Objective:This study aimed to perform an evaluation of changes in spermogram parameters after follicle-stimulating hormone(FSH)therapy in infertile males having oligo-asthenospermia at different levels of DNA fragment...Objective:This study aimed to perform an evaluation of changes in spermogram parameters after follicle-stimulating hormone(FSH)therapy in infertile males having oligo-asthenospermia at different levels of DNA fragmentation index(DFI).Materials and methods:Infertile men with oligo-asthenospermia,no underlying urogenital disease(such as varicocele),and medically fertile partners were enrolled over 1 year.Semen parameters,FSH,luteinizing hormone,and testosterone levels were determined;also,a Sperm DNA Fragmentation Assay Kit(Hamun Teb Pishro,Tehran,Iran)was used for determining sperm DFI at baseline.Participants were categorized into 3 groups based on DFI:DFI<15%(group 1),DFI of 15%-30%(group 2),and DFI>30%(group 3).All participants received subcutaneous recombinant FSH(150 mg every other day)for 6 months.Sperm specimens were tested 6months after intervention(a single sperm control test).Results:Sixty males whose average age was 28.4 years were enrolled.Only group 3(poor fertility)exhibited a significant rise in sperm concentration(p=0.001)and motility(p<0.05)after FSH treatment.Group 1(DFI<15%)and group 2(DFI of 15%-30%)showed increased mean sperm concentration and motility postintervention,although these alterations were not significantly different.Folliclestimulating hormone levels increased significantly in all 3 groups after FSH administration.Serum luteinizing hormone and testosterone levels were not significantly increased in any of the groups.Conclusions:Follicle-stimulating hormone treatment improves sperm concentration andmotility in men with oligo-asthenospermia,with significant improvements observed in men with DFI>30%.DNA fragmentation index can be a predictive indicator of response to FSH treatment in such patients.展开更多
基金funded by a research grant from Mashhad University of Medical Sciences(grant number 971700).
文摘Objective:This study aimed to perform an evaluation of changes in spermogram parameters after follicle-stimulating hormone(FSH)therapy in infertile males having oligo-asthenospermia at different levels of DNA fragmentation index(DFI).Materials and methods:Infertile men with oligo-asthenospermia,no underlying urogenital disease(such as varicocele),and medically fertile partners were enrolled over 1 year.Semen parameters,FSH,luteinizing hormone,and testosterone levels were determined;also,a Sperm DNA Fragmentation Assay Kit(Hamun Teb Pishro,Tehran,Iran)was used for determining sperm DFI at baseline.Participants were categorized into 3 groups based on DFI:DFI<15%(group 1),DFI of 15%-30%(group 2),and DFI>30%(group 3).All participants received subcutaneous recombinant FSH(150 mg every other day)for 6 months.Sperm specimens were tested 6months after intervention(a single sperm control test).Results:Sixty males whose average age was 28.4 years were enrolled.Only group 3(poor fertility)exhibited a significant rise in sperm concentration(p=0.001)and motility(p<0.05)after FSH treatment.Group 1(DFI<15%)and group 2(DFI of 15%-30%)showed increased mean sperm concentration and motility postintervention,although these alterations were not significantly different.Folliclestimulating hormone levels increased significantly in all 3 groups after FSH administration.Serum luteinizing hormone and testosterone levels were not significantly increased in any of the groups.Conclusions:Follicle-stimulating hormone treatment improves sperm concentration andmotility in men with oligo-asthenospermia,with significant improvements observed in men with DFI>30%.DNA fragmentation index can be a predictive indicator of response to FSH treatment in such patients.
