1.INTRODUCTION Hematopoietic stem cell transplantation(HSCT)is a key therapeutic approach for treating a range of hematologic and non-hematologic disorders that require CD34+hematopoietic progenitor cells(HPCs)derived...1.INTRODUCTION Hematopoietic stem cell transplantation(HSCT)is a key therapeutic approach for treating a range of hematologic and non-hematologic disorders that require CD34+hematopoietic progenitor cells(HPCs)derived from sources such as bone marrow,cord blood,or peripheral blood.In the case of peripheral blood cells harvested through apheresis,mobilization with granulocyte colony-stimulating factor(G-CSF)is commonly employed for both autologous and allogeneic donors.G-CSF can induce effective HPC mobilization through various mechanisms1;however,despite its known benefits,it may trigger adverse reactions,including a hypercoagulable state,by increasing the levels of factor VIII coagulant activity and thrombin generation,placing some donors at increased risk.2,3 Herein,we present a case of an allogeneic donor with unexpected G-CSF-induced hypercoagulability,resulting in 2 consecutive unsuccessful HPC apheresis[HPC(A)]procedures.展开更多
文摘1.INTRODUCTION Hematopoietic stem cell transplantation(HSCT)is a key therapeutic approach for treating a range of hematologic and non-hematologic disorders that require CD34+hematopoietic progenitor cells(HPCs)derived from sources such as bone marrow,cord blood,or peripheral blood.In the case of peripheral blood cells harvested through apheresis,mobilization with granulocyte colony-stimulating factor(G-CSF)is commonly employed for both autologous and allogeneic donors.G-CSF can induce effective HPC mobilization through various mechanisms1;however,despite its known benefits,it may trigger adverse reactions,including a hypercoagulable state,by increasing the levels of factor VIII coagulant activity and thrombin generation,placing some donors at increased risk.2,3 Herein,we present a case of an allogeneic donor with unexpected G-CSF-induced hypercoagulability,resulting in 2 consecutive unsuccessful HPC apheresis[HPC(A)]procedures.
