Several new treatment options for gastric cancer have been introduced but the prognosis of patients diagnosed with gastric cancer is still poor. Disease prognosis could be improved for high-risk individuals by impleme...Several new treatment options for gastric cancer have been introduced but the prognosis of patients diagnosed with gastric cancer is still poor. Disease prognosis could be improved for high-risk individuals by implementing earlier screenings. Because many patients are asymptomatic during the early stages of gastric cancer,the diagnosis is often delayed and patients present with unresectable locally advanced or metastatic disease. Cytotoxic treatment has been shown to prolong survival in general,but not all patients are responders. The application of targeted therapies and multimodal treatment has improved prognosis for those with advanced disease.However,these new therapeutic strategies do not uniformly benefit all patients.Predicting whether patients will respond to specific therapies would be of particular value and would allow for stratifying patients for personalized treatment strategies.Metabolic imaging by positron emission tomography was the first technique with the potential to predict the response of esophagogastric cancer to neoadjuvant therapy.Exploring and validating tissue-based biomarkers are ongoing processes.In this review,we discuss the status of several targeted therapies for gastric cancer,as well as proteomic and metabolic methods for investigating biomarkers for therapy response prediction in gastric cancer.展开更多
According to ancient and present Chinese sources the Eight Confluent Points are essentials of acupuncture and can treat all kinds of diseases. They exert a fundamental influence on the Twelve Regular Meridians and the...According to ancient and present Chinese sources the Eight Confluent Points are essentials of acupuncture and can treat all kinds of diseases. They exert a fundamental influence on the Twelve Regular Meridians and their mobilization can be seen as a necessity for a successful acupuncture treatment. For this they should play a major role in acupuncture. In European acupuncture teachings there is also the opinion that by too much needling of the Eight Confluent Points the qi of the organism might get exhausted which will deteriorate the patient＇s symptoms and eventually will create new symptoms. Here it will be shown that deterioration as well as the creation of new symptoms due to acupuncture is caused by not observing the contraindications in acupuncture as set up in ancient China provided that syndrome differentiation, point selection and stimulation have been correct. In opposition to this, all of the Eight Extraordinary Channels are to be activated at first and then the Twelve Regular Meridians are to be mobilized in order to achieve therapeutic effects.展开更多
基金Supported by Ministry of Education and Research of the Federal Republic of Germany,Grant No.0315508A and No.01IB10004E(to AW),SYS-Stomach to BL,FL and AW)the Deutsche Forschungsgemeinschaft,Grant No.HO 1258/3-1,No.SFB 824 TP Z02 and No.WA 1656/3-1(to AW)
文摘Several new treatment options for gastric cancer have been introduced but the prognosis of patients diagnosed with gastric cancer is still poor. Disease prognosis could be improved for high-risk individuals by implementing earlier screenings. Because many patients are asymptomatic during the early stages of gastric cancer,the diagnosis is often delayed and patients present with unresectable locally advanced or metastatic disease. Cytotoxic treatment has been shown to prolong survival in general,but not all patients are responders. The application of targeted therapies and multimodal treatment has improved prognosis for those with advanced disease.However,these new therapeutic strategies do not uniformly benefit all patients.Predicting whether patients will respond to specific therapies would be of particular value and would allow for stratifying patients for personalized treatment strategies.Metabolic imaging by positron emission tomography was the first technique with the potential to predict the response of esophagogastric cancer to neoadjuvant therapy.Exploring and validating tissue-based biomarkers are ongoing processes.In this review,we discuss the status of several targeted therapies for gastric cancer,as well as proteomic and metabolic methods for investigating biomarkers for therapy response prediction in gastric cancer.
文摘According to ancient and present Chinese sources the Eight Confluent Points are essentials of acupuncture and can treat all kinds of diseases. They exert a fundamental influence on the Twelve Regular Meridians and their mobilization can be seen as a necessity for a successful acupuncture treatment. For this they should play a major role in acupuncture. In European acupuncture teachings there is also the opinion that by too much needling of the Eight Confluent Points the qi of the organism might get exhausted which will deteriorate the patient＇s symptoms and eventually will create new symptoms. Here it will be shown that deterioration as well as the creation of new symptoms due to acupuncture is caused by not observing the contraindications in acupuncture as set up in ancient China provided that syndrome differentiation, point selection and stimulation have been correct. In opposition to this, all of the Eight Extraordinary Channels are to be activated at first and then the Twelve Regular Meridians are to be mobilized in order to achieve therapeutic effects.
