BACKGROUND Bone is the most common site of metastasis in breast cancer,yet limited data exist regarding the precise anatomical distribution of bone metastases by tumor subtype.AIM To examine the anatomical distributio...BACKGROUND Bone is the most common site of metastasis in breast cancer,yet limited data exist regarding the precise anatomical distribution of bone metastases by tumor subtype.AIM To examine the anatomical distribution of the first bone metastases in stage IV breast cancer,stratified by histological subtype.Secondary objectives include analyzing the anatomical distribution of subsequent bone metastases,Metastasis-Free Survival(MFI),Progression-Free Interval(PFI),and overall survival(OS).METHODS A retrospective cohort study was conducted on 107 adult females with stage IV breast cancer and bone metastases between 2013 and 2023.Patients were classified by histological subtype(Luminal A/B,HER2-enriched,and Triple-Negative).First and subsequent bone metastasis locations were identified via computed tomography,positron emission tomography/CT,or magnetic resonance imaging.Survival analyses included MFI,PFI,and OS.RESULTS Rib metastases were significantly more common in HER2-enriched tumors(80%,P=0.041),while scapula/clavicle metastases were more prevalent in Triple-Negative cases(37.5%,P=0.003).Subsequent bone metastases mirrored initial patterns,with pelvic involvement notably higher in HER2-enriched(60%)and luminal B(58%)patients(P=0.046).No significant differences were found in MFI,PFI,or OS among subtypes.Receptor-based analysis showed no significant variation in bone metastasis locations.CONCLUSION Breast cancer subtypes are associated with suggestive bone metastasis patterns—specifically,rib involvement in HER2-enriched and scapula/clavicle in Triple-Negative cases.While anatomical variations exist,they did not translate into differential survival or fracture risk in this cohort.展开更多
文摘BACKGROUND Bone is the most common site of metastasis in breast cancer,yet limited data exist regarding the precise anatomical distribution of bone metastases by tumor subtype.AIM To examine the anatomical distribution of the first bone metastases in stage IV breast cancer,stratified by histological subtype.Secondary objectives include analyzing the anatomical distribution of subsequent bone metastases,Metastasis-Free Survival(MFI),Progression-Free Interval(PFI),and overall survival(OS).METHODS A retrospective cohort study was conducted on 107 adult females with stage IV breast cancer and bone metastases between 2013 and 2023.Patients were classified by histological subtype(Luminal A/B,HER2-enriched,and Triple-Negative).First and subsequent bone metastasis locations were identified via computed tomography,positron emission tomography/CT,or magnetic resonance imaging.Survival analyses included MFI,PFI,and OS.RESULTS Rib metastases were significantly more common in HER2-enriched tumors(80%,P=0.041),while scapula/clavicle metastases were more prevalent in Triple-Negative cases(37.5%,P=0.003).Subsequent bone metastases mirrored initial patterns,with pelvic involvement notably higher in HER2-enriched(60%)and luminal B(58%)patients(P=0.046).No significant differences were found in MFI,PFI,or OS among subtypes.Receptor-based analysis showed no significant variation in bone metastasis locations.CONCLUSION Breast cancer subtypes are associated with suggestive bone metastasis patterns—specifically,rib involvement in HER2-enriched and scapula/clavicle in Triple-Negative cases.While anatomical variations exist,they did not translate into differential survival or fracture risk in this cohort.
