Sleep deprivation has been shown to exacerbate pain sensitivity and may contribute to the onset of chronic pain,yet the precise neural mechanisms underlying this association remain elusive.In our study,we explored the...Sleep deprivation has been shown to exacerbate pain sensitivity and may contribute to the onset of chronic pain,yet the precise neural mechanisms underlying this association remain elusive.In our study,we explored the contribution of cholinergic neurons within the medial habenula(MHb)to hyperalgesia induced by sleep deprivation in rats.Our findings indicate that the activity of MHb cholinergic neurons diminishes during sleep deprivation and that chemogenetic stimulation of these neurons can mitigate the results.Interestingly,we did not find a direct response of MHb cholinergic neurons to pain stimulation.Further investigation identified the interpeduncular nucleus(IPN)and the paraventricular nucleus of the thalamus(PVT)as key players in the pro-nociceptive effect of sleep deprivation.Stimulating the pathways connecting the MHb to the IPN and PVT alleviated the hyperalgesia.These results underscore the important role of MHb cholinergic neurons in modulating pain sensitivity linked to sleep deprivation,highlighting potential neural targets for mitigating sleep deprivation-induced hyperalgesia.展开更多
The nervous system possesses bidirectional,sophisticated and delicate communications with the immune system.These neuroimmune interactions play a vitally important role in the initiation and development of many disord...The nervous system possesses bidirectional,sophisticated and delicate communications with the immune system.These neuroimmune interactions play a vitally important role in the initiation and development of many disorders,especially neurodegenerative diseases.Although scientific advancements have made tremendous progress in this field during the last few years,neuroimmune communications are still far from being elucidated.By organizing recent research,in this review,we discuss the local and intersystem neuroimmune interactions and their roles in Alzheimer’s disease,Parkinson’s disease and amyotrophic lateral sclerosis.Unveiling these will help us gain a better understanding of the process of interplay inside the body and how the organism maintains homeostasis.It will also facilitate a view of the diseases from a holistic,pluralistic and interconnected perspective,thus providing a basis of developing novel and effective methods to diagnose,intervene and treat diseases.展开更多
基金supported by grants from the Ministry of Science and Technology of China(2021ZD0203204)the National Natural Science Foundation of China(32030052 and 31530028).
文摘Sleep deprivation has been shown to exacerbate pain sensitivity and may contribute to the onset of chronic pain,yet the precise neural mechanisms underlying this association remain elusive.In our study,we explored the contribution of cholinergic neurons within the medial habenula(MHb)to hyperalgesia induced by sleep deprivation in rats.Our findings indicate that the activity of MHb cholinergic neurons diminishes during sleep deprivation and that chemogenetic stimulation of these neurons can mitigate the results.Interestingly,we did not find a direct response of MHb cholinergic neurons to pain stimulation.Further investigation identified the interpeduncular nucleus(IPN)and the paraventricular nucleus of the thalamus(PVT)as key players in the pro-nociceptive effect of sleep deprivation.Stimulating the pathways connecting the MHb to the IPN and PVT alleviated the hyperalgesia.These results underscore the important role of MHb cholinergic neurons in modulating pain sensitivity linked to sleep deprivation,highlighting potential neural targets for mitigating sleep deprivation-induced hyperalgesia.
基金supported by grants from the National Natural Science Foundation of China(32030052 and 31530028).
文摘The nervous system possesses bidirectional,sophisticated and delicate communications with the immune system.These neuroimmune interactions play a vitally important role in the initiation and development of many disorders,especially neurodegenerative diseases.Although scientific advancements have made tremendous progress in this field during the last few years,neuroimmune communications are still far from being elucidated.By organizing recent research,in this review,we discuss the local and intersystem neuroimmune interactions and their roles in Alzheimer’s disease,Parkinson’s disease and amyotrophic lateral sclerosis.Unveiling these will help us gain a better understanding of the process of interplay inside the body and how the organism maintains homeostasis.It will also facilitate a view of the diseases from a holistic,pluralistic and interconnected perspective,thus providing a basis of developing novel and effective methods to diagnose,intervene and treat diseases.
