Diabetic wounds(DWs)are a major complication of diabetes mellitus,characterized by a complex patho-physiological microenvironment that is associated with elevated morbidity and mortality.Conventional management strate...Diabetic wounds(DWs)are a major complication of diabetes mellitus,characterized by a complex patho-physiological microenvironment that is associated with elevated morbidity and mortality.Conventional management strategies often fail to address the multifaceted nature of these wounds effectively.Recent advancements in understanding the mechanisms of DW healing have spurred the development of a plethora of bioactive dressings designed to interact with and modulate the DW microenvironment.These innovations have culminated in the introduction of the“microenvironment-sensitive with on-demand management”paradigm aimed at delivering precision therapy responsive to dynamic changes within DW.Despite these advancements,the current literature lacks a comprehensive review that cate-gorizes and evaluates active,passive,and on-demand approaches that address the DW microenviron-ment.Herein,we describe the unique pathogenic mechanisms and microenvironmental characteristics that distinguish DW from normal acute wounds.This review provides an extensive overview of contem-porary active and passive management strategies incorporating on-demand management principles designed for DW microenvironments.Furthermore,it addresses the principal challenges faced in this therapeutic domain and outlines the potential innovations that can enhance the efficacy and specificity of bioactive dressings.The insights presented here aim to guide further research and development in the on-demand management of DW to improve patient outcomes by aligning personalized therapy modali-ties with the pathophysiological realities of DW.展开更多
The Qingchengzi ore field is an important gold-polymetallic center of the North China Cra-ton.It has been recognized that the gold deposits in Qingchengzi were controlled by structures like litho-logical interfaces an...The Qingchengzi ore field is an important gold-polymetallic center of the North China Cra-ton.It has been recognized that the gold deposits in Qingchengzi were controlled by structures like litho-logical interfaces and fractures along mechanically weak bedding and foliation planes,but it still remains poorly understood how the structures affected the localization of the gold deposits.Finite element based numerical modeling was used to reproduce the deformation process of the Baiyun gold deposit during the mineralization period.Paleoproterozoic schist and marble are widely exposed in Qingchengzi,and a large part of the Baiyun gold ores occurs along the interfaces between the schist and the marble.The modeling results suggest that the mechanical contrast between the schist and the marble may be a major reason why the stress was localized along their lithological interfaces under a compressional stress regime.Two parts of their lithological interfaces were identified to be easily stress-localized and first fractured:the interface between the schist and its underlying marble at shallower levels and the one between the schist and its overlying marble at deeper levels.Stress concentration in these two parts is independent on the dipping angle and direction of the interfaces.Therefore,mineralizing fluids may have been concentrated into these two parts.The first one is consistent with the present ore bodies of the Baiyun gold deposit,and the second one could be considered for deep prospecting.These findings also provide implications for the structural controls of lithological interfaces on the mineralization in other gold deposits of this region.展开更多
Aiming at geological disaster monitoring and prevention work, a real-time monitoring and early warning system is proposed for low-power consumption of landslides to meet the needs of landslide monitoring in remote mou...Aiming at geological disaster monitoring and prevention work, a real-time monitoring and early warning system is proposed for low-power consumption of landslides to meet the needs of landslide monitoring in remote mountainous areas. The inclination angle of the mountain body was detected by a mechanical inclination sensor, and a plurality of inclination sensors were placed on each landslide body to form an array distribution. The landslide body was stereoscopically monitored. Each mesh node had a different node address, and different inclination thresholds were set in advance. When the sensor detection value reached the threshold, an alarm message was sent to the system main control end, and the main control end generated an audible and visual alarm, and an alarm message was sent at the same time. Compared with the current landslide warning system on the market, the system achieves expected results and its power consumption is extremely low. The sensor terminal of the mountain monitoring is powered by dry battery and can work for 6 years in the field without external power supply. It avoids the damages made by weather, livestock and human, and has broad application prospects.展开更多
基金supported by the National Natural Science Foundation of China(22408078,82401057,32101170)the Zhejiang Province Postdoctoral Excellence Funding Program-Special Support(ZJ2024004).
文摘Diabetic wounds(DWs)are a major complication of diabetes mellitus,characterized by a complex patho-physiological microenvironment that is associated with elevated morbidity and mortality.Conventional management strategies often fail to address the multifaceted nature of these wounds effectively.Recent advancements in understanding the mechanisms of DW healing have spurred the development of a plethora of bioactive dressings designed to interact with and modulate the DW microenvironment.These innovations have culminated in the introduction of the“microenvironment-sensitive with on-demand management”paradigm aimed at delivering precision therapy responsive to dynamic changes within DW.Despite these advancements,the current literature lacks a comprehensive review that cate-gorizes and evaluates active,passive,and on-demand approaches that address the DW microenviron-ment.Herein,we describe the unique pathogenic mechanisms and microenvironmental characteristics that distinguish DW from normal acute wounds.This review provides an extensive overview of contem-porary active and passive management strategies incorporating on-demand management principles designed for DW microenvironments.Furthermore,it addresses the principal challenges faced in this therapeutic domain and outlines the potential innovations that can enhance the efficacy and specificity of bioactive dressings.The insights presented here aim to guide further research and development in the on-demand management of DW to improve patient outcomes by aligning personalized therapy modali-ties with the pathophysiological realities of DW.
基金The work was financially funded by the National Key R&D Program of China(No.2018YFC0603802)the Basic Research Fund for Central Research Institutes(No.JYYWF20180602)the National Natural Science Foundation of China(No.41822206).
文摘The Qingchengzi ore field is an important gold-polymetallic center of the North China Cra-ton.It has been recognized that the gold deposits in Qingchengzi were controlled by structures like litho-logical interfaces and fractures along mechanically weak bedding and foliation planes,but it still remains poorly understood how the structures affected the localization of the gold deposits.Finite element based numerical modeling was used to reproduce the deformation process of the Baiyun gold deposit during the mineralization period.Paleoproterozoic schist and marble are widely exposed in Qingchengzi,and a large part of the Baiyun gold ores occurs along the interfaces between the schist and the marble.The modeling results suggest that the mechanical contrast between the schist and the marble may be a major reason why the stress was localized along their lithological interfaces under a compressional stress regime.Two parts of their lithological interfaces were identified to be easily stress-localized and first fractured:the interface between the schist and its underlying marble at shallower levels and the one between the schist and its overlying marble at deeper levels.Stress concentration in these two parts is independent on the dipping angle and direction of the interfaces.Therefore,mineralizing fluids may have been concentrated into these two parts.The first one is consistent with the present ore bodies of the Baiyun gold deposit,and the second one could be considered for deep prospecting.These findings also provide implications for the structural controls of lithological interfaces on the mineralization in other gold deposits of this region.
文摘Aiming at geological disaster monitoring and prevention work, a real-time monitoring and early warning system is proposed for low-power consumption of landslides to meet the needs of landslide monitoring in remote mountainous areas. The inclination angle of the mountain body was detected by a mechanical inclination sensor, and a plurality of inclination sensors were placed on each landslide body to form an array distribution. The landslide body was stereoscopically monitored. Each mesh node had a different node address, and different inclination thresholds were set in advance. When the sensor detection value reached the threshold, an alarm message was sent to the system main control end, and the main control end generated an audible and visual alarm, and an alarm message was sent at the same time. Compared with the current landslide warning system on the market, the system achieves expected results and its power consumption is extremely low. The sensor terminal of the mountain monitoring is powered by dry battery and can work for 6 years in the field without external power supply. It avoids the damages made by weather, livestock and human, and has broad application prospects.
