The human placenta is a transient yet crucial organ that plays a key role in sustaining the relationship between the maternal and fetal organisms.Despite its historical classification as"biowaste,"placental ...The human placenta is a transient yet crucial organ that plays a key role in sustaining the relationship between the maternal and fetal organisms.Despite its historical classification as"biowaste,"placental tissues have garnered increasing attention since the early 1900s for their significant medical potential,particularly in wound repair and surgical application.As ethical considerations regarding human placental derivatives have largely been assuaged in many countries,they have gained significant attention due to their versatile applications in various biomedical fields,such as biomedical engineering,regenerative medicine,and pharmacology.Moreover,there is a substantial trend toward various animal product substitutions in laboratory research with human placental derivatives,reflecting a broader commitment to advancing ethical and sustainable research method-ologies.This review provides a comprehensive examination of the current applications of human placental de-rivatives,explores the mechanisms behind their therapeutic effects,and outlines the future potential and directions of this rapidly advancing field.展开更多
基金supported by research grants from the Belgian Foundation against Cancer(grant OST-2022/2169 awarded to C.A.A.)the Fonds National de la Recherche Scientifique de Belgique(FNRS-PDR convention grant number T.0004.20 awarded to C.A.A.(Ph.D.scholarship awarded to H.V.)+5 种基金FNRS-CR convention grant number J.0057.22 awarded to F.D.,and FC 46825 fellowship awarded to S.M.)the UCLouvain’s Fonds spéciaux de recherche(IREC FSR22 grant awarded to C.A.A.(Ph.D.scholarship awarded to M.J.S.)IRECFSR23MOVEAND fellowship awarded to S.N.)Fondation Saint-Luc(Fetus for Life awarded to F.D.)the French Community of Belgium(ARC Grant 24/29-137 awarded to F.D.,C.W,and C.A.A.)the China Scholarship Council(Ph.D.scholarship awarded to Y.W.,F.S.,Y.L,J.Y.).
文摘The human placenta is a transient yet crucial organ that plays a key role in sustaining the relationship between the maternal and fetal organisms.Despite its historical classification as"biowaste,"placental tissues have garnered increasing attention since the early 1900s for their significant medical potential,particularly in wound repair and surgical application.As ethical considerations regarding human placental derivatives have largely been assuaged in many countries,they have gained significant attention due to their versatile applications in various biomedical fields,such as biomedical engineering,regenerative medicine,and pharmacology.Moreover,there is a substantial trend toward various animal product substitutions in laboratory research with human placental derivatives,reflecting a broader commitment to advancing ethical and sustainable research method-ologies.This review provides a comprehensive examination of the current applications of human placental de-rivatives,explores the mechanisms behind their therapeutic effects,and outlines the future potential and directions of this rapidly advancing field.
