AIM: To assess the safety and feasibility of peroral esophageal myotomy(POEM) in patients with achalasia.METHODS: From January 2012 to March 2014, 50 patients(28 men, 22 women; mean age: 42.8 years, range: 14-70 years...AIM: To assess the safety and feasibility of peroral esophageal myotomy(POEM) in patients with achalasia.METHODS: From January 2012 to March 2014, 50 patients(28 men, 22 women; mean age: 42.8 years, range: 14-70 years) underwent POEM. Pre- and postoperative symptoms were quantified using the Eckardt scoring system. Barium swallow and esophagogastroscopy were performed before and after POEM, respectively. Esophageal motility was evaluated in all patients, both preoperatively and one month after POEM treatment, using a high-resolution manometry system. Manometry data, Eckardt scores, lower esophageal sphincter pressure and barium swallow results were used to evaluate the effect of the procedure.RESULTS: POEM was successfully completed for all patients. The mean procedure time was 55.4 ± 17.3 min and the mean total length of myotomy of the circular esophagus was 10.5 ± 2.6 cm. No specific complications occurred, with the exception of two patients that developed as ymptomatic pneumomediastinum and subcutaneous emphysema. Clinical improvement in symptoms was achieved in all patients. Approximately 77.5% of patients experienced weight gain 6 mo after POEM, with an average of 4.78 kg(range: 2-15 kg). The lower esophageal sphincter resting pressure, four second integrated relaxation pressure and Eckardt scores were all significantly reduced after POEM(Ps < 0.05). A small segment of proximal esophageal peristalsis appeared postoperatively in two patients, but without normal esophageal peristalsis. The average diameter of the esophageal lumen decreased significantly from 4.39 to 3.09 cm(P < 0.01). CONCLUSION: POEM can relieve achalasia symptoms, improve gastroesophageal junction relaxation and restore esophageal body motility function, but not normal esophageal peristalsis.展开更多
Glass micropipettes with silanized inner walls can be filled with an organic solvent for voltammetric measurements in an aqueous solution. This arrangement was employed to investigate systematically the mechanism of f...Glass micropipettes with silanized inner walls can be filled with an organic solvent for voltammetric measurements in an aqueous solution. This arrangement was employed to investigate systematically the mechanism of facilitated potassium ion transfer by an ionophore dibenzo 18 crown 6(DB18C6) across a micro water/1,2 dichloroethane(W/DCE) interface supported at the tip of a silanized micropipette. Our experimental results verify that this facilitated ion transfer across the liquid/liquid interface did occur by an interfacial complexation dissociation process(TIC TID mechanism). The ratio of the diffusion coefficient of DB18C6 to that of its complexed ion in the DCE phase was calculated to be 1.74±0.07.展开更多
Dear Editor,In the late stages of the retroviral life cycle,the transcription of viral pre-m RNA is initiated at the 5′long terminal repeat(5′LTR)and terminated at the 3′LTR;the full-length and spliced viral RNAs a...Dear Editor,In the late stages of the retroviral life cycle,the transcription of viral pre-m RNA is initiated at the 5′long terminal repeat(5′LTR)and terminated at the 3′LTR;the full-length and spliced viral RNAs are transported out of the nucleus and serve as templates for the translation of viral proteins or alternatively as the full-length viral genome to be packaged into virus particles.Antisense展开更多
SiC-C films with different content of SiC were deposited with r. f. magnetron sputtering followed by argon ion bombardment. These films were then permeated by hydrogen gas under the pressure of 3.23×107 Pa for 3h...SiC-C films with different content of SiC were deposited with r. f. magnetron sputtering followed by argon ion bombardment. These films were then permeated by hydrogen gas under the pressure of 3.23×107 Pa for 3h at 500K. AES and XPS were used to analyze chemical bonding states of C and Si in the SiC-C films as well as contaminating oxygen before and after hydrogen gas permeation in order to study the effect of hydrogen on them. Related mechanism was discussed in this paper.展开更多
In this paper, we report that diisopropyl phosphoryl amino acid could be prepared with reasonable yields under solvent-free condition by adding amino acid to the mixture of diisopropyl phosphite and N-chlorodiisopropy...In this paper, we report that diisopropyl phosphoryl amino acid could be prepared with reasonable yields under solvent-free condition by adding amino acid to the mixture of diisopropyl phosphite and N-chlorodiisopropylamine.展开更多
N- (2,4-Dinitrophenyl)-4-amino-n-butyl aldehyde 3 was obtained with high yield of 80% when N- (2,4-dinitrophenyl)-L-proline 1 reacted with SOCl2 at room temperature. However, the anticipated product N- (2,4-dinitroph...N- (2,4-Dinitrophenyl)-4-amino-n-butyl aldehyde 3 was obtained with high yield of 80% when N- (2,4-dinitrophenyl)-L-proline 1 reacted with SOCl2 at room temperature. However, the anticipated product N- (2,4-dinitrophenyl)-tetrahydropyrrolyl-2- (4-methylthiophenyl) ketone 2 did not be produced. The mechanism was discussed in this article.展开更多
UV-vis and luminescence spectroscopic titration experiments show that a novel Ru(II) complex exhibits off-on-off pH luminescent switching with a maximum on-off ratio of about 100.
The coupling of capillary electrophoresis to electrospray Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) was presented for the on-line separation and detection of mixture of peptides. With th...The coupling of capillary electrophoresis to electrospray Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) was presented for the on-line separation and detection of mixture of peptides. With the ultra-high resolution and unmatchable mass measurement accuracy FT-ICR-MS provides, the separation and identification of angiotensin III, octreotide and elastin chemotactic were successfully achieved using this fabricated device, which showed its great application potential in detection and structural identification for multicomponent sample.展开更多
We present a study of the β Cephei instability strip based on a sample of 49 stars of this type. After deriving their effective temperatures and luminosities from their observed (B - V), (U - B) colors and parallaxes...We present a study of the β Cephei instability strip based on a sample of 49 stars of this type. After deriving their effective temperatures and luminosities from their observed (B - V), (U - B) colors and parallaxes we find their positions in the HR diagram to be mostly confined to the main sequence, and their masses to lie between 7 M⊙ and 30 M⊙ . Their distribution on the HR diagram matches well with our previous theoretical instability strip which has an upper bound in the luminosity and rather tight boundaries in the effective temperature.展开更多
文摘AIM: To assess the safety and feasibility of peroral esophageal myotomy(POEM) in patients with achalasia.METHODS: From January 2012 to March 2014, 50 patients(28 men, 22 women; mean age: 42.8 years, range: 14-70 years) underwent POEM. Pre- and postoperative symptoms were quantified using the Eckardt scoring system. Barium swallow and esophagogastroscopy were performed before and after POEM, respectively. Esophageal motility was evaluated in all patients, both preoperatively and one month after POEM treatment, using a high-resolution manometry system. Manometry data, Eckardt scores, lower esophageal sphincter pressure and barium swallow results were used to evaluate the effect of the procedure.RESULTS: POEM was successfully completed for all patients. The mean procedure time was 55.4 ± 17.3 min and the mean total length of myotomy of the circular esophagus was 10.5 ± 2.6 cm. No specific complications occurred, with the exception of two patients that developed as ymptomatic pneumomediastinum and subcutaneous emphysema. Clinical improvement in symptoms was achieved in all patients. Approximately 77.5% of patients experienced weight gain 6 mo after POEM, with an average of 4.78 kg(range: 2-15 kg). The lower esophageal sphincter resting pressure, four second integrated relaxation pressure and Eckardt scores were all significantly reduced after POEM(Ps < 0.05). A small segment of proximal esophageal peristalsis appeared postoperatively in two patients, but without normal esophageal peristalsis. The average diameter of the esophageal lumen decreased significantly from 4.39 to 3.09 cm(P < 0.01). CONCLUSION: POEM can relieve achalasia symptoms, improve gastroesophageal junction relaxation and restore esophageal body motility function, but not normal esophageal peristalsis.
基金Supported by Chinese Academ y of Sciences(CAS) National Natural Science Foundation of China(No. 2 982 5 111) andthe Third World Academ y of Science(TWAS) and the State Key L aboratory of Electroanalytical Chem istry of the CAS.
文摘Glass micropipettes with silanized inner walls can be filled with an organic solvent for voltammetric measurements in an aqueous solution. This arrangement was employed to investigate systematically the mechanism of facilitated potassium ion transfer by an ionophore dibenzo 18 crown 6(DB18C6) across a micro water/1,2 dichloroethane(W/DCE) interface supported at the tip of a silanized micropipette. Our experimental results verify that this facilitated ion transfer across the liquid/liquid interface did occur by an interfacial complexation dissociation process(TIC TID mechanism). The ratio of the diffusion coefficient of DB18C6 to that of its complexed ion in the DCE phase was calculated to be 1.74±0.07.
基金supported by National Natural Science Foundation of China (81371820)
文摘Dear Editor,In the late stages of the retroviral life cycle,the transcription of viral pre-m RNA is initiated at the 5′long terminal repeat(5′LTR)and terminated at the 3′LTR;the full-length and spliced viral RNAs are transported out of the nucleus and serve as templates for the translation of viral proteins or alternatively as the full-length viral genome to be packaged into virus particles.Antisense
基金National Natural Science Foundation of China (5978100)
文摘SiC-C films with different content of SiC were deposited with r. f. magnetron sputtering followed by argon ion bombardment. These films were then permeated by hydrogen gas under the pressure of 3.23×107 Pa for 3h at 500K. AES and XPS were used to analyze chemical bonding states of C and Si in the SiC-C films as well as contaminating oxygen before and after hydrogen gas permeation in order to study the effect of hydrogen on them. Related mechanism was discussed in this paper.
基金the National Natural Science Foundation of china (Grand No.20132020) for financial support the Ministry of Science and Technology the Chinese Ministry of Education and Tsinghua University
文摘In this paper, we report that diisopropyl phosphoryl amino acid could be prepared with reasonable yields under solvent-free condition by adding amino acid to the mixture of diisopropyl phosphite and N-chlorodiisopropylamine.
文摘N- (2,4-Dinitrophenyl)-4-amino-n-butyl aldehyde 3 was obtained with high yield of 80% when N- (2,4-dinitrophenyl)-L-proline 1 reacted with SOCl2 at room temperature. However, the anticipated product N- (2,4-dinitrophenyl)-tetrahydropyrrolyl-2- (4-methylthiophenyl) ketone 2 did not be produced. The mechanism was discussed in this article.
基金supported by the State Key Program of Fundamental Research (G1998061308) NNSFC (29971005+3 种基金 20023005 20071004) Beijing Natural Science Foundation (2002007) National Key Program for Fundamental Research (2001 CCD 04300) and Scientific Research Foun
文摘UV-vis and luminescence spectroscopic titration experiments show that a novel Ru(II) complex exhibits off-on-off pH luminescent switching with a maximum on-off ratio of about 100.
基金supported by the National Natural Science Foundation of China (20035010 and 20175033) and Instrumental Innovation Project of Chinese Academy of Sciences.
文摘The coupling of capillary electrophoresis to electrospray Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) was presented for the on-line separation and detection of mixture of peptides. With the ultra-high resolution and unmatchable mass measurement accuracy FT-ICR-MS provides, the separation and identification of angiotensin III, octreotide and elastin chemotactic were successfully achieved using this fabricated device, which showed its great application potential in detection and structural identification for multicomponent sample.
基金Supported by the National Natural Science Foundation of China.
文摘We present a study of the β Cephei instability strip based on a sample of 49 stars of this type. After deriving their effective temperatures and luminosities from their observed (B - V), (U - B) colors and parallaxes we find their positions in the HR diagram to be mostly confined to the main sequence, and their masses to lie between 7 M⊙ and 30 M⊙ . Their distribution on the HR diagram matches well with our previous theoretical instability strip which has an upper bound in the luminosity and rather tight boundaries in the effective temperature.
