Although graphite(G)materials dominate the commercial lithium-ion battery(LIBs)anode market due to their excellent overall performance,their limited rate performance and cycle life hinder applications in highperforman...Although graphite(G)materials dominate the commercial lithium-ion battery(LIBs)anode market due to their excellent overall performance,their limited rate performance and cycle life hinder applications in highperformance fields.To improve the cycling and rate performance of graphite anodes,this study first employed economical and eco-friendly tannic acid(TA)as a carbon coating precursor to coat graphite surfaces viaπ-πstacking interactions.In an oxygen-rich alkaline environment,tannic acid undergoes oxidation polymerization and crosslinks with formaldehyde to form a polymer matrix that coats the graphite surface.After subsequent carbonization,carbon-coated graphite material(G@C)was successfully synthesized.Carbon coatings on graphite effectively lower LIB resistance,enhance lithium-ion diffusion,and prevent exfoliation during cycling,thereby significantly boosting rate performance and prolonging the cycle life of graphite.After 500 cycles at 2C,the specific capacity of G@C was 103.7 mAh g^(-1),with a retention of 89%.However,G exhibited only 68.7 mAh g^(-1) and 85%retention under identical conditions.This carbon-coated graphite modification strategy offers a novel,green,and economical approach for designing and tailoring graphite anode materials for lithium-ion batteries with long cycle life and high rate.展开更多
Manganese-based material is a prospective cathode material for aqueous zinc ion batteries(ZIBs)by virtue of its high theoretical capacity,high operating voltage,and low price.However,the manganese dissolution during t...Manganese-based material is a prospective cathode material for aqueous zinc ion batteries(ZIBs)by virtue of its high theoretical capacity,high operating voltage,and low price.However,the manganese dissolution during the electrochemical reaction causes its electrochemical cycling stability to be undesirable.In this work,heterointerface engineering-induced oxygen defects are introduced into heterostructure MnO_(2)(δa-MnO_(2))by in situ electrochemical activation to inhibit manganese dissolution for aqueous zinc ion batteries.Meanwhile,the heterointerface between the disordered amorphous and the crystalline MnO_(2)ofδa-MnO_(2)is decisive for the formation of oxygen defects.And the experimental results indicate that the manganese dissolution ofδa-MnO_(2)is considerably inhibited during the charge/discharge cycle.Theoretical analysis indicates that the oxygen defect regulates the electronic and band structure and the Mn-O bonding state of the electrode material,thereby promoting electron transport kinetics as well as inhibiting Mn dissolution.Consequently,the capacity ofδa-MnO_(2)does not degrade after 100 cycles at a current density of 0.5 Ag^(-1)and also 91%capacity retention after 500cycles at 1 Ag^(-1).This study provides a promising insight into the development of high-performance manganese-based cathode materials through a facile and low-cost strategy.展开更多
The urgent demand for sustainable energy storage systems has driven extensive research on high-performance lithium-ion batteries(LIBs).However,graphite anodes have inherent drawbacks such as surface heterogeneity and ...The urgent demand for sustainable energy storage systems has driven extensive research on high-performance lithium-ion batteries(LIBs).However,graphite anodes have inherent drawbacks such as surface heterogeneity and limited rate performance.We developed an F/N co-doped carbon-coated graphite anode(G@FN)to tackle these challenges.Specifically,F-doping induces the formation of a highly ionically conductive LiF-rich SEI film.Furthermore,N-doping enhances the electrical conductivity of materials.This synergistic effect significantly enhances interfacial stability and lithium storage kinetics.The G@FN core-shell anode material exhibits a high specific capacity of 402.05 mAh g^(−1) and excellent cycling stability(maintaining a specific capacity of 113.19 mAh g^(−1) after 350 cycles at 2 C,with a capacity retention rate of 91.66%).This work demonstrates a simple and cost-effective artificial interfacial engineering strategy,providing methods for advancing high-rate and long-cycle-life graphite-based LIBs.展开更多
Graphite serves as a pivotal anode material in lithium-ion batteries.However,issues such as the co-embedding of solvent molecules during cycling and rapid capacity degradation at high rates have greatly hampered the p...Graphite serves as a pivotal anode material in lithium-ion batteries.However,issues such as the co-embedding of solvent molecules during cycling and rapid capacity degradation at high rates have greatly hampered the practical application and development of graphite materials.Herein,this study proposes a straightforward,cost-effective,and environmentally benign strategy for modifying graphite anodes,with the dual objectives of enhancing high-rate capability and prolonging cycle life.Using water as the primary solvent and polyacrylonitrile as the coating material,a highly conductive,flexible,and strongly bonded polymer cladding layer is designed by combining solid-liquid coating and low-temperature heat treatment technologies.This innovative design not only effectively prevents the co-embedding of solvent molecules and mitigates the volume change of graphite particles during extended cycling,but also successfully constructs a dense and efficient electron transport network on the graphite surface.Leveraging the stability advantages brought by the high electron cloud overlap of C=N bonds(comprisingσbonds andπbonds),the conductivity and structural stability of the material are enhanced.This ultimately results in the successful synthesis of the G@C-PAN core-shell material,which exhibits high-rate performance and exceptional long-cycling stability.The results indicate that the material retains a high specific capacity of 328.12 mAh·g^(-1) with 96.18%capacity retention after 250 cycles at 0.5C.Furthermore,it exhibits an impressive specific capacity retention of 97.20%after 500 cycles at 2C.This study presents a sustainable,economically viable,and scalable approach for commercializing high-performance graphite-based lithium-ion batteries.展开更多
Wound healing is one of the major global health concerns in patients with diabetes.Overactivation of pro-inflammatory M1 macrophages is associated with delayed wound healing in diabetes.miR-29ab1 plays a critical role...Wound healing is one of the major global health concerns in patients with diabetes.Overactivation of pro-inflammatory M1 macrophages is associated with delayed wound healing in diabetes.miR-29ab1 plays a critical role in diabetes-related macrophage inflammation.Hence,inhibition of inflammation and regulation of miR-29 expression have been implicated as new points for skin wound healing.In this study,the traditional Chinese medicine,puerarin,was introduced to construct an injectable and self-healing chitosan@puerarin(C@P)hydrogel.The C@P hydrogel promoted diabetic wound healing and accelerated angiogenesis,which were related to the inhibition of the miR-29 mediated inflammation response.Compared to healthy subjects,miR-29a and miR-29b1 were ectopically increased in the skin wound of the diabetic model,accompanied by upregulated M1-polarization,and elevated levels of IL-1βand TNF-α.Further evaluations by miR-29ab1 knockout mice exhibited superior wound healing and attenuated inflammation.The present results suggested that miR-29ab1 is essential for diabetic wound healing by regulating the inflammatory response.Suppression of miR-29ab1 by the C@P hydrogel has the potential for improving medical approaches for wound repair.展开更多
It is important to eliminate lipopolysaccharide(LPS)along with killing bacteria in periprosthetic joint infection(PJI)therapy for promoting bone repair due to its effect to regulate macrophages response.Although natur...It is important to eliminate lipopolysaccharide(LPS)along with killing bacteria in periprosthetic joint infection(PJI)therapy for promoting bone repair due to its effect to regulate macrophages response.Although natural antimicrobial peptides(AMPs)offer a good solution,the unknown toxicity,high cost and exogenetic immune response hamper their applications in clinic.In this work,we fabricated a nanowire-like composite material,named P@C,by combining chitosan and puerarin via solid-phase reaction,which can finely mimic the bio-functions of AMPs.Chitosan,serving as the bacteria membrane puncture agent,and puerarin,serving as the LPS target agent,synergistically destroy the bacterial membrane structure and inhibit its recovery,thus endowing P@C with good antibacterial property.In addition,P@C possesses good osteoimmunomodulation due to its ability of LPS elimination and macrophage differentiation modulation.The in vivo results show that P@C can inhibit the LPS induced bone destruction in the Escherichia coli infected rat.P@C exhibits superior bone regeneration in Escherichia coli infected rat due to the comprehensive functions of its superior antibacterial property,and its ability of LPS elimination and immunomodulation.P@C can well mimic the functions of AMPs,which provides a novel and effective method for treating the PJI in clinic.展开更多
过渡金属硫化物作为钾离子电池的高理论容量阳极,由于其电导率低、循环过程体积膨胀大,导致其倍率性能和循环稳定性较差.本文采用氧化石墨烯(GO)来控制纳米颗粒在纤维中的粒径和分布,以提高复合纤维的导电性和拉伸变形.此外,由异质结构...过渡金属硫化物作为钾离子电池的高理论容量阳极,由于其电导率低、循环过程体积膨胀大,导致其倍率性能和循环稳定性较差.本文采用氧化石墨烯(GO)来控制纳米颗粒在纤维中的粒径和分布,以提高复合纤维的导电性和拉伸变形.此外,由异质结构和氧化石墨烯组成的三维导电碳网络(ZnS-CoS@GO@CNFs)可以加速钾离子储存的动力学并稳定钾离子储存.作为钾离子电池的阳极材料,该复合材料在3 A g^(−1)下具有210 mA h g^(−1)的优异倍率性能.在2 A g^(−1)的大电流下经历2800次循环后仍表现出171 mA h g^(−1)的容量,容量保持率为97.7%.此外,当纳米纤维膜用作自支撑阳极时,仍然可以保持稳定的容量输出(在0.1 A g^(−1)下100次循环后容量为302 mA h g^(−1)).由钾离子混合电容器组装的可折叠袋状电池在多角度重复弯曲和最终恢复的情况下仍然可以安全地工作,并且可以提供大的能量密度(134 W h kg^(−1))和功率密度(5815 W kg^(−1)).优异的电化学性能进一步揭示了多功能氧化石墨烯复合纤维膜的应用前景.展开更多
The clustered regularly interspaced short palindromic repeats(CRISPR)technology has revolutionized life sciences and developed rapidly.Here,we highlight the recent advances in development and application of CRISPR tec...The clustered regularly interspaced short palindromic repeats(CRISPR)technology has revolutionized life sciences and developed rapidly.Here,we highlight the recent advances in development and application of CRISPR technologies,including the discovery of novel CRISPR systems,CRISPR base editing and imaging,and the applications of CRISPR in plant breeding,animal breeding,disease modeling and biotherapy.展开更多
Aqueous Zn-iodine(Zn-I_(2))batteries have attracted extensive research interest as an emerging redox conversion energy storage system due to the low cost and high safety.However,the shuttling effects of polyiodides ar...Aqueous Zn-iodine(Zn-I_(2))batteries have attracted extensive research interest as an emerging redox conversion energy storage system due to the low cost and high safety.However,the shuttling effects of polyiodides arising from incomplete redox conversion and inhomogeneous Zn plating on the Zn anode surface always hinder the commercial application of Zn-I_(2)batteries.In this work,a two-birds-with-one-stone strategy is reported for long-life Zn-I_(2)batteries.Based on the strategy,the sulfonate-functionalized carbon fiber not only acts as the excellent iodine limiter to inhibit iodine species shuttling,but also as the uniform Zn plating guidance layer on the Zn anode surface to prevent the inhomogeneous deposition of Zn^(2+).Consequently,a superior cycling stability(a capacity of 124 mAh g^(-1)after 10,000 cycles at 5 A g^(-1))is achieved.Theoretical calculations illustrate that sulfonate groups successfully induce charge redistribution on the carbon substrate,thereby strengthening the electronic interactions of the iodine species with the carbon substrate.The charge-enriched sulfonate groups can guide the uniform deposition of Zn^(2+)through a strong Coulombic effect with Zn^(2+).This work gives a new perspective on the integrated design of cathodes and anodes for rechargeable batteries.展开更多
基金supported by the Science and Technology Projects of the State Grid Corporation of China(5500-202323102A-1-1-ZN).
文摘Although graphite(G)materials dominate the commercial lithium-ion battery(LIBs)anode market due to their excellent overall performance,their limited rate performance and cycle life hinder applications in highperformance fields.To improve the cycling and rate performance of graphite anodes,this study first employed economical and eco-friendly tannic acid(TA)as a carbon coating precursor to coat graphite surfaces viaπ-πstacking interactions.In an oxygen-rich alkaline environment,tannic acid undergoes oxidation polymerization and crosslinks with formaldehyde to form a polymer matrix that coats the graphite surface.After subsequent carbonization,carbon-coated graphite material(G@C)was successfully synthesized.Carbon coatings on graphite effectively lower LIB resistance,enhance lithium-ion diffusion,and prevent exfoliation during cycling,thereby significantly boosting rate performance and prolonging the cycle life of graphite.After 500 cycles at 2C,the specific capacity of G@C was 103.7 mAh g^(-1),with a retention of 89%.However,G exhibited only 68.7 mAh g^(-1) and 85%retention under identical conditions.This carbon-coated graphite modification strategy offers a novel,green,and economical approach for designing and tailoring graphite anode materials for lithium-ion batteries with long cycle life and high rate.
基金funds from the National Natural Science Foundation of China(51772082 and 51804106)the Natural Science Foundation of Hunan Province(2023JJ10005)
文摘Manganese-based material is a prospective cathode material for aqueous zinc ion batteries(ZIBs)by virtue of its high theoretical capacity,high operating voltage,and low price.However,the manganese dissolution during the electrochemical reaction causes its electrochemical cycling stability to be undesirable.In this work,heterointerface engineering-induced oxygen defects are introduced into heterostructure MnO_(2)(δa-MnO_(2))by in situ electrochemical activation to inhibit manganese dissolution for aqueous zinc ion batteries.Meanwhile,the heterointerface between the disordered amorphous and the crystalline MnO_(2)ofδa-MnO_(2)is decisive for the formation of oxygen defects.And the experimental results indicate that the manganese dissolution ofδa-MnO_(2)is considerably inhibited during the charge/discharge cycle.Theoretical analysis indicates that the oxygen defect regulates the electronic and band structure and the Mn-O bonding state of the electrode material,thereby promoting electron transport kinetics as well as inhibiting Mn dissolution.Consequently,the capacity ofδa-MnO_(2)does not degrade after 100 cycles at a current density of 0.5 Ag^(-1)and also 91%capacity retention after 500cycles at 1 Ag^(-1).This study provides a promising insight into the development of high-performance manganese-based cathode materials through a facile and low-cost strategy.
基金supported by the Science and Technology Projects of the State Grid Corporation of China(5500-202323102A-1-1-ZN).
文摘The urgent demand for sustainable energy storage systems has driven extensive research on high-performance lithium-ion batteries(LIBs).However,graphite anodes have inherent drawbacks such as surface heterogeneity and limited rate performance.We developed an F/N co-doped carbon-coated graphite anode(G@FN)to tackle these challenges.Specifically,F-doping induces the formation of a highly ionically conductive LiF-rich SEI film.Furthermore,N-doping enhances the electrical conductivity of materials.This synergistic effect significantly enhances interfacial stability and lithium storage kinetics.The G@FN core-shell anode material exhibits a high specific capacity of 402.05 mAh g^(−1) and excellent cycling stability(maintaining a specific capacity of 113.19 mAh g^(−1) after 350 cycles at 2 C,with a capacity retention rate of 91.66%).This work demonstrates a simple and cost-effective artificial interfacial engineering strategy,providing methods for advancing high-rate and long-cycle-life graphite-based LIBs.
基金supported by the Science and Technology Projects of the State Grid Corporation of China(No.5500-202323102A-1-1-ZN)the Natural Science Foundation of Hunan Province(No.2023JJ10005)+1 种基金the Key Project of Hunan Provincial Department of Education(Grant No.23A0057)Youth Support Project of Hunan Normal University(Grant No.240649).
文摘Graphite serves as a pivotal anode material in lithium-ion batteries.However,issues such as the co-embedding of solvent molecules during cycling and rapid capacity degradation at high rates have greatly hampered the practical application and development of graphite materials.Herein,this study proposes a straightforward,cost-effective,and environmentally benign strategy for modifying graphite anodes,with the dual objectives of enhancing high-rate capability and prolonging cycle life.Using water as the primary solvent and polyacrylonitrile as the coating material,a highly conductive,flexible,and strongly bonded polymer cladding layer is designed by combining solid-liquid coating and low-temperature heat treatment technologies.This innovative design not only effectively prevents the co-embedding of solvent molecules and mitigates the volume change of graphite particles during extended cycling,but also successfully constructs a dense and efficient electron transport network on the graphite surface.Leveraging the stability advantages brought by the high electron cloud overlap of C=N bonds(comprisingσbonds andπbonds),the conductivity and structural stability of the material are enhanced.This ultimately results in the successful synthesis of the G@C-PAN core-shell material,which exhibits high-rate performance and exceptional long-cycling stability.The results indicate that the material retains a high specific capacity of 328.12 mAh·g^(-1) with 96.18%capacity retention after 250 cycles at 0.5C.Furthermore,it exhibits an impressive specific capacity retention of 97.20%after 500 cycles at 2C.This study presents a sustainable,economically viable,and scalable approach for commercializing high-performance graphite-based lithium-ion batteries.
基金supported by grants from the National Natural Science Foundation of China(32071344,32000938,81974326,81403029)Natural Science Foundation of Shanghai(19ZR1449100)+1 种基金Science and Technology Commission of Shanghai Municipality(19JC1415500)S&T Innovation 2025 Major Special Program of Ningbo(2019B10063).
文摘Wound healing is one of the major global health concerns in patients with diabetes.Overactivation of pro-inflammatory M1 macrophages is associated with delayed wound healing in diabetes.miR-29ab1 plays a critical role in diabetes-related macrophage inflammation.Hence,inhibition of inflammation and regulation of miR-29 expression have been implicated as new points for skin wound healing.In this study,the traditional Chinese medicine,puerarin,was introduced to construct an injectable and self-healing chitosan@puerarin(C@P)hydrogel.The C@P hydrogel promoted diabetic wound healing and accelerated angiogenesis,which were related to the inhibition of the miR-29 mediated inflammation response.Compared to healthy subjects,miR-29a and miR-29b1 were ectopically increased in the skin wound of the diabetic model,accompanied by upregulated M1-polarization,and elevated levels of IL-1βand TNF-α.Further evaluations by miR-29ab1 knockout mice exhibited superior wound healing and attenuated inflammation.The present results suggested that miR-29ab1 is essential for diabetic wound healing by regulating the inflammatory response.Suppression of miR-29ab1 by the C@P hydrogel has the potential for improving medical approaches for wound repair.
基金National Natural Science Foundation of China(U21A20100,32000938)Science and Technology Commission of Shanghai Municipality,China(19JC1415500,20ZR1465000)+1 种基金Shenzhen Science and Technology Funding(JCYJ20210324120009026)S&T Innovation 2025 Major Special Program of Ningbo(2018B10040)are acknowledged.
文摘It is important to eliminate lipopolysaccharide(LPS)along with killing bacteria in periprosthetic joint infection(PJI)therapy for promoting bone repair due to its effect to regulate macrophages response.Although natural antimicrobial peptides(AMPs)offer a good solution,the unknown toxicity,high cost and exogenetic immune response hamper their applications in clinic.In this work,we fabricated a nanowire-like composite material,named P@C,by combining chitosan and puerarin via solid-phase reaction,which can finely mimic the bio-functions of AMPs.Chitosan,serving as the bacteria membrane puncture agent,and puerarin,serving as the LPS target agent,synergistically destroy the bacterial membrane structure and inhibit its recovery,thus endowing P@C with good antibacterial property.In addition,P@C possesses good osteoimmunomodulation due to its ability of LPS elimination and macrophage differentiation modulation.The in vivo results show that P@C can inhibit the LPS induced bone destruction in the Escherichia coli infected rat.P@C exhibits superior bone regeneration in Escherichia coli infected rat due to the comprehensive functions of its superior antibacterial property,and its ability of LPS elimination and immunomodulation.P@C can well mimic the functions of AMPs,which provides a novel and effective method for treating the PJI in clinic.
基金supported by the National Natural Science Foundation of China(51772082 and 51804106)the Science and Technology Projects of the State Grid Corporation of China(5500-202323102A-1-1-ZN)the Natural Science Foundation of Hunan Province(2023JJ10005).
文摘过渡金属硫化物作为钾离子电池的高理论容量阳极,由于其电导率低、循环过程体积膨胀大,导致其倍率性能和循环稳定性较差.本文采用氧化石墨烯(GO)来控制纳米颗粒在纤维中的粒径和分布,以提高复合纤维的导电性和拉伸变形.此外,由异质结构和氧化石墨烯组成的三维导电碳网络(ZnS-CoS@GO@CNFs)可以加速钾离子储存的动力学并稳定钾离子储存.作为钾离子电池的阳极材料,该复合材料在3 A g^(−1)下具有210 mA h g^(−1)的优异倍率性能.在2 A g^(−1)的大电流下经历2800次循环后仍表现出171 mA h g^(−1)的容量,容量保持率为97.7%.此外,当纳米纤维膜用作自支撑阳极时,仍然可以保持稳定的容量输出(在0.1 A g^(−1)下100次循环后容量为302 mA h g^(−1)).由钾离子混合电容器组装的可折叠袋状电池在多角度重复弯曲和最终恢复的情况下仍然可以安全地工作,并且可以提供大的能量密度(134 W h kg^(−1))和功率密度(5815 W kg^(−1)).优异的电化学性能进一步揭示了多功能氧化石墨烯复合纤维膜的应用前景.
文摘The clustered regularly interspaced short palindromic repeats(CRISPR)technology has revolutionized life sciences and developed rapidly.Here,we highlight the recent advances in development and application of CRISPR technologies,including the discovery of novel CRISPR systems,CRISPR base editing and imaging,and the applications of CRISPR in plant breeding,animal breeding,disease modeling and biotherapy.
基金supported by the National Natural Science Foundation of China(51772082 and 51804106)the Natural Science Foundation of Hunan Province(2023JJ10005)the Science and Technology Projects of the State Grid Corporation of China(5500-202323102A-11-ZN)。
文摘Aqueous Zn-iodine(Zn-I_(2))batteries have attracted extensive research interest as an emerging redox conversion energy storage system due to the low cost and high safety.However,the shuttling effects of polyiodides arising from incomplete redox conversion and inhomogeneous Zn plating on the Zn anode surface always hinder the commercial application of Zn-I_(2)batteries.In this work,a two-birds-with-one-stone strategy is reported for long-life Zn-I_(2)batteries.Based on the strategy,the sulfonate-functionalized carbon fiber not only acts as the excellent iodine limiter to inhibit iodine species shuttling,but also as the uniform Zn plating guidance layer on the Zn anode surface to prevent the inhomogeneous deposition of Zn^(2+).Consequently,a superior cycling stability(a capacity of 124 mAh g^(-1)after 10,000 cycles at 5 A g^(-1))is achieved.Theoretical calculations illustrate that sulfonate groups successfully induce charge redistribution on the carbon substrate,thereby strengthening the electronic interactions of the iodine species with the carbon substrate.The charge-enriched sulfonate groups can guide the uniform deposition of Zn^(2+)through a strong Coulombic effect with Zn^(2+).This work gives a new perspective on the integrated design of cathodes and anodes for rechargeable batteries.
