prevention and treatment plans for OM have been noted among doctors of various specialties,which has increased the uncertainty of treatment effects.On the basis of current research evidence,this expert consensus outlines risk factors,clinical manifestations,clinical grading,ancillary examinations,diagnostic basis,prevention and treatment strategies and efficacy indicators for OM.In addition to strategies such as basic oral care,antiinflammatory and analgesic agents,anti-infective agents,pro-healing agents,and photobiotherapy recommended in previous guidelines,we also emphasize the role of traditional Chinese medicine in OM prevention and treatment.This expert consensus aims to provide references and guidance for dental physicians and oncologists in formulating strategies for OM prevention,diagnosis,and treatment,standardizing clinical practice,reducing OM occurrence,promoting healing,and improving the quality of life of patients.
基金supported financially by the National Natural Science Foundation of China(Nos.82260682,22477108,81960662,82200550)the Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform(No.2022YKZY001)+9 种基金the Yunnan Provincial Science and Technology Department(Nos.202101AT070154,202301AT0–70270 and 202401AY070001–303)the Scientific Research Fund Project of Yunnan Provincial Department of Education(No.2023Y0–797)the Program Innovative Research Team in Science and Technology in Kunming Medical University(No.CXTD202202)the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT-17R94)the Project of Innovative Research Team of Yunnan Province(No.202005AE160005)the Open Research Foundation of Yunnan Key Laboratory of Bioactive Peptides in Yunnan Province(No.HXDT-2022–1)a grant(No.2023KF007)from YNCUBFirst-Class Discipline Team of Kunming Medical University(No.2024XKTDPY12)Yunnan Revitalization Talent Support Programthe Yun Ling Scholar Project to W.-L.Xiao。
文摘Six rearranged nor-diterpenoids with 5/6/6-fused tricyclic system(1–6),and one unprecedented dimer with 5/6/6/6/6/5-fused carbon core(7)were isolated from Strophioblachia glandulosa.Spectroscopic techniques,electronic circular dichroism(ECD),quantum chemical calculations,and single-crystal X-ray diffraction analysis were used to elucidate their structures.A preliminary bioactivity assay revealed compounds 2 and 3 exhibited potent anti-myocardial hypertrophy effect in vitro by significantly inhibiting the expression levels of atrial natriuretic peptide(ANP)and myosin heavy chain 7(MYH7)proteins.Additionally,mitogen-activated protein kinase 14(Mapk14)may be involved in the regulation of compound3 on cardiac hypertrophic disease by network pharmacology prediction and experimental verification.
基金The National Key Research and Development Program of China under contract No.2021YFC2803300the National Natural Science Foundation of China under contract No.42325604+1 种基金the Ministry of Industry and Information Technology of China under contract No.CBG2N21-2-1Program of Shanghai Academic/Technology Research Leader under contract No.22XD1403600.
文摘The thaw-freezing transition period is crucial to determine the initial sea ice status prior to the freezing season.The heat and mass balance at ice-ocean interface is the major driving process.In this study,we analyze heat fluxes profile through the ice from ice surface down to basal ice-ocean interface using the data measured by 11 thermistor stringbased ice mass balance buoys(IMBs)between September and December 2018 in the Pacific sector of Arctic Ocean.The conductive heat fluxes gradually decreased from surface downward through the lower ice layers due to the thermal inertia and energy storage in the brine pockets.At the ice bottom,the oceanic heat flux decreased from(5.9±1.3)W/m^(2)in mid-September to(1.8±0.8)W/m^(2)by the end of December in response to the decreasing of available absorbed solar radiation regulated by the latitude and sea ice concentration.The initial ice thicknesses can explain the onset of ice basal growth by 44.8%(R^(2)).From 15 September to the average onset of ice basal growth by 13 November,the accumulated heat fluxes released from the ice surface to the atmosphere,caused by the cooling of the ice layer,and from the ocean to the ice bottom were estimated as 25.73 MJ/m^(2),6.49 MJ/m^(2),and 20.30 MJ/m^(2),respectively.The latter two components mainly play the roles in buffering the onset of ice basal growth.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62375131,62204119,62122036,and 62304104)the Natural Science Foundation of Jiangsu Province(Grant No.BK20220947)the Funding of NJUST(Grant No.TSXK2022D008)。
文摘Electrically tunable homojunctions based on ambipolar two-dimensional materials have attracted widespread attention in the field of intelligent vision.These devices exhibit inherent switchable positive and negative photovoltaic properties that effectively mimic the behavior of human retinal cells.However,the photovoltaic responsivity of most electrically tunable homojunctions remains significantly low due to the weak light absorption,making it challenging to meet the application requirements for high-sensitivity target detection in the field of intelligent vision.Here,we propose a gate-tunable photodiode based on two-dimensional ambipolar WSe_(2)with an asymmetric gate electrode,achieving high photovoltaic responsivity.By adjusting the gate voltage and keeping bias voltage zero,we can dynamically realize reconfigurable n-–p and n-–n homojunction states,as well as gate-tunable photovoltaic response characteristics that range from positive to negative.The maximum photovoltaic responsivity of the electrically tunable WSe_(2)homojunction is approximately 0.4 A/W,which is significantly larger than the previously reported value~0.1 A/W in homojunction devices.In addition,the responsivity can be further enhanced to approximately 1.0 A/W when the n-–p photodiode operates in reverse bias mode,enabling highsensitivity detection of targets.Our work paves the way for developing gate-tunable photodiodes with high photovoltaic responsivity and advancing high-performance intelligent vision technology.
文摘With regard to the rapid growth of China’s building area and the increasing energy consumption of buildings, green buildings have become an important issue for balancing economic development and environmental impact. However, the current evaluation systems for various types of green buildings are often unable to achieve a set of standards in practice due to the distinct regional characteristics of each region. Therefore, in view of the regional characteristics of the climate, terrain, ecology, and economic development in the cold regions of Sichuan, it is important to study the evaluation system of green residential buildings suitable for the cold regions of Sichuan. This article focuses on the regional characteristics of climate, topography, ecology, and economic development in the cold regions of Sichuan, and discusses the limitations of the current standards on the practice of green building in cold regions of Sichuan through a sociological questionnaire survey on the comfort of living in the local population. Then from the two dimensions of the advantages of traditional houses and the particularity of national culture, the strategies for the optimization and improvement of the evaluation index system for green residential buildings in the cold regions of Sichuan were proposed. After comprehensively considering the factors that affect the green residential buildings, including the regional characteristics of the cold regions of Sichuan, and the green performance of buildings, local characteristics and ethnic features were included in the evaluation system. The evaluation index system of green residential buildings in the cold regions of Sichuan, consists of 92 three-level indicators. A professional hierarchical analysis software yaahp was used to establish a multi-level hierarchical model between the indicators, and the indicators were compared with each other layer by layer to clarify the importance of the indicators. Based on this, a judgment matrix for each layer was constructed and obtained. The weight of each indicator is accurate, and the scoring mechanism and grading standards are constructed according to it. Through the calculation, the consistency test of the entire model was passed, thereby confirming the scientificity and rationality of the entire evaluation system.
文摘AIM:To investigate the function of microRNA-143(miR-143)in gastric cancer and explore the target genes of miR-143.METHODS:A quantitative real-time reverse transcription-polymerase chain reaction(RT-PCR)analysis was performed to evaluate miR-143 expression in gastric cancer cell lines.After transfecting gastric cancer cells with miR-143-5p and miR-143-3p precursors,Alamar blue and apoptosis assays were used to measure the respective proliferation and apoptosis rates.Cyclooxygenase-2(COX-2)expression was determined by realtime RT-PCR and Western blot assays after miR-143transfection.Reporter plasmids were constructed,and a luciferase reporter assay was used to identify the miR-143 binding site on COX-2.RESULTS:Both miR-143-5p and miR-143-3p were significantly downregulated in multiple gastric cancer cell lines.Forced miR-143-5p and miR-143-3p expression in gastric cancer cells produced a profound cytotoxic effect.MiR-145-5p transfection into gastric cancer cells resulted in a greater growth inhibitory effect(61.23%±3.16%vs 46.58%±4.28%,P<0.05 in the MKN-1cell line)and a higher apoptosis rate(28.74%±1.93%vs 22.13%±3.31%,P<0.05 in the MKN-1 cell line)than miR-143-3p transfection.Further analysis indicated that COX-2 expression was potently suppressed by miR-143-5p but not by miR-143-3p.The activity of a luciferase reporter construct that contained the 3’-untranslated region(UTR)of COX-2 was downregulated by miR-143-5p(43.6%±4.86%,P<0.01)but not by miR-143-3p.A mutation in the miR-145-5p binding site completely ablated the regulatory effect on luciferase activity,which suggests that there is a direct miR-145-5p binding site in the 3’-UTR of COX-2.CONCLUSION:Both miR-143-5p and miR-143-3p function as anti-oncomirs in gastric cancer.However,miR-143-5p alone directly targets COX-2,and it exhibits a stronger tumor suppressive effect than miR-143-3p.
基金This work was supported by the National Natural Science Foundations of China(Nos.81972532,81772896,81602383 and 81472524)the Science and Technology Planning Project of Guangzhou City of China(No.2017004020102).
文摘Tertiary lymphoid structures(TLS)are ectopic lymphoid structures in cancers that are largely associated with favourable prognosis.However,the prognostic value of TLSs in oral squamous cell carcinoma(OSCC)is largely unknown,and the association between tumour infiltrating lymphocytes(TILs)and TLSs has been rarely explored in OSCC.In this study,associated markers of TLS,including peripheral node address(PNAd)in high endothelial venules,CD20 in B cells and CD3 in T cells,were examined in 168 OSCC patients,and survival analysis was performed between TLS-positive and TLS-negative cohorts.We detected the presence of TILs by staining CD8+cytotoxic T cells and CD57+NK cells as well.TLSs appeared as highly organized structures in 45(26.8%)cases.TLSpositive patients had a better 5-year overall survival(OS)rate(88.9%vs.56.1%,P<0.001)and relapse-free survival(RFS)rate(88.9%vs.63.4%,P=0.002).Moreover,the presence of TLS was an independent prognostic factor for both the 5-year OS rate(hazard ratio[HR]=3.784;95%confidence interval[CI],1.498–9.562)and RFS rate(HR=3.296;95%CI,1.279–8.490)in multivariate analysis.Furthermore,a higher density of CD8+T cells and CD57+NK cells was found in TLS-positive sections than in TLS-negative counterparts(P<0.001),and their combination provided a higher predictive accuracy(AUC=0.730;95%CI,0.654–0.805).In conclusion,our results suggest that TLS is an independent positive prognostic factor for OSCC patients.These findings provide a theoretical basis for the future diagnostic and therapeutic value of TLSs in OSCC treatment.
文摘Mesenchymal stem cells(MSCs)have been widely exploited as promising candidates in clinical settings for bone repair and regeneration in view of their self-renewal capacity and multipotentiality.However,little is known about the mechanisms underlying their fate determination,which would illustrate their effectiveness in regenerative medicine.Recent evidence has shed light on a fundamental biological role of autophagy in the maintenance of the regenerative capability of MSCs and bone homeostasis.Autophagy has been implicated in provoking an immediately available cytoprotective mechanism in MSCs against stress,while dysfunction of autophagy impairs the function of MSCs,leading to imbalances of bone remodeling and a wide range of aging and degenerative bone diseases.This review aims to summarize the up-to-date knowledge about the effects of autophagy on MSC fate determination and its role as a stress adaptation response.Meanwhile,we highlight autophagy as a dynamic process and a double-edged sword to account for some discrepancies in the current research.We also discuss the contribution of autophagy to the regulation of bone cells and bone remodeling and emphasize its potential involvement in bone disease.
基金supported by the National Natural Science Foundation of China,No.81271166,81371107the Natural Science Foundation of Guangdong Province in China,No.10451008901006145
文摘Very little is known about the role of melatonin in the trigeminal system, including the function of melatonin receptor 1. In the present study, adult rats were injected with formaldehyde into the right vibrissae pad to establish a model of orofacial inflammatory pain. The distribution of melatonin re- ceptor 1 and nicotinamide adenine dinucleotide phosphate diaphorase in the caudal spinal trigeminal nucleus and trigeminal ganglion was determined with immunohistochemistry and histo- chemistry. The results show that there are significant differences in melatonin receptor 1 expression and nicotinamide adenine dinucleotide phosphate diaphorase expression in the trigeminal ganglia and caudal spinal nucleus during the early stage of orofacial inflammatory pain. Our findings sug- gest that when melatonin receptor 1 expression in the caudal spinal nucleus is significantly reduced, melatonin＇s regulatory effect on pain is attenuated.
基金The National Natural Science Foundation of China under contract Nos 41876212,41406218 and 41676176the Polar Strategy Project from Chinese Arctic and Antarctic Administration under contract No.20120317the Opening Fund of Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions,CAS,under contract Nos LPCC2018001 and LPCC2018005
文摘Annual observations of first-year ice(FYI) and second-year ice(SYI) near Zhongshan Station, East Antarctica,were conducted for the first time from December 2011 to December 2012. Melt ponds appeared from early December 2011. Landfast ice partly broke in late January, 2012 after a strong cyclone. Open water was refrozen to form new ice cover in mid-February, and then FYI and SYI co-existed in March with a growth rate of 0.8 cm/d for FYI and a melting rate of 2.7 cm/d for SYI. This difference was due to the oceanic heat flux and the thickness of ice,with weaker heat flux through thicker ice. From May onward, FYI and SYI showed a similar growth by 0.5 cm/d.Their maximum thickness reached 160.5 cm and 167.0 cm, respectively, in late October. Drillings showed variations of FYI thickness to be generally less than 1.0 cm, but variations were up to 33.0 cm for SYI in March,suggesting that the SYI bottom was particularly uneven. Snow distribution was strongly affected by wind and surface roughness, leading to large thickness differences in the different sites. Snow and ice thickness in Nella Fjord had a similar "east thicker, west thinner" spatial distribution. Easterly prevailing wind and local topography led to this snow pattern. Superimposed ice induced by snow cover melting in summer thickened multi-year ice,causing it to be thicker than the snow-free SYI. The estimated monthly oceanic heat flux was ～30.0 W/m2 in March–May, reducing to ～10.0 W/m2 during July–October, and increasing to ～15.0 W/m2 in November. The seasonal change and mean value of 15.6 W/m2 was similar to the findings of previous research. The results can be used to further our understanding of landfast ice for climate change study and Chinese Antarctic Expedition services.
基金supported by the National Natural Science Foundation of China (Grant No. 41272149)National oil and gas Projects (Grant No. 2011ZX05008-002)
文摘The crude oils typically from the CambrianLower Ordovician source rocks of Tarim Basin, NW"China, such as TD2 and TZ62S, are13C-enriched with the stable carbon isotopic ratios(VPDB) approaching-28 %.In this paper, the main research viewpoints on this issue are summarized, and combined with results from organic and inorganic carbon isotope stratum curves of the outcrop at the Ya'erdang Mountain in Tarim Basin. In addition, more alternative interpretations are discussed. On one hand, the inverse fractionation features of stable carbon and hydrogen isotopes of these crude oils may imply their protogenous nature. On the other hand, the anisotropy of source rocks and contribution from older stratum source rocks need verifying as well. For the sake of the final resolution of this issue, some further study topics are recommended.
基金supported by research funding from the National Natural Science Foundation of China (Grant nos. 41428603, 41376186, 41476170)the EU FP7 Project Eu Ru CAS(European-Russian Centre for Cooperation in the Arctic and Sub-Arctic Environmental and Climate Research,Grant no.295068)+2 种基金Academy of Finland (Grant nos. 11409391, 259537)the Liaoning Educational Committee Foundation (Grant no. L2013497)the Ocean Public Welfare Scientific Research Project of China (Grant nos. 201205007, 201205007-2)
文摘The annual cycle of the thickness and temperature of landfast sea ice in the East Siberian Sea has been examined using a one-dimensional thermodynamic model. The model was calibrated for the year August 2012-July 2013, forced using the data of the Russian weather station Kotel＇ny Island and ECMWF reanalyses. Thermal growth and decay of ice were reproduced well, and the maximum annual ice thickness and breakup day became 1.64 m and the end of July. Oceanic heat flux was 2 W.m^-2 in winter and raised to 25 W.m^-2 in summer, albedo was 0.3-0.8 depending on the surface type （snow/ice and wet/dry）. The model outcome showed sensitivity to the albedo, air temperature and oceanic heat flux. The modelled snow cover was less than 10 cm having a small influence on the ice thickness. In situ sea ice thickness in the East Siberian Sea is rarely available in publications. This study provides a method for quantitative ice thickness estimation by modelling. The result can be used as a proxy to understand the sea ice conditions on the Eurasian Arctic coast, which is important for shipping and high-resolution Arctic climate modelling.
基金This study was initialized during DAMOCLES project(Grant no.18509)which was funded by the 6th Framework Programme of the European Commission+2 种基金The initial data analysis was funded by the Research Council of Norway’s AMORA project(Grant no.#193592)The modelling work has been supported by the Academy of Finland(Contract 317999)The finalization of this work was supported by the European Union’s Horizon 2020 research and innovation programme(Grant no.727890–INTAROS).
文摘Snow depth and sea ice thickness were observed applying an ice mass balance buoy(IMB)in the drifting ice station Tara during the International Polar Year in 2007.Detailed in situ observations on meteorological variables and surface fluxes were taken during May to August.For this study,the operational analyses and short-term forecasts from two numerical weather prediction(NWP)models(ECMWF and HIRLAM)were extracted for the Tara drift trajectory.We compared the IMB,meteorological and surface flux observations against the NWP products,also applying a one-dimensional thermodynamic sea ice model(HIGHTSI)to calculate the snow and ice mass balance and its sensitivity to atmospheric forcing.The modelled snow depth time series,controlled by NWP-based precipitation,was in line with the observed one.HIGHTSI reproduced well the snowmelt onset,the progress of the melt,and the first date of snow-free conditions.HIGHTSI performed well also in the late August freezing season.Challenges remain to model the“false bottom”observed during the melting season.The evolution of the vertical temperature profiles in snow and ice was better simulated when the model was forced by in situ observations instead of NWP results.During the melting period,the nonlinear ice temperature profile was successfully modelled with both forcing options.During spring and the melting season,total sea ice mass balance was most sensitive to uncertainties in NWP results for the downward longwave radiation,followed by the downward shortwave radiation,air temperature,and wind speed.
