Background: High-dose intravenous immunoglobulin (IVIg)has become a part of the treatment armentarium in pemphigus vulgaris (PV). Some consider IVIg as an adjuvant steroid sparing agent in PV, while others as disease ...Background: High-dose intravenous immunoglobulin (IVIg)has become a part of the treatment armentarium in pemphigus vulgaris (PV). Some consider IVIg as an adjuvant steroid sparing agent in PV, while others as disease modifying that can be used as monotherapy. Methods: We report our experience with a series of 12 PV patients with severe disease treated with IVIg as an adjuvant therapy. Results: Ten of 12 patients (83% ) showed response to six cycles of IVIg, six (50% ) having complete remission and four (33% ) having a partial response. This response rate is concordant with previous reports. The therapy was well tolerated. In all 12 patients, treatment with IVIg allowed a gradual reduction of prednisone dose compared with baseline levels. Conclusion: IVIg treatmentwas beneficial as asteroid sparing agent in our series of patients with severe PV.展开更多
Background: Pityriasis lichenoides comprises a clinical and pathological spectrum of disorders. So far no highly effective treatment has been reported. Previous small studies have suggested that ultraviolet B (UVB) is...Background: Pityriasis lichenoides comprises a clinical and pathological spectrum of disorders. So far no highly effective treatment has been reported. Previous small studies have suggested that ultraviolet B (UVB) is a good alternative. Methods: This is a retrospective analysis of 29 pityriasis lichenoides patients treated in our institutionwith broad- or narrow-band UVB during the period 1996- 2002. Twenty-one of these patients had one or more previous unsuccessful treatments. Results: Complete response was achieved in 93.1% in both treatment groups, with 73% of them still relapse free after a mean follow-up of 58 and 38 months in broad- and narrow-band UVB treatment groups, respectively. Mild side-effects were observed in about one-third of the patients. Conclusion: We believe both forms of UVB are a good option for pityriasis lichenoides and should be considered as the first line in generalized cases interested in treatment.展开更多
文摘Background: High-dose intravenous immunoglobulin (IVIg)has become a part of the treatment armentarium in pemphigus vulgaris (PV). Some consider IVIg as an adjuvant steroid sparing agent in PV, while others as disease modifying that can be used as monotherapy. Methods: We report our experience with a series of 12 PV patients with severe disease treated with IVIg as an adjuvant therapy. Results: Ten of 12 patients (83% ) showed response to six cycles of IVIg, six (50% ) having complete remission and four (33% ) having a partial response. This response rate is concordant with previous reports. The therapy was well tolerated. In all 12 patients, treatment with IVIg allowed a gradual reduction of prednisone dose compared with baseline levels. Conclusion: IVIg treatmentwas beneficial as asteroid sparing agent in our series of patients with severe PV.
文摘Background: Pityriasis lichenoides comprises a clinical and pathological spectrum of disorders. So far no highly effective treatment has been reported. Previous small studies have suggested that ultraviolet B (UVB) is a good alternative. Methods: This is a retrospective analysis of 29 pityriasis lichenoides patients treated in our institutionwith broad- or narrow-band UVB during the period 1996- 2002. Twenty-one of these patients had one or more previous unsuccessful treatments. Results: Complete response was achieved in 93.1% in both treatment groups, with 73% of them still relapse free after a mean follow-up of 58 and 38 months in broad- and narrow-band UVB treatment groups, respectively. Mild side-effects were observed in about one-third of the patients. Conclusion: We believe both forms of UVB are a good option for pityriasis lichenoides and should be considered as the first line in generalized cases interested in treatment.
