The neuropeptide hormone oxytocin, which is released from the posterior pituitary gland, is involved in a number of physiological processes. Understanding of its effects is gradually increasing due to new research in ...The neuropeptide hormone oxytocin, which is released from the posterior pituitary gland, is involved in a number of physiological processes. Understanding of its effects is gradually increasing due to new research in this area. While mostly recognized as a reproductive system hormone, oxytocin also regulates other organ systems such as the brain and cardiovascular system. Recently, research has focused on unraveling its involvement in cancer, and emerging evidence suggests a potential role for oxytocin as a cancer biomarker. This review summarizes observations linking oxytocin and cancer, with a special emphasis on prostate cancer, where it may promote cell proliferation. Research suggests that oxytocin effects may depend on cell type, concentration of the hormone, its interactions with other hormones in the microenvironment, and the precise localization of its receptor on the cell membrane. Future research is needed to further elucidate the involvement of oxytocin in cancer, and whether it could be a clinical cancer biomarker or therapeutic target.展开更多
Cardiovascular disease(CVD)is the leading cause of death globally,with the majority of the adult population exposed to multiple traditional or non-traditional CVD risk factors[1].Among the latter,both acute and length...Cardiovascular disease(CVD)is the leading cause of death globally,with the majority of the adult population exposed to multiple traditional or non-traditional CVD risk factors[1].Among the latter,both acute and lengthy exposures to low temperatures can increase cardiovascular risk,particularly in individuals with an underlying CVD.The link between CVD and cold weather is reflected in a well-documented peak in cardiovascular deaths during the winter months[2].For example,investigators in Germany found that a 10°C decrease in 5-day average temperature was associated with a 1.10 relative risk of myocardial infarction[3],while in China each 1°C decrease in temperature during a cold wave increased the mortality risk from myocardial infarction by 1.82%[4].展开更多
文摘The neuropeptide hormone oxytocin, which is released from the posterior pituitary gland, is involved in a number of physiological processes. Understanding of its effects is gradually increasing due to new research in this area. While mostly recognized as a reproductive system hormone, oxytocin also regulates other organ systems such as the brain and cardiovascular system. Recently, research has focused on unraveling its involvement in cancer, and emerging evidence suggests a potential role for oxytocin as a cancer biomarker. This review summarizes observations linking oxytocin and cancer, with a special emphasis on prostate cancer, where it may promote cell proliferation. Research suggests that oxytocin effects may depend on cell type, concentration of the hormone, its interactions with other hormones in the microenvironment, and the precise localization of its receptor on the cell membrane. Future research is needed to further elucidate the involvement of oxytocin in cancer, and whether it could be a clinical cancer biomarker or therapeutic target.
基金supported by National Institutes of Health grant numbers DK120292,DK122734,HL158691,and AG062104.
文摘Cardiovascular disease(CVD)is the leading cause of death globally,with the majority of the adult population exposed to multiple traditional or non-traditional CVD risk factors[1].Among the latter,both acute and lengthy exposures to low temperatures can increase cardiovascular risk,particularly in individuals with an underlying CVD.The link between CVD and cold weather is reflected in a well-documented peak in cardiovascular deaths during the winter months[2].For example,investigators in Germany found that a 10°C decrease in 5-day average temperature was associated with a 1.10 relative risk of myocardial infarction[3],while in China each 1°C decrease in temperature during a cold wave increased the mortality risk from myocardial infarction by 1.82%[4].
