Fisetin,a naturally occurring dietary flavonoid present in fruits and vegetables such as strawberries,apples,and onions,has gained significant attention due to its broad-spectrum pharmacological activities.These inclu...Fisetin,a naturally occurring dietary flavonoid present in fruits and vegetables such as strawberries,apples,and onions,has gained significant attention due to its broad-spectrum pharmacological activities.These include potent antioxidant and anti-inflammatory effects,as well as promising anticancer and neuroprotective properties.Fisetin has demonstrated the ability to modulate key cellular pathways,induce apoptosis,inhibit tumor progression,and protect against oxidative stress and neurodegeneration.Its hepatoprotective,antiviral,and gastroprotective effects further enhance its therapeutic relevance.This review provides a comprehensive overview of fisetin’s pharmacokinetics,pharmacological activities,and the underlying molecular mechanisms driving its therapeutic effects.It also examines its toxicological profile,including safety concerns such as genotoxicity at higher concentrations.Key challenges such as poor solubility and low bioavailability are discussed,along with emerging strategies that may improve its clinical utility.In addition,the review summarizes ongoing clinical trials and outlines future research directions.Together,these insights position fisetin as a promising candidate for therapeutic development across multiple disease domains.展开更多
文摘Fisetin,a naturally occurring dietary flavonoid present in fruits and vegetables such as strawberries,apples,and onions,has gained significant attention due to its broad-spectrum pharmacological activities.These include potent antioxidant and anti-inflammatory effects,as well as promising anticancer and neuroprotective properties.Fisetin has demonstrated the ability to modulate key cellular pathways,induce apoptosis,inhibit tumor progression,and protect against oxidative stress and neurodegeneration.Its hepatoprotective,antiviral,and gastroprotective effects further enhance its therapeutic relevance.This review provides a comprehensive overview of fisetin’s pharmacokinetics,pharmacological activities,and the underlying molecular mechanisms driving its therapeutic effects.It also examines its toxicological profile,including safety concerns such as genotoxicity at higher concentrations.Key challenges such as poor solubility and low bioavailability are discussed,along with emerging strategies that may improve its clinical utility.In addition,the review summarizes ongoing clinical trials and outlines future research directions.Together,these insights position fisetin as a promising candidate for therapeutic development across multiple disease domains.
