The inflammatory process plays a central role in the development and progression of numerous pathological situations,such as inflammatory bowel disease(IBD),autoimmune and neurodegenerative diseases,metabolic syndrome...The inflammatory process plays a central role in the development and progression of numerous pathological situations,such as inflammatory bowel disease(IBD),autoimmune and neurodegenerative diseases,metabolic syndrome,and cardiovascular disorders.IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease(CD)and ulcerative colitis(UC).Both pathological situations usually involve recurring or bloody diarrhea,pain,fatigue and weight loss.There is at present no pharmacological cure for CD or UC.However,surgery may be curative for UC patients.The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes.Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants,including vegetables and fruits which are the major dietary sources of these compounds for humans,together with wine and tea.Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects.Most interest has been directed towards the antioxidant activity of flavonoids,evidencing a remarkable free-radical scavenging capacity.However,accumulating evidence suggests that flavonoids have many other biological properties,including anti-inflammatory,antiviral,anticancer,and neuroprotective activities through different mechanisms of action.The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs.展开更多
Peroxisome proliferator-activated receptorγ(PPARγ)is a transcriptional coactivator that binds to a diverse range of transcription factors.PPARγcoactivator 1(PGC-1)coactivators possess an extensive range of biologic...Peroxisome proliferator-activated receptorγ(PPARγ)is a transcriptional coactivator that binds to a diverse range of transcription factors.PPARγcoactivator 1(PGC-1)coactivators possess an extensive range of biological effects in different tissues,and play a key part in the regulation of the oxidative metabolism,consequently modulating the production of reactive oxygen species,autophagy,and mitochondrial biogenesis.Owing to these findings,a large body of studies,aiming to establish the role of PGC-1 in the neuromuscular system,has shown that PGC-1 could be a promising target for therapies targeting neuromuscular diseases.Among these,some evidence has shown that various signaling pathways linked to PGC-1αare deregulated in muscular dystrophy,leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species(ROS)production.In the light of these results,any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular dystrophies.PGC-1αis influenced by different patho-physiological/pharmacological stimuli.Natural products have been reported to display modulatory effects on PPARγactivation with fewer side effects in comparison to synthetic drugs.Taken together,this review summarizes the current knowledge on Duchenne muscular dystrophy,focusing on the potential effects of natural compounds,acting as regulators of PGC-1α.展开更多
Objective:To evaluate the response of the brown alga Dictyota dichotoma(D.dichotoma)epiphytized by the red alga Lophocladia lallemandii in Mallorca coastal waters(Balearic Islands)by means of biomarker measures.Method...Objective:To evaluate the response of the brown alga Dictyota dichotoma(D.dichotoma)epiphytized by the red alga Lophocladia lallemandii in Mallorca coastal waters(Balearic Islands)by means of biomarker measures.Methods:Samples of epiphytized and non-epiphytized D.dichotoma were collected in Cala Morlanda(East Mallorca,Balearic Islands).Markers of lipid peroxidation and activities of antioxidant enzymes were measured in D.dichotoma.Results:Lipid peroxidation measured as malondialdehyde and all the antioxidant activities measured were significantly higher in the epiphytized brown algae when compared with the control algae.Conclusions:In conclusion,the invasive algae Lophocladia lallemandii seems to produce a more oxidized status in the epiphytized D.dichotoma and cellular damage that could induce increased mortality.展开更多
文摘The inflammatory process plays a central role in the development and progression of numerous pathological situations,such as inflammatory bowel disease(IBD),autoimmune and neurodegenerative diseases,metabolic syndrome,and cardiovascular disorders.IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease(CD)and ulcerative colitis(UC).Both pathological situations usually involve recurring or bloody diarrhea,pain,fatigue and weight loss.There is at present no pharmacological cure for CD or UC.However,surgery may be curative for UC patients.The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes.Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants,including vegetables and fruits which are the major dietary sources of these compounds for humans,together with wine and tea.Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects.Most interest has been directed towards the antioxidant activity of flavonoids,evidencing a remarkable free-radical scavenging capacity.However,accumulating evidence suggests that flavonoids have many other biological properties,including anti-inflammatory,antiviral,anticancer,and neuroprotective activities through different mechanisms of action.The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs.
基金supported by the crowd funding#Sport4Therapy to Giuseppe D’Antona(Italy)supported by Instituto de Salud CarlosⅢ,Grant Number:CIBEROBN CB12/03/30038
文摘Peroxisome proliferator-activated receptorγ(PPARγ)is a transcriptional coactivator that binds to a diverse range of transcription factors.PPARγcoactivator 1(PGC-1)coactivators possess an extensive range of biological effects in different tissues,and play a key part in the regulation of the oxidative metabolism,consequently modulating the production of reactive oxygen species,autophagy,and mitochondrial biogenesis.Owing to these findings,a large body of studies,aiming to establish the role of PGC-1 in the neuromuscular system,has shown that PGC-1 could be a promising target for therapies targeting neuromuscular diseases.Among these,some evidence has shown that various signaling pathways linked to PGC-1αare deregulated in muscular dystrophy,leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species(ROS)production.In the light of these results,any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular dystrophies.PGC-1αis influenced by different patho-physiological/pharmacological stimuli.Natural products have been reported to display modulatory effects on PPARγactivation with fewer side effects in comparison to synthetic drugs.Taken together,this review summarizes the current knowledge on Duchenne muscular dystrophy,focusing on the potential effects of natural compounds,acting as regulators of PGC-1α.
基金Supported by the Spanish Ministry of Health and Consumption Affairs with grant No.CIBERobn CB12/03/30038,and Balearic Island Government and FEDER funds with grant No.23/2012.
文摘Objective:To evaluate the response of the brown alga Dictyota dichotoma(D.dichotoma)epiphytized by the red alga Lophocladia lallemandii in Mallorca coastal waters(Balearic Islands)by means of biomarker measures.Methods:Samples of epiphytized and non-epiphytized D.dichotoma were collected in Cala Morlanda(East Mallorca,Balearic Islands).Markers of lipid peroxidation and activities of antioxidant enzymes were measured in D.dichotoma.Results:Lipid peroxidation measured as malondialdehyde and all the antioxidant activities measured were significantly higher in the epiphytized brown algae when compared with the control algae.Conclusions:In conclusion,the invasive algae Lophocladia lallemandii seems to produce a more oxidized status in the epiphytized D.dichotoma and cellular damage that could induce increased mortality.
