Determining the optimal ceramic content of the ceramics-in-polymer composite electrolytes and the appropriate stack pressure can effectively improve the interfacial contact of solid-state batteries(SSBs).Based on the ...Determining the optimal ceramic content of the ceramics-in-polymer composite electrolytes and the appropriate stack pressure can effectively improve the interfacial contact of solid-state batteries(SSBs).Based on the contact mechanics model and constructed by the conjugate gradient method,continuous convolution,and fast Fourier transform,this paper analyzes and compares the interfacial contact responses involving the polymers commonly used in SSBs,which provides the original training data for machine learning.A support vector regression model is established to predict the relationship between the content of ceramics and the interfacial resistance.The Bayesian optimization and K-fold cross-validation are introduced to find the optimal combination of hyperparameters,which accelerates the training process and improves the model’s accuracy.We found the relationship between the content of ceramics,the stack pressure,and the interfacial resistance.The results can be taken as a reference for the design of the low-resistance composite electrolytes for solid-state batteries.展开更多
Influenza A viruses are important human pathogens causing periodic pandemic threats. Nonstructural protein 1 （NS1） protein of influenza A virus （NS1A） shields the virus against host defense. Here, we report the cr...Influenza A viruses are important human pathogens causing periodic pandemic threats. Nonstructural protein 1 （NS1） protein of influenza A virus （NS1A） shields the virus against host defense. Here, we report the crystal structure of NS1A RNA-binding domain （RBD） bound to a double-stranded RNA （dsRNA） at 1.7A. NS1A RBD forms a homodimer to recognize the major groove of A-form dsRNA in a length-independent mode by its conserved concave surface formed by dimeric anti-parallel a-helices, dsRNA is anchored by a pair of invariable arginines （Arg38） from both monomers by extensive hydrogen bonds. In accordance with the structural observation, isothermal titration calorimetry assay shows that the unique Arg38-Arg38 pair and two Arg35-Arg46 pairs are crucial for dsRNA binding, and that Ser42 and Thr49 are also important for dsRNA binding. Agrobacterium co-infiltration assay further supports that the unique Arg38 pair plays important roles in dsRNA binding in vivo.展开更多
Advanced atherosclerotic lesions and vascular calcification substantially increase the risk of cardiovascular events.However,effective strategies for preventing or treating advanced atherosclerosis and calcification a...Advanced atherosclerotic lesions and vascular calcification substantially increase the risk of cardiovascular events.However,effective strategies for preventing or treating advanced atherosclerosis and calcification are currently lacking.This study investigated the efficacy of DT-109(Gly-Gly-Leu)in attenuating atherosclerosis and calcification in nonhuman primates,exploring its broader therapeutic potential.In this study,twenty male cynomolgus monkeys were administered a cholesterol-rich diet ad libitum for 10 months.Then,the animals were treated either orally with DT-109(150 mg/kg/day)or a vehicle(H2O)for 5 months while continuing on the same diet.Plasma lipid levels were measured monthly and at the end of the experiment,pathological examinations of the aortas and coronary arteries and RNA sequencing of the coronary arteries were performed.To explore possible molecular mechanisms,the effects of DT-109 on smooth muscle cells(SMCs)were examined in vitro.We found that DT-109 administration significantly suppressed atherosclerotic lesion formation in both the aorta and coronary arteries.Pathological examinations revealed that DT-109 treatment reduced lesional macrophage content and calcification.RNA sequencing analysis showed that DT-109 treatment significantly downregulated the pro-inflammatory factors NLRP3,AIM2,and CASP1,the oxidative stress factors NCF2 and NCF4,and the osteogenic factors RUNX2,COL1A1,MMP2,and MMP9,while simultaneously upregulating the expression of the SMCs contraction markers ACTA2,CNN1,and TAGLN.Furthermore,DT-109 inhibited SMC calcification and NLRP3 inflammasome activation in vitro.These results demonstrate that DT-109 effectively suppresses both atherosclerosis and calcification.These findings,in conjunction with insights from our previous studies,position DT-109 as a novel multifaceted therapeutic agent for cardiovascular diseases.展开更多
In this paper,a graphene oxide(GO)composite film-coated humidity sensor is proposed based on the hollow core fiber(HCF).A segment of the HCF is spliced between two segments of the single-mode fiber(SMF).The relative h...In this paper,a graphene oxide(GO)composite film-coated humidity sensor is proposed based on the hollow core fiber(HCF).A segment of the HCF is spliced between two segments of the single-mode fiber(SMF).The relative humidity(RH)sensing characteristics of the sensor are experimentally investigated by observing the intensity shift of resonant dips in the transmission spectrum,which shows the GO composite film-coated HCF has the good stability in the measurement of humidity.The maximum humidity sensitivity of 0.12 dB/%RH is obtained in the RH range of 30%–78%.The proposed sensor has the advantages of the simple structure,easy fabrication,good stability,and high performance,which can be applied to marine climate detection,tunnel air humidity detection,agricultural testing,and other fields.展开更多
To improve the efficiency of evolutionary algorithms(EAs)for solving complex problems with large populations,this paper proposes a scalable parallel evolution optimization(SPEO)framework with an elastic asynchronous m...To improve the efficiency of evolutionary algorithms(EAs)for solving complex problems with large populations,this paper proposes a scalable parallel evolution optimization(SPEO)framework with an elastic asynchronous migration(EAM)mechanism.SPEO addresses two main challenges that arise in large-scale parallel EAs:(1)heavy communication workload from extensive information exchange across numerous processors,which reduces computational efficiency,and(2)loss of population diversity due to similar solutions generated and shared by many processors.The EAM mechanism introduces a self-adaptive communication scheme to mitigate communication overhead,while a diversity-preserving buffer helps maintain diversity by filtering similar solutions.Experimental results on eight CEC2014 benchmark functions using up to 512 CPU cores on the Australian National Computational Infrastructure(NCI)platform demonstrate that SPEO not only scales efficiently with an increasing number of processors but also achieves improved solution quality compared to state-of-the-art island-based EAs.展开更多
基金the National Natural Science Foundation of China(12102085)the Postdoctoral Science Foundation of China(2023M730504)the Sichuan Province Regional Innovation and Cooperation Project(2024YFHZ0210).
文摘Determining the optimal ceramic content of the ceramics-in-polymer composite electrolytes and the appropriate stack pressure can effectively improve the interfacial contact of solid-state batteries(SSBs).Based on the contact mechanics model and constructed by the conjugate gradient method,continuous convolution,and fast Fourier transform,this paper analyzes and compares the interfacial contact responses involving the polymers commonly used in SSBs,which provides the original training data for machine learning.A support vector regression model is established to predict the relationship between the content of ceramics and the interfacial resistance.The Bayesian optimization and K-fold cross-validation are introduced to find the optimal combination of hyperparameters,which accelerates the training process and improves the model’s accuracy.We found the relationship between the content of ceramics,the stack pressure,and the interfacial resistance.The results can be taken as a reference for the design of the low-resistance composite electrolytes for solid-state batteries.
文摘Influenza A viruses are important human pathogens causing periodic pandemic threats. Nonstructural protein 1 （NS1） protein of influenza A virus （NS1A） shields the virus against host defense. Here, we report the crystal structure of NS1A RNA-binding domain （RBD） bound to a double-stranded RNA （dsRNA） at 1.7A. NS1A RBD forms a homodimer to recognize the major groove of A-form dsRNA in a length-independent mode by its conserved concave surface formed by dimeric anti-parallel a-helices, dsRNA is anchored by a pair of invariable arginines （Arg38） from both monomers by extensive hydrogen bonds. In accordance with the structural observation, isothermal titration calorimetry assay shows that the unique Arg38-Arg38 pair and two Arg35-Arg46 pairs are crucial for dsRNA binding, and that Ser42 and Thr49 are also important for dsRNA binding. Agrobacterium co-infiltration assay further supports that the unique Arg38 pair plays important roles in dsRNA binding in vivo.
基金partially supported by the National Key R&D Program of China(No.2020YFA0803700)National Natural Science Foundation of China(No.81970425 and No.81941001)+6 种基金Natural Science Foundation of Shaanxi Province(No.2020PT-001)Innovation team program supported by Guangdong Province(2020KCXTD038)Guangdong Province Key Program of Discipline(2021ZDJS091)National Key Research and Development Program of China(2022YFA1105403)Science and Technology Planning Project of Guangdong Province(2021A1515110916)the Hong Kong-Macao Joint Research and Development Fund of Wuyi UniversityFrederick G.L.Huetwell Endowed Professor of Cardiovascular Medicine at University of Michigan(Y.E.C.).
文摘Advanced atherosclerotic lesions and vascular calcification substantially increase the risk of cardiovascular events.However,effective strategies for preventing or treating advanced atherosclerosis and calcification are currently lacking.This study investigated the efficacy of DT-109(Gly-Gly-Leu)in attenuating atherosclerosis and calcification in nonhuman primates,exploring its broader therapeutic potential.In this study,twenty male cynomolgus monkeys were administered a cholesterol-rich diet ad libitum for 10 months.Then,the animals were treated either orally with DT-109(150 mg/kg/day)or a vehicle(H2O)for 5 months while continuing on the same diet.Plasma lipid levels were measured monthly and at the end of the experiment,pathological examinations of the aortas and coronary arteries and RNA sequencing of the coronary arteries were performed.To explore possible molecular mechanisms,the effects of DT-109 on smooth muscle cells(SMCs)were examined in vitro.We found that DT-109 administration significantly suppressed atherosclerotic lesion formation in both the aorta and coronary arteries.Pathological examinations revealed that DT-109 treatment reduced lesional macrophage content and calcification.RNA sequencing analysis showed that DT-109 treatment significantly downregulated the pro-inflammatory factors NLRP3,AIM2,and CASP1,the oxidative stress factors NCF2 and NCF4,and the osteogenic factors RUNX2,COL1A1,MMP2,and MMP9,while simultaneously upregulating the expression of the SMCs contraction markers ACTA2,CNN1,and TAGLN.Furthermore,DT-109 inhibited SMC calcification and NLRP3 inflammasome activation in vitro.These results demonstrate that DT-109 effectively suppresses both atherosclerosis and calcification.These findings,in conjunction with insights from our previous studies,position DT-109 as a novel multifaceted therapeutic agent for cardiovascular diseases.
基金support from the National Natural Science Foundation of China(Grant No.62090064)Key Research&Development Program of Ningbo City(Grant No.2022Z208).
文摘In this paper,a graphene oxide(GO)composite film-coated humidity sensor is proposed based on the hollow core fiber(HCF).A segment of the HCF is spliced between two segments of the single-mode fiber(SMF).The relative humidity(RH)sensing characteristics of the sensor are experimentally investigated by observing the intensity shift of resonant dips in the transmission spectrum,which shows the GO composite film-coated HCF has the good stability in the measurement of humidity.The maximum humidity sensitivity of 0.12 dB/%RH is obtained in the RH range of 30%–78%.The proposed sensor has the advantages of the simple structure,easy fabrication,good stability,and high performance,which can be applied to marine climate detection,tunnel air humidity detection,agricultural testing,and other fields.
基金This research was funded by the Zhejiang’JIANBING’R&D Project(No.2022C01055)Zhejiang Provincial Department of Transport Technology Project(No.2024011).
文摘To improve the efficiency of evolutionary algorithms(EAs)for solving complex problems with large populations,this paper proposes a scalable parallel evolution optimization(SPEO)framework with an elastic asynchronous migration(EAM)mechanism.SPEO addresses two main challenges that arise in large-scale parallel EAs:(1)heavy communication workload from extensive information exchange across numerous processors,which reduces computational efficiency,and(2)loss of population diversity due to similar solutions generated and shared by many processors.The EAM mechanism introduces a self-adaptive communication scheme to mitigate communication overhead,while a diversity-preserving buffer helps maintain diversity by filtering similar solutions.Experimental results on eight CEC2014 benchmark functions using up to 512 CPU cores on the Australian National Computational Infrastructure(NCI)platform demonstrate that SPEO not only scales efficiently with an increasing number of processors but also achieves improved solution quality compared to state-of-the-art island-based EAs.
