BACKGROUND Skin is the largest organ in the human body and plays crucial roles in human health.Efficient and rapid healing of burn wounds is of great significance.While stem cell therapies have offered potential metho...BACKGROUND Skin is the largest organ in the human body and plays crucial roles in human health.Efficient and rapid healing of burn wounds is of great significance.While stem cell therapies have offered potential methods to treat burn wounds,relatively few have had success in clinical practice.AIM To investigate the effect of the combined application of collagen III and adiposederived stem cells(ASCs)on vascular regeneration in skin wound healing.METHODS Burn wounds were created in 18 adult male Sprague-Dawley rats,and they were randomly divided into two groups.In the treatment group,each rat was injected with 4×10^(6) Zs-Green-labeled autologous ASCs suspended in collagen III.In the control group,each rat was injected with collagen III.Each rat received six injections.Images of the wounds were acquired every 3 days.RESULTS Multiple injections of autologous ASCs improved wound closure rate more efficiently compared to the control group.Moreover,autologous ASCs do not survive long-term during the skin wound healing process.CONCLUSION This study demonstrated that multiple injections of autologous ASCs combined with collagen III accelerated burn wound healing by increasing collagen deposition and improving angiogenesis.展开更多
Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells(USCs),which were noninvasively harvested from unlimited and easily available urine, as a "fac...Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells(USCs),which were noninvasively harvested from unlimited and easily available urine, as a "factory" to obtain extracellular vesicles(USCEVs) and demonstrated that the systemic injection of USC-EVs effectively alleviates bone loss and maintains bone strength in osteoporotic mice by enhancing osteoblastic bone formation and suppressing osteoclastic bone resorption. More importantly, the anti-osteoporotic properties of USC-EVs are not notably disrupted by the age, gender, or health condition(with or without osteoporosis) of the USC donor. Mechanistic studies determined that collagen triple-helix repeat containing 1(CTHRC1) and osteoprotegerin(OPG) proteins are enriched in USC-EVs and required for USC-EV-induced pro-osteogenic and anti-osteoclastic effects. Our results suggest that autologous USC-EVs represent a promising novel therapeutic agent for osteoporosis by promoting osteogenesis and inhibiting osteoclastogenesis by transferring CTHRC1 and OPG.展开更多
As the relevance between left and right brain neurons when transmitting electrical signals of umami taste is unknown,the aim of this work was to investigate responsive regions of the brain to the umami tastant monosod...As the relevance between left and right brain neurons when transmitting electrical signals of umami taste is unknown,the aim of this work was to investigate responsive regions of the brain to the umami tastant monosodium glutamate(MSG)by using scalp-electroencephalogram(EEG)to identify the most responsive brain regions to MSG.Three concentrations of MSG(0.05,0.12,0.26 g/100 mL)were provided to participants for tasting while recoding their responsive reaction times and brain activities.The results indicated that the most responsive frequency to MSG was at 2 Hz,while the most responsive brain regions were T4 CzA2,F8 CzA2,and Fp2 CzA2.Moreover,the sensitivity of the brain to MSG was significantly higher in the right brain region.This study shows the potential of using EEG to investigate the relevance between different brains response to umami taste,which contributes to better understanding the mechanism of umami perception.展开更多
Multilevel phase-change memory is an attractive technology to increase storage capacity and density owing to its high-speed,scalable and non-volatile characteristics.However,the contradiction between thermal stability...Multilevel phase-change memory is an attractive technology to increase storage capacity and density owing to its high-speed,scalable and non-volatile characteristics.However,the contradiction between thermal stability and operation speed is one of key factors to restrain the development of phase-change memory.Here,N-doped Ge_(2)Sb_(2)Te_(5)-based optoelectronic hybrid memory is proposed to simultaneously implement high thermal stability and ultrafast operation speed.The picosecond laser is adopted to write/erase information based on reversible phase transition characteristics whereas the resistance is detected to perform information readout.Results show that when N content is 27.4 at.%,N-doped Ge_(2)Sb_(2)Te_(5)film possesses high ten-year data retention temperature of 175℃and low resistance drift coefficient of 0.00024 at 85℃,0.00170 at 120℃,and 0.00249 at 150℃,respectively,owing to the formation of Ge–N,Sb–N,and Te–N bonds.The SET/RESET operation speeds of the film reach 520 ps/13 ps.In parallel,the reversible switching cycle of the corresponding device is realized with the resistance ratio of three orders of magnitude.Four-level reversible resistance states induced by various crystallization degrees are also obtained together with low resistance drift coefficients.Therefore,the N-doped Ge_(2)Sb_(2)Te_(5)thin film is a promising phase-change material for ultrafast multilevel optoelectronic hybrid storage.展开更多
In this review paper,we discuss the properties and applications of photonic computing and analog signal processing.Photonic computational circuits have large operation bandwidth,low power consumption,and fine frequenc...In this review paper,we discuss the properties and applications of photonic computing and analog signal processing.Photonic computational circuits have large operation bandwidth,low power consumption,and fine frequency control,enabling a wide range of application-specific computational techniques that are impossible to implement using traditional electrical and digital hardware alone.These advantages are illustrated in the elegant implementation of optical steganography,the real-time blind separation of signals in the same bandwidth,and the efficient acceleration of artificial neural network inference.The working principles and use of photonic circuits for analog signal processing and neuromorphic computing are reviewed and notable demonstrated applications are highlighted.展开更多
Energy-related CO2 emissions from Tianjin’s production and household sectors during 2000–2012 were calculated based on the default carbon-emission coefficients provided by the Intergovernmental Panel on Climate Chan...Energy-related CO2 emissions from Tianjin’s production and household sectors during 2000–2012 were calculated based on the default carbon-emission coefficients provided by the Intergovernmental Panel on Climate Change.Grey relational analysis was used in this study to capture the dynamic characteristics of 12 different factors related to CO2 emissions.The results indicated that population scale and structure,industrial structure,per capita disposable income,energy consumption and structure appeared as the main drivers related to the CO2 emissions increase during the study period.Based on the research,we make the policy recommendations including optimizing the industrial structure and energy structure,improving energy efficiency and promoting low-carbon consumption.展开更多
基金Supported by the Natural Science Foundation of Hunan Province,China,No.2021JJ40638the Research Foundation of Education Bureau of Hunan Province,China,No.22B0897General Funding Project of Hunan Provincial Health Commission,China,No.202202055404.
文摘BACKGROUND Skin is the largest organ in the human body and plays crucial roles in human health.Efficient and rapid healing of burn wounds is of great significance.While stem cell therapies have offered potential methods to treat burn wounds,relatively few have had success in clinical practice.AIM To investigate the effect of the combined application of collagen III and adiposederived stem cells(ASCs)on vascular regeneration in skin wound healing.METHODS Burn wounds were created in 18 adult male Sprague-Dawley rats,and they were randomly divided into two groups.In the treatment group,each rat was injected with 4×10^(6) Zs-Green-labeled autologous ASCs suspended in collagen III.In the control group,each rat was injected with collagen III.Each rat received six injections.Images of the wounds were acquired every 3 days.RESULTS Multiple injections of autologous ASCs improved wound closure rate more efficiently compared to the control group.Moreover,autologous ASCs do not survive long-term during the skin wound healing process.CONCLUSION This study demonstrated that multiple injections of autologous ASCs combined with collagen III accelerated burn wound healing by increasing collagen deposition and improving angiogenesis.
基金supported by the National Natural Science Foundation of China (Grant nos. 81522012, 81702237, 81670807, 81871822, 81801395, 81600699, 81701383, and 81802138)the Thousand Youth Talents Plan of China (Grant no. D1119003)+8 种基金the Medicine and Health Science and Technology Innovation Project of Chinese Academy of Medical Sciences (Grant no. 2018-I2M-HL-024)the High Level Talent Gathering Project of Hunan Province (Grant nos. 2017XK2039, and 2018RS3029)the Innovation Driven Project of Central South University (Grant nos. 2016CX028,2019CX014, and 2018CX029)the Youth Foundation of Xiangya Hospital in Central South University (Grant no. 2016Q10)the Hunan Provincial Innovation Foundation for Postgraduate (Grant no. CX2018B045)the Fundamental Research Funds for the Central Universities of Central South University (Grant nos. 2017zzts211 and 2018zzts895)the Hunan Province Natural Science Foundation of China (Grant no. 2017JJ3501)the China Postdoctoral Science Foundation (Grant nos. 2017M612596, 2017M622614, and 2018M632998)the Natural Science Foundation for Distinguished Yong Scholars of Guangdong Province (Grant no. 2016A030306051)
文摘Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells(USCs),which were noninvasively harvested from unlimited and easily available urine, as a "factory" to obtain extracellular vesicles(USCEVs) and demonstrated that the systemic injection of USC-EVs effectively alleviates bone loss and maintains bone strength in osteoporotic mice by enhancing osteoblastic bone formation and suppressing osteoclastic bone resorption. More importantly, the anti-osteoporotic properties of USC-EVs are not notably disrupted by the age, gender, or health condition(with or without osteoporosis) of the USC donor. Mechanistic studies determined that collagen triple-helix repeat containing 1(CTHRC1) and osteoprotegerin(OPG) proteins are enriched in USC-EVs and required for USC-EV-induced pro-osteogenic and anti-osteoclastic effects. Our results suggest that autologous USC-EVs represent a promising novel therapeutic agent for osteoporosis by promoting osteogenesis and inhibiting osteoclastogenesis by transferring CTHRC1 and OPG.
基金supported by the National Natural Science Foundation of China(31972198,31622042)the National Key R&D Program of China(2016YFD0400803,2016YFD0401501)。
文摘As the relevance between left and right brain neurons when transmitting electrical signals of umami taste is unknown,the aim of this work was to investigate responsive regions of the brain to the umami tastant monosodium glutamate(MSG)by using scalp-electroencephalogram(EEG)to identify the most responsive brain regions to MSG.Three concentrations of MSG(0.05,0.12,0.26 g/100 mL)were provided to participants for tasting while recoding their responsive reaction times and brain activities.The results indicated that the most responsive frequency to MSG was at 2 Hz,while the most responsive brain regions were T4 CzA2,F8 CzA2,and Fp2 CzA2.Moreover,the sensitivity of the brain to MSG was significantly higher in the right brain region.This study shows the potential of using EEG to investigate the relevance between different brains response to umami taste,which contributes to better understanding the mechanism of umami perception.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62205231 and 22002102)the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(Grant No.KYCX223271)Jiangsu Key Laboratory for Environment Functional Materials。
文摘Multilevel phase-change memory is an attractive technology to increase storage capacity and density owing to its high-speed,scalable and non-volatile characteristics.However,the contradiction between thermal stability and operation speed is one of key factors to restrain the development of phase-change memory.Here,N-doped Ge_(2)Sb_(2)Te_(5)-based optoelectronic hybrid memory is proposed to simultaneously implement high thermal stability and ultrafast operation speed.The picosecond laser is adopted to write/erase information based on reversible phase transition characteristics whereas the resistance is detected to perform information readout.Results show that when N content is 27.4 at.%,N-doped Ge_(2)Sb_(2)Te_(5)film possesses high ten-year data retention temperature of 175℃and low resistance drift coefficient of 0.00024 at 85℃,0.00170 at 120℃,and 0.00249 at 150℃,respectively,owing to the formation of Ge–N,Sb–N,and Te–N bonds.The SET/RESET operation speeds of the film reach 520 ps/13 ps.In parallel,the reversible switching cycle of the corresponding device is realized with the resistance ratio of three orders of magnitude.Four-level reversible resistance states induced by various crystallization degrees are also obtained together with low resistance drift coefficients.Therefore,the N-doped Ge_(2)Sb_(2)Te_(5)thin film is a promising phase-change material for ultrafast multilevel optoelectronic hybrid storage.
文摘In this review paper,we discuss the properties and applications of photonic computing and analog signal processing.Photonic computational circuits have large operation bandwidth,low power consumption,and fine frequency control,enabling a wide range of application-specific computational techniques that are impossible to implement using traditional electrical and digital hardware alone.These advantages are illustrated in the elegant implementation of optical steganography,the real-time blind separation of signals in the same bandwidth,and the efficient acceleration of artificial neural network inference.The working principles and use of photonic circuits for analog signal processing and neuromorphic computing are reviewed and notable demonstrated applications are highlighted.
文摘Energy-related CO2 emissions from Tianjin’s production and household sectors during 2000–2012 were calculated based on the default carbon-emission coefficients provided by the Intergovernmental Panel on Climate Change.Grey relational analysis was used in this study to capture the dynamic characteristics of 12 different factors related to CO2 emissions.The results indicated that population scale and structure,industrial structure,per capita disposable income,energy consumption and structure appeared as the main drivers related to the CO2 emissions increase during the study period.Based on the research,we make the policy recommendations including optimizing the industrial structure and energy structure,improving energy efficiency and promoting low-carbon consumption.
