Milk yield and composition are critical determining factors for the early growth and development of neonates.The objective of this experiment was to comprehensively evaluate the effects of dietary sodium acetate(SA)su...Milk yield and composition are critical determining factors for the early growth and development of neonates.The objective of this experiment was to comprehensively evaluate the effects of dietary sodium acetate(SA)supplementation on the milk yield and composition of sows and the growth performance of their offspring.A total of 80 sows(Landrace×Yorkshire,3 to 6 parity)were randomly assigned to 2groups(with or without 0.1%SA)from d 85 of gestation to d 21 of lactation.The result shows that maternal 0.1%SA supplementation significantly increased sows milk yield,milk fat,immunoglobulin A(IgA)and IgG content in milk(P<0.05),with the up-regulation of short-chain fatty acids receptors(GPR41 and GPR43)expression and the activation of mammalian target of rapamycin complex C1(mTORC1)signaling pathway.Consistently,in our in vitro experiment,SA also activated m TORC1signaling in porcine mammary epithelial cells(P<0.05).Furthermore,the improvement of milk quality and quantity caused by maternal SA supplementation led to the increase in body weight(BW)and average daily weight gain(ADG)of weaning piglets,with the improvement of gut health and colonization of the beneficial bacteria(P<0.05).In conclusion,maternal supplementation of 0.1%SA improved the lactation performance(milk yield and milk fat)of sows,possibly with the activation of GPR41/GPR43-mTORC1 signaling.Furthermore,enhanced milk quality improved growth performance,gut health and the colonization of beneficial microbial flora of their piglets.展开更多
Deserts are the most distinctive landscapes in the arid zones of midlatitude Asia,producing over 600 Tg of dust annually and serving as primary sources of mineral dust for the Northern Hemisphere.This dust is carried ...Deserts are the most distinctive landscapes in the arid zones of midlatitude Asia,producing over 600 Tg of dust annually and serving as primary sources of mineral dust for the Northern Hemisphere.This dust is carried by the westerlies and the East Asian winter monsoon to downwind regions including East Asia,the northern Pacific Ocean,and even Greenland,influencing the global climate,global biogeochemical cycles,ocean productivity,Northern Hemisphere glaciations,and human health.展开更多
基金financially supported by the National Key R&D Program of China(2021YFD1300700)Guangdong Basic and Applied Basic Research Foundation(2021A1515010440 and 2023A1515012098)Science and Technology Program of Guangzhou(202102020056)。
文摘Milk yield and composition are critical determining factors for the early growth and development of neonates.The objective of this experiment was to comprehensively evaluate the effects of dietary sodium acetate(SA)supplementation on the milk yield and composition of sows and the growth performance of their offspring.A total of 80 sows(Landrace×Yorkshire,3 to 6 parity)were randomly assigned to 2groups(with or without 0.1%SA)from d 85 of gestation to d 21 of lactation.The result shows that maternal 0.1%SA supplementation significantly increased sows milk yield,milk fat,immunoglobulin A(IgA)and IgG content in milk(P<0.05),with the up-regulation of short-chain fatty acids receptors(GPR41 and GPR43)expression and the activation of mammalian target of rapamycin complex C1(mTORC1)signaling pathway.Consistently,in our in vitro experiment,SA also activated m TORC1signaling in porcine mammary epithelial cells(P<0.05).Furthermore,the improvement of milk quality and quantity caused by maternal SA supplementation led to the increase in body weight(BW)and average daily weight gain(ADG)of weaning piglets,with the improvement of gut health and colonization of the beneficial bacteria(P<0.05).In conclusion,maternal supplementation of 0.1%SA improved the lactation performance(milk yield and milk fat)of sows,possibly with the activation of GPR41/GPR43-mTORC1 signaling.Furthermore,enhanced milk quality improved growth performance,gut health and the colonization of beneficial microbial flora of their piglets.
基金supported by the Third Xinjiang Scientific Expedition and Research Program(2021xjkk0302)the National Natural Science Foundation of China project of the Basic Science Center for Tibetan Plateau Earth System(41988101)+1 种基金the Second Tibetan Plateau Scientific Expedition and Research Program(2019QZKK0602)the National Natural Science Foundation of China(42072211)。
文摘Deserts are the most distinctive landscapes in the arid zones of midlatitude Asia,producing over 600 Tg of dust annually and serving as primary sources of mineral dust for the Northern Hemisphere.This dust is carried by the westerlies and the East Asian winter monsoon to downwind regions including East Asia,the northern Pacific Ocean,and even Greenland,influencing the global climate,global biogeochemical cycles,ocean productivity,Northern Hemisphere glaciations,and human health.
