Estrogen-related receptor alpha can significantly affect cell metabolism and play key regulatory roles in healthy and diseased organisms.ERRαis also related to the onset and progression of various cancer types.ERRαi...Estrogen-related receptor alpha can significantly affect cell metabolism and play key regulatory roles in healthy and diseased organisms.ERRαis also related to the onset and progression of various cancer types.ERRαis primarily expressed in metabolically active tissues and regulates the transcription of metabolic genes in such tissues.It coordinates metabolism and energy demand,affects osteoblasts,osteoclasts,and chondrocytes,promotes muscle regeneration,participates in angiogenesis,and regulates cell aging.In this study,the literature related to the identification of ERRαin skeletal,muscular,and vascular systems was reviewed to further elucidate this receptor.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.81970760)the Natural Science Foundation of Liaoning Province(Grant No.2021-MS-201)the 345 Talent Project of Shengjing Hospital.
文摘Estrogen-related receptor alpha can significantly affect cell metabolism and play key regulatory roles in healthy and diseased organisms.ERRαis also related to the onset and progression of various cancer types.ERRαis primarily expressed in metabolically active tissues and regulates the transcription of metabolic genes in such tissues.It coordinates metabolism and energy demand,affects osteoblasts,osteoclasts,and chondrocytes,promotes muscle regeneration,participates in angiogenesis,and regulates cell aging.In this study,the literature related to the identification of ERRαin skeletal,muscular,and vascular systems was reviewed to further elucidate this receptor.
