Sumac[Rhus coriaria L.(Anacardiaceae)]is a widely used spice in the Middle East.In this study,the hepatoprotective effects of sumac fruit were evaluated using a rat model of paracetamol-induced liver injury.The experi...Sumac[Rhus coriaria L.(Anacardiaceae)]is a widely used spice in the Middle East.In this study,the hepatoprotective effects of sumac fruit were evaluated using a rat model of paracetamol-induced liver injury.The experimental design relies on the pretreatment of rats with intraperitoneal sumac extract followed by a toxic dose of paracetamol.Tissue alterations,serum levels of oxidative stress markers,as well as gene expression of immunomarkers were evaluated.Rats pre-treated with sumac displayed attenuated signs of toxicity.Upon paracetamol intoxication,sumac-pretreated animals showed a minimal increase in liver enzyme levels.In parallel,serum albumin and total protein levels were close to normal.Moreover,pretreated sumac animals had preserved hepatocyte morphology,whereas unprotected animals had necrotic deformations.Importantly,these effects were dose-dependent and comparable to the silymarin-treated positive control group.In conclusion,sumac extract offers a potential hepatoprotective regimen against xenobiotic-induced hepatotoxicity and for oxidative stress management.展开更多
基金This research was supported by the Deanship of Research,Jordan University of Science and Technology,Irbid,Jordan(Grant No.355/2020).
文摘Sumac[Rhus coriaria L.(Anacardiaceae)]is a widely used spice in the Middle East.In this study,the hepatoprotective effects of sumac fruit were evaluated using a rat model of paracetamol-induced liver injury.The experimental design relies on the pretreatment of rats with intraperitoneal sumac extract followed by a toxic dose of paracetamol.Tissue alterations,serum levels of oxidative stress markers,as well as gene expression of immunomarkers were evaluated.Rats pre-treated with sumac displayed attenuated signs of toxicity.Upon paracetamol intoxication,sumac-pretreated animals showed a minimal increase in liver enzyme levels.In parallel,serum albumin and total protein levels were close to normal.Moreover,pretreated sumac animals had preserved hepatocyte morphology,whereas unprotected animals had necrotic deformations.Importantly,these effects were dose-dependent and comparable to the silymarin-treated positive control group.In conclusion,sumac extract offers a potential hepatoprotective regimen against xenobiotic-induced hepatotoxicity and for oxidative stress management.
