The intra-islet microvasculature is a critical interface between the blood and islet endocrine cells governing a number of cellular and pathophysiological processes associated with the pancreatic tissue. A growing bod...The intra-islet microvasculature is a critical interface between the blood and islet endocrine cells governing a number of cellular and pathophysiological processes associated with the pancreatic tissue. A growing body of evidence indicates a strong functional and physical interdependency of β-cells with endothelial cells(ECs), the building blocks of islet microvasculature. Intra-islet ECs, actively regulate vascular permeability and appear to play a role in fine-tuning blood glucose sensing and regulation. These cells also tend to behave as "guardians", controlling the expression and movement of a number of important immune mediators, thereby strongly contributing to the physiology of islets. This review will focus on the molecular signalling and crosstalk between the intra-islet ECs and β-cells and how their relationship can be a potential target for intervention strategies in islet pathology and islet transplantation.展开更多
We report a 53 year-old male who suffered 18 months of foul-smelling green nasal discharge, halitosis and a heavy discomfort behind his right eye. The symptoms were consistent with chronic rhinosinusitis. The patient ...We report a 53 year-old male who suffered 18 months of foul-smelling green nasal discharge, halitosis and a heavy discomfort behind his right eye. The symptoms were consistent with chronic rhinosinusitis. The patient had a right upper molar dental extraction shortly before the onset of symptoms. A radio-opaque foreign body was noted in his right maxillary sinus on CT. During surgery a tooth resembling foreign body was removed. The patient＇s symptoms completely resolved within weeks of the removal.展开更多
Artificial intelligence is a technology that processes and analyzes information with reproducibility and accuracy.Its application in medicine,especially in the field of gastroenterology,has great potential to facilita...Artificial intelligence is a technology that processes and analyzes information with reproducibility and accuracy.Its application in medicine,especially in the field of gastroenterology,has great potential to facilitate in diagnosis of various disease states.Currently,the role of artificial intelligence as it pertains to colonoscopy revolves around enhanced polyp detection and characterization.The aim of this article is to review the current and potential future applications of artificial intelligence for enhanced quality of detection for colorectal neoplasia.展开更多
文摘The intra-islet microvasculature is a critical interface between the blood and islet endocrine cells governing a number of cellular and pathophysiological processes associated with the pancreatic tissue. A growing body of evidence indicates a strong functional and physical interdependency of β-cells with endothelial cells(ECs), the building blocks of islet microvasculature. Intra-islet ECs, actively regulate vascular permeability and appear to play a role in fine-tuning blood glucose sensing and regulation. These cells also tend to behave as "guardians", controlling the expression and movement of a number of important immune mediators, thereby strongly contributing to the physiology of islets. This review will focus on the molecular signalling and crosstalk between the intra-islet ECs and β-cells and how their relationship can be a potential target for intervention strategies in islet pathology and islet transplantation.
文摘We report a 53 year-old male who suffered 18 months of foul-smelling green nasal discharge, halitosis and a heavy discomfort behind his right eye. The symptoms were consistent with chronic rhinosinusitis. The patient had a right upper molar dental extraction shortly before the onset of symptoms. A radio-opaque foreign body was noted in his right maxillary sinus on CT. During surgery a tooth resembling foreign body was removed. The patient＇s symptoms completely resolved within weeks of the removal.
文摘Artificial intelligence is a technology that processes and analyzes information with reproducibility and accuracy.Its application in medicine,especially in the field of gastroenterology,has great potential to facilitate in diagnosis of various disease states.Currently,the role of artificial intelligence as it pertains to colonoscopy revolves around enhanced polyp detection and characterization.The aim of this article is to review the current and potential future applications of artificial intelligence for enhanced quality of detection for colorectal neoplasia.
