Dear Editor,Small extracellular vesicles(sEVs)are membranous nanovesicles involved in intercellular,communication that carry distinct cellderived molecular cargo.1 We previously characterised sEVs from human non-malig...Dear Editor,Small extracellular vesicles(sEVs)are membranous nanovesicles involved in intercellular,communication that carry distinct cellderived molecular cargo.1 We previously characterised sEVs from human non-malignant pancreatic duct cells(HPDE,hTERT-HPNE)and from PDAC cells(AsPC-1,BxPC-3 and MIA PaCa-2)2 and identified protein cargo-specific to cancer-associated sEVs?Among the proteins uniquely expressed in cancer sEVs but not in those from non-malignant cells,we focused on SLC5A3,also known as SMIT1(sodium-coupled Myo-inositol transporter-1).展开更多
基金supported by National Health and Medical Research Council(NHMRC,MRF2015523,APP1141946)Helen Amelia Hains Fellowship(D.W.G.)and Department of Defense(PR230065)supported by the Snow Medical Research Fellowship,NHMRC Investigator 2027300 and Philip Hemstritch Fellowship.
文摘Dear Editor,Small extracellular vesicles(sEVs)are membranous nanovesicles involved in intercellular,communication that carry distinct cellderived molecular cargo.1 We previously characterised sEVs from human non-malignant pancreatic duct cells(HPDE,hTERT-HPNE)and from PDAC cells(AsPC-1,BxPC-3 and MIA PaCa-2)2 and identified protein cargo-specific to cancer-associated sEVs?Among the proteins uniquely expressed in cancer sEVs but not in those from non-malignant cells,we focused on SLC5A3,also known as SMIT1(sodium-coupled Myo-inositol transporter-1).
