Mechanical forces produced from cells regulate cell functions and fate for tissue development and regeneration.Knowledge in mechanobiology thus provides new strategy for diagnosis and prosthetics.In our work,we develo...Mechanical forces produced from cells regulate cell functions and fate for tissue development and regeneration.Knowledge in mechanobiology thus provides new strategy for diagnosis and prosthetics.In our work,we develop a platform which could precisely detect cellular traction force with resolution of 100 pN,enabling quantification of chemotherapy at early stage,re-epithelialization and cell collision.Additionally,a better solution for antimicrobial dressing managing infection has been provided by modifying the surface to enable both the disruption on biofilm and the elimination of engaged planktonic bacteria.Mechanobiological study demonstrated our dual-function surface remains harmless to host mammalian cells during thermalablation.Our design could pave the way further for creating soft miniaturized medical robots that defend our living system via safe interaction down to cellular level.展开更多
Comprehensive Summary Deep-tissue physiological signals are critical for accurate disease diagnosis.Current clinical equipment,however,often falls short of enabling continuous,long-term monitoring.Wearable and implant...Comprehensive Summary Deep-tissue physiological signals are critical for accurate disease diagnosis.Current clinical equipment,however,often falls short of enabling continuous,long-term monitoring.Wearable and implantable flexible electronics offer a promising avenue for addressing this limitation,allowing in vivo signal collection and paving the way for early diagnosis and personalized treatment.A major challenge lies in ensuring that these devices seamlessly integrate with the diverse physiological microenvironments throughout the human body.展开更多
Recently,rapid advances in flexible strain sensors have broadened their application scenario in monitoring of various mechanophysiological signals.Among various strain sensors,the crack-based strain sensors have drawn...Recently,rapid advances in flexible strain sensors have broadened their application scenario in monitoring of various mechanophysiological signals.Among various strain sensors,the crack-based strain sensors have drawn increasing attention in monitoring subtle mechanical deformation due to their high sensitivity.However,early generation and rapid propagation of cracks in the conductive sensing layer result in a narrow working range,limiting their application in monitoring large biomechanical signals.Herein,we developed a stress-deconcentrated ultrasensitive strain(SDUS)sensor with ultrahigh sensitivity(gauge factor up to2.3×10^(6))and a wide working range(0%-50%)via incorporating notch-insensitive elastic substrate and microcrack-tunable conductive layer.Furthermore,the highly elastic amine-based polymer-modified polydimethylsiloxane substrate without obvious hysteresis endows our SDUS sensor with a rapid response time(2.33 ms)to external stimuli.The accurate detection of the radial pulse,joint motion,and vocal cord vibration proves the capability of SDUS sensor for healthcare monitoring and human-machine communications.展开更多
Covalent adaptable networks(CANs),which combine the benefits of traditional thermosets and thermoplastics,have attracted considerable attention.The dynamics of reversible covalent bonds and mobility of polymer chains ...Covalent adaptable networks(CANs),which combine the benefits of traditional thermosets and thermoplastics,have attracted considerable attention.The dynamics of reversible covalent bonds and mobility of polymer chains in CANs determine the topological rearrangement of the polymeric network,which is critical to their superior features,such as self-healing and reprocessing.Herein,we introduce an ionic liquid to dimethylglyoximeurethane(DOU)-based CANs to regulate both reversible bond dynamics and polymer chain mobility by cooperative chemical coupling and physical lubrication.Small-molecule model experiments demonstrated that ionic liquids can catalyze dynamic DOU bond exchange.Ionic liquid also breaks the hydrogen bonds between polymeric chains,thereby increasing their mobility.As a combined result,the activation energy of the dissociation of the dynamic network decreased from 110 to 85 kJ mol^(−1).Furthermore,as a functional moiety,the ionic liquid imparts new properties to CANs and will greatly expand their applications.For example,the consequent conductivity of resultant ionic CAN(iCAN)has demonstrated a great power to build high-performance multifunctional wearable electronics responsive to multiple stimulations including temperature,strain,and humidity.This study provides a new design principle that simultaneously uses the chemical and physical effects of two structural components to regulate material properties enabling novel applications.展开更多
In recent years,remarkable progress has been made in the research of injectable hydrogel for internal tissue healing.However,the therapeutic outcome is usually limited when the hydrogel is used for the treatment of ga...In recent years,remarkable progress has been made in the research of injectable hydrogel for internal tissue healing.However,the therapeutic outcome is usually limited when the hydrogel is used for the treatment of gastric perforation due to the high acidic gastric juice and violent deformation of the gastric wall.Regarding these challenges,we proposed an ionic nano-reservoir(INR)-based dual-network hydrogel,which has excellent adhesion and mechanical properties,and can be easily applied to the perforation site to block the perforation while promoting tissue repairing.The results showed that the first network made of polyacrylamide had cross-linked on the stomach tissue within 5 s under blue light,and enhanced the adhesion performance through mechanical interlock.The nano-hydroxyapatite acted as ionic INR,which can gradually release Ca^(2+) under acid environments to form the second network with sodium alginate and inhibit the swelling of hydrogel in gastric juice.Meanwhile,the adhesion was further enhanced through amide covalent bonds at the hydrogel-tissue interface with the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide(EDC/NHS).The dual network hydrogels obtained by the INR strategy could be employed as a potential therapeutic option for gastric perforation and other similar biomedical prolems.展开更多
Implantable neural probes,essential for brain electrophysiological research,have advanced with ultraflexible designs to mitigate immune responses and postoperativecomplications.Strategies of shuttleassisted implantati...Implantable neural probes,essential for brain electrophysiological research,have advanced with ultraflexible designs to mitigate immune responses and postoperativecomplications.Strategies of shuttleassisted implantation and temporary stiffening address issues in penetrating these probes into the target region,avoiding undesired bending.However,the risk of intraoperative bleeding remains due to these implants’necessary rigidity during insertion.Here,we describe a neural probe with mechanical compliance accompanying self-implantation along the principal axis in the absence of bleeding.Crucial to the behavior is its anisotropic relaxation,which is dominated by the cross-sectional in-plane deformation inhibition due to interchain interactions between the parallel backbones in the globally aligned polymer system.We observed the ensured upright insertion of the probe into the brain while avoiding angiorrhexis with a two-photon microscope and a high-speed camera.The probes permit electrophysiological studies with minimal foreign body responses and imageological compatibility,underscoring their clinical potential.展开更多
基金financially supported by the NTU-Northwestern Institute for Nanomedicine ( NRF-NRFI2017-07)Startup Foundation of Nanjing Medical University
文摘Mechanical forces produced from cells regulate cell functions and fate for tissue development and regeneration.Knowledge in mechanobiology thus provides new strategy for diagnosis and prosthetics.In our work,we develop a platform which could precisely detect cellular traction force with resolution of 100 pN,enabling quantification of chemotherapy at early stage,re-epithelialization and cell collision.Additionally,a better solution for antimicrobial dressing managing infection has been provided by modifying the surface to enable both the disruption on biofilm and the elimination of engaged planktonic bacteria.Mechanobiological study demonstrated our dual-function surface remains harmless to host mammalian cells during thermalablation.Our design could pave the way further for creating soft miniaturized medical robots that defend our living system via safe interaction down to cellular level.
基金supported by the National Natural Science Foundation of China(81971701).
文摘Comprehensive Summary Deep-tissue physiological signals are critical for accurate disease diagnosis.Current clinical equipment,however,often falls short of enabling continuous,long-term monitoring.Wearable and implantable flexible electronics offer a promising avenue for addressing this limitation,allowing in vivo signal collection and paving the way for early diagnosis and personalized treatment.A major challenge lies in ensuring that these devices seamlessly integrate with the diverse physiological microenvironments throughout the human body.
基金supported by the National Key Research and Development Program of China(2019YFA0210104)the National Natural Science Foundation of China(81971701)the Natural Science Foundation of Jiangsu Province(BK20201352)。
文摘Recently,rapid advances in flexible strain sensors have broadened their application scenario in monitoring of various mechanophysiological signals.Among various strain sensors,the crack-based strain sensors have drawn increasing attention in monitoring subtle mechanical deformation due to their high sensitivity.However,early generation and rapid propagation of cracks in the conductive sensing layer result in a narrow working range,limiting their application in monitoring large biomechanical signals.Herein,we developed a stress-deconcentrated ultrasensitive strain(SDUS)sensor with ultrahigh sensitivity(gauge factor up to2.3×10^(6))and a wide working range(0%-50%)via incorporating notch-insensitive elastic substrate and microcrack-tunable conductive layer.Furthermore,the highly elastic amine-based polymer-modified polydimethylsiloxane substrate without obvious hysteresis endows our SDUS sensor with a rapid response time(2.33 ms)to external stimuli.The accurate detection of the radial pulse,joint motion,and vocal cord vibration proves the capability of SDUS sensor for healthcare monitoring and human-machine communications.
基金supported by the National Key Research and Development Program of China(grant no.2021YFC2101800)the National Natural Science Foundation of China(grant nos.52173117,51733002,52073049,81971701)+7 种基金the Natural Science Foundation of Shanghai(grant nos.20ZR1402500,22ZR1400700)Shanghai Rising-Star Program(grant no.21QA1400200)Belt&Road Young Scientist Exchanges Project of Science and Technology Commission Foundation of Shanghai(grant no.20520741000)Ningbo 2025 Science and Technology Major Project(grant no.2019B10068)Science and Technology Commission of Shanghai Municipality(grant nos.20DZ2254900,20DZ2270800)the Fundamental Research Funds for the Central Universities(grant no.2232021G-02)DHU Distinguished Young Professor Program(grant no.LZA2019001)the Natural Science Funding of Jiangsu Province Grant(grant no.BK20201352).
文摘Covalent adaptable networks(CANs),which combine the benefits of traditional thermosets and thermoplastics,have attracted considerable attention.The dynamics of reversible covalent bonds and mobility of polymer chains in CANs determine the topological rearrangement of the polymeric network,which is critical to their superior features,such as self-healing and reprocessing.Herein,we introduce an ionic liquid to dimethylglyoximeurethane(DOU)-based CANs to regulate both reversible bond dynamics and polymer chain mobility by cooperative chemical coupling and physical lubrication.Small-molecule model experiments demonstrated that ionic liquids can catalyze dynamic DOU bond exchange.Ionic liquid also breaks the hydrogen bonds between polymeric chains,thereby increasing their mobility.As a combined result,the activation energy of the dissociation of the dynamic network decreased from 110 to 85 kJ mol^(−1).Furthermore,as a functional moiety,the ionic liquid imparts new properties to CANs and will greatly expand their applications.For example,the consequent conductivity of resultant ionic CAN(iCAN)has demonstrated a great power to build high-performance multifunctional wearable electronics responsive to multiple stimulations including temperature,strain,and humidity.This study provides a new design principle that simultaneously uses the chemical and physical effects of two structural components to regulate material properties enabling novel applications.
基金supported by the National Natural Science Foundation of China(81971701,51832001,and 81901873)the Natural Science Foundation of Jiangsu Province(BK20201352)the Program of Jiangsu Specially-Appointed Professor。
文摘In recent years,remarkable progress has been made in the research of injectable hydrogel for internal tissue healing.However,the therapeutic outcome is usually limited when the hydrogel is used for the treatment of gastric perforation due to the high acidic gastric juice and violent deformation of the gastric wall.Regarding these challenges,we proposed an ionic nano-reservoir(INR)-based dual-network hydrogel,which has excellent adhesion and mechanical properties,and can be easily applied to the perforation site to block the perforation while promoting tissue repairing.The results showed that the first network made of polyacrylamide had cross-linked on the stomach tissue within 5 s under blue light,and enhanced the adhesion performance through mechanical interlock.The nano-hydroxyapatite acted as ionic INR,which can gradually release Ca^(2+) under acid environments to form the second network with sodium alginate and inhibit the swelling of hydrogel in gastric juice.Meanwhile,the adhesion was further enhanced through amide covalent bonds at the hydrogel-tissue interface with the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide(EDC/NHS).The dual network hydrogels obtained by the INR strategy could be employed as a potential therapeutic option for gastric perforation and other similar biomedical prolems.
基金supported by the National Natural Science Foundation of China(81971701)the Natural Science Foundation of Jiangsu Province(BK20201352)+1 种基金the NanjingMedical University Introduced Talents Scientific Research Start-up Fund(NMUR20190003)the STI2030-Major Projects(2021ZD0202205).
文摘Implantable neural probes,essential for brain electrophysiological research,have advanced with ultraflexible designs to mitigate immune responses and postoperativecomplications.Strategies of shuttleassisted implantation and temporary stiffening address issues in penetrating these probes into the target region,avoiding undesired bending.However,the risk of intraoperative bleeding remains due to these implants’necessary rigidity during insertion.Here,we describe a neural probe with mechanical compliance accompanying self-implantation along the principal axis in the absence of bleeding.Crucial to the behavior is its anisotropic relaxation,which is dominated by the cross-sectional in-plane deformation inhibition due to interchain interactions between the parallel backbones in the globally aligned polymer system.We observed the ensured upright insertion of the probe into the brain while avoiding angiorrhexis with a two-photon microscope and a high-speed camera.The probes permit electrophysiological studies with minimal foreign body responses and imageological compatibility,underscoring their clinical potential.
