While the skin is among the most commonly affected organ systems in systemic lupus erythematosus(SLE),the role of the skin in driving disease onset remains unresolved.In their recent work,Tian et al.reported that PPAR...While the skin is among the most commonly affected organ systems in systemic lupus erythematosus(SLE),the role of the skin in driving disease onset remains unresolved.In their recent work,Tian et al.reported that PPARy deficiency in keratinocytes(KCs)leads to epidermal hypersecretion of type I IFN.The resulting IFNrich environment activates local dendritic cells(DCs),which in turn activate autoreactive T cells to precipitate SLE-like autoimmune disease[1].展开更多
In a recent study,published in Nature,Nordmann et al.identified Janus kinase inhibitors(JAKi)as a new treatment option for lifethreatening toxic epidermal necrolysis(TEN).They showed this through spatial proteomics on...In a recent study,published in Nature,Nordmann et al.identified Janus kinase inhibitors(JAKi)as a new treatment option for lifethreatening toxic epidermal necrolysis(TEN).They showed this through spatial proteomics on human skin samples combined with in vivo administration of JAKi in individuals with TEN,demonstrating rapid reepithelization and recovery of patients.1 As TEN has a high mortality rate(30-50%),2 this study offers a new avenue for targeted treatment.展开更多
文摘While the skin is among the most commonly affected organ systems in systemic lupus erythematosus(SLE),the role of the skin in driving disease onset remains unresolved.In their recent work,Tian et al.reported that PPARy deficiency in keratinocytes(KCs)leads to epidermal hypersecretion of type I IFN.The resulting IFNrich environment activates local dendritic cells(DCs),which in turn activate autoreactive T cells to precipitate SLE-like autoimmune disease[1].
文摘In a recent study,published in Nature,Nordmann et al.identified Janus kinase inhibitors(JAKi)as a new treatment option for lifethreatening toxic epidermal necrolysis(TEN).They showed this through spatial proteomics on human skin samples combined with in vivo administration of JAKi in individuals with TEN,demonstrating rapid reepithelization and recovery of patients.1 As TEN has a high mortality rate(30-50%),2 this study offers a new avenue for targeted treatment.
