The single best predictor of future fracture risk is a prior fracture at any skeletal site.However,the mechanisms underlying this relationship remain incompletely understood.Here we review three potential mechanisms u...The single best predictor of future fracture risk is a prior fracture at any skeletal site.However,the mechanisms underlying this relationship remain incompletely understood.Here we review three potential mechanisms underlying increased risk.An index fracture may reflect preexisting deficits in bone quality or impairments in physical function.Second,fracture may cause biomechanical changes that increase future fracture risk.Third,fracture induces a period of systemic bone loss that is never fully recovered.Further investigation into these mechanisms can inform treatments that prevent future fractures for individuals with a prior history of fracture.展开更多
基金The authors are supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases(NIAMS),under award number R01 AR071459.The project described was also supported by the National Center for Advancing Translational Sciences,National Institutes of Health,through grant number UL1 TR001860 and linked award TL1 TR001861.
文摘The single best predictor of future fracture risk is a prior fracture at any skeletal site.However,the mechanisms underlying this relationship remain incompletely understood.Here we review three potential mechanisms underlying increased risk.An index fracture may reflect preexisting deficits in bone quality or impairments in physical function.Second,fracture may cause biomechanical changes that increase future fracture risk.Third,fracture induces a period of systemic bone loss that is never fully recovered.Further investigation into these mechanisms can inform treatments that prevent future fractures for individuals with a prior history of fracture.
