Layered polymer suffers from a transfer barrier of photogenerated carriers resulting from the lack of interlamellar connection channels and intralayer disorder.Herein,a layer-stacked crystalline carbon nitride nanorod...Layered polymer suffers from a transfer barrier of photogenerated carriers resulting from the lack of interlamellar connection channels and intralayer disorder.Herein,a layer-stacked crystalline carbon nitride nanorod resembling an accordion(A-CNR)grafted abundant interlamellar oxygen-containing groups is ingeniously designed to break through the transfer barrier between layers without inserting any extra impurities.Density functional theory reveals that electrons are enriched near the oxygencontaining groups,promoting the extension and coupling of interlayer electron clouds.This reduces the interlamellar electrostatic potential barrier from 5.38 to 2.74 e V.Remarkably,the groups not only establish interlayer bridges but also guide carriers to the bridge entrance,further enhancing interlayer carrier transfer.Additionally,the intralayer carrier separation and transfer are also improved,profiting from the asymmetrical charge distribution and high crystallinity.A-CNR exhibits impressive photoelectric properties and photocatalytic water disinfection capability.Within 18 min irradiation,over 10~6 colony-forming units(CFU)/mL of bacteria are completely inactivated.Moreover,A-CNR can be dispersed in water over a long period benefiting from the introduced oxygen-containing groups,making it suitable for photocatalysis in the aqueous phase.The work provides a feasible and effective strategy to overcome the inherent barrier of layered polymeric photocatalysts.展开更多
Background Perforin(PRF1)gene mutation can cause the onset of hemophagocytic lymphohistiocytosis(HLH).It has reported that PRFl Ala91 Val polymorphism was related with HLH risk.In the meta-analysis,we aim to evaluate ...Background Perforin(PRF1)gene mutation can cause the onset of hemophagocytic lymphohistiocytosis(HLH).It has reported that PRFl Ala91 Val polymorphism was related with HLH risk.In the meta-analysis,we aim to evaluate the association between PRF1 Ala91 Val polymorphism and HLH risk.Methods We accomplished a meta-analysis of six published case-control studies including 391 patients with HLH and 975 controls.We evaluated the quality of each study through Newcastle-Ottawa Scale(NOS).Data analysis was performed with Stata software.Results In general,all studies were of high quality(NOS score higher than 7).There were statistically significant between the PRFl Ala91 Val polymorphism and HLH risk though the pooled analysis[for Ala/Val vs.Ala/Ala:pooled odds ratio(OR)=3.22,95%confidence interval(Cl)1.08-9.56,P=0.035,random model;for Ala/Val+Val/Val vs.Ala/Ala:pooled OR=2.96,95%Cl 1.14-7.69,P=0.025,random model].Furthermore,sensitivity analysis also revealed a relationship between PRFl Ala91Val polymorphism and HLH risk(for Ala/Val vs.Ala/Ala:pooled OR=5.236,95%Cl 2.72-10.08,P<0.000,/2=12.1%,^heterogeneity=0-332;for Ala/Val+Val/Val vs.Ala/Ala,pooled OR=4.856,95%Cl 2.66-8.85,P<0.000,/2=5.9%,Pheterogeneity=0.373).Funnel plot and Egger’s test did not indicate obvious published bias(P=0.841 for Ala/Val vs.Ala/Ala;?=0.284 for Ala/Val+Val/Val vs.Ala/Ala).Conclusion This meta-analysis indicated that PRFl Ala91 Val polymorphism affects the factor for developing HLH and future studies of PRFl Ala91 Val on the onset of HLH will be guaranteed.展开更多
Importance:Allogeneic hematopoietic stem cell transplantation(alloHSCT)is considered the only effective treatment for chronic active Epstein–Barr virus infection(CAEBV).The clinical efficacy and safety of allo-HSCT w...Importance:Allogeneic hematopoietic stem cell transplantation(alloHSCT)is considered the only effective treatment for chronic active Epstein–Barr virus infection(CAEBV).The clinical efficacy and safety of allo-HSCT with different conditioning regimens in children with CAEBV remain unclear.Objective:To evaluate the effectiveness and safety of allo-HSCT with the modified myeloablative conditioning(MAC)regimen for children with CAEBV and also the factors affecting the outcomes.Methods:We retrospectively analyzed children with CAEBV who underwent allo-HSCT with the modified MAC regimen at Beijing Children’s Hospital,Capital Medical University from October 2016 to June 2021.Data related to the clinical manifestations,engraftment,and outcome were extracted from the medical records.Results:The cohort comprised 41 patients(24 males,17 females)with a median transplantation age of 92.6(60.4,120.7)months and a median follow-up time of 28.2(15.3,40.2)months.Four patients(9.8%)died,among which three died from primary disease relapse,and one died from grade IV acute graft-versus-host diseases(aGVHD)after stopping treatment.The 3-year overall survival(OS)and 3-year event-free survival(EFS)rates were 88.8%±5.4%and 85.0%±5.7%,respectively.The 3-year OS and EFS did not significantly differ between the patients with hemophagocytic lymphohistiocytosis(HLH)and the patient without HLH(87.7%±6.8%vs.91.7%±8.0%,P=0.790;85.0%±6.9%vs.84.6%±10.0%,P=0.921),or among the patients with complete remission,partial remission,and activity disease before HSCT(all P>0.05).Multivariate analysis showed that grade III–IV aGVHD was a risk factor for mortality(Hazards ratio:11.65,95%confidence interval:1.00,136.06;P=0.050).Interpretation:Allo-HSCT with the modified MAC regimen is safe and effective for pediatric CAEBV.This treatment benefits patients with HLH or active disease.Patients with Grade III–IV aGVHD may be associated with worse outcomes.展开更多
基金supported by the National Natural Science Foundation of China(52103315)the Natural Science Foundation of Jiangsu(BK20221270)+3 种基金the Science and Technology Program of Suzhou(SS202113)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX20_0703)the Open Project of Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province(CSPC202310)the Industrial Guided Development Project of Suzhou Yangcheng Lake。
文摘Layered polymer suffers from a transfer barrier of photogenerated carriers resulting from the lack of interlamellar connection channels and intralayer disorder.Herein,a layer-stacked crystalline carbon nitride nanorod resembling an accordion(A-CNR)grafted abundant interlamellar oxygen-containing groups is ingeniously designed to break through the transfer barrier between layers without inserting any extra impurities.Density functional theory reveals that electrons are enriched near the oxygencontaining groups,promoting the extension and coupling of interlayer electron clouds.This reduces the interlamellar electrostatic potential barrier from 5.38 to 2.74 e V.Remarkably,the groups not only establish interlayer bridges but also guide carriers to the bridge entrance,further enhancing interlayer carrier transfer.Additionally,the intralayer carrier separation and transfer are also improved,profiting from the asymmetrical charge distribution and high crystallinity.A-CNR exhibits impressive photoelectric properties and photocatalytic water disinfection capability.Within 18 min irradiation,over 10~6 colony-forming units(CFU)/mL of bacteria are completely inactivated.Moreover,A-CNR can be dispersed in water over a long period benefiting from the introduced oxygen-containing groups,making it suitable for photocatalysis in the aqueous phase.The work provides a feasible and effective strategy to overcome the inherent barrier of layered polymeric photocatalysts.
基金This study was funded by National Science and Technology Key Projects(No.2017ZX09304029001)the Beijing Municipal Science&Technology Commission(No.Z171100001017050)+4 种基金the National Natural Science Foundation of China(No.81700186,81800189)the Scientific Research Common Program of Beijing Municipal Commission of Education(No.KM201710025019)the Talent Training Project-Fostering Fund of National Natural Science Foundation of Beijing Children's Hospital,Capital Medical University(No.GPY201713)the Special Fund of The Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority(No.XTZD20180202)the Guangdong Province Key Laboratory of Popular High Performance Computers of Shenzhen University(SZU-GDPHPCL2017).
文摘Background Perforin(PRF1)gene mutation can cause the onset of hemophagocytic lymphohistiocytosis(HLH).It has reported that PRFl Ala91 Val polymorphism was related with HLH risk.In the meta-analysis,we aim to evaluate the association between PRF1 Ala91 Val polymorphism and HLH risk.Methods We accomplished a meta-analysis of six published case-control studies including 391 patients with HLH and 975 controls.We evaluated the quality of each study through Newcastle-Ottawa Scale(NOS).Data analysis was performed with Stata software.Results In general,all studies were of high quality(NOS score higher than 7).There were statistically significant between the PRFl Ala91 Val polymorphism and HLH risk though the pooled analysis[for Ala/Val vs.Ala/Ala:pooled odds ratio(OR)=3.22,95%confidence interval(Cl)1.08-9.56,P=0.035,random model;for Ala/Val+Val/Val vs.Ala/Ala:pooled OR=2.96,95%Cl 1.14-7.69,P=0.025,random model].Furthermore,sensitivity analysis also revealed a relationship between PRFl Ala91Val polymorphism and HLH risk(for Ala/Val vs.Ala/Ala:pooled OR=5.236,95%Cl 2.72-10.08,P<0.000,/2=12.1%,^heterogeneity=0-332;for Ala/Val+Val/Val vs.Ala/Ala,pooled OR=4.856,95%Cl 2.66-8.85,P<0.000,/2=5.9%,Pheterogeneity=0.373).Funnel plot and Egger’s test did not indicate obvious published bias(P=0.841 for Ala/Val vs.Ala/Ala;?=0.284 for Ala/Val+Val/Val vs.Ala/Ala).Conclusion This meta-analysis indicated that PRFl Ala91 Val polymorphism affects the factor for developing HLH and future studies of PRFl Ala91 Val on the onset of HLH will be guaranteed.
基金Beijing Municipal Science&Technology Commission,Grant/Award Number:Z171100001017050National Science and Technology Key Projects,Grant/Award Number:2017ZX09304029。
文摘Importance:Allogeneic hematopoietic stem cell transplantation(alloHSCT)is considered the only effective treatment for chronic active Epstein–Barr virus infection(CAEBV).The clinical efficacy and safety of allo-HSCT with different conditioning regimens in children with CAEBV remain unclear.Objective:To evaluate the effectiveness and safety of allo-HSCT with the modified myeloablative conditioning(MAC)regimen for children with CAEBV and also the factors affecting the outcomes.Methods:We retrospectively analyzed children with CAEBV who underwent allo-HSCT with the modified MAC regimen at Beijing Children’s Hospital,Capital Medical University from October 2016 to June 2021.Data related to the clinical manifestations,engraftment,and outcome were extracted from the medical records.Results:The cohort comprised 41 patients(24 males,17 females)with a median transplantation age of 92.6(60.4,120.7)months and a median follow-up time of 28.2(15.3,40.2)months.Four patients(9.8%)died,among which three died from primary disease relapse,and one died from grade IV acute graft-versus-host diseases(aGVHD)after stopping treatment.The 3-year overall survival(OS)and 3-year event-free survival(EFS)rates were 88.8%±5.4%and 85.0%±5.7%,respectively.The 3-year OS and EFS did not significantly differ between the patients with hemophagocytic lymphohistiocytosis(HLH)and the patient without HLH(87.7%±6.8%vs.91.7%±8.0%,P=0.790;85.0%±6.9%vs.84.6%±10.0%,P=0.921),or among the patients with complete remission,partial remission,and activity disease before HSCT(all P>0.05).Multivariate analysis showed that grade III–IV aGVHD was a risk factor for mortality(Hazards ratio:11.65,95%confidence interval:1.00,136.06;P=0.050).Interpretation:Allo-HSCT with the modified MAC regimen is safe and effective for pediatric CAEBV.This treatment benefits patients with HLH or active disease.Patients with Grade III–IV aGVHD may be associated with worse outcomes.
