The emergence of insecticide resistance presents a major challenge in pest control and agriculture,while the use of conventional pesticides raises environmental and health concerns.This study addresses these issues th...The emergence of insecticide resistance presents a major challenge in pest control and agriculture,while the use of conventional pesticides raises environmental and health concerns.This study addresses these issues through the green synthesis of Ag/Fe bimetallic nanoparticles(BMNPs)using Vallaris solanacea plant extract and evaluates their eco-biological activities.The synthesized Ag/Fe BMNPs,with an average size of 30 nm as determined by SEM,were characterized by UV–Vis spectroscopy,FTIR,EDX,and SEM.In vitro assays revealed significant anti-inflammatory(91%),antioxidant(95%),anti-diabetic,anti-hemolytic,and antimicrobial activities.Additionally,the nanoparticles demonstrated 100% mortality against Sitophilus oryzae(rice weevil)and exhibited 97%degradation of the pesticide Novacide,indicating potent pesticidal and environmental remediation capabilities.Computational analysis,including molecular docking and molecular dynamics simulations,revealed strong interactions between Ag/Fe BMNPs and insecticide resistance(IR)proteins,with binding energies surpassing those of traditional pesticides,suggesting an ability to circumvent resistance mechanisms.These findings highlight the potential of Ag/Fe BMNPs as a sustainable,eco-friendly alternative for pest management and environmental applications in agriculture and beyond.展开更多
文摘The emergence of insecticide resistance presents a major challenge in pest control and agriculture,while the use of conventional pesticides raises environmental and health concerns.This study addresses these issues through the green synthesis of Ag/Fe bimetallic nanoparticles(BMNPs)using Vallaris solanacea plant extract and evaluates their eco-biological activities.The synthesized Ag/Fe BMNPs,with an average size of 30 nm as determined by SEM,were characterized by UV–Vis spectroscopy,FTIR,EDX,and SEM.In vitro assays revealed significant anti-inflammatory(91%),antioxidant(95%),anti-diabetic,anti-hemolytic,and antimicrobial activities.Additionally,the nanoparticles demonstrated 100% mortality against Sitophilus oryzae(rice weevil)and exhibited 97%degradation of the pesticide Novacide,indicating potent pesticidal and environmental remediation capabilities.Computational analysis,including molecular docking and molecular dynamics simulations,revealed strong interactions between Ag/Fe BMNPs and insecticide resistance(IR)proteins,with binding energies surpassing those of traditional pesticides,suggesting an ability to circumvent resistance mechanisms.These findings highlight the potential of Ag/Fe BMNPs as a sustainable,eco-friendly alternative for pest management and environmental applications in agriculture and beyond.
