Adenosine triphosphate(ATP)is well-known as a universal source of energy in living cells.Less known is that this molecule has a variety of important signaling func-tions:it activates a variety of specific metabotropic...Adenosine triphosphate(ATP)is well-known as a universal source of energy in living cells.Less known is that this molecule has a variety of important signaling func-tions:it activates a variety of specific metabotropic(P2Y)and ionotropic(P2X)receptors in neuronal and non-neu-ronal cell membranes.So,a wide variety of signaling func-tions well fits the ubiquitous presence of ATP in the tissues.Even more ubiquitous are protons.Apart from the unspe-cific interaction of protons with any protein,many physi-ological processes are affected by protons acting on specific ionotropic receptors--acid-sensing ion channels(ASICs).Both protons(acidification)and ATP are locally elevated in various pathological states.Using these fundamentally important molecules as agonists,ASICs and P2X receptors signal a variety of major brain pathologies.Here we briefly outline the physiological roles of ASICs and P2X receptors,focusing on the brain pathologies involving these receptors.展开更多
基金supported by the National Research Foundation of Ukraine(https:/nrfu.org.ua/en/,2020.02/0263)Die Deutsche Forschungsgemeinschaft(https://www.dfg.del,441694049).
文摘Adenosine triphosphate(ATP)is well-known as a universal source of energy in living cells.Less known is that this molecule has a variety of important signaling func-tions:it activates a variety of specific metabotropic(P2Y)and ionotropic(P2X)receptors in neuronal and non-neu-ronal cell membranes.So,a wide variety of signaling func-tions well fits the ubiquitous presence of ATP in the tissues.Even more ubiquitous are protons.Apart from the unspe-cific interaction of protons with any protein,many physi-ological processes are affected by protons acting on specific ionotropic receptors--acid-sensing ion channels(ASICs).Both protons(acidification)and ATP are locally elevated in various pathological states.Using these fundamentally important molecules as agonists,ASICs and P2X receptors signal a variety of major brain pathologies.Here we briefly outline the physiological roles of ASICs and P2X receptors,focusing on the brain pathologies involving these receptors.
