The rapidly aging population directly contributes to the increasing cases of neurological disorders.Due to the chronic progressive nature of neurodegeneration,numerous neurological conditions are considered“multifact...The rapidly aging population directly contributes to the increasing cases of neurological disorders.Due to the chronic progressive nature of neurodegeneration,numerous neurological conditions are considered“multifactorial”with systemic metabolic alterations.Even so,treatments for neurological disorders have remained unchanged for the past decades.Recently,metabolic drugs such as metformin and glucagon-like peptide 1 agonists have demonstrated promising health outcomes for neurodegeneration.展开更多
The rise of the aging population parallels the rapidly increasing cases of neurological disorders. This puts pressure on scientists and physicians to find novel methods that can prevent and treat neurodegeneration. Th...The rise of the aging population parallels the rapidly increasing cases of neurological disorders. This puts pressure on scientists and physicians to find novel methods that can prevent and treat neurodegeneration. The brain is made up of a complex network of different cell types that work in tandem to maintain systemic homeostasis.展开更多
With the industrialization of agriculture and the advancement of medical care,human life expectancy has increased considerably and continues to rise steadily.This results in novel and unprecedented challenges,namely o...With the industrialization of agriculture and the advancement of medical care,human life expectancy has increased considerably and continues to rise steadily.This results in novel and unprecedented challenges,namely obesity and neurodegeneration.展开更多
Deep brain sti mulation(DBS)is a neuromodulation tool that involves the delivery of electrical impulses to specific brain regions through implanted electrodes.The principle behind DBS is to modulate dysfunctional neur...Deep brain sti mulation(DBS)is a neuromodulation tool that involves the delivery of electrical impulses to specific brain regions through implanted electrodes.The principle behind DBS is to modulate dysfunctional neural circuits without the need for permanent structural alterations to the brain.Initially developed as a treatment for movement disorders such as Parkinson's disease(PD),DBS has expanded to encompass various neurological and psychiatric disorders.展开更多
Obesity is characterized by both central and peripheral alterations,increasing the risk for neurological and metabolic disorders.Recent evidence indicate that obesity can disrupt the glymphatic system and impair the c...Obesity is characterized by both central and peripheral alterations,increasing the risk for neurological and metabolic disorders.Recent evidence indicate that obesity can disrupt the glymphatic system and impair the clearance of cerebrospinal fluid(CSF).This can lead to the build of neurotoxic molecules,potentially explaining obesity’s risk for neurodegeneration and cognitive decline.Given that glymphatic flow is tightly regulated by sleep,and that sleep disturbances are seen in obesity,melatonin emerges as a promising candidate to target glymphatic dysfunction in obesity.In both clinical and preclinical models,exogenous melatonin improves sleep quality and enhances slow-wave sleep,which is the sleep stage when glymphatic clearance is most active.This perspective aims to explore the mechanistic links between obesity and glymphatic dysfunction,highlighting melatonin as a novel therapeutic to mitigate cognitive and neurological consequences associated with obesity through the restoration of the glymphatic system.展开更多
文摘The rapidly aging population directly contributes to the increasing cases of neurological disorders.Due to the chronic progressive nature of neurodegeneration,numerous neurological conditions are considered“multifactorial”with systemic metabolic alterations.Even so,treatments for neurological disorders have remained unchanged for the past decades.Recently,metabolic drugs such as metformin and glucagon-like peptide 1 agonists have demonstrated promising health outcomes for neurodegeneration.
文摘The rise of the aging population parallels the rapidly increasing cases of neurological disorders. This puts pressure on scientists and physicians to find novel methods that can prevent and treat neurodegeneration. The brain is made up of a complex network of different cell types that work in tandem to maintain systemic homeostasis.
文摘With the industrialization of agriculture and the advancement of medical care,human life expectancy has increased considerably and continues to rise steadily.This results in novel and unprecedented challenges,namely obesity and neurodegeneration.
文摘Deep brain sti mulation(DBS)is a neuromodulation tool that involves the delivery of electrical impulses to specific brain regions through implanted electrodes.The principle behind DBS is to modulate dysfunctional neural circuits without the need for permanent structural alterations to the brain.Initially developed as a treatment for movement disorders such as Parkinson's disease(PD),DBS has expanded to encompass various neurological and psychiatric disorders.
文摘Obesity is characterized by both central and peripheral alterations,increasing the risk for neurological and metabolic disorders.Recent evidence indicate that obesity can disrupt the glymphatic system and impair the clearance of cerebrospinal fluid(CSF).This can lead to the build of neurotoxic molecules,potentially explaining obesity’s risk for neurodegeneration and cognitive decline.Given that glymphatic flow is tightly regulated by sleep,and that sleep disturbances are seen in obesity,melatonin emerges as a promising candidate to target glymphatic dysfunction in obesity.In both clinical and preclinical models,exogenous melatonin improves sleep quality and enhances slow-wave sleep,which is the sleep stage when glymphatic clearance is most active.This perspective aims to explore the mechanistic links between obesity and glymphatic dysfunction,highlighting melatonin as a novel therapeutic to mitigate cognitive and neurological consequences associated with obesity through the restoration of the glymphatic system.
