Introduction Vascular endothelial (VE)-cadherin is localized to the endothelial borders and the adherens junctions,which are regulated by changes in mitogen activated protein kinases (MAPK),GTPases,and intracellular c...Introduction Vascular endothelial (VE)-cadherin is localized to the endothelial borders and the adherens junctions,which are regulated by changes in mitogen activated protein kinases (MAPK),GTPases,and intracellular calcium. We previously展开更多
Lymphocyte dysregulation and coagulopathy are closely correlated with the severity and fatal risks of coronavirus disease 2019(COVID-19).Patients with lymphopenia showed a remarkably higher risk of progressive thrombo...Lymphocyte dysregulation and coagulopathy are closely correlated with the severity and fatal risks of coronavirus disease 2019(COVID-19).Patients with lymphopenia showed a remarkably higher risk of progressive thrombosis and abnormal coagulation[1].Up to 80%of severely ill and deceased COVID-19 patients have been found to have diffuse alveolar damage and fibrinous thrombi[2].Autopsy studies confirmed widespread pulmonary embolism and microthrombosis in multiple organs,including but not limited to the lung,kidney,liver,heart,and brain[3].展开更多
基金supported by grants from NIH CA-125707 NSF CBET-0729091 (C D ),as well as NIH AI-065566 (A A )
文摘Introduction Vascular endothelial (VE)-cadherin is localized to the endothelial borders and the adherens junctions,which are regulated by changes in mitogen activated protein kinases (MAPK),GTPases,and intracellular calcium. We previously
基金supported by the National Natural Science Foundation of China(82273576)。
文摘Lymphocyte dysregulation and coagulopathy are closely correlated with the severity and fatal risks of coronavirus disease 2019(COVID-19).Patients with lymphopenia showed a remarkably higher risk of progressive thrombosis and abnormal coagulation[1].Up to 80%of severely ill and deceased COVID-19 patients have been found to have diffuse alveolar damage and fibrinous thrombi[2].Autopsy studies confirmed widespread pulmonary embolism and microthrombosis in multiple organs,including but not limited to the lung,kidney,liver,heart,and brain[3].
