Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the pathogen of the ongoing coronavirus disease 2019(COVID-19)global pandemic.Here,by centralizing published cell-based experiments,clinical trials,and vir...Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the pathogen of the ongoing coronavirus disease 2019(COVID-19)global pandemic.Here,by centralizing published cell-based experiments,clinical trials,and virtual drug screening data from the NCBI PubMed database,we developed a database of SARS-CoV-2 inhibitors for COVID-19,dbSCI,which includes 234 SARS-CoV-2 inhibitors collected from publications based on cell-based experiments,81 drugs of COVID-19 in clinical trials and 1305 potential SARS-CoV-2 inhibitors from bioinformatics analyses.dbSCI provides four major functions:(1)search the drug target or its inhibitor for SARS-CoV-2,(2)browse target/inhibitor information collected from cell experiments,clinical trials,and virtual drug screenings,(3)download,and(4)submit data.Each entry in dbSCI contains 18 types of information,including inhibitor/drug name,targeting protein,mechanism of inhibition,experimental technique,experimental sample type,and reference information.In summary,dbSCI provides a relatively comprehensive,credible repository for inhibitors/drugs against SARS-CoV-2 and their potential targeting mechanisms and it will be valuable for further studies to control COVID-19.展开更多
The insufficient comprehensive mechanical properties and inadequate flexibility of wearable sensors limit their bodyprotection capability,durability,and comfort.There are challenges in using flexible wearable devices ...The insufficient comprehensive mechanical properties and inadequate flexibility of wearable sensors limit their bodyprotection capability,durability,and comfort.There are challenges in using flexible wearable devices for high-performance practical applications,especially on large scales.Here,an ultrahigh-strength ultra-high-molecular-weight polyethylene braided smart yarn(UBSY)has been designed and mass produced.It is based on triboelectric nanogenerators and prepared by combining commercial ultra-high-molecular-weight polyethylene yarn and conductive yarn with a cored biaxial braided structure.Structural parameters,including the ultra-high-molecular-weight polyethylene yarn diameter,twist,and braiding pitch,are optimized to balance the mechanical properties and electrical outputs.The prepared UBSYs are characterized based on a range of reliable properties,including ultrahigh tensile strength(194.83 N),excellent abrasive resistance(up to 306 abrasive cycles),great hydrophobicity(water contact angle of 115.49°),acid and alkali splash resistance,and decent triboelectric outputs(1.5 V,3.0 nA,and 0.5 nC).An intelligent weft-knitted textile wearable sensor is fabricated with UBSY using a matured flat-knitting technique,which provides excellent mechanical strength,physical protection and comfort.Furthermore,a pair of smart elbow guards have been demonstrated to highlight UBSY-based wearable sensors’potential in outdoor sports management.In addition,equipped with a satisfactory body protective capacity against various risks and matured preparation technologies,the UBSY-based wearable sensor provides a practical solution for large-scale applications of high-performance motion sensing in complex environments.展开更多
基金supported by the Innovation and Entrepreneurship Training Program for College Students in Henan University(20221022009)the Key Scientific Research Project of Henan Province(22A310012)+1 种基金supporting program for Central Plain Young Top Talents(ZYQR201912176)the program from Academy for Advanced Interdisciplinary Studies of Henan University(Y21008L).
文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the pathogen of the ongoing coronavirus disease 2019(COVID-19)global pandemic.Here,by centralizing published cell-based experiments,clinical trials,and virtual drug screening data from the NCBI PubMed database,we developed a database of SARS-CoV-2 inhibitors for COVID-19,dbSCI,which includes 234 SARS-CoV-2 inhibitors collected from publications based on cell-based experiments,81 drugs of COVID-19 in clinical trials and 1305 potential SARS-CoV-2 inhibitors from bioinformatics analyses.dbSCI provides four major functions:(1)search the drug target or its inhibitor for SARS-CoV-2,(2)browse target/inhibitor information collected from cell experiments,clinical trials,and virtual drug screenings,(3)download,and(4)submit data.Each entry in dbSCI contains 18 types of information,including inhibitor/drug name,targeting protein,mechanism of inhibition,experimental technique,experimental sample type,and reference information.In summary,dbSCI provides a relatively comprehensive,credible repository for inhibitors/drugs against SARS-CoV-2 and their potential targeting mechanisms and it will be valuable for further studies to control COVID-19.
基金the financial support from the National Science Funds of China(52373058,11972172,52303055)the fellowship of China Postdoctoral Science Foundation 2022TQ0123+1 种基金the Natural Science Foundation of Jiangsu Province BK20221094the Key Science Research Project of Wuxi Municipal Bureau of Health Z202219。
文摘The insufficient comprehensive mechanical properties and inadequate flexibility of wearable sensors limit their bodyprotection capability,durability,and comfort.There are challenges in using flexible wearable devices for high-performance practical applications,especially on large scales.Here,an ultrahigh-strength ultra-high-molecular-weight polyethylene braided smart yarn(UBSY)has been designed and mass produced.It is based on triboelectric nanogenerators and prepared by combining commercial ultra-high-molecular-weight polyethylene yarn and conductive yarn with a cored biaxial braided structure.Structural parameters,including the ultra-high-molecular-weight polyethylene yarn diameter,twist,and braiding pitch,are optimized to balance the mechanical properties and electrical outputs.The prepared UBSYs are characterized based on a range of reliable properties,including ultrahigh tensile strength(194.83 N),excellent abrasive resistance(up to 306 abrasive cycles),great hydrophobicity(water contact angle of 115.49°),acid and alkali splash resistance,and decent triboelectric outputs(1.5 V,3.0 nA,and 0.5 nC).An intelligent weft-knitted textile wearable sensor is fabricated with UBSY using a matured flat-knitting technique,which provides excellent mechanical strength,physical protection and comfort.Furthermore,a pair of smart elbow guards have been demonstrated to highlight UBSY-based wearable sensors’potential in outdoor sports management.In addition,equipped with a satisfactory body protective capacity against various risks and matured preparation technologies,the UBSY-based wearable sensor provides a practical solution for large-scale applications of high-performance motion sensing in complex environments.
