Noninvasive treatment of pressure ulcers with undermining is often difficult. To decrease the risk of bleeding in such conditions, negative pressure wound therapy (NPWT) has been applied. We treated a pressure ulcer w...Noninvasive treatment of pressure ulcers with undermining is often difficult. To decrease the risk of bleeding in such conditions, negative pressure wound therapy (NPWT) has been applied. We treated a pressure ulcer with wide undermining using NPWT after opening drainage holes in the undermined area. This method can reduce the risk of bleeding and promote the rapid closure of the undermined area.展开更多
Organic lasers hold great promise for enabling a new class of future optoelectronics.Consequently,the development of new organic semiconductors as gain media has recently been the subject of significant interest.The m...Organic lasers hold great promise for enabling a new class of future optoelectronics.Consequently,the development of new organic semiconductors as gain media has recently been the subject of significant interest.The molecular design principle based on Einstein coefficients has been validated for achieving high gain,with para-phenylene-vinylene scaffolds recognized as one of the most crucial frameworks.In this study,we develop a stilbene tetramer derivative,QSBCz,which has significantly increased conjugation compared to the highly efficient laser material,BSBCz,resulting in a remarkably high radiative decay rate and a large gain cross-section.However,we find that the optical losses play a significant role in the light amplification of QSBCz.Indeed,a comprehensive understanding and suppression of detrimental optical loss pathways throughout the lasing process are essential,whereas the losses intrinsically associated with molecules have not been well considered.Although host–vip systems are helpful in preventing concentration quenching in aggregated states,this study reveals notable losses when using common host molecules such as 4,4′-bis(9H-carbazol-9-yl)biphenyl(CBP)and mCBP.In contrast,a BSBCz derivative is successfully employed as the host,leading to improved stimulated emission amplification.These findings indicate the importance of host–emitter interactions in lasing properties and highlight the necessity to optimize host materials for developing new laser dyes.展开更多
文摘Noninvasive treatment of pressure ulcers with undermining is often difficult. To decrease the risk of bleeding in such conditions, negative pressure wound therapy (NPWT) has been applied. We treated a pressure ulcer with wide undermining using NPWT after opening drainage holes in the undermined area. This method can reduce the risk of bleeding and promote the rapid closure of the undermined area.
基金supported by the JSPS KAKENHI(Grants 23K04879,23H05406 and 23K20039,23H01977,23H04631)and the Inamori Foundation.
文摘Organic lasers hold great promise for enabling a new class of future optoelectronics.Consequently,the development of new organic semiconductors as gain media has recently been the subject of significant interest.The molecular design principle based on Einstein coefficients has been validated for achieving high gain,with para-phenylene-vinylene scaffolds recognized as one of the most crucial frameworks.In this study,we develop a stilbene tetramer derivative,QSBCz,which has significantly increased conjugation compared to the highly efficient laser material,BSBCz,resulting in a remarkably high radiative decay rate and a large gain cross-section.However,we find that the optical losses play a significant role in the light amplification of QSBCz.Indeed,a comprehensive understanding and suppression of detrimental optical loss pathways throughout the lasing process are essential,whereas the losses intrinsically associated with molecules have not been well considered.Although host–vip systems are helpful in preventing concentration quenching in aggregated states,this study reveals notable losses when using common host molecules such as 4,4′-bis(9H-carbazol-9-yl)biphenyl(CBP)and mCBP.In contrast,a BSBCz derivative is successfully employed as the host,leading to improved stimulated emission amplification.These findings indicate the importance of host–emitter interactions in lasing properties and highlight the necessity to optimize host materials for developing new laser dyes.
