Chamaedorea seifrizii is a bamboo plant that is mainly used for its air-purifying properties and ornamental value.Due to the scarcity of reports on its phytochemical constitutes,this study was aimed at chemical profil...Chamaedorea seifrizii is a bamboo plant that is mainly used for its air-purifying properties and ornamental value.Due to the scarcity of reports on its phytochemical constitutes,this study was aimed at chemical profiling,phytochemical analysis and evaluation of its in-vitro biological activities of acetone extracts of auxiliary inflorescence and fruits of Chamaedorea seifrizii accompanied by in-silico analysis.Standard techniques were employed for phytochemical screening of phenolics,flavonoids and tannins and anti-oxidant and anti-inflammatory tests.In-silico analysis coupled with molecular dynamics simulation was also conducted to find out interaction of some components to inflammatory responses.Bioactive compounds in auxiliary inflorescence and fruit extracts were studied using a gas chromatography-flame ionization detector(GC-FID).Numerous antioxidant tests were carried out,including those for 2,2-diphenyl-1-picrylhydrazyl(DPPH),hydroxyl radicals,and nitric oxide radicals and shown that all both extracts depicted exorbitant levels of activities with values ranging from 48 to 96%.Results of GC-FID revealed maximum 18-22 constituents in acetone fractions with phenethyl cinnamate and hinokione as predominant components in auxiliary inflorescence and fruits,respectively.In addition,a strong anti-inflammatory activity was observed with acetone containing extracts.In-silico analysis validated the interaction of phytocomponents to inflammation initiation enzymes.Phytochemicals found in Chamaedorea seifrizii extracts may have pharmacological,antioxidant and anti-inflammatory properties.Chamaedorea seifrizii may be used in this study to produce new herbal remedies for a range of illnesses,perhaps resulting in the development of novel drugs.展开更多
基金Dept of Science and Technology,Govt.of India,DST/SEED/SCSP/STI/2019/253.
文摘Chamaedorea seifrizii is a bamboo plant that is mainly used for its air-purifying properties and ornamental value.Due to the scarcity of reports on its phytochemical constitutes,this study was aimed at chemical profiling,phytochemical analysis and evaluation of its in-vitro biological activities of acetone extracts of auxiliary inflorescence and fruits of Chamaedorea seifrizii accompanied by in-silico analysis.Standard techniques were employed for phytochemical screening of phenolics,flavonoids and tannins and anti-oxidant and anti-inflammatory tests.In-silico analysis coupled with molecular dynamics simulation was also conducted to find out interaction of some components to inflammatory responses.Bioactive compounds in auxiliary inflorescence and fruit extracts were studied using a gas chromatography-flame ionization detector(GC-FID).Numerous antioxidant tests were carried out,including those for 2,2-diphenyl-1-picrylhydrazyl(DPPH),hydroxyl radicals,and nitric oxide radicals and shown that all both extracts depicted exorbitant levels of activities with values ranging from 48 to 96%.Results of GC-FID revealed maximum 18-22 constituents in acetone fractions with phenethyl cinnamate and hinokione as predominant components in auxiliary inflorescence and fruits,respectively.In addition,a strong anti-inflammatory activity was observed with acetone containing extracts.In-silico analysis validated the interaction of phytocomponents to inflammation initiation enzymes.Phytochemicals found in Chamaedorea seifrizii extracts may have pharmacological,antioxidant and anti-inflammatory properties.Chamaedorea seifrizii may be used in this study to produce new herbal remedies for a range of illnesses,perhaps resulting in the development of novel drugs.
