Background:Great diversity exists in the parenting pattern of altricial birds,which has long been considered as an adaptive response to specific environmental conditions but not to their life-history style.Methods:We ...Background:Great diversity exists in the parenting pattern of altricial birds,which has long been considered as an adaptive response to specific environmental conditions but not to their life-history style.Methods:We examined the egg-laying and nestling-raising pattern of the Grey-backed Shrike(Lanius tephronotus)that breeds only once a year on the Tibetan Plateau.We compared the dietary composition to that of its sympatric competitor,the Brown-cheeked Laughing Thrush(Trochalopteron henrici)that breeds twice a year.Results:Female Grey-backed Shrikes produced a fixed clutch size of five,with increasing egg size by their laying sequence.The last offspring in the brood is disadvantageous in the size hierarchy because it hatches later.However,they had the largest fledgling body mass.These findings indicate that Grey-backed Shrikes adopt the brood survival strategy in both the egg and nestling phases.Moreover,males and females exhibit no sexual division in providing parental care as they made an equal contribution to the total amount of food delivered to their brood.This parenting pattern of Grey-backed Shrikes,as well as their dietary items,differ significantly from those of the Brown-cheeked Laughing Thrush.Conclusions:We suggest that the differentiation in life-history style between sympatric competitors,rather than a behavioral response to specific environmental conditions,plays a decisive role in driving avian parenting strategy diversification.展开更多
Two questions in the research of animal personality—whether there is a correlation between a personality trait and individual reproductive success,and what is the genetic basis underlying a personality trait—remain ...Two questions in the research of animal personality—whether there is a correlation between a personality trait and individual reproductive success,and what is the genetic basis underlying a personality trait—remain unresolved.We addressed these two questions in three shrub-nesting birds,the Azure-winged Magpie(Cyanopica cyanus,AM),White-collared Blackbird(Turdus albocinctus,WB),and Brown-cheeked Laughingthrush(Trochalopteron henrici,BL).The personality type of an individual was first identified according to its response to a territorial intruder.Then,we compared the fleeing distance,breeding parameters,and differential expressed genes(DEGs) in the brain transcriptome between bold and shy breeders.In the three species,bold breeders exhibited more aggressiveness towards an intruder of their territory than did shy breeders.The reproductive success of bold breeders was significantly higher than that of shy breeders in AM but not in WB and BL.The three species shared one DEG,crabp1,which was up-regulated in bold relative to in shy individuals.By regulating the expression of corticotropin-releasing hormone,higher crabp1 gene expression can decrease cellular response to retinoic acid.Therefore,bold individuals are insensitive to external stresses and able to exhibit more aggressiveness to intruders than their shier counterparts.Aggressiveness is beneficial to bold individuals in AM but not in WB and BL because the former could evoke neighbors to make the same response of defending against intruders but the latter could not.Although a personality trait may have the same genetic basis across species,its correlation with reproductive success depends largely on the life history style of a species.展开更多
Altricial birds often display biased preferences in providing parental care for their dependent offspring,especially during food shortages.During this process,such inflexible rules may result in provisioning errors.To...Altricial birds often display biased preferences in providing parental care for their dependent offspring,especially during food shortages.During this process,such inflexible rules may result in provisioning errors.To demonstrate how parents optimize their provisioning strategies,we proposed a“diagnosis model”of parental care to posit that parents will undergo a diagnosis procedure to test whether selecting against some particular offspring based on phenotype is an optimal strategy.We tested this model in an asynchronous hatching bird,the Azure-winged Magpie Cyanopica cyanus,based on 10 years of data about demography and parental provisioning behaviors.Given their higher daily survival rates,core offspring(those hatched on the first day)merits an investment priority compared with their marginal brood mates(those hatched on later days).However,a marginal offspring also merited a priority if it displayed greater weight gain than the expected value at the early post-hatching days.Parents could detect such a marginal offspring via a diagnosis strategy,in which they provisioned the brood at the diagnosis stage by delivering food to every nestling that begged,then biased food toward high-value nestlings at the subsequent decision stage by making a negative response to the begging of low-value nestlings.In this provisioning strategy,the growth performance of a nestling became a more reliable indicator of its investment value than its hatching order or competitive ability.Our findings provide evidence for this“diagnosis model of parental care”wherein parents use a diagnosis method to optimize their provisioning strategy in brood reduction.展开更多
Chronic subdural hematoma(CSDH)is a disease characterized by capsuled blood products that progressively occupy the intracranial space,causing intracranial hypertension and compression in the brain.CSDH frequently occu...Chronic subdural hematoma(CSDH)is a disease characterized by capsuled blood products that progressively occupy the intracranial space,causing intracranial hypertension and compression in the brain.CSDH frequently occurs in all demographics,especially in the elderly,but the pathogenesis of CSDH remains unclear.In this review,we discuss the origin,development,and current treatment strategies of CSDH.For thefirst time,we analyzed the cellular and molecular compositions of hematoma membranes with a focus on neomembrane formation,a complex early-stage interactive event in hematoma pathogenesis.We hypothesize that in patients with CSDH,dural border cells(DBCs)might be induced to synthesize collagen or serum proteins might accumulate at the dura and arachnoid layers at the site of injury,thereby encapsulating the hemorrhage.Membrane formation may trigger inflammatory responses after subdural hemorrhage,promotingfibroblast-involved extracellular matrix(ECM)deposition and aberrant angiogenesis within the outer membrane.Consequently,ECM deposition and angiogenesis mutually influence each other and are modulated by inflammatory processes.By illustrating the complex and interactive mechanism of neomembrane formation,we aim to provide a novel insight into CSDH pathogenesis and propose directions for future research as well as advancements in treatment strategies for this disease.展开更多
Nest sanitation behavior of altricial birds has been selected to reduce the exposure of young to pathogens,parasites,or predators,and thus to maintain the health and safety of nestlings(Guigueno and Sealy 2012).During...Nest sanitation behavior of altricial birds has been selected to reduce the exposure of young to pathogens,parasites,or predators,and thus to maintain the health and safety of nestlings(Guigueno and Sealy 2012).During the process of nest sanitation,caregivers either carry away the fecal sacs of nestlings or directly eat them.Given that adults endure higher risk of being infected by pathogens during fecal consumption(Potti et al.2007),it remains a puzzle about why adults consume the nestling feces when they can transport them.Several hypotheses have been proposed to explain the fecal consumption behavior of altricial birds,including the nutrition hypothesis(Gliick 1988),economic hypothesis(Hurd et al.1991),and predation hypothesis(Ibanez-Alamo et al.2013).展开更多
Inclusive fitness theory posits that altruistic behaviors,which are directed more likely towards relatives,should be favored by natural selection.However,the prevalence of alternative parenting behaviors in offspring ...Inclusive fitness theory posits that altruistic behaviors,which are directed more likely towards relatives,should be favored by natural selection.However,the prevalence of alternative parenting behaviors in offspring selection,including rejecting their own offspring and accepting the offspring of others,remains poorly understood within the context of parental care evolution.In order to investigate the factors that prompt the occurrence of alternative parenting behaviors,we designed a series of experiments in the Azure-winged Magpie(Cyanopica cyanus).By manipulating the nest spatial position or offspring age/number and parent-offspring familiarity,we addressed how parents provided parental care for the manipulated offspring.In the nest resettlement experiment,the probability of parents rejecting their own offspring significantly increased with nest-moving distances while decreased with offspring ages.In the cross-fostering experiments,the probability of parents provisioning unrelated young significantly decreased with the age difference between cross-fostered chicks.In the nest duplication experiments,where parents were given a choice between familiar offspring and unfamiliar unrelated chicks or between unfamiliar offspring and familiar unrelated chicks,the probability of both alternative parenting behaviors was significantly influenced by the time when parental association with their offspring was deprived.We conclude that as offspring phenotypic traits become individualized and fixed at a special developmental stage,parents gradually acquire the capacity for offspring recognition by associating with them.Any factors that disrupt parent-offspring association or introduce unrelated young into the nest prior to this critical timeline can result in the occurrence of alternative parenting behaviors.展开更多
Class-incremental learning studies the problem of continually learning new classes from data streams.But networks suffer from catastrophic forgetting problems,forgetting past knowledge when acquiring new knowledge.Amo...Class-incremental learning studies the problem of continually learning new classes from data streams.But networks suffer from catastrophic forgetting problems,forgetting past knowledge when acquiring new knowledge.Among different approaches,replay methods have shown exceptional promise for this challenge.But performance still baffles from two aspects:(i)data in imbalanced distribution and(ii)networks with semantic inconsistency.First,due to limited memory buffer,there exists imbalance between old and new classes.Direct optimisation would lead feature space skewed towards new classes,resulting in performance degradation on old classes.Second,existing methods normally leverage previous network to regularise the present network.However,the previous network is not trained on new classes,which means that these two networks are semantic inconsistent,leading to misleading guidance information.To address these two problems,we propose BCSD(BiaMix contrastive learning and memory similarity distillation).For imbalanced distribution,we design Biased MixUp,where mixed samples are in high weight from old classes and low weight from new classes.Thus,network learns to push decision boundaries towards new classes.We further leverage label information to construct contrastive learning in order to ensure discriminability.Meanwhile,for semantic inconsistency,we distill knowledge from the previous network by capturing the similarity of new classes in current tasks to old classes from the memory buffer and transfer that knowledge to the present network.Empirical results on various datasets demonstrate its effectiveness and efficiency.展开更多
The mortality rate of acute severe intraventricular hematoma is extremely high, and the rate of disability in survivors is high. Intraventricular hematoma has always been a difficult problem for clinical treatment. Al...The mortality rate of acute severe intraventricular hematoma is extremely high, and the rate of disability in survivors is high. Intraventricular hematoma has always been a difficult problem for clinical treatment. Although minimally invasive endoscopic hematoma evacuation is widely used to treat this disease, the technique still has room for improvement. Equipment for the intra-neuroendoscopic technique（INET） consists of two of our patented inventions： a transparent sheath（Patent No. ZL 200820046232.0） and a hematoma aspirator（Patent No. ZL 201520248717.8）. This study explored the safety and efficacy of INET by comparing it with extraventricular drainage in combination with urokinase thrombolytic therapy. This trial recruited 65 patients with severe intraventricular hemorrhage, including 35（19 men and 16 women, aged 53.2 ± 8.7 years） in the INET group and 30（17 men and 13 women, aged 51.5 ± 7.9 years） in the control group（extraventricular drainage plus urokinase thrombolytic therapy）. Our results showed that compared with the control group, the INET group exhibited lower intraventricular hemorrhage volumes, shorter intensive care-unit monitoring and ventricular drainage-tube placement times, and fewer incidences of intracranial infection, secondary bleeding, and mortality. Thus, the prognosis of survivors had improved remarkably. These findings indicate that INET is a safe and efficient new method for treating severe intraventricular hematoma. This trial was registered with Clinical Trials.gov（NCT02515903）.展开更多
Recently, as location-based social network(LBSN) rapidly grow, point-of-interest(POI) recommendation has become an important way to help people locate interesting places. Nowadays, there have been deep studies conduct...Recently, as location-based social network(LBSN) rapidly grow, point-of-interest(POI) recommendation has become an important way to help people locate interesting places. Nowadays, there have been deep studies conducted on the geographical and social influence in the point-of-interest recommendation model based on the rating prediction. The fact is, however, relying solely on the rating fails to reflect the user's preferences very accurately, because the users are most concerned with the list of ranked point-of-interests(POIs) on the actual output of recommender systems. In this paper, we propose a co-pairwise ranking model called Geo-Social Bayesian Personalized Ranking model(GSBPR), which is based on the pairwise ranking with the exploiting geo-social correlations by incorporating the method of ranking learning into the process of POI recommendation. In this model, we develop a novel BPR pairwise ranking assumption by injecting users' geo-social preference. Based on this assumption, the POI recommendation model is reformulated by a three-level joint pairwise ranking model. And the experimental results based on real datasets show that the proposed method in this paper enjoys better recommendation performance compared to other state-of-the-art POI recommendation models.展开更多
Dear editor, P-glycoprotein （P-gp, also known as ATP-binding cassette transport sub-family B member 1, ABCB1） is a potent ATP-dependent efflux pump for a wide variety of drugs. Although studies of its substrates are...Dear editor, P-glycoprotein （P-gp, also known as ATP-binding cassette transport sub-family B member 1, ABCB1） is a potent ATP-dependent efflux pump for a wide variety of drugs. Although studies of its substrates are abundant [ 1, 2], and ABCB1 is a well-conserved gene, there is increasing evi- dence that its polymorphisms affect substrate specificity [3]. A previous study reported that the synonymous single nucleotide polymorphism （SNP） C3435T （rs1045642） affects the timing of co-translational folding and insertionof P-gp into the membrane,展开更多
Sexual conflict in producing and raising offspring is a critical issue in evolutionary ecology research.Individual experience affects their breeding performance,as measured by such traits of provisioning of offspring ...Sexual conflict in producing and raising offspring is a critical issue in evolutionary ecology research.Individual experience affects their breeding performance,as measured by such traits of provisioning of offspring and engagement in extra-pair copulations,and may cause an imbalance in sexual conflict.Thus,divorce is hypothesized to occur within aged social pairs,irrespective of current reproductive success.This concept was explored in the azure-winged magpie Cyanopica cyanus by investigating the divorce of a social pair and its relationship to their changes in breeding performance with prior experience.Females engaging in extra-pair copulation may intensify sexual conflicts and may be the main reason for divorce.Once divorced,females repairing with an inexperienced male realized higher reproductive success than that repairing with an experienced male;males repairing with an experienced female realized higher reproductive success than that repairing with an inexperienced female.This finding indicates that the fitness consequence of divorce depends on the breeding experience of new mates.Divorced females can obtain more extra-pair copulations,whereas divorced males cannot,when they repair with inexperienced breeders.Divorced females provisioned a brood at lower rates than inexperienced females whereas divorced males had no such difference.It appears that divorced females can obtain an advantage in sexual conflicts with inexperienced mates in future reproduction.Consequently,females are probably more active than males in divorcing their aged mates so as to select an inexperienced male as a new mate.Azure-winged magpies thus provide novel insights into the implicaticns of sexual conflict in birds.展开更多
In altricial birds,to address which cues are used by parents to recognize their offspring,and when they switch between cues during reproduction,it has not been well determined.In this study,we address this questi on i...In altricial birds,to address which cues are used by parents to recognize their offspring,and when they switch between cues during reproduction,it has not been well determined.In this study,we address this questi on in a Tibetan populatio n of the azure-winged magpie Cyanopica cyan us f by examining the dependence of parents on a nest's spatial position in offspring recognition.During the egg and nestling phases,azure-winged magpie nests were translocated to new positions across various distances from their original site,and parental responses to the translocated nests were investigated.Our findings show that a nesfs spatial position is not connected with the survival of its young,but might be used as a cue in parental offspring recognition.When nests are translocated to a new position within a certain distance,parents could recognize their nests and returned to resume their parenting behaviors.Parental dependence on the nest's spatial position in offspring recognition is higher during the egg phase than during the nestling phase,and it decreases with the growth of nestlings.After nestlings reach a certain age,the nest's spatial position was no longer used by pare nts as the single cue for offspring recog nition.These findings suggest that azure-winged magpies switch their cues in offspring recog nition during the differe nt stages of reproduction.After parent-offspring communication has been established,the offspring's phenotypic traits may become a more reliable cue than the nests spatial position in offspring recognition.展开更多
Conspecific animals in the wild use limited resources—such as food,nest site,and mating opportunities—very differently(Shuster and Wade 2003),which has been widely considered a consequence of phenotypic diversity(Sh...Conspecific animals in the wild use limited resources—such as food,nest site,and mating opportunities—very differently(Shuster and Wade 2003),which has been widely considered a consequence of phenotypic diversity(Shuster 2010).展开更多
Road safety has long been considered as one of the most important issues.Numerous studies have been conducted to investigate crashes with significant progress,whereas most of the work concentrates on the lifespan peri...Road safety has long been considered as one of the most important issues.Numerous studies have been conducted to investigate crashes with significant progress,whereas most of the work concentrates on the lifespan period of roadways and safety influencing factors.This paper undertakes a systematic literature review from the crash procedure to identify the state-of-the-art knowledge,advantages and disadvantages of crash risk,crash prediction,crash prevention and safety of connected and autonomous vehicles(CAVs).As a result of this literature review,substantive issues in general,data source and modeling selection are discussed,and the outcome of this study aims to provide the summary of crash knowledge with potential insight into both traditional and emerging aspects,and guide the future research direction in safety.展开更多
Dispersal is an individual life-history trait that can influence the ecological and evolutionary dynamics of both the source and recipient populations.Current studies of animal dispersal have paid little attention to ...Dispersal is an individual life-history trait that can influence the ecological and evolutionary dynamics of both the source and recipient populations.Current studies of animal dispersal have paid little attention to how the responses of residents in a recipient population affect the social resettlement of dispersers into a new habitat.We addressed this question in the blue-breasted quail Synoicus chinensis by designing an outsider introduction experiment to simulate a scenario of interaction between residents and dispersers.In the experiment,we introduced an unfamiliar quail into a group of 3 differently ranked residents and then examined their behavioral responses to the arrival of the outsider.We found that all residents made negative responses by pecking at the outsider to maintain their pecking order,in which high-ranked residents displayed significantly greater intensity than those of lower ranks.This result highlighted that adverse behavioral responses of residents would prevent outsiders from obtaining hierarchical dominance in the recipient group.Moreover,the residents’sex ratio,their relative ages to the outsiders,and whether outsiders counter-pecked at the residents all influenced the probability of outsiders prevailing against the residents.Those outsiders that displayed counter-peck courage were more likely to gain higher dominance and hence resettle into the recipient group successfully.Our findings suggest that resident groups may impose a selection among dispersers via adverse behavioral responses.Therefore,social factors that can influence the resettlement step of dispersers in a new habitat should be accounted for in future studies of animal dispersal.展开更多
Traffic signal control(TSC)systems are one essential component in intelligent transport systems.However,relevant studies are usually independent of the urban traffic simulation environment,collaborative TSC algorithms...Traffic signal control(TSC)systems are one essential component in intelligent transport systems.However,relevant studies are usually independent of the urban traffic simulation environment,collaborative TSC algorithms and traffic signal communication.In this paper,we propose(1)an integrated and cooperative Internet-of-Things architecture,namely General City Traffic Computing System(GCTCS),which simultaneously leverages an urban traffic simulation environment,TSC algorithms,and traffic signal communication;and(2)a general multi-agent reinforcement learning algorithm,namely General-MARL,considering cooperation and communication between traffic lights for multi-intersection TSC.In experiments,we demonstrate that the integrated and cooperative architecture of GCTCS is much closer to the real-life traffic environment.The General-MARL increases the average movement speed of vehicles in traffic by 23.2%while decreases the network latency by 11.7%.展开更多
Predator–prey interaction has long been an interesting item in the research of animal behaviors.Given that live prey can damage their predators,predators must trade foraging efficiency for safety while hunting,but th...Predator–prey interaction has long been an interesting item in the research of animal behaviors.Given that live prey can damage their predators,predators must trade foraging efficiency for safety while hunting,but the extent of this trade-off is not yet clear.Tiger beetles display diversity in their diets and hunting strategies,and hence,they become an ideal system to address how self-security affects foraging efficiency.We addressed this question in captive adult tiger beetles Cicindela gemmata.By offering several types of arthropod and plant foods,we confirmed that C.gemmata is carnivorous.We found that C.gemmata hunt by either ambushing or chasing their prey,and that they switch between strategies based on differences in the number of prey,the prey status and encounter rate,and the number of predators.Ambushing success increased with the number of prey but decreased with prey encounter rate.Chasing success decreased as prey body size and encounter rate increased.Foraging Cicindela gemmata often gave up an attack when it was nonfatal.This active giving up of hunting may be a consequence of a trade-off between foraging efficiency and self-security.Therefore,it is an adaptive response to the risk of injury when hunting for larger live prey.展开更多
Cyclic core dendritic polymer is a new type of synthetic polymer.We describe the first synthesis of a serial dendrimers with a core of 1,4,7,10-tetraazacyclododecane.The ability of generation 4 of dendrimers to functi...Cyclic core dendritic polymer is a new type of synthetic polymer.We describe the first synthesis of a serial dendrimers with a core of 1,4,7,10-tetraazacyclododecane.The ability of generation 4 of dendrimers to function as an effective gene delivery vectors was also investigated.Results from fluorescent in situ hybridization(FISH)show that the dendrimer has good affinity to both DNA and human small intestine cancer metastatic(HICMA)cells.the LacZ gene was highly expressed in the cells.展开更多
基金Financial support was provided by the National Natural Sciences Foundation of China(Grant No.31672299,31572271 and 31772465)the Natural Science Foundation of Xizang Province of China(2016ZR-NY-05)。
文摘Background:Great diversity exists in the parenting pattern of altricial birds,which has long been considered as an adaptive response to specific environmental conditions but not to their life-history style.Methods:We examined the egg-laying and nestling-raising pattern of the Grey-backed Shrike(Lanius tephronotus)that breeds only once a year on the Tibetan Plateau.We compared the dietary composition to that of its sympatric competitor,the Brown-cheeked Laughing Thrush(Trochalopteron henrici)that breeds twice a year.Results:Female Grey-backed Shrikes produced a fixed clutch size of five,with increasing egg size by their laying sequence.The last offspring in the brood is disadvantageous in the size hierarchy because it hatches later.However,they had the largest fledgling body mass.These findings indicate that Grey-backed Shrikes adopt the brood survival strategy in both the egg and nestling phases.Moreover,males and females exhibit no sexual division in providing parental care as they made an equal contribution to the total amount of food delivered to their brood.This parenting pattern of Grey-backed Shrikes,as well as their dietary items,differ significantly from those of the Brown-cheeked Laughing Thrush.Conclusions:We suggest that the differentiation in life-history style between sympatric competitors,rather than a behavioral response to specific environmental conditions,plays a decisive role in driving avian parenting strategy diversification.
基金provided by the National Natural Science Foundation of China (Grant 32071491, 31772465, 31672299, 31572271, and 32260128)the Natural Sciences Foundation of the Tibetan (XZ202101ZR0051G)。
文摘Two questions in the research of animal personality—whether there is a correlation between a personality trait and individual reproductive success,and what is the genetic basis underlying a personality trait—remain unresolved.We addressed these two questions in three shrub-nesting birds,the Azure-winged Magpie(Cyanopica cyanus,AM),White-collared Blackbird(Turdus albocinctus,WB),and Brown-cheeked Laughingthrush(Trochalopteron henrici,BL).The personality type of an individual was first identified according to its response to a territorial intruder.Then,we compared the fleeing distance,breeding parameters,and differential expressed genes(DEGs) in the brain transcriptome between bold and shy breeders.In the three species,bold breeders exhibited more aggressiveness towards an intruder of their territory than did shy breeders.The reproductive success of bold breeders was significantly higher than that of shy breeders in AM but not in WB and BL.The three species shared one DEG,crabp1,which was up-regulated in bold relative to in shy individuals.By regulating the expression of corticotropin-releasing hormone,higher crabp1 gene expression can decrease cellular response to retinoic acid.Therefore,bold individuals are insensitive to external stresses and able to exhibit more aggressiveness to intruders than their shier counterparts.Aggressiveness is beneficial to bold individuals in AM but not in WB and BL because the former could evoke neighbors to make the same response of defending against intruders but the latter could not.Although a personality trait may have the same genetic basis across species,its correlation with reproductive success depends largely on the life history style of a species.
基金This work was supported by the National Natural Science Foundation of China(grants 31370417,31572271,31772465,32071491).
文摘Altricial birds often display biased preferences in providing parental care for their dependent offspring,especially during food shortages.During this process,such inflexible rules may result in provisioning errors.To demonstrate how parents optimize their provisioning strategies,we proposed a“diagnosis model”of parental care to posit that parents will undergo a diagnosis procedure to test whether selecting against some particular offspring based on phenotype is an optimal strategy.We tested this model in an asynchronous hatching bird,the Azure-winged Magpie Cyanopica cyanus,based on 10 years of data about demography and parental provisioning behaviors.Given their higher daily survival rates,core offspring(those hatched on the first day)merits an investment priority compared with their marginal brood mates(those hatched on later days).However,a marginal offspring also merited a priority if it displayed greater weight gain than the expected value at the early post-hatching days.Parents could detect such a marginal offspring via a diagnosis strategy,in which they provisioned the brood at the diagnosis stage by delivering food to every nestling that begged,then biased food toward high-value nestlings at the subsequent decision stage by making a negative response to the begging of low-value nestlings.In this provisioning strategy,the growth performance of a nestling became a more reliable indicator of its investment value than its hatching order or competitive ability.Our findings provide evidence for this“diagnosis model of parental care”wherein parents use a diagnosis method to optimize their provisioning strategy in brood reduction.
基金This research was funded by Guangdong Natural Science Foundation(2020A1515010289)Shenzhen Key Medical Discipline Construction Fund(Shenzhen Key Medical Discipline 2020-2024)Shenzhen Science and Technology Innovation Foundation(Shenzhen Technology Key Project JSGG20211029095400001).
文摘Chronic subdural hematoma(CSDH)is a disease characterized by capsuled blood products that progressively occupy the intracranial space,causing intracranial hypertension and compression in the brain.CSDH frequently occurs in all demographics,especially in the elderly,but the pathogenesis of CSDH remains unclear.In this review,we discuss the origin,development,and current treatment strategies of CSDH.For thefirst time,we analyzed the cellular and molecular compositions of hematoma membranes with a focus on neomembrane formation,a complex early-stage interactive event in hematoma pathogenesis.We hypothesize that in patients with CSDH,dural border cells(DBCs)might be induced to synthesize collagen or serum proteins might accumulate at the dura and arachnoid layers at the site of injury,thereby encapsulating the hemorrhage.Membrane formation may trigger inflammatory responses after subdural hemorrhage,promotingfibroblast-involved extracellular matrix(ECM)deposition and aberrant angiogenesis within the outer membrane.Consequently,ECM deposition and angiogenesis mutually influence each other and are modulated by inflammatory processes.By illustrating the complex and interactive mechanism of neomembrane formation,we aim to provide a novel insight into CSDH pathogenesis and propose directions for future research as well as advancements in treatment strategies for this disease.
基金Financial support was provided by the National Natural Sciences Foundation of China(Grant 31572271,31672299,and 31772465).
文摘Nest sanitation behavior of altricial birds has been selected to reduce the exposure of young to pathogens,parasites,or predators,and thus to maintain the health and safety of nestlings(Guigueno and Sealy 2012).During the process of nest sanitation,caregivers either carry away the fecal sacs of nestlings or directly eat them.Given that adults endure higher risk of being infected by pathogens during fecal consumption(Potti et al.2007),it remains a puzzle about why adults consume the nestling feces when they can transport them.Several hypotheses have been proposed to explain the fecal consumption behavior of altricial birds,including the nutrition hypothesis(Gliick 1988),economic hypothesis(Hurd et al.1991),and predation hypothesis(Ibanez-Alamo et al.2013).
基金provided by the National Natural Sciences Foundation of China (Grant 32071491,31772465,31672299,31572271,and 32260128)。
文摘Inclusive fitness theory posits that altruistic behaviors,which are directed more likely towards relatives,should be favored by natural selection.However,the prevalence of alternative parenting behaviors in offspring selection,including rejecting their own offspring and accepting the offspring of others,remains poorly understood within the context of parental care evolution.In order to investigate the factors that prompt the occurrence of alternative parenting behaviors,we designed a series of experiments in the Azure-winged Magpie(Cyanopica cyanus).By manipulating the nest spatial position or offspring age/number and parent-offspring familiarity,we addressed how parents provided parental care for the manipulated offspring.In the nest resettlement experiment,the probability of parents rejecting their own offspring significantly increased with nest-moving distances while decreased with offspring ages.In the cross-fostering experiments,the probability of parents provisioning unrelated young significantly decreased with the age difference between cross-fostered chicks.In the nest duplication experiments,where parents were given a choice between familiar offspring and unfamiliar unrelated chicks or between unfamiliar offspring and familiar unrelated chicks,the probability of both alternative parenting behaviors was significantly influenced by the time when parental association with their offspring was deprived.We conclude that as offspring phenotypic traits become individualized and fixed at a special developmental stage,parents gradually acquire the capacity for offspring recognition by associating with them.Any factors that disrupt parent-offspring association or introduce unrelated young into the nest prior to this critical timeline can result in the occurrence of alternative parenting behaviors.
基金supported by the National Natural Science Foundation of China(62176188).
文摘Class-incremental learning studies the problem of continually learning new classes from data streams.But networks suffer from catastrophic forgetting problems,forgetting past knowledge when acquiring new knowledge.Among different approaches,replay methods have shown exceptional promise for this challenge.But performance still baffles from two aspects:(i)data in imbalanced distribution and(ii)networks with semantic inconsistency.First,due to limited memory buffer,there exists imbalance between old and new classes.Direct optimisation would lead feature space skewed towards new classes,resulting in performance degradation on old classes.Second,existing methods normally leverage previous network to regularise the present network.However,the previous network is not trained on new classes,which means that these two networks are semantic inconsistent,leading to misleading guidance information.To address these two problems,we propose BCSD(BiaMix contrastive learning and memory similarity distillation).For imbalanced distribution,we design Biased MixUp,where mixed samples are in high weight from old classes and low weight from new classes.Thus,network learns to push decision boundaries towards new classes.We further leverage label information to construct contrastive learning in order to ensure discriminability.Meanwhile,for semantic inconsistency,we distill knowledge from the previous network by capturing the similarity of new classes in current tasks to old classes from the memory buffer and transfer that knowledge to the present network.Empirical results on various datasets demonstrate its effectiveness and efficiency.
基金funded by a grant from the Clinical Research Project of Shenzhen Health and Family Planning Commission in China,No.SZLY2018007a grant from the Science and Technology Planning Project of Shenzhen City of China,No.JCYJ 20150403101028210+2 种基金a grant from the Science and Technology Development and Cultivation Project of Southern Medical University of China,No.KJ 20161115the Guangdong Provincial Medical Research Fund in China,No.A2016545the Shenzhen Health Planning Commission Research Fund in China,No.201601013,201506009
文摘The mortality rate of acute severe intraventricular hematoma is extremely high, and the rate of disability in survivors is high. Intraventricular hematoma has always been a difficult problem for clinical treatment. Although minimally invasive endoscopic hematoma evacuation is widely used to treat this disease, the technique still has room for improvement. Equipment for the intra-neuroendoscopic technique（INET） consists of two of our patented inventions： a transparent sheath（Patent No. ZL 200820046232.0） and a hematoma aspirator（Patent No. ZL 201520248717.8）. This study explored the safety and efficacy of INET by comparing it with extraventricular drainage in combination with urokinase thrombolytic therapy. This trial recruited 65 patients with severe intraventricular hemorrhage, including 35（19 men and 16 women, aged 53.2 ± 8.7 years） in the INET group and 30（17 men and 13 women, aged 51.5 ± 7.9 years） in the control group（extraventricular drainage plus urokinase thrombolytic therapy）. Our results showed that compared with the control group, the INET group exhibited lower intraventricular hemorrhage volumes, shorter intensive care-unit monitoring and ventricular drainage-tube placement times, and fewer incidences of intracranial infection, secondary bleeding, and mortality. Thus, the prognosis of survivors had improved remarkably. These findings indicate that INET is a safe and efficient new method for treating severe intraventricular hematoma. This trial was registered with Clinical Trials.gov（NCT02515903）.
基金supported by National Basic Research Program of China (2012CB719905)National Natural Science Funds of China (41201404)Fundamental Research Funds for the Central Universities of China (2042018gf0008)
文摘Recently, as location-based social network(LBSN) rapidly grow, point-of-interest(POI) recommendation has become an important way to help people locate interesting places. Nowadays, there have been deep studies conducted on the geographical and social influence in the point-of-interest recommendation model based on the rating prediction. The fact is, however, relying solely on the rating fails to reflect the user's preferences very accurately, because the users are most concerned with the list of ranked point-of-interests(POIs) on the actual output of recommender systems. In this paper, we propose a co-pairwise ranking model called Geo-Social Bayesian Personalized Ranking model(GSBPR), which is based on the pairwise ranking with the exploiting geo-social correlations by incorporating the method of ranking learning into the process of POI recommendation. In this model, we develop a novel BPR pairwise ranking assumption by injecting users' geo-social preference. Based on this assumption, the POI recommendation model is reformulated by a three-level joint pairwise ranking model. And the experimental results based on real datasets show that the proposed method in this paper enjoys better recommendation performance compared to other state-of-the-art POI recommendation models.
基金supported by the project of Science Fund for Creative Research Groups of the National Natural Science Foundation of China(81221002)Rational Medication Application Patterns of Schizophrenia(BMU20140430) of Peking University Health Science Center
文摘Dear editor, P-glycoprotein （P-gp, also known as ATP-binding cassette transport sub-family B member 1, ABCB1） is a potent ATP-dependent efflux pump for a wide variety of drugs. Although studies of its substrates are abundant [ 1, 2], and ABCB1 is a well-conserved gene, there is increasing evi- dence that its polymorphisms affect substrate specificity [3]. A previous study reported that the synonymous single nucleotide polymorphism （SNP） C3435T （rs1045642） affects the timing of co-translational folding and insertionof P-gp into the membrane,
基金Financial support was provided by the National Natural Sciences Foundation of China(Grant 31772465 and 31572271)the Fundamental Research Funds for the Central Universities,China(lzujbky-2017-147).
文摘Sexual conflict in producing and raising offspring is a critical issue in evolutionary ecology research.Individual experience affects their breeding performance,as measured by such traits of provisioning of offspring and engagement in extra-pair copulations,and may cause an imbalance in sexual conflict.Thus,divorce is hypothesized to occur within aged social pairs,irrespective of current reproductive success.This concept was explored in the azure-winged magpie Cyanopica cyanus by investigating the divorce of a social pair and its relationship to their changes in breeding performance with prior experience.Females engaging in extra-pair copulation may intensify sexual conflicts and may be the main reason for divorce.Once divorced,females repairing with an inexperienced male realized higher reproductive success than that repairing with an experienced male;males repairing with an experienced female realized higher reproductive success than that repairing with an inexperienced female.This finding indicates that the fitness consequence of divorce depends on the breeding experience of new mates.Divorced females can obtain more extra-pair copulations,whereas divorced males cannot,when they repair with inexperienced breeders.Divorced females provisioned a brood at lower rates than inexperienced females whereas divorced males had no such difference.It appears that divorced females can obtain an advantage in sexual conflicts with inexperienced mates in future reproduction.Consequently,females are probably more active than males in divorcing their aged mates so as to select an inexperienced male as a new mate.Azure-winged magpies thus provide novel insights into the implicaticns of sexual conflict in birds.
基金Financial support was provided by the National Natural Sciences Foundation of China(Grant 31772465 and 31572271).
文摘In altricial birds,to address which cues are used by parents to recognize their offspring,and when they switch between cues during reproduction,it has not been well determined.In this study,we address this questi on in a Tibetan populatio n of the azure-winged magpie Cyanopica cyan us f by examining the dependence of parents on a nest's spatial position in offspring recognition.During the egg and nestling phases,azure-winged magpie nests were translocated to new positions across various distances from their original site,and parental responses to the translocated nests were investigated.Our findings show that a nesfs spatial position is not connected with the survival of its young,but might be used as a cue in parental offspring recognition.When nests are translocated to a new position within a certain distance,parents could recognize their nests and returned to resume their parenting behaviors.Parental dependence on the nest's spatial position in offspring recognition is higher during the egg phase than during the nestling phase,and it decreases with the growth of nestlings.After nestlings reach a certain age,the nest's spatial position was no longer used by pare nts as the single cue for offspring recog nition.These findings suggest that azure-winged magpies switch their cues in offspring recog nition during the differe nt stages of reproduction.After parent-offspring communication has been established,the offspring's phenotypic traits may become a more reliable cue than the nests spatial position in offspring recognition.
基金Financial support was provided by the National Natural Sciences Foundation of China(Grant 32071491,31772465,31572271,and 31370417)。
文摘Conspecific animals in the wild use limited resources—such as food,nest site,and mating opportunities—very differently(Shuster and Wade 2003),which has been widely considered a consequence of phenotypic diversity(Shuster 2010).
基金supported by National Natural Science Foundation of China(No:72131008)National Key Research and Development Program(No:2022YFC3800103-03).
文摘Road safety has long been considered as one of the most important issues.Numerous studies have been conducted to investigate crashes with significant progress,whereas most of the work concentrates on the lifespan period of roadways and safety influencing factors.This paper undertakes a systematic literature review from the crash procedure to identify the state-of-the-art knowledge,advantages and disadvantages of crash risk,crash prediction,crash prevention and safety of connected and autonomous vehicles(CAVs).As a result of this literature review,substantive issues in general,data source and modeling selection are discussed,and the outcome of this study aims to provide the summary of crash knowledge with potential insight into both traditional and emerging aspects,and guide the future research direction in safety.
基金Financial support was provided by the National Natural Sciences Foundation of China(Grant 32071491 and 31772465)the Natural Sciences Foundation of the Tibetan(XZ202101ZR0051G).
文摘Dispersal is an individual life-history trait that can influence the ecological and evolutionary dynamics of both the source and recipient populations.Current studies of animal dispersal have paid little attention to how the responses of residents in a recipient population affect the social resettlement of dispersers into a new habitat.We addressed this question in the blue-breasted quail Synoicus chinensis by designing an outsider introduction experiment to simulate a scenario of interaction between residents and dispersers.In the experiment,we introduced an unfamiliar quail into a group of 3 differently ranked residents and then examined their behavioral responses to the arrival of the outsider.We found that all residents made negative responses by pecking at the outsider to maintain their pecking order,in which high-ranked residents displayed significantly greater intensity than those of lower ranks.This result highlighted that adverse behavioral responses of residents would prevent outsiders from obtaining hierarchical dominance in the recipient group.Moreover,the residents’sex ratio,their relative ages to the outsiders,and whether outsiders counter-pecked at the residents all influenced the probability of outsiders prevailing against the residents.Those outsiders that displayed counter-peck courage were more likely to gain higher dominance and hence resettle into the recipient group successfully.Our findings suggest that resident groups may impose a selection among dispersers via adverse behavioral responses.Therefore,social factors that can influence the resettlement step of dispersers in a new habitat should be accounted for in future studies of animal dispersal.
基金supported by the National Natural Science Foundation of China(Grant Nos.61673150,11622538).
文摘Traffic signal control(TSC)systems are one essential component in intelligent transport systems.However,relevant studies are usually independent of the urban traffic simulation environment,collaborative TSC algorithms and traffic signal communication.In this paper,we propose(1)an integrated and cooperative Internet-of-Things architecture,namely General City Traffic Computing System(GCTCS),which simultaneously leverages an urban traffic simulation environment,TSC algorithms,and traffic signal communication;and(2)a general multi-agent reinforcement learning algorithm,namely General-MARL,considering cooperation and communication between traffic lights for multi-intersection TSC.In experiments,we demonstrate that the integrated and cooperative architecture of GCTCS is much closer to the real-life traffic environment.The General-MARL increases the average movement speed of vehicles in traffic by 23.2%while decreases the network latency by 11.7%.
基金The procedures of insect capture and measurement are under the Wildlife Conservation Law of China(20170101).
文摘Predator–prey interaction has long been an interesting item in the research of animal behaviors.Given that live prey can damage their predators,predators must trade foraging efficiency for safety while hunting,but the extent of this trade-off is not yet clear.Tiger beetles display diversity in their diets and hunting strategies,and hence,they become an ideal system to address how self-security affects foraging efficiency.We addressed this question in captive adult tiger beetles Cicindela gemmata.By offering several types of arthropod and plant foods,we confirmed that C.gemmata is carnivorous.We found that C.gemmata hunt by either ambushing or chasing their prey,and that they switch between strategies based on differences in the number of prey,the prey status and encounter rate,and the number of predators.Ambushing success increased with the number of prey but decreased with prey encounter rate.Chasing success decreased as prey body size and encounter rate increased.Foraging Cicindela gemmata often gave up an attack when it was nonfatal.This active giving up of hunting may be a consequence of a trade-off between foraging efficiency and self-security.Therefore,it is an adaptive response to the risk of injury when hunting for larger live prey.
基金supported by the National Natural Science Foundation of China.
文摘Cyclic core dendritic polymer is a new type of synthetic polymer.We describe the first synthesis of a serial dendrimers with a core of 1,4,7,10-tetraazacyclododecane.The ability of generation 4 of dendrimers to function as an effective gene delivery vectors was also investigated.Results from fluorescent in situ hybridization(FISH)show that the dendrimer has good affinity to both DNA and human small intestine cancer metastatic(HICMA)cells.the LacZ gene was highly expressed in the cells.
