Prosthesis implantation and fat transplantation are common breast reconstructionmethods.In general,prosthesis implantation alone does not achieve a realistic enough appearance,and fat transplantation alone is difficul...Prosthesis implantation and fat transplantation are common breast reconstructionmethods.In general,prosthesis implantation alone does not achieve a realistic enough appearance,and fat transplantation alone is difficult to achieve in the correct capacity.To date,no reports have focused on methods of combining fat with implanted prostheses for breast reconstruction.Using a newly designed bionic ink(i.e.,polyether F127 diacrylate(F127DA)&poly(ethylene glycol)diacrylate(PEGDA))and projection-based three-dimensional bioprinting(PBP),we report the development of a new method for printing porous prostheses.PEGDA was used to improve the printing precision of the prosthesis by increasing the gel point of F127DA and reducing the impact of external temperature.The compression modulus of the printed prosthesis was very close to that of prostheses currently used in clinical practice and to that of natural breasts.Finally,stromal vascular fraction gel(SVF-gel),a human fat extract,was injected into the pores of the synthesized prostheses to prepare a prosthesis mixed with adipose tissue.These were implanted subcutaneously in nude mice to observe their biological performance.After 14 and 28 days of observation,the prosthesis showed good biocompatibility,and adipose tissues grew well in and around the prosthesis.This result shows that a porous prosthesis containing pre-placed adipose tissues is a promising breast reconstruction material.展开更多
Piezoresistive pressure sensors offer high accuracy,high sensitivity,and a compact form factor,making them widely adopted in aerospace applications.However,conventional designs are constrained by sensing materials and...Piezoresistive pressure sensors offer high accuracy,high sensitivity,and a compact form factor,making them widely adopted in aerospace applications.However,conventional designs are constrained by sensing materials and structural limitations,hindering pressure monitoring at temperatures exceeding 600℃.Stable and repeatable pressure measurement over a wide temperature and frequency range remains a significant challenge.In this work,a ceramicbased nitrogen-doped ITO(ITON)piezoresistive pressure sensor is proposed.By utilizing an Al_(2)O_(3)ceramic structure and ITO material,the issue of operational temperature limitations is effectively addressed,thereby enabling stable sensor output at high temperatures.Results show that the sensitivity of the sensor reaches 236 mV/mA/MPa at 900℃.The linearity of the sensor is less than 3.74%FS in the range from 25℃to 900℃.The frequency response of the sensor exceeds 409 kHz across temperatures spanning 25℃to 1000℃,with an ultra-fast response time of 12μs.In addition,the resistance of the sensor chip increased by only 2.4%and 0.8%after being immersed in H_(2)SO_(4)and NaOH solutions for 70 hours,respectively.Thus,the developed sensor demonstrates significant potential for pressure measurement in high-temperature and wide frequency domain environments.展开更多
基金This work was supported by the National Key Research andDevelopment Program of China(No.2018YFA0703000)the National Natural Science Foundation of China(Nos.T2121004,52235007,and 82203602)+2 种基金Zhejiang Provincial Natural Science Foundation of China under Grant No.LQ22H160020 to JWThis work was also supported by Start-up Funding of Zhejiang Provincial People’s Hospital(No.ZRY2021A001 to JW)Basic Scientific Research Funds of Department of Education of Zhejiang Province(No.KYQN202109 to JW).
文摘Prosthesis implantation and fat transplantation are common breast reconstructionmethods.In general,prosthesis implantation alone does not achieve a realistic enough appearance,and fat transplantation alone is difficult to achieve in the correct capacity.To date,no reports have focused on methods of combining fat with implanted prostheses for breast reconstruction.Using a newly designed bionic ink(i.e.,polyether F127 diacrylate(F127DA)&poly(ethylene glycol)diacrylate(PEGDA))and projection-based three-dimensional bioprinting(PBP),we report the development of a new method for printing porous prostheses.PEGDA was used to improve the printing precision of the prosthesis by increasing the gel point of F127DA and reducing the impact of external temperature.The compression modulus of the printed prosthesis was very close to that of prostheses currently used in clinical practice and to that of natural breasts.Finally,stromal vascular fraction gel(SVF-gel),a human fat extract,was injected into the pores of the synthesized prostheses to prepare a prosthesis mixed with adipose tissue.These were implanted subcutaneously in nude mice to observe their biological performance.After 14 and 28 days of observation,the prosthesis showed good biocompatibility,and adipose tissues grew well in and around the prosthesis.This result shows that a porous prosthesis containing pre-placed adipose tissues is a promising breast reconstruction material.
基金supported in part by the Aviation Science Fund under Grant 20230012063001 and Grant 2019ZD063001in part by the Science&Technology Program of Liaoning Province Fund under Grant 2023JH1/10400044.
文摘Piezoresistive pressure sensors offer high accuracy,high sensitivity,and a compact form factor,making them widely adopted in aerospace applications.However,conventional designs are constrained by sensing materials and structural limitations,hindering pressure monitoring at temperatures exceeding 600℃.Stable and repeatable pressure measurement over a wide temperature and frequency range remains a significant challenge.In this work,a ceramicbased nitrogen-doped ITO(ITON)piezoresistive pressure sensor is proposed.By utilizing an Al_(2)O_(3)ceramic structure and ITO material,the issue of operational temperature limitations is effectively addressed,thereby enabling stable sensor output at high temperatures.Results show that the sensitivity of the sensor reaches 236 mV/mA/MPa at 900℃.The linearity of the sensor is less than 3.74%FS in the range from 25℃to 900℃.The frequency response of the sensor exceeds 409 kHz across temperatures spanning 25℃to 1000℃,with an ultra-fast response time of 12μs.In addition,the resistance of the sensor chip increased by only 2.4%and 0.8%after being immersed in H_(2)SO_(4)and NaOH solutions for 70 hours,respectively.Thus,the developed sensor demonstrates significant potential for pressure measurement in high-temperature and wide frequency domain environments.
