In order to enhance the service life of refractories for melting and casting of titanium alloy,preparation of yttrium oxide coatings on the refractories surface is an effective solution.The improvement of thermal shoc...In order to enhance the service life of refractories for melting and casting of titanium alloy,preparation of yttrium oxide coatings on the refractories surface is an effective solution.The improvement of thermal shock stability of the coating is beneficial to its spalling resistance during the high-temperature service,and the available slurry with good performance is the prerequisite.The effects of the varieties and contents of dispersant(sodium tripolyphosphate,sodium hexametaphosphate,sodium pyrophosphate,citric acid and polycarboxylate ammonium salt)and binder(aluminum dihydrogen phosphate,zirconium acetate and yttria sol)on the stability,rheological and thixotropic properties of yttrium oxide waterbased slurry were investigated,and the effects of slurry composition design on the thermal shock resistance of the coating were focused.The results showed that the introduction of polycarboxylate ammonium salt as dispersant significantly improved the stability of the slurry,and the varieties of the binders had significant effects on the dispersibility of the slurry.When aluminum dihydrogen phosphate and polycarboxylate ammonium salt were used as binder and dispersant,respectively,the slurry had better stability,suitable rheological and thixotropic properties.By using aluminum dihydrogen phosphate as binder,the coating had good thermal shock resistance and no obvious cracks were observed for the coating after thermal shock,which was attributed to the yttrium aluminate binding phase generated in the coating.An effective method was provided for preparing yttrium oxide coatings with enhanced thermal shock resistance applied in the process of titanium alloy melting and casting.展开更多
Blade rubbing faults cause detrimental impact on the operation of aeroengines. Most of the existing studies on blade rubbing in the shaft-disk-blade-casing(SDBC) system have overlooked the elastic deformation of the b...Blade rubbing faults cause detrimental impact on the operation of aeroengines. Most of the existing studies on blade rubbing in the shaft-disk-blade-casing(SDBC) system have overlooked the elastic deformation of the blade, while some only consider the whirl of the rotor, neglecting its spin. To address these limitations, this paper proposes a dynamic model with large rotation for the SDBC system. The model incorporates the spin and whirl of the rotor, enabling the realistic reproduction of multiblade rubbing faults. To verify the accuracy of the SDBC model with large rotation and demonstrate its capability to effectively consider the rotational effects such as the centrifugal stiffening and gyroscopic effects, the natural characteristics and dynamic responses of the proposed model are compared with those obtained from reported research and experimental results. Furthermore, the effects of the rotating speed, contact stiffness,and blade number on the dynamic characteristics of the SDBC system with multi-blade rubbing are investigated. The results indicate that the phase angle between the rotor deflection and the unbalance excitation force increases with the increasing rotating speed,which significantly influences the rubbing penetration of each blade. The natural frequency of the SDBC system with rubbing constrain can be observed in the acceleration response of the casing and the torsional response of the shaft, and the frequency is related to the contact stiffness. Moreover, the vibration amplitude increases significantly with the product of the blade number under rubbing, and the rotating frequency approaches the natural frequency of the SDBC system. The proposed model can provide valuable insight for the fault diagnosis of rubbing in bladed rotating machinery.展开更多
Massive machine type communication aims to support the connection of massive devices,which is still an important scenario in 6G.In this paper,a novel cluster-based massive access method is proposed for massive multipl...Massive machine type communication aims to support the connection of massive devices,which is still an important scenario in 6G.In this paper,a novel cluster-based massive access method is proposed for massive multiple input multiple output systems.By exploiting the angular domain characteristics,devices are separated into multiple clusters with a learned cluster-specific dictionary,which enhances the identification of active devices.For detected active devices whose data recovery fails,power domain nonorthogonal multiple access with successive interference cancellation is employed to recover their data via re-transmission.Simulation results show that the proposed scheme and algorithm achieve improved performance on active user detection and data recovery.展开更多
Developing high-performance lithium-ion batteries (LIBs) with high energy density, rate capability and long cycle life are essential for the ever-growing practical application. Among all battery components, the binder...Developing high-performance lithium-ion batteries (LIBs) with high energy density, rate capability and long cycle life are essential for the ever-growing practical application. Among all battery components, the binder plays a key role in determining the preparation of electrodes and the improvement of battery performance, in spite of a low usage amount. The main function of binder is to bond the active material, conductive additive and current collector together and provide electron and ion channels to improve the kinetics of electrochemical reaction. With the ever-increasing requirement of high energy density by LIBs, technical challenges such as volume expansion and active material dissolution are attracting worldwide attentions, where binder is thought to provide a new solution.There are two main categories (organic solvent soluble binder and water-soluble binder) and abundant polar functional groups providing adhesion ability. It is of great significance to timely summarize the latest progress in battery binders and present the principles for designing novel binders with both robust binding interaction and outstanding electrode stabilization function. This review begins with an introduction of the binding mechanism and the related binding forces, including mechanical interlocking forces and interfacial forces. Then, we discussed four different strategies (the enhancement of binding force,the formation of three-dimensional (3D) network, the enhancement of conductivity and binders with special functions) for constructing ideal binder system in order to satisfy the specific demands of different batteries, such as LIBs and lithium–sulfur (Li–S) batteries. Finally, some prospective and promising directions of binder design are proposed based on the existing and emerging binders and guide the development of the next-generation LIBs.展开更多
In this letter,the Ti-doped NbO_(x)-based selector is applied to SiNOx-based resistive random-access memory(RRAM),forming Pt/NbOx(Ti-doped)/SiNO_(x)/Ti one selector-one RRAM device(1S1R),to suppress the sneak path cur...In this letter,the Ti-doped NbO_(x)-based selector is applied to SiNOx-based resistive random-access memory(RRAM),forming Pt/NbOx(Ti-doped)/SiNO_(x)/Ti one selector-one RRAM device(1S1R),to suppress the sneak path current.The fabricated 1S1R exhibits stable direct current(DC)endurance(>200 cycles),suitable memory window(>40),matched selectivity(>40)and high uniformity of switching parameters.展开更多
With the continuous development of technology, face recognition technology has played an important role in police work. In order to get a clear face image, image preprocessing technology is needed. This paper mainly p...With the continuous development of technology, face recognition technology has played an important role in police work. In order to get a clear face image, image preprocessing technology is needed. This paper mainly proposes illumination compensation technology and reconstruction technology based on symmetry.展开更多
Objective:Glycogen synthase kinase-3β(GSK3β)has been recognized as a suppressor of Wnt/β-catenin signaling,which is critical for the stemness maintenance of breast cancer stem cells.However,the regulatory mechanism...Objective:Glycogen synthase kinase-3β(GSK3β)has been recognized as a suppressor of Wnt/β-catenin signaling,which is critical for the stemness maintenance of breast cancer stem cells.However,the regulatory mechanisms of GSK3βprotein expression remain elusive.Methods:Co-immunoprecipitation and mass spectral assays were performed to identify molecules binding to GSK3β,and to characterize the interactions of GSK3β,heat shock protein 90(Hsp90),and co-chaperones.The role of PGK1 in Hsp90 chaperoning GSK3βwas evaluated by constructing 293T cells stably expressing different domains/mutants of Hsp90α,and by performing a series of binding assays with bacterially purified proteins and clinical specimens.The influences of Hsp90 inhibitors on breast cancer stem cell stemness were investigated by Western blot and mammosphere formation assays.Results:We showed that GSK3βwas a client protein of Hsp90.Hsp90,which did not directly bind to GSK3β,interacted with phosphoglycerate kinase 1 via its C-terminal domain,thereby facilitating the binding of GSK3βto Hsp90.GSK3β-bound PGK1 interacted with Hsp90 in the“closed”conformation and stabilized GSK3βexpression in an Hsp90 activity-dependent manner.The Hsp90 inhibitor,17-AAG,rather than HDN-1,disrupted the interaction between Hsp90 and PGK1,and reduced GSK3βexpression,resulting in significantly reduced inhibition ofβ-catenin expression,to maintain the stemness of breast cancer stem cells.Conclusions:Our findings identified a novel regulatory mechanism of GSK3βexpression involving metabolic enzyme PGK1-coupled Hsp90,and highlighted the potential for more effective cancer treatment by selecting Hsp90 inhibitors that do not affect PGK1-regulated GSK3βexpression.展开更多
The thermal transport properties of NiNB_(2)O_(6)as anode material for lithium-ion battery and the effect of strain were studied by machine learning interatomic potential combined with Boltzmann transport equation.The...The thermal transport properties of NiNB_(2)O_(6)as anode material for lithium-ion battery and the effect of strain were studied by machine learning interatomic potential combined with Boltzmann transport equation.The results show that the lattice thermal conductivity of NiNB_(2)O_(6)along the three crystal directions[100],[010],and[001]are 0.947 W·m^(-1)·K^(-1),0.727 W·m^(-1)·K^(-1),and 0.465 W·m^(-1)·K^(-1),respectively,indicating the anisotropy of the lattice thermal conductivity of NiNB_(2)O_(6).This anisotropy of the lattice thermal conductivity stems from the significant difference of phonon group velocities in different crystal directions of NiNB_(2)O_(6).When the tensile strain is applied along the[001]crystal direction,the lattice thermal conductivity in all three directions decreases.However,when the compressive strain is applied,the lattice thermal conductivity in the[100]and[010]crystal directions is increased,while the lattice thermal conductivity in the[001]crystal direction is abnormally reduced due to the significant inhibition of compressive strain on the group velocity.These indicate that the anisotropy of thermal conductivity of NiNB_(2)O_(6)can be enhanced by the compressive strain,and reduced by the tensile strain.展开更多
Significantly enhanced electroluminescence performance and stability of all-inorganic perovskite light-emitting devices(PeLEDs) have been achieved by adding triton X-100 into the perovskite precursors.The small perovs...Significantly enhanced electroluminescence performance and stability of all-inorganic perovskite light-emitting devices(PeLEDs) have been achieved by adding triton X-100 into the perovskite precursors.The small perovskite grains arranged tightly and formed large grains as the triton X-100 were introduced.Thus the nonradiative defects originated from Pb atoms at the grain boundaries were highly passivated by triton X-100 and resulted in the promotion of PeLED performance,including a turn-on voltage of 3.2 V,a brightness of 63500 cd/m^(2),a current efficiency of 17.4 cd/A,and a prolonged lifetime of 2 h in air.展开更多
Comprehensive Summary For coordination-insertion olefin polymerization,the development of novel transition-metal catalysts has drawn extensive attention in this field.In this contribution,we designed a series of hemil...Comprehensive Summary For coordination-insertion olefin polymerization,the development of novel transition-metal catalysts has drawn extensive attention in this field.In this contribution,we designed a series of hemilabileα-diimine nickel catalysts bearing oxygen atom as neighboring group.The steric hindrance and oxygen atom number of these nickel complexes(Ni1—Ni4)could be adjusted,which influenced ethylene(co)polymerization processes.展开更多
The synthesis and design of transition metal catalysts have attracted extensive attention in ethylene polymer-ization.In this work,a series of α-diimine nickel catalysts(Ni1-Ni4)bearing ether substituents were design...The synthesis and design of transition metal catalysts have attracted extensive attention in ethylene polymer-ization.In this work,a series of α-diimine nickel catalysts(Ni1-Ni4)bearing ether substituents were designed and synthesized.The steric hindrance of these catalysts was systematically modulated by varying the ether groups,which directly influenced their ethylene(co)polymerization performances.These catalysts showed exceptionally high activities(up to 10^(7) g·mol^(-1)·h^(-1)).The resulting polyethylene displayed a broad range of branching densities(22 to 92/1000C)and high polymer molecular weights(up to 59.8×10^(4) g·mol^(-1)).Polyethylene produced by Ni1 and Ni2 exhibited outstanding mechanical properties and elastic recovery performance.Furthermore,these catalysts efficiently catalyzed ethylene copolymerization with diverse polar monomers,yielding copolymers with incorporation ratios ranging from 0.24%to 1.43%.展开更多
The application of electrochemical technologies for chemical and fuel synthesis offers a significantly more eco-friendly method than traditional industrial practice.However,electrochemical synthesis in aqueous solutio...The application of electrochemical technologies for chemical and fuel synthesis offers a significantly more eco-friendly method than traditional industrial practice.However,electrochemical synthesis in aqueous solutions often involves a sluggish oxygen evolution reaction(OER)at the anode,yielding products that are less economically viable and leading to inefficient energy use.This challenge has prompted extensive research into replacing the OER with fast,value-added oxidation reactions(OER alternatives)in electrolysis systems.In this review,we summarize the latest research progress in coupled electrochemical systems that integrate OER al-ternatives with reduction reactions,beyond hydrogen evolution reactions,in aqueous solutions to synthesize dual value-added products.After providing a general overview,we start by introducing two key factors:(i)electrolytic devices and(ii)advanced characterization techniques for mechanism investigation.The focus then shifts to catalysts developed so far and their corresponding catalytic mechanisms,and to the electrochemical performance of these hybrid electrolysis systems.Finally,we outline and discuss the challenges and prospects for these inte-grated electrochemical systems to offer insights into future research directions and applications.We envision that this review will provide a panorama of electrolysis systems for dual value-added products,thereby fostering the development of green synthesis with zero carbon emissions.展开更多
Plant genetic transformation strategies serve as essential tools for the genetic engineering and advanced molecular breeding of plants.However,the complicated operational protocols and low efficiency of cur-rent trans...Plant genetic transformation strategies serve as essential tools for the genetic engineering and advanced molecular breeding of plants.However,the complicated operational protocols and low efficiency of cur-rent transformation strategies restrict the genetic modification of most plant species.This paper de-scribes the development of the regenerative activity–dependent in planta injection delivery(RAPID)method based on the active regeneration capacity of plants.In this method,Agrobacterium tumefaciens is delivered to plant meristems via injection to induce transfected nascent tissues.Stable transgenic plants can be obtained by subsequent vegetative propagation of the positive nascent tissues.The method was successfully used for transformation of plants with strong regeneration capacity,including different genotypes of sweet potato(Ipomoea batatas),potato(Solanum tuberosum),and bayhops(Ipo-moea pes-caprae).Compared with traditional transformation methods,RAPID has a much higher trans-formation efficiency and shorter duration,and it does not require tissue culture procedures.The RAPID method therefore overcomes the limitations of traditional methods to enable rapid in planta transformation and can be potentially applied to a wide range of plant species that are capable of active regeneration.展开更多
Background With the gradual increase of infertility in the world,among which male sperm problems are the main factor for infertility,more and more couples are using computer-assisted sperm analysis(CASA)to assist in t...Background With the gradual increase of infertility in the world,among which male sperm problems are the main factor for infertility,more and more couples are using computer-assisted sperm analysis(CASA)to assist in the analysis and treatment of infertility.Meanwhile,the rapid development of deep learning(DL)has led to strong results in image classification tasks.However,the classification of sperm images has not been well studied in current deep learning methods,and the sperm images are often affected by noise in practical CASA applications.The purpose of this article is to investigate the anti-noise robustness of deep learning classification methods applied on sperm images.Methods The SVIA dataset is a publicly available large-scale sperm dataset containing three subsets.In this work,we used subset-C,which provides more than 125,000 independent images of sperms and impurities,including 121,401 sperm images and 4,479 impurity images.To investigate the anti-noise robustness of deep learning classification methods applied on sperm images,we conducted a comprehensive comparative study of sperm images using many convolutional neural network(CNN)and visual transformer(VT)deep learning methods to find the deep learning model with the most stable anti-noise robustness.Results This study proved that VT had strong robustness for the classification of tiny object(sperm and impurity)image datasets under some types of conventional noise and some adversarial attacks.In particular,under the influence of Poisson noise,accuracy changed from 91.45%to 91.08%,impurity precison changed from 92.7%to 91.3%,impurity recall changed from 88.8%to 89.5%,and impurity F1-score changed 90.7%to 90.4%.Meanwhile,sperm precision changed from 90.9%to 90.5%,sperm recall changed from 92.5%to 93.8%,and sperm F1-score changed from 92.1%to 90.4%.Conclusion Sperm image classification may be strongly affected by noise in current deep learning methods;the robustness with regard to noise of VT methods based on global information is greater than that of CNN methods based on local information,indicating that the robustness with regard to noise is reflected mainly in global information.展开更多
Polyolefin vitrimers are polymer networks bearing reversible covalent crosslinking points, enabling them to be reprocessed and recycled. In this contribution, a series of polyolefin vitrimers were designed based on th...Polyolefin vitrimers are polymer networks bearing reversible covalent crosslinking points, enabling them to be reprocessed and recycled. In this contribution, a series of polyolefin vitrimers were designed based on the acetoacetate-functionalized polyolefin copolymers, which were produced through the direct copolymerization of ethylene with polar comonomers using a phosphinesulfonate palladium catalyst. The pendant acetoacetate group could mediate several characteristic reactions, such as the Michael addition reaction, ketone-amine condensation and metal coordination reaction. As such, structurally adjustable polyolefin vitrimers can be accessed by introducing various dynamic crosslinking bonds, including disulfide exchange, transamination of vinylogous urethane and labile metal coordination bond. The utilization of different crosslinking reactions and the mole ratio of crosslinkers significantly impact the material properties of the resultant polymers. Specifically, the generated polyolefin vitrimers demonstrated excellent reprocessability and closed-loop recycling properties. The study in this work provides an efficient strategy to access various polyolefin vitrimers.展开更多
基金financially supported by the National Natural Science Foundation of China(No.U21A2057).
文摘In order to enhance the service life of refractories for melting and casting of titanium alloy,preparation of yttrium oxide coatings on the refractories surface is an effective solution.The improvement of thermal shock stability of the coating is beneficial to its spalling resistance during the high-temperature service,and the available slurry with good performance is the prerequisite.The effects of the varieties and contents of dispersant(sodium tripolyphosphate,sodium hexametaphosphate,sodium pyrophosphate,citric acid and polycarboxylate ammonium salt)and binder(aluminum dihydrogen phosphate,zirconium acetate and yttria sol)on the stability,rheological and thixotropic properties of yttrium oxide waterbased slurry were investigated,and the effects of slurry composition design on the thermal shock resistance of the coating were focused.The results showed that the introduction of polycarboxylate ammonium salt as dispersant significantly improved the stability of the slurry,and the varieties of the binders had significant effects on the dispersibility of the slurry.When aluminum dihydrogen phosphate and polycarboxylate ammonium salt were used as binder and dispersant,respectively,the slurry had better stability,suitable rheological and thixotropic properties.By using aluminum dihydrogen phosphate as binder,the coating had good thermal shock resistance and no obvious cracks were observed for the coating after thermal shock,which was attributed to the yttrium aluminate binding phase generated in the coating.An effective method was provided for preparing yttrium oxide coatings with enhanced thermal shock resistance applied in the process of titanium alloy melting and casting.
基金Project supported by the National Science and Technology Major Project of China (No. 2017-V-0009)the National Natural Science Foundation of China (Nos. 12032015 and 12121002)the National Funding Program for Postdoctoral Researchers of China (No. GZC20231586)。
文摘Blade rubbing faults cause detrimental impact on the operation of aeroengines. Most of the existing studies on blade rubbing in the shaft-disk-blade-casing(SDBC) system have overlooked the elastic deformation of the blade, while some only consider the whirl of the rotor, neglecting its spin. To address these limitations, this paper proposes a dynamic model with large rotation for the SDBC system. The model incorporates the spin and whirl of the rotor, enabling the realistic reproduction of multiblade rubbing faults. To verify the accuracy of the SDBC model with large rotation and demonstrate its capability to effectively consider the rotational effects such as the centrifugal stiffening and gyroscopic effects, the natural characteristics and dynamic responses of the proposed model are compared with those obtained from reported research and experimental results. Furthermore, the effects of the rotating speed, contact stiffness,and blade number on the dynamic characteristics of the SDBC system with multi-blade rubbing are investigated. The results indicate that the phase angle between the rotor deflection and the unbalance excitation force increases with the increasing rotating speed,which significantly influences the rubbing penetration of each blade. The natural frequency of the SDBC system with rubbing constrain can be observed in the acceleration response of the casing and the torsional response of the shaft, and the frequency is related to the contact stiffness. Moreover, the vibration amplitude increases significantly with the product of the blade number under rubbing, and the rotating frequency approaches the natural frequency of the SDBC system. The proposed model can provide valuable insight for the fault diagnosis of rubbing in bladed rotating machinery.
基金supported by Natural Science Foundation of China(62122012,62221001)the Beijing Natural Science Foundation(L202019,L211012)the Fundamental Research Funds for the Central Universities(2022JBQY004)。
文摘Massive machine type communication aims to support the connection of massive devices,which is still an important scenario in 6G.In this paper,a novel cluster-based massive access method is proposed for massive multiple input multiple output systems.By exploiting the angular domain characteristics,devices are separated into multiple clusters with a learned cluster-specific dictionary,which enhances the identification of active devices.For detected active devices whose data recovery fails,power domain nonorthogonal multiple access with successive interference cancellation is employed to recover their data via re-transmission.Simulation results show that the proposed scheme and algorithm achieve improved performance on active user detection and data recovery.
基金financially supported by the National Key R&D Program of China (No. 2019YFA0705104)Guangdong Province Science and Technology Department under Project (No. 2020A0505100014)。
文摘Developing high-performance lithium-ion batteries (LIBs) with high energy density, rate capability and long cycle life are essential for the ever-growing practical application. Among all battery components, the binder plays a key role in determining the preparation of electrodes and the improvement of battery performance, in spite of a low usage amount. The main function of binder is to bond the active material, conductive additive and current collector together and provide electron and ion channels to improve the kinetics of electrochemical reaction. With the ever-increasing requirement of high energy density by LIBs, technical challenges such as volume expansion and active material dissolution are attracting worldwide attentions, where binder is thought to provide a new solution.There are two main categories (organic solvent soluble binder and water-soluble binder) and abundant polar functional groups providing adhesion ability. It is of great significance to timely summarize the latest progress in battery binders and present the principles for designing novel binders with both robust binding interaction and outstanding electrode stabilization function. This review begins with an introduction of the binding mechanism and the related binding forces, including mechanical interlocking forces and interfacial forces. Then, we discussed four different strategies (the enhancement of binding force,the formation of three-dimensional (3D) network, the enhancement of conductivity and binders with special functions) for constructing ideal binder system in order to satisfy the specific demands of different batteries, such as LIBs and lithium–sulfur (Li–S) batteries. Finally, some prospective and promising directions of binder design are proposed based on the existing and emerging binders and guide the development of the next-generation LIBs.
基金financially supported by the National Natural Science Foundation of China(No.61904050)the Science and Technology Major Project of Hubei(Nos.2020AAA005 and 2020AEA017)+1 种基金the Scientific Research Project of Education Department of Hubei Province(No.Q20181009)Hubei Key Laboratory of Advanced Memories。
文摘In this letter,the Ti-doped NbO_(x)-based selector is applied to SiNOx-based resistive random-access memory(RRAM),forming Pt/NbOx(Ti-doped)/SiNO_(x)/Ti one selector-one RRAM device(1S1R),to suppress the sneak path current.The fabricated 1S1R exhibits stable direct current(DC)endurance(>200 cycles),suitable memory window(>40),matched selectivity(>40)and high uniformity of switching parameters.
文摘With the continuous development of technology, face recognition technology has played an important role in police work. In order to get a clear face image, image preprocessing technology is needed. This paper mainly proposes illumination compensation technology and reconstruction technology based on symmetry.
基金This work was supported by grants from the NSFC Shandong Joint Fund(Grant No.U1606403)the National Natural Science Foundation of China(Grant No.81673450)+4 种基金the State Key Program of the National Natural Science Foundation of China(Grant No.82030074)the NSFC-Shandong Joint Fund(Grant No.U1906212)the Qingdao National Laboratory for Marine Science and Technology(Grant No.2015ASKJ02)the National Science and Technology Major Project for Significant New Drugs Development(Grant No.2018ZX09735-004)the Shandong Provincial Natural Science Foundation(major basic research projects,Grant No.ZR2019ZD18).
文摘Objective:Glycogen synthase kinase-3β(GSK3β)has been recognized as a suppressor of Wnt/β-catenin signaling,which is critical for the stemness maintenance of breast cancer stem cells.However,the regulatory mechanisms of GSK3βprotein expression remain elusive.Methods:Co-immunoprecipitation and mass spectral assays were performed to identify molecules binding to GSK3β,and to characterize the interactions of GSK3β,heat shock protein 90(Hsp90),and co-chaperones.The role of PGK1 in Hsp90 chaperoning GSK3βwas evaluated by constructing 293T cells stably expressing different domains/mutants of Hsp90α,and by performing a series of binding assays with bacterially purified proteins and clinical specimens.The influences of Hsp90 inhibitors on breast cancer stem cell stemness were investigated by Western blot and mammosphere formation assays.Results:We showed that GSK3βwas a client protein of Hsp90.Hsp90,which did not directly bind to GSK3β,interacted with phosphoglycerate kinase 1 via its C-terminal domain,thereby facilitating the binding of GSK3βto Hsp90.GSK3β-bound PGK1 interacted with Hsp90 in the“closed”conformation and stabilized GSK3βexpression in an Hsp90 activity-dependent manner.The Hsp90 inhibitor,17-AAG,rather than HDN-1,disrupted the interaction between Hsp90 and PGK1,and reduced GSK3βexpression,resulting in significantly reduced inhibition ofβ-catenin expression,to maintain the stemness of breast cancer stem cells.Conclusions:Our findings identified a novel regulatory mechanism of GSK3βexpression involving metabolic enzyme PGK1-coupled Hsp90,and highlighted the potential for more effective cancer treatment by selecting Hsp90 inhibitors that do not affect PGK1-regulated GSK3βexpression.
基金the National Natural Science Foundation of China(Grant Nos.12074115 and 11874145)the Natural Science Foundation of Hunan Province,China(Grant No.2021JJ30202)。
文摘The thermal transport properties of NiNB_(2)O_(6)as anode material for lithium-ion battery and the effect of strain were studied by machine learning interatomic potential combined with Boltzmann transport equation.The results show that the lattice thermal conductivity of NiNB_(2)O_(6)along the three crystal directions[100],[010],and[001]are 0.947 W·m^(-1)·K^(-1),0.727 W·m^(-1)·K^(-1),and 0.465 W·m^(-1)·K^(-1),respectively,indicating the anisotropy of the lattice thermal conductivity of NiNB_(2)O_(6).This anisotropy of the lattice thermal conductivity stems from the significant difference of phonon group velocities in different crystal directions of NiNB_(2)O_(6).When the tensile strain is applied along the[001]crystal direction,the lattice thermal conductivity in all three directions decreases.However,when the compressive strain is applied,the lattice thermal conductivity in the[100]and[010]crystal directions is increased,while the lattice thermal conductivity in the[001]crystal direction is abnormally reduced due to the significant inhibition of compressive strain on the group velocity.These indicate that the anisotropy of thermal conductivity of NiNB_(2)O_(6)can be enhanced by the compressive strain,and reduced by the tensile strain.
基金Project supported by the National Key Research and Development Program of China(Grant Nos.2018YFA0305900 and 2016YFA0300404)the National Natural Science Foundation of China(Grant Nos.11874172,11374120,11634004,and 51320105007)the Science and Technology Innovative Research Project of Jilin University,China(Grant No.2017TD-01)。
文摘Significantly enhanced electroluminescence performance and stability of all-inorganic perovskite light-emitting devices(PeLEDs) have been achieved by adding triton X-100 into the perovskite precursors.The small perovskite grains arranged tightly and formed large grains as the triton X-100 were introduced.Thus the nonradiative defects originated from Pb atoms at the grain boundaries were highly passivated by triton X-100 and resulted in the promotion of PeLED performance,including a turn-on voltage of 3.2 V,a brightness of 63500 cd/m^(2),a current efficiency of 17.4 cd/A,and a prolonged lifetime of 2 h in air.
基金supported by National Key R&D Program of China(No.2021YFA1501700)Natural Science Foundation of Anhui Province(2308085Y35,2023AH030002)+2 种基金Hefei Natural Science Foundation(202304)CAS Project for Young Scientists in Basic Research(No.YSBR-094)2023 Youth Innovation Foundation ofUniversity of Science and Technologyof China(WK2060000074).
文摘Comprehensive Summary For coordination-insertion olefin polymerization,the development of novel transition-metal catalysts has drawn extensive attention in this field.In this contribution,we designed a series of hemilabileα-diimine nickel catalysts bearing oxygen atom as neighboring group.The steric hindrance and oxygen atom number of these nickel complexes(Ni1—Ni4)could be adjusted,which influenced ethylene(co)polymerization processes.
基金supported by National Key R&D Program of China(No.2021YFA1501700)National Natural Science Foundation of China(No.52025031,22261142664,52403016)+1 种基金Fundamental Research Funds for the Central Universities(No.WK2060000074)CAS Project for Young Scientists in Basic Research(No.YSBR-094).
文摘The synthesis and design of transition metal catalysts have attracted extensive attention in ethylene polymer-ization.In this work,a series of α-diimine nickel catalysts(Ni1-Ni4)bearing ether substituents were designed and synthesized.The steric hindrance of these catalysts was systematically modulated by varying the ether groups,which directly influenced their ethylene(co)polymerization performances.These catalysts showed exceptionally high activities(up to 10^(7) g·mol^(-1)·h^(-1)).The resulting polyethylene displayed a broad range of branching densities(22 to 92/1000C)and high polymer molecular weights(up to 59.8×10^(4) g·mol^(-1)).Polyethylene produced by Ni1 and Ni2 exhibited outstanding mechanical properties and elastic recovery performance.Furthermore,these catalysts efficiently catalyzed ethylene copolymerization with diverse polar monomers,yielding copolymers with incorporation ratios ranging from 0.24%to 1.43%.
基金supported by the National Natural Science Foundation of China(No.22209183,22225902,U22A20436,52436005)the National key Research&Development Program of China(2022YFE0115900,2021YFA1501500)+2 种基金the CAS-Commonwealth Scientific and Industrial Research Organization(CSIRO)Joint Research Projects(121835KYSB20200039)Advanced Talents of Jiangsu University,China(Grant No.23JDG027)Natural Science Foundation of Fujian Province(2021J05100).
文摘The application of electrochemical technologies for chemical and fuel synthesis offers a significantly more eco-friendly method than traditional industrial practice.However,electrochemical synthesis in aqueous solutions often involves a sluggish oxygen evolution reaction(OER)at the anode,yielding products that are less economically viable and leading to inefficient energy use.This challenge has prompted extensive research into replacing the OER with fast,value-added oxidation reactions(OER alternatives)in electrolysis systems.In this review,we summarize the latest research progress in coupled electrochemical systems that integrate OER al-ternatives with reduction reactions,beyond hydrogen evolution reactions,in aqueous solutions to synthesize dual value-added products.After providing a general overview,we start by introducing two key factors:(i)electrolytic devices and(ii)advanced characterization techniques for mechanism investigation.The focus then shifts to catalysts developed so far and their corresponding catalytic mechanisms,and to the electrochemical performance of these hybrid electrolysis systems.Finally,we outline and discuss the challenges and prospects for these inte-grated electrochemical systems to offer insights into future research directions and applications.We envision that this review will provide a panorama of electrolysis systems for dual value-added products,thereby fostering the development of green synthesis with zero carbon emissions.
基金supported by grants from the Key Area Research and Development Program of Guangdong Province (2022B1111230001)the Science and Technology Projects in Guangzhou (E3330900-01)+3 种基金the National Natural Science Foundation of China-Guangdong Joint Fund (U1701234)the Guangdong Special Support Plan Project (2019TQ05N140)the Guangzhou Municipal Science and Technology Project (202201010641)the Guangdong Forestry Bureau (Key Laboratory of Plant Ex Situ Protection and Utilization in South China) (E336030011).
文摘Plant genetic transformation strategies serve as essential tools for the genetic engineering and advanced molecular breeding of plants.However,the complicated operational protocols and low efficiency of cur-rent transformation strategies restrict the genetic modification of most plant species.This paper de-scribes the development of the regenerative activity–dependent in planta injection delivery(RAPID)method based on the active regeneration capacity of plants.In this method,Agrobacterium tumefaciens is delivered to plant meristems via injection to induce transfected nascent tissues.Stable transgenic plants can be obtained by subsequent vegetative propagation of the positive nascent tissues.The method was successfully used for transformation of plants with strong regeneration capacity,including different genotypes of sweet potato(Ipomoea batatas),potato(Solanum tuberosum),and bayhops(Ipo-moea pes-caprae).Compared with traditional transformation methods,RAPID has a much higher trans-formation efficiency and shorter duration,and it does not require tissue culture procedures.The RAPID method therefore overcomes the limitations of traditional methods to enable rapid in planta transformation and can be potentially applied to a wide range of plant species that are capable of active regeneration.
基金supported by the National Natural Science Foundation of China(Grant No.82220108007).
文摘Background With the gradual increase of infertility in the world,among which male sperm problems are the main factor for infertility,more and more couples are using computer-assisted sperm analysis(CASA)to assist in the analysis and treatment of infertility.Meanwhile,the rapid development of deep learning(DL)has led to strong results in image classification tasks.However,the classification of sperm images has not been well studied in current deep learning methods,and the sperm images are often affected by noise in practical CASA applications.The purpose of this article is to investigate the anti-noise robustness of deep learning classification methods applied on sperm images.Methods The SVIA dataset is a publicly available large-scale sperm dataset containing three subsets.In this work,we used subset-C,which provides more than 125,000 independent images of sperms and impurities,including 121,401 sperm images and 4,479 impurity images.To investigate the anti-noise robustness of deep learning classification methods applied on sperm images,we conducted a comprehensive comparative study of sperm images using many convolutional neural network(CNN)and visual transformer(VT)deep learning methods to find the deep learning model with the most stable anti-noise robustness.Results This study proved that VT had strong robustness for the classification of tiny object(sperm and impurity)image datasets under some types of conventional noise and some adversarial attacks.In particular,under the influence of Poisson noise,accuracy changed from 91.45%to 91.08%,impurity precison changed from 92.7%to 91.3%,impurity recall changed from 88.8%to 89.5%,and impurity F1-score changed 90.7%to 90.4%.Meanwhile,sperm precision changed from 90.9%to 90.5%,sperm recall changed from 92.5%to 93.8%,and sperm F1-score changed from 92.1%to 90.4%.Conclusion Sperm image classification may be strongly affected by noise in current deep learning methods;the robustness with regard to noise of VT methods based on global information is greater than that of CNN methods based on local information,indicating that the robustness with regard to noise is reflected mainly in global information.
基金supported by the National Natural Science Foundation of China (21971230, U19B6001)the Natural Science Foundation of Anhui Province (2308085Y35, 2023AH030002)+1 种基金the Hefei Natural Science Foundation (202304)the strong support from Professor Changle Chen (University of Science and Technology of China)。
文摘Polyolefin vitrimers are polymer networks bearing reversible covalent crosslinking points, enabling them to be reprocessed and recycled. In this contribution, a series of polyolefin vitrimers were designed based on the acetoacetate-functionalized polyolefin copolymers, which were produced through the direct copolymerization of ethylene with polar comonomers using a phosphinesulfonate palladium catalyst. The pendant acetoacetate group could mediate several characteristic reactions, such as the Michael addition reaction, ketone-amine condensation and metal coordination reaction. As such, structurally adjustable polyolefin vitrimers can be accessed by introducing various dynamic crosslinking bonds, including disulfide exchange, transamination of vinylogous urethane and labile metal coordination bond. The utilization of different crosslinking reactions and the mole ratio of crosslinkers significantly impact the material properties of the resultant polymers. Specifically, the generated polyolefin vitrimers demonstrated excellent reprocessability and closed-loop recycling properties. The study in this work provides an efficient strategy to access various polyolefin vitrimers.
