As an emerging technology to convert environmental high-entropy energy into electrical energy,triboelectric nanogenerator(TENG)has great demands for further enhancing the service lifetime and output performance in pra...As an emerging technology to convert environmental high-entropy energy into electrical energy,triboelectric nanogenerator(TENG)has great demands for further enhancing the service lifetime and output performance in practical applications.Here,an ultra-robust and high-performance rotational triboelectric nanogenerator(R-TENG)by bearing charge pumping is proposed.The R-TENG composes of a pumping TENG(P-TENG),an output TENG(O-TENG),a voltage-multiplying circuit(VMC),and a buffer capacitor.The P-TENG is designed with freestanding mode based on a rolling ball bearing,which can also act as the rotating mechanical energy harvester.The output low charge from the P-TENG is accumulated and pumped to the non-contact O-TENG,which can simultaneously realize ultralow mechanical wear and high output performance.The matched instantaneous power of R-TENG is increased by 32 times under 300 r/min.Furthermore,the transferring charge of R-TENG can remain 95%during 15 days(6.4×10^(6)cycles)continuous operation.This work presents a realizable method to further enhance the durability of TENG,which would facilitate the practical applications of high-performance TENG in harvesting distributed ambient micro mechanical energy.展开更多
Osteoporosis is majorly caused by an imbalance between osteoclastic and osteogenic niches. Despite thedevelopment of nationally recognized first-line anti-osteoporosis drugs, including alendronate (AL), their lowbioav...Osteoporosis is majorly caused by an imbalance between osteoclastic and osteogenic niches. Despite thedevelopment of nationally recognized first-line anti-osteoporosis drugs, including alendronate (AL), their lowbioavailability, poor uptake rate, and dose-related side effects present significant challenges in treatment. Thiscalls for an urgent need for more effective bone-affinity drug delivery systems. In this study, we produced hybridstructures with bioactive components and stable fluffy topological morphology by cross-linking calcium andphosphorus precursors based on mesoporous silica to fabricate nanoadjuvants for AL delivery. The subsequentgrafting of -PEG-DAsp8 ensured superior biocompatibility and bone targeting capacity. RNA sequencing revealedthat these fluffy nanoadjuvants effectively activated adhesion pathways through CARD11 and CD34 molecularmechanisms, hence promoting cellular uptake and intracellular delivery of AL. Experiments showed that smalldoseAL nanoadjuvants effectively suppress osteoclast formation and potentially promote osteogenesis. In vivoresults restored the balance between osteogenic and osteoclastic niches against osteoporosis as well as theconsequent significant recovery of bone mass. Therefore, this study constructed a drug nanoadjuvant withpeculiar topological structures and high bone targeting capacities, efficient intracellular drug delivery as well asbone bioactivity. This provides a novel perspective on drug delivery for osteoporosis and treatment strategies forother bone diseases.展开更多
Body area network has attracted extensive attention for its applications in athletics,medical,diagnosis,and rehabilitation training in the next generation personalized health care solutions.Here,a contact-separation d...Body area network has attracted extensive attention for its applications in athletics,medical,diagnosis,and rehabilitation training in the next generation personalized health care solutions.Here,a contact-separation direct current triboelectric nanogenerators(CSDC-TENGs)based selfpowered wireless body area network(SWBAN)is reported that enables multi-joint movements monitoring for human motion.The CSDC-TENG is designed as a flexible active sensor with an internal contact switch,and the flexible substrate makes the TENG-sensor stick onto skin easily.Due to the internal switch,the CSDC-TENG could generate a DC current,a large instantaneous output voltage exceeds 700 V,and an instantaneous power can reach 1.076 W,which is more than 23000 times higher than that of the traditional contact-separation mode TENG in same size and materials without the switch.By coupling with flexible coil,the fixed high-frequency radio signals can be modulated and emitted clearly ranging from 6 to 16 MHz,which can be wirelessly received and demodulated through a reader.Moreover,the SWBAN is demonstrated in a real time monitoring system for joints motion.This work has realized the wearable TENG for self-powered wireless real-time monitoring of body movements driven by low-frequency human daily activities,which may promote a tremendous development of intelligent healthcare,wireless sensing system and body area network.展开更多
Friction occurs in our daily lives, and statistics have shown that it consumes approximately 1/3 of the primary energy. In addition,mechanical interface friction significantly impacts the efficiency,noise, accuracy, c...Friction occurs in our daily lives, and statistics have shown that it consumes approximately 1/3 of the primary energy. In addition,mechanical interface friction significantly impacts the efficiency,noise, accuracy, corrosion, reliability, and operational lifespans of equipment. Several studies have revealed various methods for reducing the coefficient of friction (COF) to the superlubricity state(COF <0.01) through efficient lubrication technology.展开更多
基金supported by the National Natural Science Foundation of China(Nos.51922023,61874011)Fundamental Research Funds for the Central Universities(E1EG6804)
文摘As an emerging technology to convert environmental high-entropy energy into electrical energy,triboelectric nanogenerator(TENG)has great demands for further enhancing the service lifetime and output performance in practical applications.Here,an ultra-robust and high-performance rotational triboelectric nanogenerator(R-TENG)by bearing charge pumping is proposed.The R-TENG composes of a pumping TENG(P-TENG),an output TENG(O-TENG),a voltage-multiplying circuit(VMC),and a buffer capacitor.The P-TENG is designed with freestanding mode based on a rolling ball bearing,which can also act as the rotating mechanical energy harvester.The output low charge from the P-TENG is accumulated and pumped to the non-contact O-TENG,which can simultaneously realize ultralow mechanical wear and high output performance.The matched instantaneous power of R-TENG is increased by 32 times under 300 r/min.Furthermore,the transferring charge of R-TENG can remain 95%during 15 days(6.4×10^(6)cycles)continuous operation.This work presents a realizable method to further enhance the durability of TENG,which would facilitate the practical applications of high-performance TENG in harvesting distributed ambient micro mechanical energy.
基金National Natural Science Foundation of China 82172233(X.Y.)Shanghai Baoshan District Science and Technology Commission medical health project 21-E-52(B.F.).
文摘Osteoporosis is majorly caused by an imbalance between osteoclastic and osteogenic niches. Despite thedevelopment of nationally recognized first-line anti-osteoporosis drugs, including alendronate (AL), their lowbioavailability, poor uptake rate, and dose-related side effects present significant challenges in treatment. Thiscalls for an urgent need for more effective bone-affinity drug delivery systems. In this study, we produced hybridstructures with bioactive components and stable fluffy topological morphology by cross-linking calcium andphosphorus precursors based on mesoporous silica to fabricate nanoadjuvants for AL delivery. The subsequentgrafting of -PEG-DAsp8 ensured superior biocompatibility and bone targeting capacity. RNA sequencing revealedthat these fluffy nanoadjuvants effectively activated adhesion pathways through CARD11 and CD34 molecularmechanisms, hence promoting cellular uptake and intracellular delivery of AL. Experiments showed that smalldoseAL nanoadjuvants effectively suppress osteoclast formation and potentially promote osteogenesis. In vivoresults restored the balance between osteogenic and osteoclastic niches against osteoporosis as well as theconsequent significant recovery of bone mass. Therefore, this study constructed a drug nanoadjuvant withpeculiar topological structures and high bone targeting capacities, efficient intracellular drug delivery as well asbone bioactivity. This provides a novel perspective on drug delivery for osteoporosis and treatment strategies forother bone diseases.
基金supported by the National Key R&D Project from Minister of Science and Technology(2021YFB3200301)the National Natural Science Foundation of China(Nos.52250112,51922023)Fundamental Research Funds for the Central Universities(E1EG6804).
文摘Body area network has attracted extensive attention for its applications in athletics,medical,diagnosis,and rehabilitation training in the next generation personalized health care solutions.Here,a contact-separation direct current triboelectric nanogenerators(CSDC-TENGs)based selfpowered wireless body area network(SWBAN)is reported that enables multi-joint movements monitoring for human motion.The CSDC-TENG is designed as a flexible active sensor with an internal contact switch,and the flexible substrate makes the TENG-sensor stick onto skin easily.Due to the internal switch,the CSDC-TENG could generate a DC current,a large instantaneous output voltage exceeds 700 V,and an instantaneous power can reach 1.076 W,which is more than 23000 times higher than that of the traditional contact-separation mode TENG in same size and materials without the switch.By coupling with flexible coil,the fixed high-frequency radio signals can be modulated and emitted clearly ranging from 6 to 16 MHz,which can be wirelessly received and demodulated through a reader.Moreover,the SWBAN is demonstrated in a real time monitoring system for joints motion.This work has realized the wearable TENG for self-powered wireless real-time monitoring of body movements driven by low-frequency human daily activities,which may promote a tremendous development of intelligent healthcare,wireless sensing system and body area network.
基金supported by the National Natural Science Foundation of China (52250112, 62104020, and 52275197)Beijing Natural Science Foundation (3232019)。
文摘Friction occurs in our daily lives, and statistics have shown that it consumes approximately 1/3 of the primary energy. In addition,mechanical interface friction significantly impacts the efficiency,noise, accuracy, corrosion, reliability, and operational lifespans of equipment. Several studies have revealed various methods for reducing the coefficient of friction (COF) to the superlubricity state(COF <0.01) through efficient lubrication technology.
