Syzygium cumini Linn.,commonly known as Jamun,is a member of the Myrtaceae family and is also referred to by synonyms such as Eugenia djouant Perr.,Eugenia cumini,Eugenia jambolana Lam.,Syzygium jambolana Lam.,and Myr...Syzygium cumini Linn.,commonly known as Jamun,is a member of the Myrtaceae family and is also referred to by synonyms such as Eugenia djouant Perr.,Eugenia cumini,Eugenia jambolana Lam.,Syzygium jambolana Lam.,and Myrtus cumini Linn.This review provides an overview of its medicinal value,including taxonomical classification,geographic distribution,cultivation techniques,pharmacognostical aspects,phytochemical constituents,traditional uses,and pharmacological applications.In India,‘Ram Jamun’or‘Raja Jamun’is cultivated in the north,while the‘Paras’variety is grown in central regions.Various components of S.cumini fruits are utilized to enhance the nutritional quality of wines,jellies,jams,and fermented products.Rich in essential nutrients like vitamins,carbohydrates,minerals,antioxidants,and anthocyanins,S.cumini also contains bioactive phytoconstituents such as gallic acid,tannins,and polyphenols,which contribute to its pharmacological properties.Traditionally,black plums have been used as carminatives,diuretics,and remedies for stomach ailments,spleen enlargement,diarrhea,and urinary retention.Additionally,S.cumini has been historically administered to women post-abortion and is recognized for its role in managing diabetes and dysentery.Polyphenolic compounds in Jamun exhibit potential therapeutic benefits against diabetes,arthritis,cancer,asthma,and cardiovascular diseases.Given its promising ethnopharmacological profile,extensive research has been conducted on various plant parts,highlighting their antioxidant,antifungal,antibacterial,antidiabetic,and anticancer properties.This review aims to provide a comprehensive understanding of Syzygium cumini’s traditional and therapeutic significance,serving as a valuable resource for future research.展开更多
BACKGROUND Sacubitril/valsartan is a first-in-class angiotensin receptor neprilysin inhibitor(ARNI)which combines an angiotensin receptor blocker(valsartan)with sacubitril,an inhibitor of the enzyme neprilysin.By virt...BACKGROUND Sacubitril/valsartan is a first-in-class angiotensin receptor neprilysin inhibitor(ARNI)which combines an angiotensin receptor blocker(valsartan)with sacubitril,an inhibitor of the enzyme neprilysin.By virtue of combined effect of blocking the action of angiotensin-II and inhibiting the breakdown of natriuretic peptides,ARNIs have beneficial role in heart failure(HF).AIM To evaluate the effect of sacubitril/valsartan on N-terminal pro-B-type natriuretic peptide(NT-pro BNP),inflammatory marker[high-sensitivity C-reactive protein(hs-CRP)],and quality of life when given as add-on to standard therapy in patients with HF.METHODS Sacubitril/valsartan as add-on therapy for improvement in HF study was a randomised controlled trial conducted from July 2023 to November 2024 in a public tertiary care hospital in India.Eligible patients were randomised in 1:1 ratio to either of the 2 study arms:(1)Group A(sacubitril/valsartan+standard treatment);and(2)Group B(standard treatment)for 12 weeks.Primary end point was change in NT-pro BNP levels at 12 weeks from baseline.Secondary endpoints included(1)Change in hs-CRP levels;(2)Change in World Health Organisation Quality of Life Questionnaire(WHOQOL-BREF)score;and(3)Incidence of treatment-related adverse events or worsening HF.Statistical analysis was done using Statistical Package for the Social Sciences trial version 29.0 and P<0.05 was considered significant.RESULTS Out of 124 patients screened,80 were enrolled of which 25 patients in each group were available for per-protocol analysis.At baseline,both the groups were comparable.Sacubitril/valsartan group exhibited a statistically significant greater reduction in NT-pro BNP(-35.91±28.01 vs 24.68±31.86;P<0.0001)and hs-CRP(-2.87±3.22 vs 0.76±1.60;P<0.0001)levels at 12 weeks compared to standard treatment group.There was also a greater improvement in quality of life with sacubitril/valsartan group(overall change in WHOQOL-BREF:13.16±8.73 in sacubitril/valsartan vs-4.12±6.25 in standard treatment arm).No major adverse events were reported in two groups.CONCLUSION Sacubitril/valsartan demonstrated significant improvements in HF biomarkers,inflammation,and quality of life without compromising safety supporting its role as an effective addition to standard HF therapy.Further research is needed to evaluate its long-term benefits on mortality and cardiac remodeling.展开更多
Objective:To identify the risk factors for acquiring scrub typhus infection among all age group.Methods:A case-control study was carried out from June to December 2019 in collaboration with the Department of Health Se...Objective:To identify the risk factors for acquiring scrub typhus infection among all age group.Methods:A case-control study was carried out from June to December 2019 in collaboration with the Department of Health Services,Kerala.136 Of serologically confirmed scrub typhus reported during 2018 were included and 270 age and sex-matched healthy controls were selected randomly from different locations in the same area where the cases were reported.The risk factors identified were compared between cases and controls,using univariate and multivariable logistic regression analysis to identify the risk factors for scrub typhus infection.Results:Some key factors like house type with individuals residing in houses with concrete roofs are associated with a higher risk of scrub typhus infection compared to tiled roofs(aOR 0.14,95%CI 0.36-0.56,P=0.005).Housewives exhibit a significantly higher risk(aOR 3.97,95%CI 2.15-8.94,P=0.038)of scrub typhus infection.Environmental factors,including the presence of rats(aOR 3.48,95%CI 1.19-6.53,P=0.023),the presence of domestic animals(aOR 2.98,95%CI 1.67-5.19,P<0.001),wet agricultural fields around the house(aOR 3.64,95%CI 1.50-6.54,P<0.001),and hygiene practices like not changing clothes after work(aOR 2.64,95%CI 1.37-4.68,P=0.024),and disposing of the wastes in their own yard(aOR 4.79,95%CI 3.78-9.55,P=0.043)are identified as significant high-risk factors for scrub typhus infection.Conclusions:These findings will be very useful to create awareness among the public and to undertake a detailed control strategy for scrub typhus.展开更多
Aluminium toxicity in acid soils having pH below 5.5, affects the production of staple food crops, vegetables and cash crops worldwide. About 50% of the world’s potentially arable lands are acidic. It is trivalent ca...Aluminium toxicity in acid soils having pH below 5.5, affects the production of staple food crops, vegetables and cash crops worldwide. About 50% of the world’s potentially arable lands are acidic. It is trivalent cationic form i.e. Al3+ that limits the plant’s growth. Absorbed Aluminium inhibits root elongation and adversely affects plant growth. Recently researches have been conducted to understand the mechanism of Aluminium toxicity and resistance which is important for stable food production in future. Aluminium resistance depends on the ability of the plant to tolerate Aluminium in symplast or to exclude it to soil. Physiological and molecular basis of Aluminium toxicity and resistance mechanism are important to understand for developing genetically engineered plants for Al toxicity resistance. This paper provides an overview of the state of art in this field.展开更多
OBJECTIVE： Different parts of Murraya paniculata have been used traditionally for treating several ailments including mental disorders. The present study was designed to evaluate the antianxiety and antidepressant po...OBJECTIVE： Different parts of Murraya paniculata have been used traditionally for treating several ailments including mental disorders. The present study was designed to evaluate the antianxiety and antidepressant potential of M. paniculata leaves using elevated plus maze model and forced swim test, respectively. METHODS： Extracts of M. panicu/ata made with petroleum ether （60-80 ℃）, chloroform, ethanol and water were evaluated for antianxiety and antidepressant activity. The anxiolytic chloroform extract was subjected to column chromatography, yielding five fractions （F1-F5）. Fraction F5 （100 mg/kg）, which showed notable anxiolytic activity, was further chromatographed to get four subfractions （F5.1-F5.4）. Simultaneously, the ethano extract was partitioned with ethyl acetate to obtain ethyl acetate soluble fraction （EASF） and ethyl acetate insoluble fraction. Phytochemical screening of bioactive extracts/fractions and detection of mahanimbine in M paniculata leaf extract by thin-layer chromatography was also carried out. RESULTS： Fraction F5.3 （25 mg/kg） and EASF （20 mg/kg） showed significant anxiolytic and antidepressant activity, respectively. Thin-layer chromatography and phytochemical screening demonstrated the absence of mahanimbine in M. paniculata leaves. Coumarins were observed to be responsible for the anxiolytic activity. CONCLUSION： The results validate the traditional use of M. paniculata leaves in the treatment of menta disorders.展开更多
Lanthanides(Ln(Ⅲ))based compounds as light-emitting materials have emerged as successful agents in high-performance defense and lighting systems,magnets,bio-markers,and circuitry.Therefore,they have recently gained m...Lanthanides(Ln(Ⅲ))based compounds as light-emitting materials have emerged as successful agents in high-performance defense and lighting systems,magnets,bio-markers,and circuitry.Therefore,they have recently gained much attention as energy-saving and cost-effective luminescent materials and their applications in analyte detection.The present review summarizes powerful features and recent developments of organo-lanthanide complexes in lighting applications with a particular focus on visible light emitters,including Eu(Ⅲ),Tb(Ⅲ),Sm(Ⅲ),and Dy(Ⅲ)ions.In addition,this review discusses the most relevant aspects of photosensitization,such as the structure,property,functionalization of primary and secondary ligands,and molecular geometry.In addition,coordination sites of organo-lanthanide complexes and their applications collectively contribute to the improved performance of innovative luminescent materials.Finally,the current challenges and key recommendations for advancing organolanthanides in material science are provided.展开更多
This review aims to fill the voids and to update the checklist of sandfly fauna along with its spatial distribution in India.Resource databases i.e.either online or offline were searched to deduce the information to s...This review aims to fill the voids and to update the checklist of sandfly fauna along with its spatial distribution in India.Resource databases i.e.either online or offline were searched to deduce the information to systematize the Indian sandfly fauna.Articles/data retrieved were screened and analysed to further update the available latest checklist.The species name and authorship were given in accord with the International Code for Zoological Nomenclature.We compiled an updated checklist of reported Indian sandfly species along with their state-wise distribution till 2022 as per published literature.Kerala has maximum number of species reports when compared to other endemic states and states with pockets of transmission.Phlebotomus argentipes is the most widely distributed,recorded so far,followed by other Sergentomiya and Phlebotomus species in India.In this review,we have also described the vector and non-vector species of sandfly prevalent in different parts of the country.Phlebotoiella eoindianensis,an amber fossil sandfly species recorded from Gujarat might be older than other records of Indian sandfly fauna.So far 69 species(4 genera and 15 subgenera/groups)of Phlebotomine sandflies have been recorded in India.Proper knowledge of species diversity and its distribution is a prerequisite for planning a systematic vector control strategy and disease management.展开更多
An easy, safe, solvent free and effective method for the synthesis of pyrazole-substituted chalcones has been achieved by grinding pyrazole aldehydes and acetophenones in the presence of activated barium hydroxide （C...An easy, safe, solvent free and effective method for the synthesis of pyrazole-substituted chalcones has been achieved by grinding pyrazole aldehydes and acetophenones in the presence of activated barium hydroxide （C-200） in high yield within short span of time. All reactions were carried out just by grinding the two reactants in the presence of activated barium hydroxide （C-200）. Results are also compared with sodium hydroxide and potassium hydroxide.展开更多
Mosquito-borne diseases such as malaria,filariasis,dengue,chikungunya,Japanese encephalitis,yellow fever and Zika contribute significantly to health problems of developing as well as developed nations.Vector control i...Mosquito-borne diseases such as malaria,filariasis,dengue,chikungunya,Japanese encephalitis,yellow fever and Zika contribute significantly to health problems of developing as well as developed nations.Vector control is central to control of vector borne diseases.In the last four-five decades,biological control methods have been inducted in the integrated vector management strategy,advocated nationally as well as globally by the World Health Organization.Currently,biological control of vectors is globally acknowledged as the best available strategy in the wake of growing concerns about vector resistance as well as adverse effects of insecticides on the environment and non-target fauna co-inhabiting the same ecological niches as vectors.In India and elsewhere,efforts are ongoing to screen newer isolates to bring forth new biolarvicidal products of public health importance.In this review,by carrying out extensive literature survey,we discuss advances thus far and the prospects of bacilli-based control of vectors and vector borne diseases.展开更多
The present article concentrates on the propagation of generalized surface acoustic waves in a composite struc- ture consisting of piezoelectric and non-piezoelectric semiconductor media. The mathematical model of the...The present article concentrates on the propagation of generalized surface acoustic waves in a composite struc- ture consisting of piezoelectric and non-piezoelectric semiconductor media. The mathematical model of the problem is depicted by a set of partial differential equations of motion, Gauss equation in piezoelectric and elec- tron diffusion equation in semiconductor along with boundary conditions to be satisfied at the interface. The secular equation that governs the propagation of surface waves has been derived in compact form after obtaining the formal solution. The analytic expressions for displacements, stresses, piezoelectric potential and electron concentration during the surface wave propagation at the interface have also been obtained. The numerical solu- tion of the secular equation is carried out for the cadmium selenide and silicon composite by employing fixed point functional iteration numerical method along with irreducible Cardano method. The computer simulated results with the help of MATLAB software in respect of dispersion curves, attenuation coefficient, displace- ments, stresses, carrier concentration and piezoelectric potential are presented graphically. This work may be useful in surface acoustic wave (SAW) devices and electronic industry.展开更多
The propagation of acoustic waves in a homogeneous isotropic semiconducting layer sandwiched between two homogeneous transversely isotropic piezoelectric halfspaces has been investigated. The mathematical model of the...The propagation of acoustic waves in a homogeneous isotropic semiconducting layer sandwiched between two homogeneous transversely isotropic piezoelectric halfspaces has been investigated. The mathematical model of the problem is depicted by a set of partial differential equations of motion, Gauss equation in piezoelectric material and electron diffusion equation in semiconductor along with the boundary conditions to be satisfied at the piezoelectric-semiconductor interfaces. The secular equations describing the symmetric and asymmetric modes of wave propagation have been derived in compact form after obtaining the analytical expressions for various field quantities that govern the wave motion. The complex secular equation has been solved numerically using functional interaction method along with irreducible cardano method. The computer simulated results are obtained with the help of MATLAB software for 6 mm cadmium selenide (CdSe) piezoelectric material and n-type silicon (Si) semiconductor in respect of dispersion curve, attenuation and specific loss factor of energy dissipation for symmetric (sym) and asymmetric (asym) modes of wave propagation. The study may find applications in non-destructive testing, resonators, waveguides etc.展开更多
A software (EQK_SRC_PARA) has been developed to estimate spectral parameters of earthquake source spectrum, namely: low frequency displacement spectral level (Ω0), corner frequency above which spectrum decays with a ...A software (EQK_SRC_PARA) has been developed to estimate spectral parameters of earthquake source spectrum, namely: low frequency displacement spectral level (Ω0), corner frequency above which spectrum decays with a rate of 2 (fc), the cut-off frequency above which the spectrum again decays (fmax) and the rate of decay above fmax (N). A Brune’s source model [1,2] that yield a fall-off of 2 beyond corner frequency is considered with high cut-off frequency factor presented by Boore [3] that fits well for frequencies greater than fmax. The software EQK_SRC_PARA is written in MATLAB and uses input data in Sesame ASCII Format (SAF) format. The obtained spectral parameters have been used to estimate source parameters (e.g., seismic moment, source dimension and stress drop etc.) and to develop scaling laws for the study region. The cut-off frequency “fmax” can also be studied and interpreted to confirm about its origin.展开更多
An expeditious and effective method for synthesis of isoxazoline from aldoximes and activated alkenes using cetyltrimethylammonium cerium nitrate at room temperature is described.Reaction was completed within short ti...An expeditious and effective method for synthesis of isoxazoline from aldoximes and activated alkenes using cetyltrimethylammonium cerium nitrate at room temperature is described.Reaction was completed within short time period in high yields at room temperature.展开更多
In tropical countries like India,malaria has been one of the most common parasitic illnesses leading to frequent hospitalization and causing major economic burden among the masses. Although Plasmodium vivax infection ...In tropical countries like India,malaria has been one of the most common parasitic illnesses leading to frequent hospitalization and causing major economic burden among the masses. Although Plasmodium vivax infection is considered to be benign,in contrast to Plasmodium, falciparum infection which is notorious for its severe splenic complications can occur frequently. Splenomegaly tends not to receive special attention,as it is not usually accompanied by any symptoms and can be gradually resolved via standard antimalarial therapy.Splenic infarction, although rarely attributable to malaria in an endemic region with high parasitemia,can be a rare presentation of this disease entity.展开更多
Non typhoidal Salmonella species are thought to be potentially infectious to humans.We isolated Salmonella enteritidis from a 10-year-old boy with fever and thrombocytopenia.We reviewed the literature conceming infect...Non typhoidal Salmonella species are thought to be potentially infectious to humans.We isolated Salmonella enteritidis from a 10-year-old boy with fever and thrombocytopenia.We reviewed the literature conceming infections caused by Salmonella but we could not find any such case report from India.展开更多
In the present work,zinc oxide(ZnO)and silver(Ag)doped ZnO nanostructures are synthesized using a hydrothermal method.Structural quality of the products is attested using X-ray diffraction,which confirms the hexagonal...In the present work,zinc oxide(ZnO)and silver(Ag)doped ZnO nanostructures are synthesized using a hydrothermal method.Structural quality of the products is attested using X-ray diffraction,which confirms the hexagonal wurtzite struc-ture of pure ZnO and Ag-doped ZnO nanostructures.XRD further confirms the crystallite orientation along the c-axis,(101)plane.The field emission scanning electron microscope study reveals the change in shape of the synthesized ZnO particles from hexagonal nanoparticles to needle-shaped nanostructures for 3 wt%Ag-doped ZnO.The optical band gaps and lattice strain of nanostructures is increased significantly with the increase of doping concentration of Ag in ZnO nanostructure.The anti-microbial activity of synthesized nanostructures has been evaluated against the gram-positive human pathogenic bacteria,Staphylococcus aureus via an agarose gel diffusion test.The maximum value of zone of inhibition(22 mm)is achieved for 3 wt%Ag-doped ZnO nanostructure and it clearly demonstrates the remarkable antibacterial activity.展开更多
Herein, a stable and efficient CoS_(2)-ReS_(2) electrocatalyst is successfully constructed by using the different molar ratios of CoS_(2) on ReS_(2). The size and morphology of the catalysts are significantly changed ...Herein, a stable and efficient CoS_(2)-ReS_(2) electrocatalyst is successfully constructed by using the different molar ratios of CoS_(2) on ReS_(2). The size and morphology of the catalysts are significantly changed after the CoS_(2) is grown on ReS_(2), providing regulation of the catalytic activity of ReS_(2). Particularly, the optimized CoS_(2)-ReS_(2) shows superior electrocatalytic properties with a low voltage of 1.48 V at 20 mA cm^(-2) for overall water splitting in 1.0 M KOH, which is smaller than the noble metal-based catalysts(1.77 V at 20 mA cm^(-2)). The XPS, XAS, and theoretical data confirm that the interfacial regulation of ReS_(2) by CoS_(2) can provide rich edge catalytic sites, which greatly optimizes the catalytic kinetics and drop the energy barrier for oxygen/hydrogen evolution reactions. Our results demonstrated that interfacial engineering is an efficient route for fabricating high-performance water splitting electrocatalysts.展开更多
This work reports the cost-effective growth of Mg:PbI2 nanostructures with 0,1,2.5 and 5.0 wt.%Mg doping concentrations.Structural,vibrational,morphological properties are analyzed using x-ray diffraction(XRD),Raman s...This work reports the cost-effective growth of Mg:PbI2 nanostructures with 0,1,2.5 and 5.0 wt.%Mg doping concentrations.Structural,vibrational,morphological properties are analyzed using x-ray diffraction(XRD),Raman spectroscopy and scanning electron microscopy(SEM).XRD and Raman studies confirm the monophasic hexagonal system of Mg:PbI2,and no additional impurity peaks are detected.The Scherrer formula is used to determine sizes of crystallites to be in the range of 47-52 nm.EDX/SEM e-mapping analyses confirm the incorporation of Mg in PbI2 matrix and its uniform distribution throughout the sample.The hexagonal nanosheet-and nanoplate-like morphologies are detected in SEM images for pure and Mg-doped PbI2.An optical band gap of nanostructures is obtained from Tauc’s relation to be in the range 3.0-3.25 eV.Dielectric and electrical properties are found in significant enhancement as Mg doping in PbI2 matrix,also the conduction mechanism is discussed.展开更多
In the present work the electronic density of states of liquid,viz.,Zintli alloys,have been studied only at the composition of their maximum resistivity to have an elementary idea about the behaviors of the alloys wit...In the present work the electronic density of states of liquid,viz.,Zintli alloys,have been studied only at the composition of their maximum resistivity to have an elementary idea about the behaviors of the alloys with respect to nearly free electron behavior.The study reveals that the anomalous electronic behavior of liquid Li-Pb,Na-Pb,Li-Sn,and Na-Sn can be attributed to the preferential ordering of unlike atoms.展开更多
文摘Syzygium cumini Linn.,commonly known as Jamun,is a member of the Myrtaceae family and is also referred to by synonyms such as Eugenia djouant Perr.,Eugenia cumini,Eugenia jambolana Lam.,Syzygium jambolana Lam.,and Myrtus cumini Linn.This review provides an overview of its medicinal value,including taxonomical classification,geographic distribution,cultivation techniques,pharmacognostical aspects,phytochemical constituents,traditional uses,and pharmacological applications.In India,‘Ram Jamun’or‘Raja Jamun’is cultivated in the north,while the‘Paras’variety is grown in central regions.Various components of S.cumini fruits are utilized to enhance the nutritional quality of wines,jellies,jams,and fermented products.Rich in essential nutrients like vitamins,carbohydrates,minerals,antioxidants,and anthocyanins,S.cumini also contains bioactive phytoconstituents such as gallic acid,tannins,and polyphenols,which contribute to its pharmacological properties.Traditionally,black plums have been used as carminatives,diuretics,and remedies for stomach ailments,spleen enlargement,diarrhea,and urinary retention.Additionally,S.cumini has been historically administered to women post-abortion and is recognized for its role in managing diabetes and dysentery.Polyphenolic compounds in Jamun exhibit potential therapeutic benefits against diabetes,arthritis,cancer,asthma,and cardiovascular diseases.Given its promising ethnopharmacological profile,extensive research has been conducted on various plant parts,highlighting their antioxidant,antifungal,antibacterial,antidiabetic,and anticancer properties.This review aims to provide a comprehensive understanding of Syzygium cumini’s traditional and therapeutic significance,serving as a valuable resource for future research.
文摘BACKGROUND Sacubitril/valsartan is a first-in-class angiotensin receptor neprilysin inhibitor(ARNI)which combines an angiotensin receptor blocker(valsartan)with sacubitril,an inhibitor of the enzyme neprilysin.By virtue of combined effect of blocking the action of angiotensin-II and inhibiting the breakdown of natriuretic peptides,ARNIs have beneficial role in heart failure(HF).AIM To evaluate the effect of sacubitril/valsartan on N-terminal pro-B-type natriuretic peptide(NT-pro BNP),inflammatory marker[high-sensitivity C-reactive protein(hs-CRP)],and quality of life when given as add-on to standard therapy in patients with HF.METHODS Sacubitril/valsartan as add-on therapy for improvement in HF study was a randomised controlled trial conducted from July 2023 to November 2024 in a public tertiary care hospital in India.Eligible patients were randomised in 1:1 ratio to either of the 2 study arms:(1)Group A(sacubitril/valsartan+standard treatment);and(2)Group B(standard treatment)for 12 weeks.Primary end point was change in NT-pro BNP levels at 12 weeks from baseline.Secondary endpoints included(1)Change in hs-CRP levels;(2)Change in World Health Organisation Quality of Life Questionnaire(WHOQOL-BREF)score;and(3)Incidence of treatment-related adverse events or worsening HF.Statistical analysis was done using Statistical Package for the Social Sciences trial version 29.0 and P<0.05 was considered significant.RESULTS Out of 124 patients screened,80 were enrolled of which 25 patients in each group were available for per-protocol analysis.At baseline,both the groups were comparable.Sacubitril/valsartan group exhibited a statistically significant greater reduction in NT-pro BNP(-35.91±28.01 vs 24.68±31.86;P<0.0001)and hs-CRP(-2.87±3.22 vs 0.76±1.60;P<0.0001)levels at 12 weeks compared to standard treatment group.There was also a greater improvement in quality of life with sacubitril/valsartan group(overall change in WHOQOL-BREF:13.16±8.73 in sacubitril/valsartan vs-4.12±6.25 in standard treatment arm).No major adverse events were reported in two groups.CONCLUSION Sacubitril/valsartan demonstrated significant improvements in HF biomarkers,inflammation,and quality of life without compromising safety supporting its role as an effective addition to standard HF therapy.Further research is needed to evaluate its long-term benefits on mortality and cardiac remodeling.
文摘Objective:To identify the risk factors for acquiring scrub typhus infection among all age group.Methods:A case-control study was carried out from June to December 2019 in collaboration with the Department of Health Services,Kerala.136 Of serologically confirmed scrub typhus reported during 2018 were included and 270 age and sex-matched healthy controls were selected randomly from different locations in the same area where the cases were reported.The risk factors identified were compared between cases and controls,using univariate and multivariable logistic regression analysis to identify the risk factors for scrub typhus infection.Results:Some key factors like house type with individuals residing in houses with concrete roofs are associated with a higher risk of scrub typhus infection compared to tiled roofs(aOR 0.14,95%CI 0.36-0.56,P=0.005).Housewives exhibit a significantly higher risk(aOR 3.97,95%CI 2.15-8.94,P=0.038)of scrub typhus infection.Environmental factors,including the presence of rats(aOR 3.48,95%CI 1.19-6.53,P=0.023),the presence of domestic animals(aOR 2.98,95%CI 1.67-5.19,P<0.001),wet agricultural fields around the house(aOR 3.64,95%CI 1.50-6.54,P<0.001),and hygiene practices like not changing clothes after work(aOR 2.64,95%CI 1.37-4.68,P=0.024),and disposing of the wastes in their own yard(aOR 4.79,95%CI 3.78-9.55,P=0.043)are identified as significant high-risk factors for scrub typhus infection.Conclusions:These findings will be very useful to create awareness among the public and to undertake a detailed control strategy for scrub typhus.
文摘Aluminium toxicity in acid soils having pH below 5.5, affects the production of staple food crops, vegetables and cash crops worldwide. About 50% of the world’s potentially arable lands are acidic. It is trivalent cationic form i.e. Al3+ that limits the plant’s growth. Absorbed Aluminium inhibits root elongation and adversely affects plant growth. Recently researches have been conducted to understand the mechanism of Aluminium toxicity and resistance which is important for stable food production in future. Aluminium resistance depends on the ability of the plant to tolerate Aluminium in symplast or to exclude it to soil. Physiological and molecular basis of Aluminium toxicity and resistance mechanism are important to understand for developing genetically engineered plants for Al toxicity resistance. This paper provides an overview of the state of art in this field.
基金funded by the University Grant Commission,New Delhi,India-110002(Grant number F.4-1/2006(BSR)/5-94/2007)
文摘OBJECTIVE： Different parts of Murraya paniculata have been used traditionally for treating several ailments including mental disorders. The present study was designed to evaluate the antianxiety and antidepressant potential of M. paniculata leaves using elevated plus maze model and forced swim test, respectively. METHODS： Extracts of M. panicu/ata made with petroleum ether （60-80 ℃）, chloroform, ethanol and water were evaluated for antianxiety and antidepressant activity. The anxiolytic chloroform extract was subjected to column chromatography, yielding five fractions （F1-F5）. Fraction F5 （100 mg/kg）, which showed notable anxiolytic activity, was further chromatographed to get four subfractions （F5.1-F5.4）. Simultaneously, the ethano extract was partitioned with ethyl acetate to obtain ethyl acetate soluble fraction （EASF） and ethyl acetate insoluble fraction. Phytochemical screening of bioactive extracts/fractions and detection of mahanimbine in M paniculata leaf extract by thin-layer chromatography was also carried out. RESULTS： Fraction F5.3 （25 mg/kg） and EASF （20 mg/kg） showed significant anxiolytic and antidepressant activity, respectively. Thin-layer chromatography and phytochemical screening demonstrated the absence of mahanimbine in M. paniculata leaves. Coumarins were observed to be responsible for the anxiolytic activity. CONCLUSION： The results validate the traditional use of M. paniculata leaves in the treatment of menta disorders.
基金Project supported by the Human Resource Development Group(HRDG)Council of Scientific&Industrial Research(CSIR),New Delhi,India(09/105(0266)-2018-EMR-1)。
文摘Lanthanides(Ln(Ⅲ))based compounds as light-emitting materials have emerged as successful agents in high-performance defense and lighting systems,magnets,bio-markers,and circuitry.Therefore,they have recently gained much attention as energy-saving and cost-effective luminescent materials and their applications in analyte detection.The present review summarizes powerful features and recent developments of organo-lanthanide complexes in lighting applications with a particular focus on visible light emitters,including Eu(Ⅲ),Tb(Ⅲ),Sm(Ⅲ),and Dy(Ⅲ)ions.In addition,this review discusses the most relevant aspects of photosensitization,such as the structure,property,functionalization of primary and secondary ligands,and molecular geometry.In addition,coordination sites of organo-lanthanide complexes and their applications collectively contribute to the improved performance of innovative luminescent materials.Finally,the current challenges and key recommendations for advancing organolanthanides in material science are provided.
基金supported by the Indian Council of Medical Research,New Delhi[Grant No.6/9-7(331)/2020/ECD-II].
文摘This review aims to fill the voids and to update the checklist of sandfly fauna along with its spatial distribution in India.Resource databases i.e.either online or offline were searched to deduce the information to systematize the Indian sandfly fauna.Articles/data retrieved were screened and analysed to further update the available latest checklist.The species name and authorship were given in accord with the International Code for Zoological Nomenclature.We compiled an updated checklist of reported Indian sandfly species along with their state-wise distribution till 2022 as per published literature.Kerala has maximum number of species reports when compared to other endemic states and states with pockets of transmission.Phlebotomus argentipes is the most widely distributed,recorded so far,followed by other Sergentomiya and Phlebotomus species in India.In this review,we have also described the vector and non-vector species of sandfly prevalent in different parts of the country.Phlebotoiella eoindianensis,an amber fossil sandfly species recorded from Gujarat might be older than other records of Indian sandfly fauna.So far 69 species(4 genera and 15 subgenera/groups)of Phlebotomine sandflies have been recorded in India.Proper knowledge of species diversity and its distribution is a prerequisite for planning a systematic vector control strategy and disease management.
文摘An easy, safe, solvent free and effective method for the synthesis of pyrazole-substituted chalcones has been achieved by grinding pyrazole aldehydes and acetophenones in the presence of activated barium hydroxide （C-200） in high yield within short span of time. All reactions were carried out just by grinding the two reactants in the presence of activated barium hydroxide （C-200）. Results are also compared with sodium hydroxide and potassium hydroxide.
文摘Mosquito-borne diseases such as malaria,filariasis,dengue,chikungunya,Japanese encephalitis,yellow fever and Zika contribute significantly to health problems of developing as well as developed nations.Vector control is central to control of vector borne diseases.In the last four-five decades,biological control methods have been inducted in the integrated vector management strategy,advocated nationally as well as globally by the World Health Organization.Currently,biological control of vectors is globally acknowledged as the best available strategy in the wake of growing concerns about vector resistance as well as adverse effects of insecticides on the environment and non-target fauna co-inhabiting the same ecological niches as vectors.In India and elsewhere,efforts are ongoing to screen newer isolates to bring forth new biolarvicidal products of public health importance.In this review,by carrying out extensive literature survey,we discuss advances thus far and the prospects of bacilli-based control of vectors and vector borne diseases.
文摘The present article concentrates on the propagation of generalized surface acoustic waves in a composite struc- ture consisting of piezoelectric and non-piezoelectric semiconductor media. The mathematical model of the problem is depicted by a set of partial differential equations of motion, Gauss equation in piezoelectric and elec- tron diffusion equation in semiconductor along with boundary conditions to be satisfied at the interface. The secular equation that governs the propagation of surface waves has been derived in compact form after obtaining the formal solution. The analytic expressions for displacements, stresses, piezoelectric potential and electron concentration during the surface wave propagation at the interface have also been obtained. The numerical solu- tion of the secular equation is carried out for the cadmium selenide and silicon composite by employing fixed point functional iteration numerical method along with irreducible Cardano method. The computer simulated results with the help of MATLAB software in respect of dispersion curves, attenuation coefficient, displace- ments, stresses, carrier concentration and piezoelectric potential are presented graphically. This work may be useful in surface acoustic wave (SAW) devices and electronic industry.
文摘The propagation of acoustic waves in a homogeneous isotropic semiconducting layer sandwiched between two homogeneous transversely isotropic piezoelectric halfspaces has been investigated. The mathematical model of the problem is depicted by a set of partial differential equations of motion, Gauss equation in piezoelectric material and electron diffusion equation in semiconductor along with the boundary conditions to be satisfied at the piezoelectric-semiconductor interfaces. The secular equations describing the symmetric and asymmetric modes of wave propagation have been derived in compact form after obtaining the analytical expressions for various field quantities that govern the wave motion. The complex secular equation has been solved numerically using functional interaction method along with irreducible cardano method. The computer simulated results are obtained with the help of MATLAB software for 6 mm cadmium selenide (CdSe) piezoelectric material and n-type silicon (Si) semiconductor in respect of dispersion curve, attenuation and specific loss factor of energy dissipation for symmetric (sym) and asymmetric (asym) modes of wave propagation. The study may find applications in non-destructive testing, resonators, waveguides etc.
文摘A software (EQK_SRC_PARA) has been developed to estimate spectral parameters of earthquake source spectrum, namely: low frequency displacement spectral level (Ω0), corner frequency above which spectrum decays with a rate of 2 (fc), the cut-off frequency above which the spectrum again decays (fmax) and the rate of decay above fmax (N). A Brune’s source model [1,2] that yield a fall-off of 2 beyond corner frequency is considered with high cut-off frequency factor presented by Boore [3] that fits well for frequencies greater than fmax. The software EQK_SRC_PARA is written in MATLAB and uses input data in Sesame ASCII Format (SAF) format. The obtained spectral parameters have been used to estimate source parameters (e.g., seismic moment, source dimension and stress drop etc.) and to develop scaling laws for the study region. The cut-off frequency “fmax” can also be studied and interpreted to confirm about its origin.
文摘An expeditious and effective method for synthesis of isoxazoline from aldoximes and activated alkenes using cetyltrimethylammonium cerium nitrate at room temperature is described.Reaction was completed within short time period in high yields at room temperature.
文摘In tropical countries like India,malaria has been one of the most common parasitic illnesses leading to frequent hospitalization and causing major economic burden among the masses. Although Plasmodium vivax infection is considered to be benign,in contrast to Plasmodium, falciparum infection which is notorious for its severe splenic complications can occur frequently. Splenomegaly tends not to receive special attention,as it is not usually accompanied by any symptoms and can be gradually resolved via standard antimalarial therapy.Splenic infarction, although rarely attributable to malaria in an endemic region with high parasitemia,can be a rare presentation of this disease entity.
文摘Non typhoidal Salmonella species are thought to be potentially infectious to humans.We isolated Salmonella enteritidis from a 10-year-old boy with fever and thrombocytopenia.We reviewed the literature conceming infections caused by Salmonella but we could not find any such case report from India.
基金the research facilities in the Department of Physics,Ch.Charan Singh University,Meerut,Uttar Pradesh,India.This work was supported by the UGC,Govt.of India[No.F.30-303/2016(BSR),F.D.Dy.No.11299]。
文摘In the present work,zinc oxide(ZnO)and silver(Ag)doped ZnO nanostructures are synthesized using a hydrothermal method.Structural quality of the products is attested using X-ray diffraction,which confirms the hexagonal wurtzite struc-ture of pure ZnO and Ag-doped ZnO nanostructures.XRD further confirms the crystallite orientation along the c-axis,(101)plane.The field emission scanning electron microscope study reveals the change in shape of the synthesized ZnO particles from hexagonal nanoparticles to needle-shaped nanostructures for 3 wt%Ag-doped ZnO.The optical band gaps and lattice strain of nanostructures is increased significantly with the increase of doping concentration of Ag in ZnO nanostructure.The anti-microbial activity of synthesized nanostructures has been evaluated against the gram-positive human pathogenic bacteria,Staphylococcus aureus via an agarose gel diffusion test.The maximum value of zone of inhibition(22 mm)is achieved for 3 wt%Ag-doped ZnO nanostructure and it clearly demonstrates the remarkable antibacterial activity.
基金supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)(NRF-2022R1A2C2093415) and (NRF-2018R1A2B6006721)Institute for Basic Science of Korea (IBS-R011-D1)the Korea Medical Device Development Fund grant funded by the Korean government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (Project Number: KMDF_PR_20200901_0004)。
文摘Herein, a stable and efficient CoS_(2)-ReS_(2) electrocatalyst is successfully constructed by using the different molar ratios of CoS_(2) on ReS_(2). The size and morphology of the catalysts are significantly changed after the CoS_(2) is grown on ReS_(2), providing regulation of the catalytic activity of ReS_(2). Particularly, the optimized CoS_(2)-ReS_(2) shows superior electrocatalytic properties with a low voltage of 1.48 V at 20 mA cm^(-2) for overall water splitting in 1.0 M KOH, which is smaller than the noble metal-based catalysts(1.77 V at 20 mA cm^(-2)). The XPS, XAS, and theoretical data confirm that the interfacial regulation of ReS_(2) by CoS_(2) can provide rich edge catalytic sites, which greatly optimizes the catalytic kinetics and drop the energy barrier for oxygen/hydrogen evolution reactions. Our results demonstrated that interfacial engineering is an efficient route for fabricating high-performance water splitting electrocatalysts.
基金Project supported by the Deanship of Scientific Research at King Khalid University(Grant No.R.G.P1/207/41)the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding Program,and Deanship of Research,University of Hail.
文摘This work reports the cost-effective growth of Mg:PbI2 nanostructures with 0,1,2.5 and 5.0 wt.%Mg doping concentrations.Structural,vibrational,morphological properties are analyzed using x-ray diffraction(XRD),Raman spectroscopy and scanning electron microscopy(SEM).XRD and Raman studies confirm the monophasic hexagonal system of Mg:PbI2,and no additional impurity peaks are detected.The Scherrer formula is used to determine sizes of crystallites to be in the range of 47-52 nm.EDX/SEM e-mapping analyses confirm the incorporation of Mg in PbI2 matrix and its uniform distribution throughout the sample.The hexagonal nanosheet-and nanoplate-like morphologies are detected in SEM images for pure and Mg-doped PbI2.An optical band gap of nanostructures is obtained from Tauc’s relation to be in the range 3.0-3.25 eV.Dielectric and electrical properties are found in significant enhancement as Mg doping in PbI2 matrix,also the conduction mechanism is discussed.
文摘In the present work the electronic density of states of liquid,viz.,Zintli alloys,have been studied only at the composition of their maximum resistivity to have an elementary idea about the behaviors of the alloys with respect to nearly free electron behavior.The study reveals that the anomalous electronic behavior of liquid Li-Pb,Na-Pb,Li-Sn,and Na-Sn can be attributed to the preferential ordering of unlike atoms.
