Colorectal cancer is the third most diagnosed malignancy and the second-leading cause of cancer-related deaths worldwide.Management includes a combination of surgery,radiotherapy,and systemic therapy that is tailored ...Colorectal cancer is the third most diagnosed malignancy and the second-leading cause of cancer-related deaths worldwide.Management includes a combination of surgery,radiotherapy,and systemic therapy that is tailored to the stage of the disease.However,each tumor has a unique genetic profile that influences the treatment response and the overall prognosis.Biomarkers guide treatment decisions,but many chemotherapeutics lack reliable predictors.To bridge this gap patient-derived xenograft models were developed and are valuable preclinical tools.These systems utilize patient-derived tumor tissue grafted into an animal host that provides a platform for personalized drug profiling.This article surveyed recent advances in mouse and zebrafish colorectal cancer patient-derived xenografts,emphasizing their clinical utility for functional precision oncology.We explored the impact of these models on translational research,discussed current limitations,and outlined key priorities for future development.展开更多
基金Supported by the European Union,the Romanian Government and the Health Program(Medical Applications of High-Power Lasers-Dr.LASER),cod MySMIS2021/SMIS2021+326475.
文摘Colorectal cancer is the third most diagnosed malignancy and the second-leading cause of cancer-related deaths worldwide.Management includes a combination of surgery,radiotherapy,and systemic therapy that is tailored to the stage of the disease.However,each tumor has a unique genetic profile that influences the treatment response and the overall prognosis.Biomarkers guide treatment decisions,but many chemotherapeutics lack reliable predictors.To bridge this gap patient-derived xenograft models were developed and are valuable preclinical tools.These systems utilize patient-derived tumor tissue grafted into an animal host that provides a platform for personalized drug profiling.This article surveyed recent advances in mouse and zebrafish colorectal cancer patient-derived xenografts,emphasizing their clinical utility for functional precision oncology.We explored the impact of these models on translational research,discussed current limitations,and outlined key priorities for future development.
