Background: In this study, we investigated whether adjunction of glucose- insulin- potassium(GIK) infusion to primary percutaneous coronary intervention(PCI) affects hemodynamics in patients with an acute myocardial i...Background: In this study, we investigated whether adjunction of glucose- insulin- potassium(GIK) infusion to primary percutaneous coronary intervention(PCI) affects hemodynamics in patients with an acute myocardial infarction. Methods: Hemodynamic measurements were performed in a subset of patients(n=81) in the GIPS 2, starting immediately after PCI and continued for 12 hours. Results: Cardiac index values were stable in both groups. During the first measurements, diastolic pulmonary artery pressure and the pulmonary capillary wedge pressure(PCWP) were significantly higher in the non- GIK group(diastolic pulmonary artery pressure 15± 5 vs 18± 7 mm Hg, P=.028 and PCWP 14± 6 vs 18± 7 mm Hg, P=.030). There was a decrease in PCWP from 18± 7 to 15± 6 mm Hg in the non- GIK group during the first 6 hours, whereas the pressures remained at 14± 6 mm Hg in the GIK group. This difference in pattern of change did not reach statistical significance in the analysis of the interaction of PCWP by GIK group(P=.065). Conclusions: Glucose- insulin- potassium infusion as adjunctive therapy to PCI in patients with acute myocardial infarction, without overt signs of heart failure, did not negatively affect hemodynamics.展开更多
文摘Background: In this study, we investigated whether adjunction of glucose- insulin- potassium(GIK) infusion to primary percutaneous coronary intervention(PCI) affects hemodynamics in patients with an acute myocardial infarction. Methods: Hemodynamic measurements were performed in a subset of patients(n=81) in the GIPS 2, starting immediately after PCI and continued for 12 hours. Results: Cardiac index values were stable in both groups. During the first measurements, diastolic pulmonary artery pressure and the pulmonary capillary wedge pressure(PCWP) were significantly higher in the non- GIK group(diastolic pulmonary artery pressure 15± 5 vs 18± 7 mm Hg, P=.028 and PCWP 14± 6 vs 18± 7 mm Hg, P=.030). There was a decrease in PCWP from 18± 7 to 15± 6 mm Hg in the non- GIK group during the first 6 hours, whereas the pressures remained at 14± 6 mm Hg in the GIK group. This difference in pattern of change did not reach statistical significance in the analysis of the interaction of PCWP by GIK group(P=.065). Conclusions: Glucose- insulin- potassium infusion as adjunctive therapy to PCI in patients with acute myocardial infarction, without overt signs of heart failure, did not negatively affect hemodynamics.
