The development of water-soluble hexanuclear cluster complexes of low toxicity is a promising task due to their potential biomedical applications such as bioimaging and photodynamic therapy.Herein,we present the synth...The development of water-soluble hexanuclear cluster complexes of low toxicity is a promising task due to their potential biomedical applications such as bioimaging and photodynamic therapy.Herein,we present the syntheses of two new water-soluble hexarhenium cluster complexes with terminal amphiphilic phosphine ligands,and delineate their photoluminescence and X-ray excited optical luminescence(XEOL)properties.These cluster complexes,namely[{Re_(6)Q_(8)}(PPh_(2)CH_(2)CH_(2)COO)_(6)]^(4−)(Q=S(1);Se,(2)),have the least cytotoxicity among all the tested hexanuclear metal-clusters,are capable of penetrating into cells and exhibit moderate photodynamic toxicity toward Hep-2 cells.展开更多
The chaotropic character of Keggin-type polyoxotungstate anions was evaluated with respect to their ability to bind toγ-cyclodextrin(γ-CD)by varying the global charge density of the nanometer-sized polyanion.
基金supported by the Russian Science Foundation[grant no.15-15-10006]the Czech Science Foundation[grant no.18-05076S]the Ministry of science and higher education of RF[no.0333-2017-0002].
文摘The development of water-soluble hexanuclear cluster complexes of low toxicity is a promising task due to their potential biomedical applications such as bioimaging and photodynamic therapy.Herein,we present the syntheses of two new water-soluble hexarhenium cluster complexes with terminal amphiphilic phosphine ligands,and delineate their photoluminescence and X-ray excited optical luminescence(XEOL)properties.These cluster complexes,namely[{Re_(6)Q_(8)}(PPh_(2)CH_(2)CH_(2)COO)_(6)]^(4−)(Q=S(1);Se,(2)),have the least cytotoxicity among all the tested hexanuclear metal-clusters,are capable of penetrating into cells and exhibit moderate photodynamic toxicity toward Hep-2 cells.
基金supported by a public grant overseen by the French National Research Agency as part of the“Investissements d’Avenir”program(Labex Charm3at,ANR-11-LABX-0039-grant)as well as the CNRS-MOMENTUMThis research is also supported by the China Scholarship Council(CSC)to S.Y.(201904910419).The authors are grateful to Flavien Bourdreux and Cyrielle Rey for their help with elemental analyses.
文摘The chaotropic character of Keggin-type polyoxotungstate anions was evaluated with respect to their ability to bind toγ-cyclodextrin(γ-CD)by varying the global charge density of the nanometer-sized polyanion.
