Cancer treatment has witnessed the emergence of innovative stimuli-responsive nanotherapeutics aiming to overcome limitations associated with traditional drug delivery systems.Metal-organic frameworks(MOFs),a subset o...Cancer treatment has witnessed the emergence of innovative stimuli-responsive nanotherapeutics aiming to overcome limitations associated with traditional drug delivery systems.Metal-organic frameworks(MOFs),a subset of inorganic nanomaterials,are known for their porous structures and versatile applications in integrated cancer diagnosis and therapy.Their noteworthy features include customizable porosity,diverse chemical configurations,adjustable sizes and shapes,and the potential for surface functionalization.The study delved into conventional cancer therapies,provided an overview of MOFs,and discussed various MOF synthesis approaches.Furthermore,this review explored the development of stimuli-responsive MOFs to enhance targeted drug delivery and bioimaging,improving the overall efficacy of cancer treatment,and investigated the applications of stimuli-responsive multifunctional MOFs in nanostructures activated by factors influencing precise drug delivery and bioimaging in cancers.pH,light,ions,temperature,magnetic field,redox reactions,and ATP contribute to the precise control of drug delivery and bioimaging processes.Designed multifunctional MOFs exhibit characteristic changes in response to external and internal stimuli,proving advantageous for drug release and bioimaging.Surface-modified MOFs with responsive features demonstrate excellent biocompatibility with noncancerous cells,efficient drug-loading capabilities,and nanocarrier-mediated targeted drug delivery to cancerous cells.Therefore,the innovative strategy of inorganic nanoscale MOFs with responsive properties holds significant promise for targeted therapeutic drug delivery and imaging across diverse malignancies.The growing interest in stimuli-activated MOFs will open new opportunities in cancer theragnostic applications.展开更多
Graphene oxide(GO)and mesoporous silica nanoparticle(MSN)have been documented as advanced nanocarriers for drug delivery due to their unique and versatile properties.The design of GO-MSN nanocomposite offers a large s...Graphene oxide(GO)and mesoporous silica nanoparticle(MSN)have been documented as advanced nanocarriers for drug delivery due to their unique and versatile properties.The design of GO-MSN nanocomposite offers a large surface area,adjustable pore size,biocompatibility,and low cytotoxicity.The application of acyclovir(ACV)(BCS:III)is suffering from poor permeability,low bioavailability,etc.Hence,the use of GO-MSN nanocomposite for the delivery of ACV may overcome the limitations of ACV.Therefore,the present work aims to design the lipid-coated ACV-loaded GO-MSN(LC-ACV-GO-MSN)nanocomposites.In brief,the design of experiments(DoE,32 response surface methodology)approach was preferred for the development of GO-MSN nanocomposite.The loading of ACV in nanocomposite was done passive loading whereas the coating of lipids was done using a modified thin film hydration technique.At last,different spectral characterizations were performed.The output demonstrated that the entrapment efficiency of ACV-MSN and ACV-GO-MSN was 51.13%and 71.86%,respectively.Afterward,the designed LC-ACV-GO-MSN and ACV-GO-MSN nanocomposite shows 93.40%and 80.74%in vitro drug release,respectively.In conclusion,the design of LC-ACV-GO-MSN nanocomposite using optimized GO-MSN followed lipid coating offers the modified release.Therefore,in the future,LC-ACV-GO-MSN nanocomposite can be used for the delivery of ACV and other drug molecules with a high payload and enhanced release profile.We hope the current proof of concept may provide advantages over existing methods and emphasize the significance of protocells in cargo delivery systems.展开更多
文摘Cancer treatment has witnessed the emergence of innovative stimuli-responsive nanotherapeutics aiming to overcome limitations associated with traditional drug delivery systems.Metal-organic frameworks(MOFs),a subset of inorganic nanomaterials,are known for their porous structures and versatile applications in integrated cancer diagnosis and therapy.Their noteworthy features include customizable porosity,diverse chemical configurations,adjustable sizes and shapes,and the potential for surface functionalization.The study delved into conventional cancer therapies,provided an overview of MOFs,and discussed various MOF synthesis approaches.Furthermore,this review explored the development of stimuli-responsive MOFs to enhance targeted drug delivery and bioimaging,improving the overall efficacy of cancer treatment,and investigated the applications of stimuli-responsive multifunctional MOFs in nanostructures activated by factors influencing precise drug delivery and bioimaging in cancers.pH,light,ions,temperature,magnetic field,redox reactions,and ATP contribute to the precise control of drug delivery and bioimaging processes.Designed multifunctional MOFs exhibit characteristic changes in response to external and internal stimuli,proving advantageous for drug release and bioimaging.Surface-modified MOFs with responsive features demonstrate excellent biocompatibility with noncancerous cells,efficient drug-loading capabilities,and nanocarrier-mediated targeted drug delivery to cancerous cells.Therefore,the innovative strategy of inorganic nanoscale MOFs with responsive properties holds significant promise for targeted therapeutic drug delivery and imaging across diverse malignancies.The growing interest in stimuli-activated MOFs will open new opportunities in cancer theragnostic applications.
基金The researchers affiliated with the Faculty of Pharmacy,Nootan Pharmacy College,Sankalchand Patel University,Visnagar 384315,Gujarat,India,express their satisfaction,attributing it to the essential resources available that facilitate their research endeavors.
文摘Graphene oxide(GO)and mesoporous silica nanoparticle(MSN)have been documented as advanced nanocarriers for drug delivery due to their unique and versatile properties.The design of GO-MSN nanocomposite offers a large surface area,adjustable pore size,biocompatibility,and low cytotoxicity.The application of acyclovir(ACV)(BCS:III)is suffering from poor permeability,low bioavailability,etc.Hence,the use of GO-MSN nanocomposite for the delivery of ACV may overcome the limitations of ACV.Therefore,the present work aims to design the lipid-coated ACV-loaded GO-MSN(LC-ACV-GO-MSN)nanocomposites.In brief,the design of experiments(DoE,32 response surface methodology)approach was preferred for the development of GO-MSN nanocomposite.The loading of ACV in nanocomposite was done passive loading whereas the coating of lipids was done using a modified thin film hydration technique.At last,different spectral characterizations were performed.The output demonstrated that the entrapment efficiency of ACV-MSN and ACV-GO-MSN was 51.13%and 71.86%,respectively.Afterward,the designed LC-ACV-GO-MSN and ACV-GO-MSN nanocomposite shows 93.40%and 80.74%in vitro drug release,respectively.In conclusion,the design of LC-ACV-GO-MSN nanocomposite using optimized GO-MSN followed lipid coating offers the modified release.Therefore,in the future,LC-ACV-GO-MSN nanocomposite can be used for the delivery of ACV and other drug molecules with a high payload and enhanced release profile.We hope the current proof of concept may provide advantages over existing methods and emphasize the significance of protocells in cargo delivery systems.
