A novel low molecular weight compound polysaccharide(LMW-CPS) was identified from a specific combination of Chinese herb ingredients.The monosaccharide composition of LMW-CPS was consisted of single arabinose,which ha...A novel low molecular weight compound polysaccharide(LMW-CPS) was identified from a specific combination of Chinese herb ingredients.The monosaccharide composition of LMW-CPS was consisted of single arabinose,which had an α-L-furanose configuration with an average molecular weight of 2.06 kDa.NMR spectra and monosaccharide constitution analyses revealed that it had a backbone of→5)-α-L-Araf-(1→with α-L-Araf(1→as the terminal residue.In vitro experiments found that it could lead to apoptosis and inhibit hepatocellular carcinoma cell proliferation by arresting them in the S phase.In vivo experiments showed that it protected immune organs such as the thymus and spleen,enhanced immune cell activities,stimulated cytokine release,augmented the abundance of CD8,CD3,CD4,and CD 19 positive lymphocytes,and markedly impeded solid hepatocellular carcinoma progression in mice.Hematoxylin and eosin staining and cell cycle examination also indicated that LMW-CPS arrested hepatocellular carcinoma cells at the S phase to induce apoptosis.These findings indicated its promising potential for the treatment of hepatocellular carcinoma.展开更多
The internal flow of a droplet in the nonlinear extensional flow field will exhibit more than two internal circulations with the variation of nonlinear intensity(E).In this paper,the effect of positions and sizes of i...The internal flow of a droplet in the nonlinear extensional flow field will exhibit more than two internal circulations with the variation of nonlinear intensity(E).In this paper,the effect of positions and sizes of internal circulations on internal mass transfer rate of a single spherical droplet in a nonlinear extensional flow field is studied and compared with that in a linear extensional flow field.The simulation results show that when E≥0,there are two symmetrical internal circulations in the droplet,which is the same with that in a linear extensional flow.The limit value of mass transfer rate Sh is 15,which is equal to that in a linear extensional flow,no matter how large E is.When E≤-3/7,the number of internal flow circulation of a droplet increase to four and the transfer rate Sh increases.When E=-1,the maximum internal transfer rate Sh equals 30 which is twice of that in a linear extensional flow.The generation of new flow circulations in droplets and the circulation positions will enhance mass transfer when E≤-3/7,which provides a new idea for enhancing the internal mass transfer rate of droplets.展开更多
This work systematically simulates the external mass transfer from/to a spherical drop and solid particle suspended in a nonlinear uniaxial extensional creeping flow.The mass transfer problem is governed by three dime...This work systematically simulates the external mass transfer from/to a spherical drop and solid particle suspended in a nonlinear uniaxial extensional creeping flow.The mass transfer problem is governed by three dimensionless parameters:the viscosity ratio(λ),the Peclet number(Pe),and the nonlinear intensity of the flow(E).The existing mass transfer theory,valid for very large Peclet numbers only,is expanded,by numerical simulations,to include a much larger range of Peclet numbers(1≤Pe≤105).The simulation results show that the dimensionless mass transfer rate,expressed as the Sherwood number(5 h),agrees well with the theoretical results at the convection-dominated regime(Pe>103).Only when E>5/4,the simulated Sh for a solid sphere in the nonlinear uniaxial extensional flow is larger than theoretical results because the theory neglects the effect of the vortex formed outside the particle on the rate of mass transfer.Empirical correlations are proposed to predict the influence of the dimensionless governing parameters(λ,Pe,E)on the Sherwood number(Sh).The maximum deviations of all empirical correlations are less than 15%when compared to the numerical simulated results.展开更多
基金supported by the National Key Research and Development Program of China (2022YFF1100904)the Tianjin Key R&D Program (21YFSNSN00110)+2 种基金the Science and Technology Planning Project of State Administration for Market Regulation (2019MK005, 2020MK010, 2022MK012)Tianjin Administration for Market Regulation (2019-W20)State Criteria for Food Safety (spaq-2020-08, spaq-2020-31, spaq-2021-07, spaq-2022-05)。
文摘A novel low molecular weight compound polysaccharide(LMW-CPS) was identified from a specific combination of Chinese herb ingredients.The monosaccharide composition of LMW-CPS was consisted of single arabinose,which had an α-L-furanose configuration with an average molecular weight of 2.06 kDa.NMR spectra and monosaccharide constitution analyses revealed that it had a backbone of→5)-α-L-Araf-(1→with α-L-Araf(1→as the terminal residue.In vitro experiments found that it could lead to apoptosis and inhibit hepatocellular carcinoma cell proliferation by arresting them in the S phase.In vivo experiments showed that it protected immune organs such as the thymus and spleen,enhanced immune cell activities,stimulated cytokine release,augmented the abundance of CD8,CD3,CD4,and CD 19 positive lymphocytes,and markedly impeded solid hepatocellular carcinoma progression in mice.Hematoxylin and eosin staining and cell cycle examination also indicated that LMW-CPS arrested hepatocellular carcinoma cells at the S phase to induce apoptosis.These findings indicated its promising potential for the treatment of hepatocellular carcinoma.
基金supported by the National Key Research and Development Program of China(2021YFC2902502)the National Natural Science Foundation of China(22078320,22035007)+4 种基金the NSFC-EU project(31961133018)the Shandong Provincial Key Research and Development Program(2022CXGC020106)the Shandong Key Research and Development Program(International Cooperation Office)(2019GHZ018)the Shandong Province Postdoctoral Innovative Talents Support Plan(SDBX2020018)the External Cooperation Program of BIC,Chinese Academy of Sciences(122111KYSB20190032)。
文摘The internal flow of a droplet in the nonlinear extensional flow field will exhibit more than two internal circulations with the variation of nonlinear intensity(E).In this paper,the effect of positions and sizes of internal circulations on internal mass transfer rate of a single spherical droplet in a nonlinear extensional flow field is studied and compared with that in a linear extensional flow field.The simulation results show that when E≥0,there are two symmetrical internal circulations in the droplet,which is the same with that in a linear extensional flow.The limit value of mass transfer rate Sh is 15,which is equal to that in a linear extensional flow,no matter how large E is.When E≤-3/7,the number of internal flow circulation of a droplet increase to four and the transfer rate Sh increases.When E=-1,the maximum internal transfer rate Sh equals 30 which is twice of that in a linear extensional flow.The generation of new flow circulations in droplets and the circulation positions will enhance mass transfer when E≤-3/7,which provides a new idea for enhancing the internal mass transfer rate of droplets.
基金support and helpful insight.This work was supported by the National Key Research and Development Program(2021YFC2902502)the National Natu-ral Science Foundation of China(21938009,91934301,22078320)+5 种基金the Major Scientific and Technological Innovation Projects in Shan-dong Province(2019JZZY010302)the Shandong Key Research and Development Program(International Cooperation Office)(2019GHZ018)the Shandong Province Postdoctoral Innovative Talents Support Plan(SDBX2020018)the External Cooperation Program of BIC,Chinese Academy of Sciences(122111KYSB20190032)Chemistry and Chemical Engineering Guangdong Laboratory(1922006)GHfund B(202107021062).
文摘This work systematically simulates the external mass transfer from/to a spherical drop and solid particle suspended in a nonlinear uniaxial extensional creeping flow.The mass transfer problem is governed by three dimensionless parameters:the viscosity ratio(λ),the Peclet number(Pe),and the nonlinear intensity of the flow(E).The existing mass transfer theory,valid for very large Peclet numbers only,is expanded,by numerical simulations,to include a much larger range of Peclet numbers(1≤Pe≤105).The simulation results show that the dimensionless mass transfer rate,expressed as the Sherwood number(5 h),agrees well with the theoretical results at the convection-dominated regime(Pe>103).Only when E>5/4,the simulated Sh for a solid sphere in the nonlinear uniaxial extensional flow is larger than theoretical results because the theory neglects the effect of the vortex formed outside the particle on the rate of mass transfer.Empirical correlations are proposed to predict the influence of the dimensionless governing parameters(λ,Pe,E)on the Sherwood number(Sh).The maximum deviations of all empirical correlations are less than 15%when compared to the numerical simulated results.
